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상피성 난소종양에서 SPARC 발현과 임상병리학적 연관성에 관한 연구
박상일 ( Sang Il Park ),이의돈 ( Eui Don Lee ),서동수 ( Dong Soo Suh ),김기형 ( Ki Hyung Kim ),윤만수 ( Man Soo Yoon ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.12
목적 Secreted protein acidic and rich in cysteine (SPARC)는 세포 부착과 운동, 세포 분화, 세포 증식, 그리고 혈관형성 등에 영향을 주는 기질세포 당단백이다. 이 물질은 다양한 암세포의 증식과 억제에 관련된 것으로 알려져 왔다. 본 연구의 목적은 난소상피종양 발생 및 진행에 있어 SPARC 발현양상과 임상병리학적 인자들과의 상관관계를 알아보고자 한다. 연구방법 수술 후 획득한 악성 상피성 난소종양 69예, 경계성 종양 18예, 양성종양 10예 그리고 정상 난소 조직을 대상으로 하였고, SPARC 단백의 발현은 면역조직화학염색을 통하여 조사하였다. 후향적 분석을 통하여 환자의 성향과 표본을 분석하였다. 결과 SPARC 면역조직화학염색에서 정상 난소 조직의 경우 거의 모든 조직에서 간질세포가 양성 소견을 보였으며, 일부 양성 및 경계성 종양 조직에서도 양성 소견을 보였다(100%, 94.7%, and 100%). 반면 명확한 침윤을 보이는 상피성 난소암으로 진행할수록 간질세포에 대한 SPARC 단백 발현은 의미 있게 감소하는 경향을 보였고(63.8% [44/69]), 면역반응 점수도 유의하게 감소되었다(P < 0.001). 상피성 난소암에서의 SPARC의 발현은 International Federation of Gynecology and Obstetrics 병기와 유의한 상관관계가 있었다. 그러나 조직학적 유형, 종양 분화도, 핵등급, 세포분열 수, 종양의 크기, 국소재발, 원격전이, 그리고 생존율 등의 다른 임상병리학적 인자들과는 유의한 상관관계를 보이지 않았다. 결론 본 연구는 SPARC 단백 발현의 감소는 종양의 악성도와 유의하게 관련되어 있으며 SPARC는 상피종양 발생과정에 있어 종양억제 인자로서 작용함을 보여준다. Objective Secreted protein acidic and rich in cysteine (SPARC) is an extracellular matrix-associated protein implicated in the modulation of cell adhesion, migration, cell cycle regulation, and angiogenesis. It has been associated with the progression or suppression of various cancers. This study was aimed at correlating SPARC protein expression with tumor progression and clinicopathological features in ovarian epithelial tumors. Methods Epithelial ovarian cancer (n=69), borderline tumor (n=18), benign tumor (n=10) and normal ovary tissues were obtained after operation. SPARC protein expression was examined using immunohistochemistry. With a retrospective review, patients` characteristics and slide samples were analyzed. Results Cytoplasmic SPARC immunoreactivity was observed in stromal cells in nearly all cases of normal ovary, benign and borderline tumors (100%, 94.7%, and 100%). In contrast, SPARC was detected in the stroma of 63.8% (44/69) and the score of immunoreactivity was significantly reduced in malignant tumors (P<0.001). SPARC expression in ovarian epithelial cancers was significantly associated with International Federation of Gynecology and Obstetrics stage. However, it was not correlated with other clinicopathologic parameters, including histologic type, tumor grade, nuclear grade, mitosis, tumor size, local recurrence, distant metastasis, and survival. Conclusion This study showed that reduction of SPARC expression in ovarian epithelial tumors is significantly correlated with tumor invasiveness and SPARC may act as tumor suppressor.
