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      • 관류 전산화단층촬영(CT Perfusion)에서 HU값에 따른 색지도(Color mapping)에 대한 연구

        배성근(Seong Keun Bae),정성민(Sung Min Chung),엄민지(Min Ji Um),추상덕(Sang Deok Chu) 대한CT영상기술학회 2011 대한CT영상기술학회지 Vol.13 No.2

        목적 수술 후 관류검사를 한 환자를 대상으로 SSS(superior sagittal sinus) & MCA(middle cerebral artery)의 혈류량의 최고치(Peak)와 CT값(HU)의 평균값을 구하여 CT관류 Program을 이용하여 검사자들이 동일한 색조치(Window Level, W.L)로 균일하고 객관성 있는 색지도(color mapping)를 하기 위함이다. 대상 및 방법 2009년 3월부터 2009년 11월까지 본원에서 수술 후 관류검사를 한 남성:여성(60:40), 나이분포 20~70세, 평균나이 55세의 120명의 환자를 대상으로 하였다. 관류영상획득을 위해 somatom Sensation 16 scanner(Simens, Enlarge Germany)를 사용하여 80 kvp, 209 mAs, 12 mm slice thickness로 기저핵이 잘보이는 부위에서 40초간 80장의 영상을 얻었다. 조영제는 4.5cc/sec로 40cc 자동주입 하였고, 이어서 같은 속도로 saline 10cc를 추가로 정맥에 주입하였다. 관류영상분석은 동일한 회사의 관류 Program(Simens, Wizard)을 사용하여 MIP, CBF, CBV, MTT 네 가지 관류영상을 얻었다. 결과 네 가지의 관류영상(MIP, CBF, CBV, MTT)에서 radiologist, operator A, B, C가 SSS, MCA, SSS-MCA에서 얻은 HU값으로 적절한 색지도를 한 결과 SSS의 HU값을 이용한 영상평가가 가장 적절한 색조치를 보였다. 결론 각각의 검사자는 SSS의 HU값을 기준으로 하여 MIP, CBF, CBV, MTT의 색조치를 Window level(W. L)값을 이용하여 균일하고 객관성 있는 색지도를 함으로써 판독에 좋은 영상을 얻을 수 있다. I. Purpose To maintain objectivity of color mapping using the same window level by each operator through CT Perfusion program while comparing the blood flow of arteries and veins and mean value of CT value(H. U) on target patients being examined CT Perfusion after brain operation. II. Meterial and Methods Ftp May to November in 2009, 100 patients (age range: 20-70, mean: 55, male: 60 persons, female: 40 persons) were participated. 80 Images were displayed in an aqusition time of 40 secs, onregion of basal ganglia using Somatom Sensation 16 (Simens, Enlarge Germany) for perfusion image aquisition with 80 Kvp, 209 mAs, 12 mm slice thickness. contrast materials were injected by auto injector (medrad) with 40 cc at 4.5 cc/sec continually injected 10 cc saline by same velocity. 4 types images MIP(maximum intensity projection), CBF(cerebral blood flow), CBV(cerebral blood volume), MTT(mean transit time) were obtained by using perfusion program(Seimence, Wizard). III. Result Radiologists and operators evaluated data through color mapping of proper W. value participations patients obtained data from SSS, MCA, SSS-MCA on 4 type images(MIP, BF, CBV, MTT) as a result, MIP80, CBF 0~100:60~65, 100~00:70~75, 200~300:76~80, 300~00:80~85, 400~500:88~90), 500~600:90~95, CBV 0~100:70~75, 100~00:75~80, 200~00:80~90, 300~00:90~95, 400~00:95~100, 500~600:100~105, MTT 0~00:100~105, 100~200:115~200, 200~300:120~125, 300~400:125~130, 400~500:130~140, 500~600:140~150 also, the higher value of HU, the faster time of time peak on SSS and MCA. IV. Conclusions Each operator obtain good image by color maping maintaining objectivity between MIP, CBF, CBV, MTT, by standard SSS.

