임상 ; 결혼 이주자 산모와 아기의 주산기 임상적 특징: 내국인 산모 및 신생아와 비교

백인환 ( In Hwan Baek ),김천수 ( Chun Soo Kim ),이상락 ( Sang Lak Lee ),김종인 ( Jong In Kim ) 대한주산의학회 2011 Perinatology Vol.22 No.2

목적: 최근 한국인 남성과 국제결혼 후 국내에서 생활하는 외국인 여성이 증가하는 추세이다. 이 연구는 결혼 이주자산모와 신생아의 주산기 관리의 기초 자료를 얻고자 시행하였다. 방법: 2005년 1월부터 2009년 12월까지 계명대학교 동산의료원에 입원한 결혼 이주자 산모와 이들에서 태어난 신생아를 대상으로 의무기록과 방사선 영상소견 등을 후향적으로 조사하였다. 이와 비교할 대조군은 출생연도와 재태주령, 태아수, 성별 등을 동일한 조건으로 맞춘 내국인 산모와 이들에서 태어난 신생아 중에서 2배수 무작위 추출하였다. 결과: 연구기간 동안 총 5,158명(남아: 52.7%, 여아: 47.3%)의 아기가 태어났다. 이 중 내국인 산모군 아기가 5,046명 (97.8%)였고, 결혼 이주자 산모군 아기는 66명(1.3%), 기타 외국인 산모군 아기가 48명(0.9%)였다. 결혼 이주자 산모의 국적은 베트남이 43명(63.2%)로 가장 많았고, 그 외에 중국 13명(19.1%), 필리핀 6명(8.8%) 등의 순이었다. 산모의 연령은 이주자군(24.1±4.6세)이 대조군(32.7±4.0세)에 비해 적었고, 배우자의 연령은 이주자군(42.3±7.1세)이 내국인 산모군(35.1±4.5세)보다 많았다(P<0.001). 분만 무렵 산모의 체중은 이주자군(59.2±10.5 kg)이 대조군(69.1±9.1 kg)보다 적었다(P<0.001). 산모 유병율 중 B형간염 표면항원(HBsAg) 양성율은 이주자군(13.8%)이 대조군(3.8%)보다 높았다 (P<0.05). 자궁 내 발육부전은 이주자군에서 더 많았고, 고혈압과 당뇨는 대조군에서 더 많았으나 통계적 유의성은 없었다. 이주자 아기군의 출생체중(2,680±630 g)과 두위(32.4±2.3 cm)는 대조군(2,870±590 g 및 33.2±2.1 cm)보다 작았다(P<0.05). 출생신장은 양 군간 비슷하였다(47.3±3.3 cm 대 47.8±3.3 cm). 아기의 주산기 유병율은 양군에서 비슷하였다. 결론: 결혼 이주자 산모는 HBsAg 양성율이 높고 배우자의 연령이 많은 경향이 있다. 또한 이들에서 태어난 아기는 출생체중과 두위 등의 신체계측에서 내국인 산모의 신생아와 차이가 있으므로 영유아기 성장 발달에 대한 추가적인 평가가 필요하다. Purpose: Nowadays, the population of foreign women who are married to Korean men is increasing. This study was undertaken to get clinical data for perinatal care of marriage immigrant women and their babies. Methods: Retrospective analysis of medical records was conducted on marriage immigrant women and their babies who were admitted at Dongsan Medical Center, Keimyung University over a 5-year period (Jan. 2005- Dec. 2009). Additionally, birth year-, gestational age-, number (s) of fetus-, and gender-matched native parturient women and their babies were selected by random sampling with twice the number as the control group. Results: Total 5,158 babies were born during the study period (male: 52.7%, female: 47.3%). The number of babies born from native mothers was 5,046 (97.8%). Babies born from immigrant women and other foreign mothers were 66 (1.3%) and 48 (0.9%), respectively. The most common nationality of immigrant women was Vietnam (n=43, 65.2%), and the others were China (n=13, 19.7%) and Philippines (n=6, 9.1%). Immigrant women (24.1±4.6 yr) were younger than native parturients (32.7±4.0 yr), and spouses were older in immigrant group (42.3±7.1 yr) than the control (35.1±4.5 yr) ( P<0.001). The body weight of the immigrant women (59.2±10.5 kg) were lighter than the control (69.1±9.1 kg) around delivery ( P<0.001). In maternal morbidity, the incidence of hepatitis B surface (HBs) antigenemia was higher in immigrant women (13.8%) than the control (3.8%) ( P<0.05). Intrauterine growth retardation was more frequently developed in immigrant women, whereas hypertension and diabetes were more frequent in the control, but not significant. In babies born from immigrant women, birth weight (2,680±630 g) and head circumference (32.4±2.3 cm) were less than that (2,870±590 g and 33.2±2.1 cm) of native mothers` babies (P<0.05). Birth height was similar in two groups (47.3±3.3 cm vs. 47.8±3.3 cm). There were no differences between two groups in terms of presence of perinatal diseases in babies. Conclusions: Marriage immigrant women have a higher incidence of HBs antigenemia and their spouses tend to be elders. Babies born from immigrant women may show significant differences in physical measures including birth weight and head circumference in comparison with native mothers` babies. Therefore followup evaluation of growth and development during infancy is necessary.

