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서제덕(Je-Duck Suh),명훈(Hoon Myung),강나라(Nara Kang),정필훈(Pill-Hoon Choung) 대한구강악안면외과학회 2005 대한구강악안면외과학회지 Vol.31 No.5
Purpose: To determine the role of Insulin-like Growth Factor-I (IGF-I) in the regulation of Vascular Endothelial Growth Factor (VEGF) expression in MG-63 cells and then to find the mechanism b which this regulation occurs. Materials and methods: MG-63 cells were grown to confluence in 60-mm dishes. To determine the effects of IGF-I on expression of VEGF mRNA according to time and concentration, the cells were treated with 10 nM IGF-I, following isolation of total RNA and Northern blot analysis after 1, 2, 4, 8, 12, 24 hours and after 2 hours of treatment with 0.5, 2, 10, 25, 50 nM IGF-I respectively, isolation of total RNA and Northern blot analysis were followed. To determine the mechanism of action of IGF-I, inhibitors such as hydroxyurea (76.1 ㎍/㎖), actinomycin D (2.5 ㎍/㎖), cycloheximide (10 ㎍/㎖) were added 1 hour after treatment of 10 nM IGF-I. Results: 1. the expression of VEGF mRNA was increased with treatment of IGF-I. 2. The expression of VEGF mRNA was increased according to time- and concentration dependent manner of IGF-I. 3. The effect of IGF-I was decreased by hydroxyuera, actinomycin D, but not by cycloheximide. Conclusion: IGF-I regulate the expression of VEGF mRNA in the level of DNA synthesis and transcription. These results could suggest that IGF-I plays an important role in angiogenesis in the process of new bone formation and remodeling.
정일혁,한기덕,서제덕,황경균,Chung, Il-Hyuk,Han, Ki-Deok,Suh, Je-Duck,Hwang, Kyung-Gyun 대한악안면성형재건외과학회 2005 Maxillofacial Plastic Reconstructive Surgery Vol.27 No.5
This study investigated the mandibular fractures that were treated at the Seoul National University Boramae Hospital in order to analyze the characteristics of mandibular fractures and the relationship between the causes and injury patterns. A total of 141 patients with mandibular fractures who were treated between 1996 and 2004 were analyzed retrospectively. The male to female ratio in the patient group was 5.13:1, and the mean age was 33.7 years. The most common etiologic factor was assaults (45.4%), and which was followed by activities associated with daily-life (40.4%) includeding falls, stumbling, collisions, and traffic accidents (11.3%). Single fracture sites were present in 75 patients (53.2%), two or more fracture sites were observed in other patients, and a total of 211 fracture sites were observed. The mandibular angle fractures (46.7%) was the most common in case of single fractures, and symphysis and angle fractures (45.4%) was most common in multiple fractures. Through out overall fracture sites, the most common fracture site was the symphysis (41.2%), followed by the angle (32.2%) and condyle (18.5%). Among assault and falls-related injuries, the common involving sites were the symphysis, and followed by the body and condyle. In case of traffic accidents, the symphysis fracture was the most common, and which was followed by the condyle and angle fractures. This study documented the characteristics of the mandibular fractures. The results demonstrate that preventive measures according to these characteristics will need to be implemented in order to minimize the risk of maxillofacial injuries. 저자 등은 1996년 1월부터 2004년 12월까지 서울대학교 보라매병원 구강악안면외과에서 치료받은 141명의 하악골 골절 환자의 임상적 연구를 통하여 다음을 알 수 있었다. 1. 전체 환자에서 남,녀 성별 발생빈도는 5.13대 1로 남자에서 호발 하였으며, 연령대별로는 20대에서 가장 빈발하였고 (30.5%), 그 다음 30대, 40대 (22.7%) 순이었다. 2. 하악골 골절의 원인으로 폭행 (45.4%), 낙상, 추락 및 충돌 (40.4%), 교통사고 (11.3%) 순이었다. 3. 골절부의 위치는 하악 정중부 (41.2%), 우각부(32.2%), 과두부 골절(18.5%)의 순으로 나타났으며, 단일 골절의 경우 하악 우각부 골절이 (46.7%)로 가장 많았고, 두 군데 이상의 골절의 하악 정중부 및 우각부 동시 골절이 가장 많았다 (45.5%). 4. 교통사고로 인한 하악 골절은 정중부, 과두부, 우각부 골절의 순으로 발생 빈도를 보였고, 폭력과 낙상, 추락 및 충돌 등으로 인한 골절의 경우 정중부, 우각부, 과두부 골절 순으로 발생빈도를 보였다.
