메틸 5-하이드록시 디나프로 [1,2-2'',3''] 후란-7,12 디온 6-카복시레이트의 물성 및 변색기전

장혜선(Hae Seon Jang),박유미(You Mie Park),강경환(Kyoung Hwan Kang),우영아(Young Ah Woo),박정일(Jeong Hill Park),김박광(Bak Kwang Kim) 대한약학회 1993 약학회지 Vol.37 No.2

Physico-chemical properties of methyl 5-hydroxy-dinaphtho[1,2-2'',3''] furan-7, 12-dione-6-carboxylate(MHDDC) were examined. The yellowish color of the solution at pH 8 below changes to a bluish color when the solution is basified to pH 10 above. This color change was presumed to a change of the molecular structure from a quinoid-type to a quinoid-type with the dissociation to the hydroxyl group as shown in chart 1.

CDM을 이용한 소형 밀폐 공간 내의 소음제어

박장관(Jang-kwan Park),구춘근(Choon-keun Koo),이해수(Hae-soo Lee),정찬수(Chan Soo Chung) 대한전기학회 1999 대한전기학회 학술대회 논문집 Vol.1999 No.7

농촌지역의 법정-기간내 출생신고율과 신고된 생년월일의 정확도

박정한,이창익,김장락,송정흡,예민해,조성억,Park, Jung-Han,Lee, Chang-Yik,Kim, Jang-Rak,Song, Jung-Hup,Yeh, Min-Hae,Cho, Seong-Eok 대한예방의학회 1988 예방의학회지 Vol.21 No.1

우리 나라의 최근 농촌 지역에서의 출생 신고의 법정 기간내 신고율과 출생 신고의 정확도를 알아보기 위해 경북 군위군에 거주하는 모든 유배우 가임 여성 4,014명을 1985년 4월 1일부터 1987년 3월 31일까지 2년간 면보건요원들이 추적 조사하여 찾아낸 모든 출생아 766명의 출생일자와 1987년 9월 30일자로 면사무소의 주민 등록 대장을 열람하여 얻은 동기간내 출생한 것으로 신고된 944건의 출생 신고 기록을 대조하였다. 추적 조사한 766명중 576명(75.2%)이 출생후 6개월 이내에 신고된 것으로 확인되었으며 96명 (12.5%)은 출생신고를 하였다고 진술하였으나 기록이 없었다. 추적 조사에 등록되어 있고 생후 6개월 이내에 출생신고가 확인된 576명의 법정 신고 기간인 30일 이래 신고율은 61.3%였다. 법정 기간내 신고율은 산모의 연령이 20세 미만이거나 35세 이상인 경우, 교육 수준은 국민학교 졸업자에서 그리고 출산 순위가 늦을수록 낮았다. 출생 월별 신고율은 10월부터 3월 시아의 출생아가 4월에서 9월 사이의 농번기의 출생아에 비해 높았다. 신생아기에 사망한 7명은 모두 출생 신고를 하지 않았다. 추적 조사에 등록되어 있고 6개월 이내에 출생 신고가 확인된 576명의 실제 출생 연월일과 주민등록표의 출생 연월일의 일치율은 78.0%였고 6.8%는 실제 출생일보다 더 이른 날짜로 신고되어 있고 15.3%는 더 늦은 날짜로 신고되어 있었다. 일치율은 산모의 연령이 35세 이상인 경우에 54.5%로 그리고 출산 순위가 4순위 이상일 때 56.3%로 특별히 낮았다. 또 산모의 학력이 높을수록 일치율이 높았으며, 남아가 여아보다 높았다. 3월에 출생한 경우에 실제 출생일보다 이른 날짜로 신고하는 율이 17.4%로 다른 달에 비해 높았고 이들은 대부분이 음력으로 신고하였는데 이것은 취학 연령을 고려한 것으로 생각된다. 최근 우리 나라 농촌 지역의 법정 기간내 신고율 및 신고의 정화도는 향상되고 있으나 아직도 선진국에 비해 낮은 편이며 출생 신고 자료에 의한 영아 사망률은 매우 부정확한 실정이다. 법정 기간내 신고율과 신고 내용의 정확도를 높히기 위해 분만 개조를 한 의료인으로 하여금 부모의 주소지로 직접 출생 신고를 하도록 하고 비의료인에 의한 가정 분만의 경우에는 현행 신고 제도대로 하는 것이 권장된다. To measure the birth registration rate and the validity of birth registration data in rural area, all of the 4,014 married women under 49 years of age who had not been sterilized in Gunwee county of Kyungpook province were followed by Myun health workers for 2 years from April 1, 1985 to March 31, 1987 and 766 births were detected. All of the birth registration records of Myun offices were reviewed on September 30, 1987 and 944 births which occurred within the above mentioned period were found. Actual birth date obtained by follow-up study were compared with the birth date on registration card. Among 766 births detected by follow-up study,576 births(75.2%) which were reported within 6 months after birth were ascertained on the official registration records and 96 births(12.5%) were not found on the records although mother stated that the birth was registered. The registration rate within legal due date was 61.3% among 576 births detected by follow-up study and also ascertained on the official records. The registration rate within legal due date was lower in mothers under 20 years of age and above 35 years and in mothers who had only primary education. It was decreased as the birth order increased. The registration rate was higher in births occurred from October to March than births occurred from April to September. All of the births of 7 neonatal deaths were not reported. The registered birth date was consistent with the actual birth date in 78.0%. Birth date on record was earlier than the actual birth date in 6.8% and later in 15.3%. The consistency rate was lower in mothers above 35 years of age(54.5%), and in infants of 4th birth order and above(56.3%). The rate was increased as the maternal education level increased. The rate of boys was higher than that of girls. A higher percentage(17.4%) of infants born in March was registered with earlier date than the actual birth date and most of these registered birth dates were lunar calendar date. This might be related with the age for entering the primary school. The study findings revealed that the birth registration rate within legal due date and accuracy of report have been increased in recent years, but the infant mortality rate derived from the birth registration seems to be very inaccurate. It is suggested to let the medical personnel who delivered the baby report the birth by mail directly to the current address of parent while infants delivered at home without professional attendant may comply with the present registration system.

