http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Effects of sevoflurane on neuronal cell damage after severe cerebral ischemia in rats
박희평,정은주,김미현,황중원,임영진,민성원,김종수,전영태 대한마취통증의학회 2011 Korean Journal of Anesthesiology Vol.61 No.4
Background: The aim of this study was to investigate the neuroprotective effects of sevoflurane after severe forebrain ischemic injury. We also examined the relationship between the duration of ischemia and neuronal cell death. Methods: Male Sprague-Dawley rats (300-380 g) were subjected to 6 (each n = 6) or 10 min (each n = 10) of near-complete forebrain ischemia while anesthetized with either 50 mg/kg of zoletil given intraperitoneally or inhaled sevoflurane (2.3%). Ischemia was induced by bilateral common carotid artery occlusion plus hemorrhagic hypotension (26-30 mmHg). Histologic outcomes were measured 7 days after ischemia in CA1 pyramidal cells of the rat hippocampus. Results: The mean percentage of necrotic cells in the hippocampal CA1 area decreased in the sevoflurane group compared to the zoletil group (25% vs. 40% after 6 min ischemia, respectively: P = 0.004 and 44% vs. 54% after 10min of ischemia, respectively P = 0.03). The percentage of apoptotic cells was similar in all groups. The percentage of necrotic cells in each anesthetic groups was significantly higher in the 10 min ischemia group compared to the 6 min ischemia group (P = 0.004 in the sevoflurane group, P = 0.03 in the zoletil group). Conclusions: The present data show that sevoflurane has neuroprotective effects in rats subjected to near-complete cerebral ischemia. Longer duration of ischemia is associated with more neuronal injury when compared to ischemia of shorter duration.
박희평,오용석 대한정맥마취학회 2002 정맥마취 Vol.6 No.1
Background: Pain is the most important factor responsible for ineffective ventilation and cough in patients undergoing thoracotomy. Intravenous patient-controlled analgesia (PCA) is widely used for postoperative pain control. Opoid contained PCA is likely to increase the incidence of postoperative nausea and vomiting (PONV). We studied the effect of PCA on patients with thoracotomy. Method: After consciousness was recovered from anesthetic emergence, PCA was connected to 85 patients in postanesthetic recovery room or intensive care unit. The PCA regimen was composed of ketorolac, fentanyl and morphine, and the doses of drugs was adjusted according to patient's age and sex. The PCA was set at basal rate 0.5 ml/hr, bolus dose 1 ml, lockout time 10 min. The incidence and severity of nausea, vomiting, sedation, pain and other side effects were assessed at 1, 4, 8, 12, 18, 24, 36, 48, 60 and 72 hr postoperatively. Result: The highest VAS score was 5.7 on 1hr postoperatively. As time went by, VAS score decreased to 3.1. PONV occurred in 31 patients. The incidence of PONV is higher in female than in male (P < 0.01). Sedation occurred in 40 patients, and drowsy state is most common. Both pruritus and urinary retention occurred in 12 patients respectively. Respiratory depression below 8 breaths/min was not observed in all subjects. Conclusion: The use of PCA on patients undergoing thoracotomy represented satisfactory pain relief except immediate postoperative period. Side effects, such as PONV and sedation, were successfully treated by supportive care and temporary hold of infusion of PCA.