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독활기생탕가미방이 Dexamethasone 처리 조골세포에 미치는 영향
백선은 ( Seon Eun Baek ),장새별 ( Sae Byul Jang ),유정은 ( Jeong Eun Yoo ),유동열 ( Dong Youl Yoo ) 대한한방부인과학회 2016 大韓韓方婦人科學會誌 Vol.29 No.2
Objectives: In this study, the author aimed to evaluate the effects of water extract of Dokwhalgisaeng-tang Gamibang (DGG) on osteoblast proliferation in murine calvarial cells. Methods: The osteoblast separated from murine calvariae was cultivated and evaluated the cell function. After the addition of DGG on the culture medium, we determined the effect of DGG on the cell proliferation, protein synthesis, alkaline phosphatase activity, collagen synthesis, and cell viability of the cultivated osteoblast in the presence of dexamethasone. Results: DGG increased the survival rate, proliferation, alkaline phosphatase (ALP) activity, protein synthesis and collagen synthesis of rat calvarial osteoblast in the presence of dexamethasone. Conclusions: DGG might improve the osteoporosis resulted from augmentation of osteoblast proliferation.
갱년기장애 진단기기 사용에 대한 지침 개발 : 문헌검토 및 설문조사
백선은 ( Seon-eun Baek ),박은지 ( Eun-ji Park ),김동일 ( Dong-il Kim ),이인선 ( In-seon Lee ),유정은 ( Jeong-eun Yoo ) 대한한방부인과학회 2017 大韓韓方婦人科學會誌 Vol.30 No.3
Objectives: This study was aimed to develop a guideline for the application of diagnostic devices for menopausal syndrome. Methods: We conducted a literature review and a questionnaire survey on diagnostic devices including Digital Infrared Thermal Imaging (DITI), pulse diagnosis device, Heart Rate Variability (HRV), body composition analyzer, Yangdorak. Results: We retrieved some clinical values for usage of devices from the articles. Especially, DITI was useful to identify the pattern of body temperature distribution. The respondents answered that they diagnosed menopausal syndrome by using body composition analyzer (62.3%), DITI (60%), HRV (60%), pulse diagnosis device (45.7%), Yangdorak (34.3%). The respondents answered that they don`t use diagnostic devices when they diagnosed menopausal syndrome because of absence of device, cost, difficulty of interpretation, substitution of another diagnostic method. After experts survey, it was recommended to use DITI, HRV, body composition analyzer. There was no consensus on the use of pulse diagnosis device, Yangdorak in diagnosing menopausal syndrome. Conclusions: We developed a guideline for the application of diagnostic devices for menopausal syndrome.
위축성 질염의 좌훈 치료 연구에 관한 체계적 문헌 고찰
백선은 ( Seon Eun Baek ),장새별 ( Sae Byul Jang ),최경희 ( Kyung Hee Choi ),유정은 ( Jeong Eun Yoo ) 대한한방부인과학회 2016 大韓韓方婦人科學會誌 Vol.29 No.1
Objectives: The purpose of this systematic review was to overview and evaluate the effectiveness of fumigation treatment for women with atrophic vaginitis. Methods: We searched articles from Pubmed, Chinese Academic Journals (CAJ) and Oasis online databases. Searching keywords were ‘fumigation’, ‘atrophic vaginitis’, ‘vaginitis’, ‘陰道炎’, ‘膣炎’, ‘老年性 陰道炎’, ‘坐熏’, ‘熏洗’, ‘熏浴’, ‘좌훈요법’, ‘질염’, ‘위축성질염’. After searching the articles, we performed quality assessment using Cochrane risk of bias (RoB) tool. Results: Among the 142 articles were searched, 5 randomized controlled clinical trials (RCTs) were finally selected. All of 5 studies showed that fumigation treatment has significant effect on atrophic vaginitis in terms of the effectiveness rate, but 3 studies were not statistically significant. Conclusions: Our systematic review found encouraging but limited evidence of fumigation therapy for atrophic vaginitis. We recommend clinical trials which obtain stronger evidence without the demerits of trial design.
보허탕가감방과 침구치료로 호전된 자궁절제술 환자 치험 3례
백선은 ( Seon Eun Baek ),장새별 ( Sae Byul Jang ),유정은 ( Jeong Eun Yoo ),최경희 ( Kyung Hee Choi ),유동열 ( Dong Youl Yoo ) 대한한방부인과학회 2015 大韓韓方婦人科學會誌 Vol.28 No.3
Objectives: The purpose of this study is to report the effect of Boheo-tang Gagambang (BG) with acupuncture and moxa treatments on the after-effects of hysterectomy. Methods: Three women who were undertaken a hysterectomy within a month were enrolled in this study. They complained of abdominal pain, low back pain, nausea, fatigue, etc. BG was prescribed 3 times a day and the acupuncture and moxa treatments were applied to decrease pain and improve the symptoms. Results: After the acupuncture and moxa treatments with BG, symptoms were markedly decreased. Conclusions: These clinical cases indicated that BG were effective in the treatments for patients who were undertaken a hysterectomy.