사무소 건물의 에너지성능기준 시행에 관한 연구

박상동,박효순,우정선,신기식,장해진,태춘섭,Park, Sang-Dong,Park, Hyo-Sun,U, Jeong-Seon,Sin, Gi-Sik,Jang, Hae-Jin,Tae, Chun-Seop 대한건축사협회 1986 建築士 Vol.1986 No.12

서울시 경기종합지수 개발에 관한 연구

박희석(Hee-Seok Park),조달호(Dal-Ho Cho),홍나미(Na-Mi Hong),장보혜(Bo-Hae Jang) 서울연구원 2006 서울연구원 정책과제연구보고서 Vol.- No.-

골 주사 검사를 이용한 부주상골의 평가와 예후 및 치료에 대한 임상적 의의

박성해,이준영,장현웅,Park, Sung Hae,Lee, Jun Young,Jang, Hyun Woong 대한족부족관절학회 2018 대한족부족관절학회지 Vol.22 No.2

Purpose: To evaluate the clinical significance and usefulness of a bone scan in accessory navicular bone. Materials and Methods: Eighty-five patients with foot pain and accessory navicular bone on radiography, who underwent bone scan from 2012 to 2015, were analyzed retrospectively. The subjects was divided into a symptomatic and asymptomatic group according to the presence of navicular bone tenderness. The grade of bone scan uptake was divided into 3 grades. Age, gender, grade of bone scan and size of the accessory navicular bone were analyzed. The symptomatic group were divided into a low (grade 0, 1) and high uptake (grade 2) group to determine the appropriate treatment. The low uptake group was treated conservatively for 3 months. The high uptake group was initially treated conservatively for 3 months and surgery was performed if pain persisted. For the clinical evaluation, the visual analogue scale, American Orthopaedic Foot and Ankle Society midfoot scale were evaluated in the first examination and last follow-up date. The patient's satisfaction grade was also evaluated at the last follow-up. Results: The asymptomatic group mostly showed no uptake in the bone scan. On the other hand, some patients in the asymptomatic group showed an increase in uptake. In these patients, the size of accessory navicular bone was related to the grade of bone scan uptake, showing that the bone scan uptake grade can be predicted when applying different cut off values for the bone size. The symptomatic group mostly showed uptake in the bone scan and the grade of uptake had a positive correlation with the size of the accessory navicular bone (p<0.05). Age and gender were not related to the bone scan uptake. In the clinical evaluation, conservative and surgical treatment showed a good outcome. Conclusion: The bone scan uptake grade alone cannot be used to completely predict the symptoms. On the other hand, the size of the accessory bone can increase the bone scan uptake. Therefore, the size of the accessory bone, and patient symptoms should be considered in patients with a high uptake when deciding treatment.