      • KCI등재
      • SCOPUSKCI등재
      • 미세정자주입술로 임신이 된 남자태아의 Y 염색체 미세결실의 Vertical Transmission, de novo, 그리고 Expansion의 연구

        김현아,이숙환,조성원,정혜진,손수민,강수진,배성근,김수희,윤태기,Kim, Huyn-Ah,Lee, Sook-Hwan,Cho, Sung-Won,Jeong, Hye-Jin,Son, Soo-Min,Kang, Soo-Jin,Bae, Seong-Keun,Kim, Soo-Hee,Yoon, Tae-Ki 대한생식의학회 2004 Clinical and Experimental Reproductive Medicine Vol.31 No.2

        Objectives: Despite severe oligospermia, males with Y chromosome microdeletion can achieve conception through ICSI (Intracytoplasmic Sperm Injection). However, ICSI may not only result in the transmission of microdeletions but also the expansion of deletion to the offspring. The purpose of this study was to screen vertical transmission, expansion of microdeletions and de novo deletion in male fetuses conceived by ICSI. Materials and Methods: A total of 32 ICSI treated patients with their 33 (a case of twin) male fetuses conceived by ICSI were used to make this study group. Sequence-tagged sites (STSs)-based PCR analyses were performed on genomic DNA isolated from peripheral blood of fathers and from the amniocytes of male fetuses. Ten primer pairs namely, sY134, sY138, MK5, sY152, sY147, sY254, sY255, SPGY1, sY269 and sY158 were used. The samples with deletions were verified at least three times. Results: We detected a frequency of 12.5% (4 of the 32 patients) of microdeletions in ICSI patients. In 4 patients with detected deletions, two patients have proven deletions on single STS marker and their male fetuses have the identical deletion in this region. Another two patients have two and three deletions, but their male fetuses have more than 3 deletions which include deletions to their father's. Meanwhile, seven male fetuses, whose fathers were analyzed to have all 10 STS markers present, have deletions present in at least one or more of the markers. Conclusions: Although the majority of deletions on the Y chromosome are believed to arise de novo, in some cases a deletion has been transmitted from the fertile father to the infertile patient. In other cases the deletion was transmitted through ICSI treatment, it is likely that one sperm cell is injected through the oocyte's cytoplasm and fertilization can be obtained from spermatozoa. Our tests for deletion were determined by PCR and our results show that the ICSI treatment may lead to vertical transmission, expansion and de novo Y chromosome microdeletions in male fetuses. Because the sample group was relatively small, one should be cautious in analyzing these data. However, it is important to counsel infertile couples contemplating ICSI if the male carries Y chromosomal microdeletions.

      • 항문의 괄약근이 약하여 CT Colonography Catheter로 검사가 어려운 환자를 대상으로 Rectal tip의 효율성 분석

        김영남(Young Nam Kim),손은영(Eun Young Son),배성근(Sung Keun Bae) 대한CT영상기술학회 2015 대한CT영상기술학회지 Vol.17 No.1

