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스트론튬(Strontium)이 도핑된 다공성 BCP 뼈 이식제가 조골세포에 미치는 영향
변인선,서형석,이병택,송호연,Byun, In-Seon,Sarkar, Swapan Kumar,Seo, Hyung-Seok,Lee, Byong-Taek,Song, Ho-Yeon 한국재료학회 2010 한국재료학회지 Vol.20 No.3
In this study, we investigated primary biocompatibility and osteogenic gene expression of porous granular BCP bone substitutes with or without strontium (Sr) doping. In vitro biocompatibility was investigated on fibroblasts like L929 cells and osteoblasts like MG-63 cells using a cell viability assay (MTT) and one cell morphological observation by SEM, respectively. MTT results showed a cell viability percent of L929 fibroblasts, which was higher in Sr-BCP granules (98-101%) than in the non-doped granules (92-96%, p < 0.05). Osteoblasts like MG-63 cells were also found to proliferate better on Sr-doped BCP granules (01-111%) than on the non-doped ones (92-99%, p < 0.05) using an MTT assay. As compared with pure BCP granules, SEM images of MG-63 cells grown on sample surfaces confirmed that cellular spreading, adhesion and proliferation were facilitated by Sr doping on BCP. Active filopodial growth of MG-63 cells was also observed on Sr-doped BCP granules. The cells on Sr-doped BCP granules were well attached and spread out. Gene expression of osteonectin, osteopontin and osteoprotegrin were also evaluated using reverse transcriptase polymerase chain reaction (RT-PCR), which showed that the mRNA phenotypes of these genes were well maintained and expressed in Sr-doped BCP granules. These results suggest that Sr doping in a porous BCP granule can potentially enhance the biocompatibility and bone ingrowth capability of BCP biomaterials.
대식세포가 β-tricalcium Phosphate 뼈이식제의 생분해에 미치는 영향
김영희,변인선,오익현,민영기,양훈모,이병택,송호연,Kim, Young-Hee,Jyoti, Anirban,Byun, In-Sun,Oh, Ik-Hyun,Min, Young-Ki,Yang, Hun-Mo,Lee, Byong-Taek,Song, Ho-Yeon 한국세라믹학회 2008 한국세라믹학회지 Vol.45 No.10
Various calcium phosphate bioceramics are distinguished by their excellent biocompatibility and osteoconductivity. Especially, the exceptional biodegradability of $\beta$-TCP makes it a bone graft substitute of choice in many clinical applications. The activation of osteoclasts, differentiated from macrophage precursor cells, trigger a cell-mediated resorption mechanism that renders $\beta$-TCP biodegradable. Based on this evidence, we studied the biodegradation process of granular-type $\beta$-TCP bone graft substitute through in vitro and in vivo studies. Raw 264.7 cells treated with RANKL and M-CSF differentiated into osteoclasts with macrophage-like properties, as observed with TRAP stain. These osteoclasts were cultured with $\beta$-TCP nano powders synthesized by microwave-assisted process. We confirmed the phagocytosis of osteoclasts by observing $\beta$-TCP particles in their phagosomes via electron microscopy. No damage to the osteoclasts during phagocytosis was observed, nor did the $\beta$-TCP powders show any sign of cytotoxicity. We also observed the histological changes in subcutaneous tissues of rats implanted with granule-type $\beta$-TCP synthesized by fibrous monolithic process. The $\beta$-TCP bone graft substitute was well surrounded with fibrous tissue, and 4 months after implantation, 60% of its mass had been biodegraded. Also, histological findings via H&E stain showed a higher level of infiltration of lymphocytes as well as macrophages around the granule-type $\beta$-TCP. From the results, we have concluded that macrophages play an important role in the biodegradation process of $\beta$-TCP bone graft substitutes.
이용주(Yong-Joo Lee),정진석(Jin-Seok Jeong),변인선(In-Sun Byun) 대한공간정보학회 2009 한국지형공간정보학회 학술대회 Vol.2009 No.4
본 연구는 유비쿼터스 환경기반의 도시시설물 관리방안을 제시한다. 상황인식기술은 유비쿼터스 환경에서의 필수적인 요소기술로서 각종 도시시설물 관리에 적용된다면 시설물관리(안전점검, 유지관리 등)의 효용성을 높이고 재해ㆍ재난에 따른 피해를 줄일 수 있다. 또한 유비쿼터스도시의 핵심요소인 서비스의 다양화에도 기여할 것이다. 이를 위해서 시설물관리의 전반적인 프로세스를 분석하고 상황인식기술을 적용할 수 있도록 터널관리를 사례로 제시하였다.
정진석(Jeong Jin Seok),이용주(Lee Yong Joo),변인선(Byun In Sun),김태훈(Kim Tae Hoon),송용학(Song Yong Hak) 대한공간정보학회 2009 대한공간정보학회지 Vol.17 No.2
상황인식기술은 유비쿼터스 환경에서의 필수적인 요소기술로 자리매김하고 있다. 특히 유비쿼터스도시를 구성하는 3대 요소인 유비쿼터스도시기반시설에 있어서도 상황인식기술은 매우 중요한 위치를 차지한다. 본 연구에서는 지능형 시설물 상황인식 모듈개발을 위해 상수도관의 파열에 따른 누수사고를 다양한 상황으로 가정하고 이에 대한 시나리오 및 처리과정을 제시하였다. 시설물에 대한 상황별 시나리오는 향후 상황인식 모듈개발 또는 모델링의 토대가 될 것이다. Recently, context-awareness computing becomes prerequisite to pervasive computing, called ubiquitous paradigm. Especially, it plays much of roll as a part of the ubiquitous infrastructures, one of three ubiquitous city components. This paper proposes the optimized procedures to deal with the various hypothetical water-leaking situations in the water supply systems. These procedures suggested in this paper will be employed to develop the context-awareness modules or models for urban infrastructure maintenance in the future works.