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김부경,최영식,석광혁,이종진,Gina Jieun Hong,P M. Afidchao,정지영 고신대학교(의대) 고신대학교 의과대학 학술지 2018 고신대학교 의과대학 학술지 Vol.33 No.1
Objectives: Iodine deficiency causes multiple health problems. Previously we reported that 96% of high school students in Tuguegarao, Philippines had adequate iodine levels. However, iodine deficiency-associated problems remain among adults in the Philippines. Therefore, we evaluated iodine nutritional status and goiter prevalence among adults, including pregnant women, in Tuguegarao, Philippines. Methods: A total of 245 adults, including 31 pregnant women, provided samples for urinary iodine analysis, and all pregnant women completed a questionnaire about iodine deficiency. Results: The median urinary iodine level was 164.0 ± 138.4 g/L; 38.4% of the participants were iodine deficient, according to the International Council for Control of Iodine Deficiency Disorders (ICCIDD) criteria. No severe iodine deficiency was observed. Among the 31 pregnant women, 24 (77.5%) fell into the iodine deficient category defined by a stricter World Health Organization (WHO) guideline, in which iodine deficiency is considered when urinary iodine levels are below 150 g/L. Almost half (42%) of the pregnant women were unaware of the harmful effects of iodine deficiency on the human body and their fetus. Conclusions: Although iodine nutritional status in the Philippines has improved, iodine deficiency still exists among adults, especially among pregnant women. Therefore, our study strongly suggests that a better strategy should be established to monitor iodine nutritional status among adults continually, and to focus on populations susceptible to iodine deficiency, including pregnant women and women of reproductive age, to achieve the total elimination of iodine deficiency.
심인수,최명원,민예지,석광혁,김지연,정지영,옥철호,박인달 대한미생물학회 2016 Journal of Bacteriology and Virology Vol.46 No.1
Tuberculosis (TB) patients are normally treated with a combination of antibiotics. However, with improper or incompletetreatment of antibiotics, the disease may progress to multidrug-resistant TB (MDR-TB). The treatment of MDR-TB is verycostly and inefficient. Therefore, there is a great demand of new therapeutic approaches for MDR-TB such as photodynamictherapy. In this study, we tried to optimize the conditions for photodynamic inactivation of TB using methylene blue as aphotosensitizer. Different combinations of methylene blue concentrations and light doses were tested for their photodynamiceffects to A549 cells or Mycobacterium smegmatis (M. smegmatis). We also tested the effect of photodynamic therapyon ciprofloxacin-resistant M. smegmatis. Methylene blue treatment alone did not affect the survival rates of A549 cellsor bacteria up to 5 μg/ml. When the A549 and M. smegmatis cells treated with methylene blue were irradiated with laserlight (wavelength, 630 nm), photodynamic inactivation of cells was increased in methylene blue concentration- and lightdose-dependent manners. Interestingly, the ciprofloxacin-resistant M. smegmatis exhibited higher level of susceptibilityto methylene blue-mediated photodynamic inactivation. This study suggests that photodynamic therapy at 3.6 J/cm2 inthe presence of 5 μg/ml methylene blue may be an appropriate range for therapy due to the high bactericidal activity againsthigh level of ciprofloxacin-resistant M. smegmatis and the low damaging effect to mammalian cells. This study demonstratesthat photodynamic therapy could be a potential alternative for MDR-TB treatment.
Excessive Iodine Status among School-Age Children in Korea: A First Report
최영식,옥소영,권석영,정상봉,석광혁,김영진,김부경,정지영 대한내분비학회 2017 Endocrinology and metabolism Vol.32 No.3
Background: Korea is considered an iodine sufficient country, and several studies have been conducted regarding iodine status in healthy Korean adults, pregnant women, and preschool children. However, data on iodine status in Korean school-age children are lacking. Therefore, the iodine nutrition status of Korean school-age children was investigated by measuring urine iodine concentration (UIC). Methods: This cross-sectional study conducted between April and September 2016 comprised 373 school-age children. UIC was determined using a modified microplate method employing ammonium persulfate digestion followed by Sandell-Kolthoff reaction. Results: The median UIC was 458.2 μg/L. Excessive iodine intake (>300 μg/L) was found in 286 children (76.7%), with extremely high values exceeding 1,000 μg/L in 19.6% of subjects. Insufficient iodine intake (<100 μg/L) was observed in eight children (2.1%). UIC values were not significantly different between sexes. Conclusion: Korean school-age children showed excessive iodine intake. Therefore, education regarding adequate iodine intake in school-age children is needed.