        Purpose : This study was intended to explore efficiency of computed tomographic colonography (CTC) exam by employing rectal tip that is used for double contrast barium enema (DCBE) by targeting the patient for whom CTC catheter exam is difficult. Materials and methods : From March, 2013 to February, 2014, CTC exam was performed by employing rectal tip that is used for DCBE by targeting 34 patients (18 men, 16 women: mean age respectively, 79 and 77 years) for whom CTC catheter exam is difficult. As exam equipment, 16 MDCT (Somatom Sensation16, Siemens, Germany) and Automatic CO2 Insufflator (E.Z. EM, Inc. USA) were used. As an exam method, whether rectal tip escapes out of anus by injecting CO2 gas under supine and prone position by employing rectal tip for the patients for whom CTC catheter exam is difficult and rectal tip is useful for CTC exam while rectal pressure of automatic CO2 insufflator is maintained and colorectal distention works well was explored. Results : For 31 patients(91%) among 34 persons who underwent CTC exam by rectal tip, observation from rectum to ileocecal valve was possible under balanced rectal pressure and for 3 patients(9%), as rectal tip balloon escaped out from anus, CTC exam could be substituted by using compression bandage to thigh. In an exam using rectal tip contrary to a case of using CTC catheter, efficiency of exam could be confirmed for all 34 patients as thick catheter held weak part of anal sphincter and rectal tip with large balloon complemented the part where gas is discharged out of anus. Conclusion : It could be confirmed that exam efficiency and accuracy of rectal tip was enhanced for the patients for whom CTC exam was difficult as anal sphincter is weak and CO2 gas is discharged out. In this hospital, rectal tip is used for the patients for whom CTC exam is difficult and it is considered that this method could be also usefully applied to other hospitals where CTC catheter is used. 목적 : CT 대장내시경(CT Colongraphy : 이하 CTC) 검사가 실패한 원인 중 한가지는 환자의 항문 괄약근이 약하여 Catheter balloon이 항문 밖으로 빠져 나오거나 가스가 밖으로 유출되어 검사가 어려운 경우가 종종 발생한다. 본 논문은 CTC Catheter로 검사가 어려운 환자를 대상으로 DCBE(Double Contrast Barium Enema : 이하 DCBE)에 사용하는 Rectal tip을 사용하여 CTC 검사의 효율성을 알아보고자 하였다. 대상 및 방법 : 2013년 3월부터 2014년 2월까지 CTC Catheter로 검사가 어려운 34명을 대상으로 DCBE에 사용하는 Rectal tip을 사용하여 CTC검사를 시행하였다. 성별로는 남성이 18명, 여성이 16명이었고, 평균 연령은 남자가 79세 여자가 77세였다. 검사기기는 16 MDCT(Somatom Sensation16, Siemens, Germany)와, Automatic CO2 Insufflator(EㆍZㆍEM, Inc, USA)를 사용하였다. 검사방법은 CTC Catheter로 검사가 어려운 환자를 대상으로 Rectal tip을 사용하여 supine 과 prone position에서 CO2 gas 주입으로 Rectal tip이 항문 밖으로 유출되지 않는지, Automatic CO2 Insufflator의 직장 압력이 유지되고, 대장의 팽창이 잘 되면서 Rectal tip이 CT Colonography 검사에 유용한지 알아보고자 하였다. 결과 : Rectal tip으로 CTC 검사를 시행한 34명 중 31명(91%)이 직장의 압력이 유지되면서 직장에서 회맹판까지 관찰이 가능하였고, 3명(9%)에서는 Rectal tip balloon이 항문 밖으로 빠져 나와 대퇴부에 압박 붕대를 사용하여 CTC검사를 대체할 수 있었다. Rectal tip을 사용한 검사에서는 CTC Catheter를 사용할 때와 달리 항문의 괄약근이 약한 부분을 두꺼운 Catheter가 잡아주고 가스가 항문 밖으로 유출되는 부분은 balloon이 큰 Rectal tip에서 보완이 되어 34명 모두에서 검사의 효율성을 확인할 수 있었다. 결론 : Rectal tip은 항문의 괄약근이 약하고 CO2 gas가 밖으로 유출되어 CT Colonography 검사가 어려운 환자에서 검사의 효율성과 정확성이 향상 되는 것을 알 수 있었다. 이에 본원에서는 CT Colonography 검사가 어려운 환자에 사용하고 있으며 CTC Catheter를 사용하는 타 병원에도 유용하게 적용할 수 있으리라 생각된다.

      • 氣-固系 流動層裝置의 分散板에 의한 影響에 관한 硏究

        배성근 國立 昌原大學校 産業技術硏究所 1992 産技硏論文集 Vol.6 No.-

        The efficient operation of a fluidized bed is very much dependent upon distributor performance, which in turn depends on its design parameters. The work reported here deals with the characteristics of distributor related to the good fluidization. Specifically, multi orifice distributors of different geometries, percent open area and orifice diameter have been investigated in activated carbon and sand fluidized bed reactor of 73mm ID as a function of air fluidizing velocity. The pressure drop data for all the distributors have been correlated by a single equation with the open ratio of the distributor and the superficial velocity. Uniform operation of fluidized bed is significantly related to the open ratio and orifice diameter. The value of the pressure drop, being defined as the ratio of pressure drop across the distributor plate to the pressure drop across the bed, is very important parameter for the design of distributor and Siegel's equation is the most reasonable for the object.

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