컴퓨터 단층촬영을 이용한 중안모 계측과 상악골 절단술에의 응용
정필훈,유충규,이은경,서제덕,정일혁,Choung, Pill-Hoon,Yoo, Chung-Kyu,Lee, Eun-Kyung,Suh, Je-Duck,Chung, Il-Hyuk 대한악안면성형재건외과학회 2006 Maxillofacial Plastic Reconstructive Surgery Vol.28 No.3
Various methods have been used in the past to indirectly analyze the craniofacial region. Among these, the lateral and posterior-anterior cephalometircs are used for the evaluation of the dentofacial deformities. However, cephalometircs create inaccuracies because of the inherent enlargement and distortion of the image. The interpretation of cephalometric films is also problematic: the number of anatomic landmarks that can be identified accurately is limited, and the overlap of structures on a radiograph making locating these landmarks difficult. To overcome these problems, computed tomography(CT) has been recommended as an useful modality in the diagnosis, surgical planning, and follow-up of craniofacial anomalies. There is no significant enlargement or distortion of the image, overlap of structure, or tracing error. And the number of anatomic landmarks is vast. The purpose of this study was to examine the orbit and midfacial region using Occlusal Maxillary CT, consisted of slices parallel to the occlusal plane. Based on these CT scan, we provide the data that could be applied to monitor an individual patient's skeletal pattern and the guide to the maxillary osteotomy.
이종호(Jong-Ho Lee),서제덕(Je-Duck Suh),이은진(Eun-Jin Lee),명훈(Hoon Myoung),황순정(Soon-Jung Hwang),최진영(Jin-Young Choi),정필훈(Pill-Hoon Chung),김명진(Myung-Jin Kim) 대한구강악안면외과학회 2002 대한구강악안면외과학회지 Vol.28 No.5
Ameloblastoma of the maxilla is an unusual epithelial tumor of odontogenic origin. According to many authors and reports, ameloblastoma account for approximately 1% of all tumors of the jaws, but when pseudotumors and cysts are excluded, the ratio rises to 11%. Of these tumors,80% originate in the mandible, while 20% originate in the maxilla. Although it is considered benign histopathologically, it can behave in a slowly growing infiltrative fashion, with multiple recurrences and eventual intracranial, or even distant, spread. We clinically analyzed common site in maxilla, radiographic findings, recurrence rate, duration between treatment and recurrence, the presence and site of distant metastasis in 15 patients who were diagnosed as ameloblastoma of the maxilla and took treatments from 1985 to 1999 in Dept. of Oral and Maxillofacial Surgery, Dental Hospital, Seoul National University. In this paper, treatment outcomes and our clinical experiences of maxillary ameloblastoma are reported with review of literatures.
치조정 골 소실이 심한 경우와 치간 사이 공간이 부족한 경우에서의 미니 임프란트 식립
서미현,유충규,이은경,정다운,서제덕,정일혁,Seo, Mi-Hyun,Yoo, Chung-Kyu,Lee, Eun-Kyung,Jung, Da-Unn,Suh, Je-Duck,Chung, Il-Hyuk 대한악안면성형재건외과학회 2009 Maxillofacial Plastic Reconstructive Surgery Vol.31 No.1
Purpose: This study presents the use of mini implants for fixed restoration and implant supported overdenture to enable the practitioner to overcome the anatomic obstacles of ridge width and narrow interdental space. Patients and methods: This study consisted of 9 patients who required single implants for one or two teeth replacement and 1 patient who required implant supported overdenture after mandiblectomy, iliac bone graft due to ghost cell tumor. The ages ranged from 29 to 70 years (mean 51). All patients were in good health. Clinical and radiographs were taken pretreatment, postoperatively, during rehabilitation, and at follow ups. Results: Total implant survival rate was 94.7%. One implant was removed due to its mobility as a result of bad bone quality (Type IV) and patient's carelessness (Heavy smoker). All patients except one reported complete satisfaction regarding to function, aesthetics, and phonetics. Radiographic follow up every 3months postoperatively showed success in achieving function and maintaining marginal bone level. Conclusion: Clinician can overcome both severe ridge deficiency and small interdental space with mini implant.
