http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Recent studies on micro-/nano-sized biomaterials for cancer immunotherapy
박옥,유경희,정희정,목혜정 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.1
To overcome the suppressive tumor microenvironment and boost the antitumor effect of the immune system, recent studies have focused on a diverse range of immune checkpoint molecules. Several immune checkpoint molecules are currently approved for clinical use, including immunotherapy using antibodies against cytotoxic T-lymphocyte antigen-4 and programmed cell death protein-1. Biomaterials such as particle-based systems, scaffolds, and conjugates have been harnessed to elevate the biological performance of immune modulators in vivo by enhancing their delivery efficiency and in vivo half-life. In particular, microparticles are advantageous for the sustained release of encapsulated immune stimulators and selective intracellular delivery to phagocytic APCs such as dendritic cells and macrophages for activation of cell-mediated immune responses through cytotoxic T cells. Nanoparticles have ideal properties for targeted delivery of immune-regulating molecules to tumor-draining lymph nodes after systemic injection. More recent therapeutic approaches, including combination therapy of immune checkpoint molecules with small molecular anticancer or anti-inflammation drugs, may help to broaden the range of current therapeutic targets and lower side effects. Taken together, particle-based biomaterials could enhance therapeutic outcomes of current biotherapies (antibodies, cells, and genes), and—more importantly—of immunotherapy combined with chemotherapies.
박옥,최보율,Park, Ok,Choi, Bo-Youl 대한예방의학회 2007 예방의학회지 Vol.40 No.4
Effective communicable disease surveillance systems are the basis of the national disease prevention and control. Following the increase in emerging and re-emerging infectious diseases since late 1990s, the Korean government has strived to enhance surveillance and response system. Since 2000, sentinel surveillance, such as influenza sentinel surveillance, pediatric sentinel surveillance, school-based sentinel surveillance and ophthalmological sentinel surveillance, was introduced to improve the surveillance activities. Electronic reporting system was developed in 2000, enabling the establishment of national database of reported cases. Disweb, a portal for sharing communicable disease information with the public and health care workers, was developed. In general, the survey results on usefulness and attributes of the system, such as simplicity, flexibility, acceptability, sensitivity, timeliness, and representa-tiveness, received relatively high recognition. Compared to the number of paid cases of national health insurance, reported cases by national notifiable disease surveillance system, and various sentinel surveillance system, the result of the correlation analysis was high. According to the research project conducted by KCDC, the reporting rate of physicians in 2004 has also greatly improved, compared with that in 1990s. However, continuous efforts are needed to further improve the communicable disease surveillance system. Awareness of physicians on communicable disease surveillance system must be improved by conducting education and information campaigns on a continuous basis. We should also devise means for efficient use of various administrative data including cause of death statistics and health insurance. In addition, efficiency of the system must be improved by linking data from various surveillance system.
박옥임,김경신,정혜정 한국가족관계학회 1999 한국가족관계학회지 Vol.4 No.2
The purposes of this research were to find out general trends of wife abuse and to investigate the differences and effects of related variables. The data were obtained through 441 women living in Kwangju, Chonnam and Chonbuk. The major findings were as follows: 1) The scores of wife abuse permission and occurrence were relatively low. And patriarchal attitudes were revealed to be modernized. 2) Significant differences in wife abuse permission were found according to wife's job, family value orientations and the acceptance level of common notion about wife abuse. Wife abuse occurrence were different according to education, job, marriage satisfaction, depression, and psychological abuse permission. 3) In analyzing the causal effects among related variables, wife abuse permission were affected by the acceptance level of common notion, marital power, and self-esteem. Also wife abuse occurrence were influenced by depression, marriage satisfaction, and women's education.
박옥임(Ok-Im Park),문희(Hee Moon) 한국엔터테인먼트산업학회 2015 한국엔터테인먼트산업학회논문지 Vol.9 No.2
이 연구는 감정노동과 여성간호사의 생식건강과의 관계를 확인하고 감정노동이 생식건강에 미치는 영향을 알아보기 위하여 시도되었다. 연구대상은 병원에 근무하는 간호사 259명으로 하였으며 구조화된 설문지인 감정노동 측정도구와 생식건강 측정도구를 사용하여 측정하였다. 자료분석은 SPSS 17.0 Program을 이용하였으며 감정노동과 생식건강의 관계 및 생식건강에 미치는 영향을 파악하기 위하여 피어슨 상관계수와 회귀분석으로 분석하였다. 본 연구의 결과는 다음과 같다. 여성간호사의 생식건강은 연령, 학력, 교대 근무에 따라 차이가 있었으며 감정노동과 생식건강은 유의한 정의 상관관계로 감정노동이 증가할수록 생식건강의 위험이 높아짐을 알 수 있었다. 여성간호사의 생식건강에 영향을 미치는 요인은 감정노동이었으며 생식건강에 대한 설명력은 13%이었다. 이상의 연구결과 감정노동이 여성간호사의 생식건강에 중요하게 영향을 미치는 요인임을 알 수 있었다. 따라서 여성간호사의 생식건강 증진을 위해 향후 감정노동을 관리할 수 있는 중재프로그램의 개발이 필요할 것이다. This research has been carried out to examine the effects of emotional labor on female reproductive system and the influence factors. In doing so, 259 nurses from hospitals have been given with structured questionnaires including emotional labor and reproductive system health measurements. To analyse collected data, SPSS 17.0 program has been employed. Further, the effects of emotional labor on reproductive system have been analyzed through Pearson"s Correlation Coefficient and Stepwise multiple Regression. The results are as follows. There have been differences in the state of female reproductive system according to age, education and work rotation. In addition, a positive correlation between the two factors that the risks of reproductive system increases with increase in the level of emotional labor The influence factors for female reproductive system are age, and emotional labor. Among them, emotional labor has been found to be most influential. The explanatory power of these variables has been 13%. According to these findings, emotional labor has been found to influence female reproductive system mostly. Therefore, there needs to be mediate program for managing to improve the state of female reproductive system.