Cohort Infant Mortality Rate of Gunwee and Hapchun Counties and an MCH Center in Taegu

박정한,예민해,천병렬,송정흡,김귀연,김장락,조성억,김현,정한진,조재연,Park, Jung-Han,Yeh, Min-Hae,Chun, Byung-Yeol,Song, Jung-Hub,Kim, Gui-Yeon,Kim, Jang-Rak,Cho, Sung-Euk,Kim, Hyun,Chung, Han-Jin,Cho, Jae-Yeon The Korean Society for Preventive Medicine 1990 예방의학회지 Vol.23 No.1

1985년 4월 1일부터 1987년 3월 31일 사이에 경상북도 군위군에 거주하는 49세이하의 가임여성들과 1987년 3월 1일부터 1988년 2월 28일 사이에 경상남도 합천군에 거주하는 49세이하의 가임여성들 그리고 1985년 4월 1일부터 1987년 3월 31일 사이에 대구시 남구 모자보건센터에 분만을 위해 찾아온 모든 임산부들을 대상으로 이들에게서 태어난 출생아들을 두 군지역에서는 생후 1년간 그리고 모자보건센터에서 출생한 경우는 생후 27일간 추적하여 영아사망률과 신생아 사망률을 각각 조사하였다. 조사기간중에 군위군과 합천군에서 출생한 1,359명의 영아들 가운데 생후 1년 동안에 17명이 사망하여 농촌지역의 영아사망률은 출생아 1,000명당 12.5이었다. 총 영아사망중 신생아사망이 82.4% 그리고 신생아 후기 사망이 17.6%를 차지하였다. 대구시 남구 모자보건센터에 내원한 산모들에게 태어난 6,001명의 출생아들 가운데 4,834명(80.6%)만이 생후 27일까지 추적되었는데 이들 중 36명이 사망하여 신생아 사망률은 출생아 1,000명당 7,4명이었다. 추적된 산모와 추적 안된 산모의 특성 및 신생아 체중을 비교한 결과 현저한 차이를 나타내지 않았다. 신생아 후기 사망률의 비를 6 : 4로 가정했을 때 모자보건센터에서 출생한 영아의 영아사망률은 출생아 1,000명당 12.3명으로 추정되었다. 군위군과 합천군의 영아사망률과 대구시 남구 모자보건센터에서 관찰된 신생아사망률, 영아사망의 사망시기별 분포와 영아사망원인 그리고 저체중아출생률을 고려할 때 1985년부터 1988년 사이의 한국의 영아사망률은 출생아 1,000명당 12에서 15명일 것으로 추정되었다. We followed up all the infants born to the married women under 50 years of age residing in Gunwee county, Kyungpook Province, between 1 April 1985 and 31 March 1987, and those born to the married women under 50 years residing in Hapchun County, Kyungnam Province, between 1 March 1987 and 28 February 1988, to their first birthday. Likewise, we followed up the infants born to the women who visited the MCH Center of South District Health Center in Taegu City for delivery between 1 April 1985 and 31 March 1987 to the 27th day after birth and obtained the infant mortality rate and the neonatal mortality rate, respectively. There were 17 infant deaths among 1,359 live births in Gunwee and Hapchun Counties and the infant mortality rate was 12.5 per 1,000 live births. Out of 17 infant deaths, 82.4 percent were neontal death and 17.6 percent were postnonatal deaths. Out of the 6,001 live births born to the women visited the MCH Center, 4,834 infants (80.6%) were followed up to the 27th day after birth. Of these 4,834 infants, 36 infants died before the 28th day after birth and thus the neonatal mortality rate was 7.4 per 1,000 live births. Comparison of the maternal characteristics and the birth weight between infants who were followed up and those who were lost to follow-up showed no significant differences. Assuming that the neonatal and postneounatal mortality ratio had been 6:4, the infant mortality rate for the infants born at the MCH Center would have been 12.3 per 1,000 live births. Taking such findings into consideration as the infant mortality rate observed in Gunwee and Hapchun Counties, the neonatal mortality rate at the MCH Center, the causes of infant deaths, and the low birth weight incidence rate, a conservative estimate of infant mortality rate of Korea would be between 12 and 15 per 1,000 live births in $1985{\sim}1988$.