남매에서 발생한 선천 지질 부신 과다형성

백인환 ( In Hwan Baek ),김천수 ( Chun Soo Kim ) 대한주산의학회 2010 Perinatology Vol.21 No.2

Congenital laryngeal atresia is a rare cause of airway obstruction that is almost always lethal within short period of time after birth unless diagnosed prenatally and emergency tracheostomy was performed. Other life-threatening anomalies such as tracheoesophageal fistula, gastrointestinal or urinary anomalies, and VATER syndrome are often associated with laryngeal atresia. Recently, we experienced a case of congenital laryngeal atresia with diaphragmatic hernia, ear and skull anomalies, not diagnosed prenatally, died of asphyxia due to intubation failure, and confirmed by autopsy. We report this case with a brief review of the literatures.

랫드에게 도세탁셀 정맥투여 후 약물동태학적 모델링과 시뮬레이션 연구

백인환(In hwan Baek) 대한약학회 2017 약학회지 Vol.61 No.1

Docetaxel is an anti-mitotic chemotherapy agent that is approved for treatment of malignancies including breast, gastric, prostate and non-small cell lung cancer. The aim of the study was to investigate the pharmacokinetics of docetaxel after intravenous administration to rats using noncompartmental analysis and quantitative modeling approaches. Ten SD rats administered 5 mg/kg of Taxotere?? intravenously and the plasma concentrations of docetaxel were measured by liquid chromatography- tandem mass spectrometry. The data were analyzed by modeling approaches using ADAPT5 and model discrimination was determined by the likelihood-ratio test. The concentration at time 0 was 398.7±71.9 ng/mL, and the area under the plasma concentration-versus-time curve from time zero to the last measurable concentration was 436.3 ±157.2 ng·h/ mL. The two-compartment model with first-order elimination was sufficient to explain the pharmacokinetic properties after single intravenous administration of docetaxel to rats. Simulation was achieved to predict the plasma concentration profiles of docetaxel for multiple dosing, several dose, formulation releasing rate and volume of distribution. This study provides pharmacokinetic information in rats that will aid future development of improved formulations for docetaxel.

소방공무원 체력관리가 현장대응능력에 미치는 영향에 관한 연구 : 참여동기, 운동몰입 및 운동지속과 팀워크 향상관계를 중심으로

권혁(Hyeok Kwon),김동영(Dong Young Kim),김희동(Hee Dong Kim),백인환(In Hwan Baek) 한국화재소방학회 2021 한국화재소방학회논문지 Vol.35 No.3

재난 규모가 거대화되면서 많은 소방공무원이 체력적 한계를 경험하고, 체력의 중요성을 인식하고 있다, 소방활동특성상 팀워크가 매우 중요한데, 부족한 체력 수준은 현장 활동 중 팀워크 저하의 원인이 될 수 있고, 이는 현장 대응능력의 저하와 직결되는 부분이다. 본 연구는 체력단련프로그램인 크로스핏을 경험한 직원을 통하여 체력단련이 팀워크에 미치는 영향 관계를 분석하였고, 그 결과 소방 크로스핏의 참여동기는 운동지속에 영향을 미치고, 이러한 운동지속 요인은 소방공무원 팀워크 향상에 기여하는 것을 가설 검증을 통하여 확인하였다. 결국 체력관리를 통해 팀워크를향상시키는 것이 소방공무원의 현장 대응 역량을 강화할 수 있는 가장 기본적인 정책임을 추론할 수 있었다.또한 소방공무원 각 개인의 운동 습관 및 운동 주기 등 현실태와 소방공무원 체력향상 프로그램에 대한 선호도 조사를 시행하여소방공무원 체력단련의 현실태를 진단 또는 분석하여 문제점을 파악함으로써 향후 소방공무원에 적합한 체력관리 프로그램 개발과 제도개선에 필요한 자료를 확보하였다. As the scale of a disaster increases, many firefighters experience physical limitations. Physical strength and teamworkare of great importance in firefighting, and insufficient physical strength can cause a decline in teamwork during fieldactivities through a decline in the ability to respond. This study analyzed the effect of physical fitness training on teamworkamong employees who experienced CrossFit, a fitness training program, and found that the motivation to participate infirefighting CrossFit has an effect on the continuation of exercise. The factors promoting the continuation of exerciseinclude firefighting officials. It was confirmed through hypothesis testing that CrossFit contributed to the improvement ofteamwork, suggesting that improving teamwork through physical fitness is the most basic policy to strengthen firefighters’field response capabilities. In addition, we conducted a survey of the actual condition of each firefighter’s exercise habits,exercise cycles, and preferences for the fitness improvement program and analyzed their physical fitness training to facilitatemanagement program development and system improvement.

