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A Thyroglossal Duct Cyst Causing Obstructive Sleep Apnea in Adult
정한진,김정훈,이철희,정영준,모지훈 대한이비인후과학회 2013 Clinical and Experimental Otorhinolaryngology Vol.6 No.3
Obstructive sleep apnea (OSA) is a common disorder. It usually results from the structural compromise of the upper airway. In patients with OSA, the obstruction predominantly occurs along the pharyngeal airway, and also a variety of tumors have been reported to cause such a condition. We present here the case of a thyroglossal duct cyst causing OSA in adult. This case demonstrates that thyroglossal duct cyst or some kind of mass lesions in the airway lesions should be considered in the differential diagnosis of OSA patients.
Genetic and morphological divergence of Euphorbia esula and E. maackii in Korea (Euphorbiaceae)
정한진,박기룡 한국식물분류학회 2012 식물 분류학회지 Vol.42 No.4
To understand morphological and genetic differentiation between Euphorbia esula and E. maackii we examined 12 morphological characters and 11 isozyme loci from 14 populations of two species. Species of E. esula complex (A = 1.63, P = 44.83, He = 0.198) in Korea maintain nearly as high as the genetic diversity reported in East Asian E. jolkinii and E. fauriei while lower than those of E. ebracteolata and E. pekinensis in Korea. Although the ranges of most morphological character variation of the two species overlap, E. esula and E. maackii were well recognized by the combination of the morphological traits, and the result of UPGMA phenogram supports the two distinct species inhibited in Korea. However, isozyme data do not support the recognition of E. esula and E. maackii. The discordance between morphological and allozyme data should be explained by the recent divergence or gene flow via introgressive hybridization between two species.
양성자 펌프 억제제가 인후두 역류증과 동반된 만성 비부비동염에 미치는 영향
정한진,김지환,강민혁,이동욱 대한이비인후과학회 2019 대한이비인후과학회지 두경부외과학 Vol.62 No.3
Background and Objectives Laryngopharyngeal reflux (LPR) is a prevalent condition with an increasing incidence, and several recent studies have reported the association of LPR with chronic rhinosinusitis (CRS). In this study, we studied the effect of proton-pump inhibitors (PPIs) on symptom improvement for LPR and comorbid CRS. Subjects and Method Enrolled in the study from January 2017 to December 2017 were 164 patients (54 male, 110 female, mean age 48.8 years) who were diagnosed as LPR by reflux symptom index (RSI) or reflux finding scores (RFS) and comorbid CRS. Sino-Nasal Outcome Test (SNOT)-20 and Lund-Kennedy endoscopic scores were evaluated for CRS severity. The study group was divided into PPI treatment group (Ilaprazole 20 mg, once a day for 8 weeks) and non-treatment group. The RSI, RFS, SNOT-20, and Lund-Kennedy endoscopic scores were repeated at the end of treatment. Results Ninety-two patients were prescribed PPI and 72 patients were not. Initial RSI, RFS, SNOT-20, and Lund-Kennedy score did not differ between the two groups. RSI and RFS decreased significantly after eight weeks of PPI medication (p=0.002 and p<0.001, respectively). In the non-treatment group, only RFS showed statistically significant decrease. SNOT-20 and Lund-Kennedy endoscopic scores decreased significantly in the treatment group (p=0.005 and p<0.001, respectively) compared to the non-treatment group. Conclusion The results of our study suggest that PPI treatment for 8 weeks was effective in reducing signs and symptoms of both LPR and CRS.
Pigmented Basal Cell Carcinoma of the Nipple-Areola Complex in an Elderly Woman
정한진,전재훈,김호연,이석종,김도원,이원주,정진향 대한피부과학회 2011 Annals of Dermatology Vol.23 No.-
Basal cell carcinoma (BCC), which frequently occurs in sun-exposed areas of the head and neck region, is the most common cutaneous malignancy. The nipple-areola complex (NAC) is an uncommon site for BCC to develop. BCCs in this region display more aggressive behavior and a greater potential to spread than when found in other anatomical sites. This paper outlines the case of 67-year-old female with a solitary asymptomatic black plaque on the right areola. The lesion was initially recognized as Paget’s disease of the nipple by a general surgeon. However, the histopathological features showed a tumor mass of basaloid cells, a peripheral palisading arrangement and scattered pigment granules. Finally, the patient was diagnosed with pigmented BCC of the NAC and was referred to the department of dermatology. Positron emission tomography-computed tomography revealed the absence of distant metastasis. A wide excision was done. The lesion resolved without recurrence or metastasis during 14 months of follow-up. (Ann Dermatol 23(S2) S201∼S204, 2011)
정한진,한두희 대한이비인후과학회 2023 대한이비인후과학회지 두경부외과학 Vol.66 No.2
Health impacts of particulate matter (PM) have become a global concern. PM tends to affectpatients with allergic diseases, such as allergic rhinitis (AR), more severely. Many epidemio-logical studies have shown that PM increases outpatient clinic visits as well as the prevalenceand severity of AR, while decreasing the quality of life of AR patients. However, the exactmechanisms underlying the effects of PM on the development and exacerbation of AR are stillpoorly understood. Various mechanisms are involved in the effects of PM on AR, includingimmunological response, oxidative stress, epithelial barrier dysfunction, allergic sensitization,and epigenetic modification. This article reviews epidemiological and clinical studies on theeffects of PM on AR, and the mechanisms by which PM aggravates AR.
시린지리스 전기방사를 통한 부직포 기반 건조 콜라겐 마스크팩 제조
정한진,이소연,윤재중,이경진 한국고분자학회 2022 폴리머 Vol.46 No.3
마스크 팩은 다양한 유효 물질을 함유하며 피부 개선을 위해 이용되고 있으나, 최근 1회용 플라스틱 지지체 이용의 최소화를 위해 건조 형태의 마스크 팩에 대한 많은 연구가 진행되고 있다. 본 연구에서는 유효 물질인 저분자량 콜라겐과 고분자량 히알루론산을 기반으로 하여 시린지리스 전기방사를 통해 나노 섬유 부직포를 제조하였다. 이를 통해 마스크 팩의 표면적을 향상시키고 유효 물질의 전달 속도를 개선하고자 하였다. 고분자 용액 조성을 조절하고 모폴로지를 관찰하여 전기 방사성이 용이하면서도 유효 물질인 콜라겐이 다량 함유된 부직포 기반 마스크팩을 제조할 수 있었다. 또한 물 분사 시 건조된 콜라겐 부직포가 용해되는 것을 통해 건조 마스크 팩으로서의 응용 가능성을 확인하였다.