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지방중소도시의 도심재생을 위한 도심재생 정책 및 제도에 관한 비교연구
박상제(Park Sang-Je),정재용(Chung Jae-Yong) 대한건축학회 2009 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.29 No.1(계획계)
The present study induced suggestions by comparing downtown regeneration policies of the United States?England?Japan, which are advanced countries of downtown regeneration business, with our country's policy to criticize the downtown regeneration policy of our country's local small and mid-sized cities.
하홍석(Ha Hong-Seok),허재원(Huh Jae-Won),김대수(Kim Dae-Soo),박상제(Park Sang-Je),배진한(Bae Jin-Han),안궁(Ahn Kung),윤세은(Yun Se-Eun),김희수(Kim Heui-Soo) 한국생명과학회 2009 생명과학회지 Vol.19 No.4
유전자의 융합으로 인한 돌연변이는 염색체 재배열, 트랜스스플라이싱, 유전자간 스플라이싱으로 인하여 야기된다고 알려져 있다. 우리는 두 개의 서로 다른 유전자의 pre-mRNA의 융합으로 인하여 만들어지는 트랜스 스플라이싱의 전사 산물에 관심을 가져, 인간의 태아 줄기 세포에서 이러한 돌연변이 양상을 분석하였다. 배아줄기세포의 mRNA에서 트랜스 스플라이싱 전사체 70개를 탐지해 내고, 이들의 융합되는 패턴에 따라 5'UTR-5'UTR, 5'UTR-3'UTR, 3'UTR-3'UTR, 5'UTRCDS, 3'UTR-CDS, CDS-CDS의 6개의 유형으로 분류하여 분석하였다. 두 유전자의 융합되는 영역은 UTR영역보다 CDS에서 풍부하였는데, 이러한 이유는 많은 인트론 수로 인해 야기되는 것으로 추정된다. 융합되는 유전자의 염색체상의 위치분석 결과, 17번과 19번 염색체가 융합유전자의 활성화를 나타내었다. 이러한 연구결과는 향후 융합유전자와 인간의 질병연구에 크게 기여할 것으로 사료된다. Genetic mutations by gene fusion result from chromosomal rearrangement, trans-splicing, and intergenic splicing. Trans-splicing is a phenomenon in which two pre-mRNAs grow together into one. We analyzed the trans-splicing products in embryonic stem cells. By using bioinformatic tools, 70 trans-splicing transcripts were identified. They are classified into 6 types according to fusion pattern: 5'UTR-5'UTR, 5'UTR-3'UTR, 3'UTR-3'UTR, 5'UTR-CDS, 3'UTR-CDS, CDS-CDS. The fusion products are more abundant in CDS regions than in UTR regions, which contain multiple intron numbers. Chromosome analysis showing gene fusion via trans-splicing indicated that chromosomes 17 and 19 were activated. These data are of great use for further studies in relation to fusion genes and human diseases.
위장관 출혈을 동반한 원발성 양성 소장 간질종양 1 예
서길동(Kil Dong Seo),김명준(Myung Jun Kim),김수형(Su Hyung Kim),김일두(Il Doo Kim),허정호(Jeong Ho Heo),이채원(Chae Won Lee),박상제(Sang Je Park),김상현(Sang Hyun Kim),조성락(Sung Rak Cho) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.5
The origin and clinical behavior of gastrointestinal stromal tumors (GISTs) have been a source of recent speculation and controversy. GIST has been applied to mesenchymal tumors that represent neither their typical leiomyomas nor schwannomas. GISTs are spindle cell tumors occurring mainly in adults with 5-year survivals in 50-56% and 10-year survivals in 35-43%. Because of its indolent and slow-growing nature, it is difficult to define it as malignancy. We report a case of benign stromal tumor of the proximal jejunum presenting melena in a 32-year-old male. Small bowel series and computed tomography of the abdomen revealed submucosal tumor in the proximal jejunum. Histological studies on the surgical resection specimen revealed a gastrointestinal stromal tumor of a benign type with no evidence of metastasis. The patient was treated with local excision of the tumor and is now in a favorable state. (Korean J Gastroenterol 2001;38:371-375)
박희승,김우성,이영석,최성호,김만조,박상제,김은규,최세림,송동주,엄정섭 대한소화기내시경학회 2001 Clinical Endoscopy Vol.23 No.3
Carcinoid tumors of the rectum are relatively uncommon and comprise only about one percent of all rectal neoplasms. Typically, rectal carcinoids present as small, solitary submucosal nodules and have benign course. But, multicentricity is rare. The frequency of an associated second malignancy is about 13%. The explanation of the high frequency of other neoplasms associated with carcinoid tumors is still unclear. We have experienced two cases of multiple carcinoid tumors of the rectum, one was coexisted with adenocarcinoma of the sigmoid colon. They presented with mass on the right inguinal area and hematochezia. Carcnoids was found incidentally. Because the tumors measured 15 mm or less in diameter, did not infiltrate beyond the submucosal layer and had no histological atypia, carcinoids was treated by endoscopic polypectomy and mucosal resection. Thereafter, one underwent surgery for adenocarcinoma of the sigmoid colon. Herein we present our experience with reviewed literatures.
Dieulafoy 양 병변에 의한 십이지장게실 출혈 1 예
김상현,김경환,이동현,송철수,정노원,박상제,김은규,하홍성,나일환,황윤이,성은영,최익수,신영기 대한소화기내시경학회 2001 Clinical Endoscopy Vol.23 No.1
Duodenal diverticula are first reported by Chomel in 1710. Duodenal diverticula are relatively common in adults with a prevalence of 23% in SRCP. The most duodenal diverticulum is asymptomatic. Complications such as obstruction, cholangitis, blliary stones, ulceration, perforation and hemorrhage can occur in approximately 10%. However, relatively few cases of bleeding from a duodenal diverticulum have been reported. The cause of bleeding from a duodenal diverticulum is uncertain and various suspected etiologies were suggested, such as ectopic gastric mucosa, stasis-induced ulceration, erosion into major vessels, aortoenteric fistuias, intradiverticujar polyp, aspirin-induced erosion. We report a case of a bleeding duodenal diverticulum by a Dieulafoy-like lesion and suggest this 1esion as one of posslble causes of blee4ng in duodenal diverticulum.
이동현,최익수,송철수,정노원,박상제,김은규,하홍성,성은영,신영기,고우석,강경하 대한소화기학회 2000 대한소화기학회지 Vol.36 No.2
Ganglioneuromatosis is a benign tumor composed of ganglion cells, nerve fibers and spindle-shaped neural cells of probable schwann cell origin. They mostly occur in the retroperitoneum and posterior mediastinum. Gastrointestinal ganglioneuromatosis is rarely encountered in clinical practice. It may be associated with systemic disease such as multiple endocrine neoplasia IIb, von Recklinghausen's disease, juvenile polyposis and tuberous sclerosis. To our knowledge, it is the first report which presents a colonic ganglioneuromatosis combined with colonic adenoma.