당뇨병 및 골다공증 치료제의 효율적인 신약개발을 위한 생체표지자 및 대리 결과 변수의 역할 및 활용

성수현,윤휘열,백인환,강원구,장정윤,서경원,권광일,Seong, Soo-Hyeon,Yun, Hwi-Yeol,Baek, In-Hwan,Kang, Won-Ku,Chang, Jung-Yun,Seo, Kyung-Won,Kwon, Kwang-Il 대한약학회 2008 약학회지 Vol.52 No.5

Recently, the FDA (Food and Drug Administration) of the United States and many advanced countries remark biomarkers and surrogate endpoints as a critical path tool on model based drug development. Economic, technical and social profit on model based drug development like a reduction of the length of research and development have been achieved. Therefore we summarize previous studies about biomarkers and surrogate endpoints and suggest a development direction of therapeutic agents. In diabetes mellitus (DM) and osteoporosis, there are remarkable increases in number of patients and most of patients take medicine during their whole lifetime. For this reason, many patients with DM and osteoporosis have a tolerance on their medicine. We expect that research and development on biomarkers and surrogate endpoints will contribute to new drug development on DM and osteoporosis. Biomarkers for DM are blood levels of glucose, insulin, ${HbA}_{1c}$, CRP, alpha-glucosidase, adiponectin and DPP-4. Among these, validated surrogate endpoints for DM are blood levels of glucose, insulin and ${HbA}_{1c}$ Biomarkers for osteoporosis are BMD, BMC, trabecular volume, ICTP, DPD, osteocalcin, the activity of osteoclast and production of osteoblast. The validated surrogate endpoints for osteoporosis are BMD only. This review summarizes all suggested biomarkers and surrogate endpoints in DM and osteoporosis. The biomarkers are classified by drugs, and the method of validation for surrogate endpoints is suggested. This information would contribute to suggest a direction of DM and osteoporosis therapeutic agent development.

유전자 알고리즘을 이용한 광조형장치의 작업변수 결정

전근수(Keun Su Jun),백인환(In Hwan Baek) 한국정밀공학회 2000 한국정밀공학회 학술발표대회 논문집 Vol.2000 No.10월

트랜지스터용 p-형 산화물 반도체(니켈 산화물, 주석 산화물, 구리 산화물) 최신 동향 분석

최민기(Minki Choe),전다희(Dahui Jeon),황인홍(Inhong Hwang),백인환(In-Hwan Baek) 한국세라믹학회 2023 세라미스트 Vol.26 No.1

Over the past decade, many research groups have been striving to develop high-performance p-type switching oxide materials for implementing complementary metal-oxide-semiconductor (CMOS) thin film devices. However, realizing p-type oxide thin film transistors (TFTs) whose electrical properties are comparable to n-type oxide TFTs has been challenging. This is because of inherent characteristics of p-type oxide materials such as the high formation energy of native acceptors and high hole effective mass caused by localized hole transport path. Developing a p-type oxide with a delocalized hole transport pathway and low hole formation energy is crucial for the production of CMOS circuits utilizing oxide thin films. NiO, SnO, and CuOx are being actively studied as candidate materials that satisfy these requirements. This review discusses the latest advances in the synthesis method of p-type binary oxide thin films and the approach for electrical performance enhancement.