원발성 월경곤란증의 뜸 치료에 대한 체계적 문헌고찰 및 메타분석
이혜인,백선은,이호정,박경선,이진무,유정은,Lee, Hye-In,Baek, Seon-Eun,Lee, Ho-Jung,Park, Kyoung-Sun,Lee, Jin-Moo,Yoo, Jeong-Eun 대한한방부인과학회 2017 大韓韓方婦人科學會誌 Vol.18 No.4
Objectives: The purpose of this study is to investigate the effectiveness of moxibustion for primary dysmenorrhea (PD). Methods: We searched 10 electronic databases (CNKI, WANFANG, VIP, AMED, CiNii, Embase, PubMed, Cochrane, OASIS, Korea Traditional Knowledge Portal) to identify eligible studies published before November 2016. We included randomized controlled clinical trials (RCTs) using moxibustion for primary dysmenorrhea. The methodological quality of each RCT was assessed by the Cochrane risk of bias tool. Results: Ten RCT studies were eligible in our review. The overall risk of bias was evaluated as unclear. The meta-analysis of 4 trials indicated that favorable results for the use of moxibustion. Conclusions: This systematic review and meta-analysis of clinical trials suggests that moxibustion can achieve good efficacy for PD patients. However, because of studies included analysis was biased due to unclear risk of bias and unreliable study design, future high-quality RCT studies are needed to determine the association moxibustion with PD.
이지연,백선은,박은지,안수연,이다희,하기태,유정은,Lee, Ji-Yeon,Baek, Seon-Eun,Park, Eun-Ji,Ahn, Soo-Yeon,Lee, Da-Hee,Ha, Ki-Tae,Yoo, Jeong-Eun 대한한방부인과학회 2018 大韓韓方婦人科學會誌 Vol.31 No.2
Objectives: The aim of this study is the development of the questionnaire for pattern identification of Liver-qi stagnation infertility. Methods: We conducted a literature review and retrieved the symptoms and diagnosis from Korean and Chinese literatures which mentioned pattern identification of Liver-qi stagnation infertility. Based on the findings, We conducted three times expert Delphi surveys on selection of question items and determination of weight. Results: 12 questionnaire items for subjects and 4 questionnaire items for researchers were selected from 19 references. From expert delphi surveys, we finally determined 14 questionnaire items (10 items for subjects, 4 items for researchers) which are clinically significant and obtained weight of question items. Conclusions: Questionnaire for pattern identification of Liver-qi stagnation infertility was developed through experts' discussion. Further study is required to identify the validity and reliability of this pattern identification instrument for Liver-qi stagnation infertility.
박은지 ( Eun-ji Park ),장새별 ( Sae-byul Jang ),백선은 ( Seon-eun Baek ),김선경 ( Seon-kyung Kim ),유호룡 ( Ho-ryong Yoo ),유정은 ( Jeong-eun Yoo ),정인철 ( In-chul Jung ) 대한한방부인과학회 2017 大韓韓方婦人科學會誌 Vol.30 No.1
Objectives: Polycystic Ovarian Syndrome (PCOS) is characterized by ovulatory disorder, polycystic ovaries and clinical or laboratory hyperandrogenemia, also associated with an increased risk of various other long-term complications. The purpose of this study is to develop a standard instrument of pattern identifications in Korean medicine for PCOS. Methods: We retrieved the patterns and symptoms from Korean and Chinese literatures which mentioned pattern identifications of PCOS. In order to develop the instrument, we took the consultation from the advisor committee based on the collected informations from literatures. Finally the questionnaire of pattern identification for PCOS was developed. Results: 1) 5 pattern identifications and 53 symptoms and signs were selected from 20 references. 2) We obtained the mean weights which reflected the standard deviations from each symptom of the pattern by 15 experts. 3) We designed the Korean medicine Instrument on pattern identification for PCOS. It was composed of 61 questions, 44 of patient-reported format and 17 of assessor-reported format. Conclusions: Instrument of pattern identification for PCOS was developed through experts` discussion. Further study is required to identify the validity and reliability of this pattern identification instrument for PCOS.