백서 두개골 결손부의 골재생에 fibrin glue가 미치는 영향에 관한 실험적 연구
임재석,장현석,윤정주,이의석,박은용,서제덕,Rim, Jae-Suk,Jang, Hyon-Seok,Eune, Jung-Ju,Lee, Eui-Seok,Park, Eun-Yong,Suh, Je-Duck 대한악안면성형재건외과학회 2005 Maxillofacial Plastic Reconstructive Surgery Vol.27 No.5
Fibrin glue is composed of fibrinogen and thrombin and used in various regions for multiple use. Basic principle is that thrombin converts fibrinogen to fibrin in the presence of $Ca^{2+}$. The structure of fibrin is loose at the beginning, but after about 5 minutes a tight structure is formed under the influence of factor VIII which changes fibrin monomer into fibrin polymer. Fibrin glue is used for tissue adhesive, suture, local hemostasis, wound healing, closure of subdural space. Fibrin adhesive has been used in oral and maxillofacial surgery for hemostasis after tooth extraction in patients with coagulation disorders, skin graft fixation, reattachment of periodontal flaps, in combination with autogenous bone chips to fill the bony cavities following cyst removal, and for securing the hydroxyapatite granules for maxillary alveolar ridge augmentation. This study was designed for researching influence of fibrin glue during healing phase after making artificial bone defect.
관골궁 골절의 정복시 수술 중 C-Arm 사용의 유용성: 증례보고
서미현,천강용,윤준용,유충규,이은경,이원덕,서제덕,Seo, Mi-Hyun,Cheon, Kang-Yong,Yun, Jun-Yong,Yoo, Chung-Kyu,Lee, Eun-Kyung,Lee, Won-Deok,Suh, Je-Duck 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.4
The zygoma is second most commonly vulnerable facial bone in fracture, in number only by nasal fractures. It is difficult to evaluate reduction state intraoperatively, because almost surgeons reduce the fractured zygoma by blind method. We suggest the use of orthopedic C-arm intraoperatively. We use plain radiography, CT to evaluate preoperative state. Gilles approach or intraoral approach were used to reduce the fractured zygomatic arch. The C-arm was positioned at chin area, used to evaluate reduction intraoperatively. We got postoperative image by CT or submento-vertex view. There are variable methods to evaluate reduction intraoperatively: palpation, ultrasonography, CT, plain films. C-arm is considered superior diagnostic tool to other methods. The use of intraoperative C-arm was very efficient, it could bring better results.
반안면왜소증 환자의 안면비대칭 해소를 위한 늑연골 이식 및 악교정 수술의 동시 이용: 증례보고
서미현,천강용,윤준용,유충규,이은경,이원덕,서제덕 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.4
The zygoma is second most commonly vulnerable facial bone in fracture, in number only by nasal fractures. It is difficult to evaluate reduction state intraoperatively, because almost surgeons reduce the fractured zygoma by blind method. We suggest the use of orthopedic C-arm intraoperatively. We use plain radiography,CT to evaluate preoperative state. Gilles` approach or intraoral approach were used to reduce the fractured zygomatic arch. The C-arm was positioned at chin area, used to evaluate reduction intraoperatively. We got postoperative image by CT or submento-vertex view. There are variable methods to evaluate reduction intraoperatively: palpation, ultrasonography, CT, plain films. C-arm is considered superior diagnostic tool to other methods. The use of intraoperative C-arm was very efficient, it could bring better results.