조영제 사용 전 피부반응검사 후 발생한 조영제 과민반응의 발생 빈도와 임상 양상

박보배 ( Bo Bae Park ),박창한 ( Chang Han Park ),노인영 ( In Young Nho ),김해성 ( Hae Sung Kim ),강남규 ( Nam Kyu Kang ),장석일 ( Suk Il Chang ),김장민 ( Jang Min Kim ) 대한천식알레르기학회(구 대한알레르기학회) 2016 Allergy Asthma & Respiratory Disease Vol.4 No.6

Purpose: Hypersensitivity reactions to contrast media (CM) are one of the most common causes of drug adverse reactions. The overall prevalence of immediate hypersensitivity reaction (IHR) was 0.16%-7.7% to nonionic CM. Although IHR to CM has been traditionally considered nonallergic, there is growing evidence that the mechanism of IHR to CM is mediated by IgE. It can be severe, even fatal, and a legal problem. To reduce IHR, the prescreening skin test is on the rise. Methods: We reviewed cases of IHR to CM during enhanced computed tomography (CT) from 2008 to 2015 at a secondary hospital in South Korea. Patients who underwent enhanced CT were performed the 2-step prescreening skin test before nonionic CM-enhanced CT. If patients had adverse reactions to CM, the reactions were reported. IHR to CM was defined as an immediate reaction within 1 hour after CM administration. The Ring and Messmer system was used to classify the severity of reactions by grades I to IV, and we defined grades III and IV as severe reactions. Results: A total of 30,105 CM-enhanced CT cases were recruited from 2008 to 2015. A total 46 patients with CM adverse reactions were reported. The IHR were noted in 30 of the total patients (0.1%), of which 6 had severe reaction. Conclusion: The prevalences of IHR and severe IHR to CM were 0.1% and 0.02%, respectively. Further studies are needed to evaluate the usefulness of prescreening skin tests to prevent IHR to CM. (Allergy Asthma Respir Dis 2016:4:442-448)

한라산 천연보호구역 내 5.16 도로 인근 산림토양의 분류

박원표(Won-Pyo Park),장진현(Jin-Hyeon Jang),고석형(Suk-Hyung Ko),현해남(Hae-Nam Hyun),송관철(Kwan-Cheol Song) 한국토양비료학회 2022 한국토양비료학회 학술발표회 초록집 Vol.2022 No.10

메틸 5-히드록시 디나프로[1, 2-2'', 3'']푸란-7, 12 디온 6-카복시레이트의 미량분석

박유미(You Mie Park),장혜선(Hae Seon Jang),강경환(Kyoung Hwan Kang),김경님(Kyung Nim Kim),장성기(Seong Ki Jang),김박광(Bak Kwang Kim) 대한약학회 1993 약학회지 Vol.37 No.3

UV and high performance liquid chromatographic methods for the quantitative analysis of methyl 5-hydroxy-dinaphtho [1, 2-2'', 3''] furan-7,12-dione-6-carboxylate(MHDDC) in urine and blood were developed. The correlation coefficients of the calibration curves of MHDDC in chloroform, methanol and dioxane solution were 0.999, 0.997 and 0.998, respectively. MHDDC was resolved within 15 min and had a detection limit of 2~5ng at S/N 3 by using a reversed-phase column with two solvents (MeOH, HAc).