중등도 이상의 암성통증을 호소하는 노인 환자에 대한 고용량의 마약성 진통제의 이용: 전향적 관찰 연구
김정은(Jung Eun Kim),최윤선(Youn Seon Choi),이경희(Kyung Hee Lee),김준석(Jun Suk Kim),고수진(Su Jin Koh),백선경(Sun Kyung Baek),김시영(Si Young Kim),송홍숙(Hong Suk Song),임보라미(Bo Rami Lim) 대한임상노인의학회 2016 대한임상노인의학회지 Vol.17 No.1
Background: Despite the large number of elderly individuals who are dying of cancer in Korea, the quality of pain management remains poor. Thus, in this study, the safety and efficacy of using high-dose opioids to treat has been evaluated pain in elderly patients with cancer. Methods: Data from cancer patients (N=94) aged ≥65 years who were administered high-doses of opioids (≥120 mg/day) were collected at 38 hospitals between February 2009 and March 2010. After 8 weeks, changes in pain severity were examined using a numeric rating scale; in addition, the opioid dosages, quality of life parameters, and opioid-based adverse events were investigated. Results: Ninety-two patients were prescribed opioids at the beginning of the study and followed for 8 weeks. The mean pain intensity changed from 5.61±1.56 at baseline to 4.02±2.17 (P<0.001) after 8 weeks. The mean opioid dosage, expressed as oral morphine equivalents, changed from 178.86±76.88 at baseline to 288.54±389.09 (P=0.0025) after 8 weeks. The quality of life parameters, including daily activities, ambulation, and sleep, improved significantly after 8 weeks (P<0.001). At baseline, 44 patients (47.8%) complained of adverse effects such as constipation, dizziness, and nausea; the frequency of adverse events did not increase after 8 weeks. Conclusion: The use of high-dose opioids for treating cancer pain is safe, effective, and tolerable in elderly patients.
장새별 ( Sae Byul Jang ),백선은 ( Seon Eun Baek ),최경희 ( Kyung Hee Choi ),유정은 ( Jeong Eun Yoo ) 대한한방부인과학회 2016 大韓韓方婦人科學會誌 Vol.29 No.2
Objectives: Gyejibokryeong-hwan (GBH), a traditional Korean herbal medicine, has been widely used for the treatment of the blood stasis syndrome. This study is purposed to analyze the experimental research trend of GBH in Korea for developing further research plan. Methods: A search of Korean research database-Oasis, RISS and KISS- and Pubmed was carried out for publications until 2015, for the words, ``Guizhifulingwan``, ``Gyejibokryeonghwan``, or ``Keishibukuryogan``. Then study selection is conducted according to PRISMA guidelines, studies not related or using modified formula or administered for human are excluded, 48 studies are included in this review, finally. We analyzed studies by research method, subject, outcome measure, and result of the study. Results: There were 31 in vivo studies about the effect of GBH on platelet aggregation, anti-oxidant, blood viscosity, and hypercholesterolemia, etc. 12 in vitro studies were about the effect of GBH on the cervical carcinoma, chronic kidney disease, uterine myoma, hepatocarcinoma, atherosclerosis, cancer chemo-prevent. 9 ex vivo studies were about the effect of GBH on the platelet aggregation, chronic kidney disease, ovaulatory disorder, and rheumarthritis. Conclusions: We proposed the translational research of GBH involving scientific discoveries and developing practical applications by investigating the concept of blood stasis syndrome in terms of current physiopathological mechanism.
원발성 월경곤란증의 뜸 치료에 대한 체계적 문헌고찰 및 메타분석
이혜인 ( Hye-in Lee ),백선은 ( Seon-eun Baek ),이호정 ( Ho-jung Lee ),박경선 ( Kyoung-sun Park ),이진무 ( Jin-moo Lee ),유정은 ( Jeong-eun Yoo ) 대한한방부인과학회 2017 大韓韓方婦人科學會誌 Vol.30 No.2
Objectives: The purpose of this study is to investigate the effectiveness of moxibustion for primary dysmenorrhea (PD). Methods: We searched 10 electronic databases (CNKI, WANFANG, VIP, AMED, CiNii, Embase, PubMed, Cochrane, OASIS, Korea Traditional Knowledge Portal) to identify eligible studies published before November 2016. We included randomized controlled clinical trials (RCTs) using moxibustion for primary dysmenorrhea. The methodological quality of each RCT was assessed by the Cochrane risk of bias tool. Results: Ten RCT studies were eligible in our review. The overall risk of bias was evaluated as unclear. The meta-analysis of 4 trials indicated that favorable results for the use of moxibustion. Conclusions: This systematic review and meta-analysis of clinical trials suggests that moxibustion can achieve good efficacy for PD patients. However, because of studies included analysis was biased due to unclear risk of bias and unreliable study design, future high-quality RCT studies are needed to determine the association moxibustion with PD.