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김기호 ( Ki Ho Kim ),김기수 ( Ki Soo Kim ),김영희 ( Young Heui Kim ),고강일 ( Kang Ii Ko ),박선희 ( Sun Hee Park ),김진국 ( Jin Guk Kim ),최현진 ( Hyun Jin Chio ),고수연 ( Su Yeon Ko ),배윤주 ( Yoon-joo Bae ),김용민 ( Yong-min Kim 대한화장품학회 2006 대한화장품학회지 Vol.32 No.2
피부 각질층내의 아미노산 조성비율과 유사한 조성비로 amino acid complex을 제조하고, 제조된 amino acid complex가 피부에 미치는 영향을 알아보기 위해 세포 생존율, TIMP-1 발현 증가율, 보습 및 각질량 변화를 측정하였다. 연구 결과 amino acid complex는 독성이 없는 안전한 물질로 우수한 보습력 및 보습유지효과와 ascorbic acid와 유사한 TIMP-1 발현량 증가로 주름 예방 및 개선에 효과를 가지고 있으며, 각질량 감소 및 감소유지효과로 자극이 있는 AHA 대체 물질로의 가능성을 보였다. 따라서, amino acid complex는 다기능을 가진 노화방지 화장료 기능성분으로 유용하게 사용될 수 있음을 확인하였다. Amino acid complex was made with the composition of amino acids quite similar to that of stratum corneum on the skin. In order to evaluate the efficacy of amino acid complex on the skin as an active cosmetic ingredient, we measured cytotoxicity. TIMP-1 expression, moisturizing effect and the amount of horny substance. In cytotoxicity assay, amino acid complex did not show any cytotoxicity. In moisturizing effect test using corneometer, it showed very good moisturizing effect. In TIMP-1 mRNA assay using RT-PCR, moo acid complex showed the increase of TIMP-1 expression, suggesting that amino acid complex have anti-wrinkle effect. Therefore, amino acid complex may be useful as an active ingredient for anti-aging.
배윤주,조영주,김혜옥,윤견일,한운섭,김옥경 梨花女子大學校 醫科大學 醫科學硏究所 1986 EMJ (Ewha medical journal) Vol.9 No.2
From April 1981 to March 1985, a clinical study was made at the Intcrnal Medicine department of Ewha Womans University Hospital on 13 patients with IgA nephropathy. The following results were obtained. 1) The mean age of patients was 27 years, the male to femle ratio was 1.2:1. The most common chief complaint was gross hematuria(38%). 2) In urinalysis, hematuria and proteinuria were noted 100% and 92%, respectively. Creatinine clearance was decreased than normal range of creatinine clearance. ASO titer, immunoglobulin and C3 level were normal range. 3) Kidney biopsy finding showed minor mesangeal change in 62% of patients. IgA deposition was noted in all patients.
최규복,한경숙,김미경,배윤주,이순남,경난호 梨花女子大學校 醫科大學 醫科學硏究所 1985 EMJ (Ewha medical journal) Vol.8 No.1
Gilbert's Syndrome is the name most frequently used to describe a condition which has been called constitutional heptic dysfunction, familial nonhemolytic jaundice of icterus intermittens juvenilis. It is characterized by a benign, persistent, but vari-able elevation of the plasma unconjugated bilirubin. A 27-year-old man was admitted because of general malaise, anorexia, sore throat and slight icteric sclera. On physical examination, there were mild icteric sclera and slightly injected pharynx. The liver was palpable 1 finger breath BRCM and the spleen was also palpable I finger breadth BLCM. Hematologic studies reve-aled slight anemia with slightly elevated corrected reticulocyte count. Liver func-tion tests were normal except for slightly elevated serum total bilirbin. Histolog-ic findings of the liver showed nonspecific findings of mild cholestasis. Reduction in caloric intake to 300 calrory a day for 72 hours resulted in a significant increase in the plasma bilirubin concentration(especially unconjugated form) in this patient. Now he has no subjective symptoms and leads a normal activity without specific treatment.