신약 개발을 위한 참당귀(Angelica gigas Nakai) 추출 Decursin과 Decursinol Angelate의 약리 작용

손추영(Chu-Young Son),송규용(Gyu-Yong Song),강재선(Kwang-Il Kwon),권광일(Kwang-Il Kwon),백인환(In-Hwan Baek) 대한약학회 2009 약학회지 Vol.53 No.6

Traditionally, Cham dang-gui (Angelica gigas Nakai) is one of the most popular herbal medicines in Asian countries including Korea. A. gigas has been used as a functional food product for treatment anemia, women’s health care, a sedative, an anodyne or a tonic agent. Decursin and decursinol angelate isolated from the roots of A. gigas are pyranocoumarin compounds. Recently, as the global herbal medication market is increasing, investigations about pharmacological effects of decursin and decursinol angelate are rapidly increasing. We summarized previous studies about pharmacological effects of decursin and decursinol angelate, and reviewed relation with pharmacological effects of decursin and decursinol angelate on human disorder, focused on the approach for new drug development. Pharmacological effects of decursin and decursinol angelate were classified as anti-tumor activity, anti-bacterial activity, improvements of the circulating system, inhibition of cytochrome P-450 activity, anti-inflammation activity, anti-oxidant activity and cognitive-enhancing activites. The activity of A. gigas with improvement of the circulating system may have wide therapeutic potential for circulatory diseases, including diabetes, hyperlipidemia and atherosclerosis. Also, anti-inflammation ctivity A. gigas may be beneficial for the treatment and prevention of asthma, atopic dermatitis and rheumatism arthritis. This relation could potentially lead to the development of herbal new drugs. In order to development a new drug containing decursin and decursinol angelate, it is also necessary to consider the safety profile, and the information in this review would contribute to development a new drug from herbal medicine.

인체에서 carvedilol의 심혈관계 작용에 대한 PK/PD modeling

백인환,윤민혁,윤휘열,남진경,권광일 충남대학교 약학대학 의약품개발연구소 2007 藥學論文集 Vol.22 No.-

The objective of the present study was to determine and characterize the relationship between the cardiovascular effect and plasma concentration of carvedilol by PK/PD modeling in human. A group of 32 healthy males received oral doses of 25 mg carvedilol, and blood samples were collected thirteen times for up to 30 hours after the drug administration. The effect of carvedilol on blood pressure was measured during the same period. This experiment was analyzed using the liquid-liquid extractions of carvedilol by HPLC with fluorescence detection. Pharmacokinetics parameters of carvedilol were calculated using the two-compartment model with first-order absorption. The average value of C_(max), T_(max), CL/F (apparent clearance), V/F (apparent volume of distribution) and half-life of carvedilol were 62.74 ± 20.12 ng/ml, 1.26 ± 0.86 hrs, 94.64 ± 46.01 L/hr, 1561.78 ± 941.94 L, 12.47 hr, respectively. To explain the relationship between the cardiovascular effect and plasma concentration of carvedilol, plasma drug concentrations were linked to the observed SBP and DBP via a effect compartment with a sigmoid Emax model. The model parameters were estimated by using ADAPT Ⅱ program. This PK/PD model could describe the relationship between plasma concentrations of carvedilol and cardiovascular effect such as the aspects of decreasing blood pressure and the time delay between plasma concentration and pharmaco-dynamic data.

혈소판 응집 억제제의 효과 측정법에 대한 고찰과 지원자에서 Triflusal의 혈소판 응집 억제능 평가

이병요,장힘찬,백인환,윤휘열,권광일 충남대학교 약학대학 의약품개발연구소 2010 藥學論文集 Vol.25 No.-

The anti-platelet agent is a member of a class of pharmaceuticals that decreases platelet aggregation and inhibits thrombus formation. They are effective in the arterial circulation and widely used in primary and secondary prevention of thrombotic cerebrovascular or cardiovascular disease. As a method for estimating the effects of anti-platelet agent, platelet aggregation was conventionally measured using the optical method or the impedance method. Several alternate methods currently in development or recently developed were considered, including luminescence method, flow cytometry, laser-light scattering method, and Verify Now-P2Y12 assay. Principles, advantages, and disadvantages of the optical method, impedance method, and the other alternate platelet aggregation methods were discussed in this report. 15 human volunteers were recruited for the evaluation of the efficacy of triflusal using the optical method. After the oral administration of a single dose of 900mg, 15 subjects received eight doses administered at 24-hour intervals of 600mg triflusal. Using platelet rich-plasma from above subjects, we performed baseline platelet aggregation test induced by adenosine diphosphate(ADP), collagen, and arachidonic acid. The results of platelet aggregation test after triflusal administration were compared with the baseline study. Triflusal significantly inhibited platelet aggregation induced by ADP (33.0±21.3%) and arachidonic acid (99.1±1.2%), respectively. Therefore, we concluded that anti-platelet aggregation effect of triflusal can be studied successfully with the optical method. Each of the platelet aggregation methods has value for evaluating the effects by various mechanisms of the anti-platelet agents. The ideal method for estimating the platelet aggregation as it relates to safety and efficacy in patients treated with anti-platelet agents will need to be determined in clinical trials.