박연보 ( Youn Bo Park ),강희정 ( Hee Jung Kang ),권흥만 ( Hung Man Kwon ),안상진 ( Sang Jin Ahn ),양석환 ( Suk Hwan Yang ),태연주 ( Yeun Ju Tae ),진영희 ( Young Hee Chin ),조현구 ( Hyon Koo Jo ),이복자 ( Bok Ja Lee ),구선회 ( Sun 대한임상검사과학회 2004 대한임상검사과학회지(KJCLS) Vol.36 No.2
The sample collection room(SCR) will have much more influence than all the other departments for the improvement of hospital image, if anyone coming to the SCR in the hospital goes back with the perfect complacency and because most clients who have much stresses and fatigues pay a final visit to the SCR via receipt-diagnosis- acceptance process. SCR has improved its image for the purpose of gratifying clients, in order for clients to visit the hospital again, the quality improvement(QI) team in the Diagnosis Inspection Medical Department has come to a conclusion as follows. The degree of client gratification before improvement marks 65.9 point, but the degree after improvement was 74.2 point. Therefore, satisfaction has increased by 8.3 points. The degree of client gratification in groups before improvement marks (1) service parts-89.2 points (2) facilities and environments-49.1 point (3) toilet facilities-46.3 point. But its gratification after improvement marks (1) 92.5 point (2) 60.1 point (3) 61.0 point. Therefore the degree of satisfaction has increased by (1) 3.3 point, (2) 11.0 point, (3) 14.7 point. The progress of facility improvement plans and the exclusion of improvement on the facility contents in the hospital have made facilities and environments of SCR and toilet facilities to be poorly improved. Although service parts have a good mark, and the facilities and environments are not scoring well, the whole degree clients`` gratification of SCR couldn``t be helped by the low grade. Therefore the bottom line for the clients`` gratification of SCR in the future is to ameliorate the facilities and environments. SCR will take the clients`` gratification survey every year and if any items get low marks, that is, below 90 point throughout the survey, SCR will immediately starts the improvement work for the clients`` gratification with operating the programs of controlling quality continually, and SCR should induce the operation of services, participating in the kind campaign drive for clients. So SCR will adopt the incentive system for the best staff members who perform these kinds of services.
길경 Saponin이 고지방식이를 한 흰쥐의 혈청, 간장 및 분변 지질 함량에 미치는 영향
박무희(Mu-Hee Park),이영주(Young-Ju Lee),황성원(Sung-Wong Hwang),한준표(Jun-Pyo Han),배만종(Man-Jong Bae) 한국식품영양과학회 1994 한국식품영양과학회지 Vol.23 No.4
6주간 고지방식이를 섭취한 흰쥐에 있어서 길경 saponin이 지방 축적 억제와 대사에 미치는 영향을 검토하고자 혈청과 간장 및 분변 중 지방 성분을 생화학적으로 분석하여 다음과 같은 결과를 얻었다. 1. 혈청 및 간장중의 총지질, 총콜레스테롤 및 중성지방 함량은 길경 saponin군이 대조군에 비하여 유의한 감소를 보였다. 2. 분변 중 총지질 및 총콜레스테롤 함량은 대조군과 비교할 때 길경 saponin군이 다소 배설이 증가되었으나, 유의성은 인정되지 않았다. This study was conducted to investigate the effect of Platycodi radix saponin (PRS) on the reduction of lipid status in rats fed on high fat diet for 6 weeks after which lipid contents were measured in serum, liver and feces. The results obtained from this study are as follows; That the levels of total lipid, total cholesterol and triglyceride in serum and liver were significantly lower in the PRS group as compared with the control group. The contents of total lipid and total cholesterol excreted in the feces were tended to be slightly increase in PRS group compared to the control group, which were not significant.
일본과 한국의 기능성 유제품의 규격기준 및 시장현황에 관한 연구
박다정,이단원,박정민,신진호,김지연,전상록,송태석,윤성식,김진만,Bak, Da-Jeong,Lee, Dan-Won,Park, Jung-Min,Shin, Jin-Ho,Kim, Ji-Youn,Jeon, Sang-Rok,Song, Tae-Suk,Yoon, Sung-Sik,Kim, Jin-Man 한국축산식품학회 2009 한국축산식품학회지 Vol.29 No.4
Changing health awareness has had an important effect on the functional food industry and is creating greater market opportunities. Unfortunately, there is no statement on functional dairy products in the Processing of Livestock Products Act. As a result, there is confusion in the market and legal difficulties with regard to the advertising of functional dairy products. This study was carried out to improve the current standardization of functional dairy products by comparing the domestic Health/Functional Food Act with the Japanese Health Promotion Law, and by investigating scientific data and articles from various literature and the Internet. In Japan, the Ministry of Health, Labor, and Welfare (MHLW) officially presented the Food with Health Claims (FHC) system that consists of Food with Nutrient Function Claims (FNFC), and innovated Food for Specified Health Uses (FOSHU). In 2005, the FOSHU system was changed to include several new subsystems: Current, Standardized, Reduction of disease risk, and Qualified FOSHU. Finally, to manufacture FOSHU, scientific evidence pertaining to such products must be examined by MHLW. Since FNFC was allowed, only 12 vitamins, ${\beta}-carotene$, and five minerals were approved, though without scientific evidence of efficacy. The Korean Health/Functional Food Act requires that health/functional foods (HFFs) be marketed in measured doses. There are two types of HFFs: generic and product-specific. There are 67 ingredients listed in the act for generic HFFs, and if an HFF has a new active ingredient, it is considered a product-specific HFF. Product-specific HFFs must be approved by the Korean Food and Drug Administration (KFDA). With the present standards, it is impossible to label and advertise functional dairy products with health/functional claims. Government agencies must cooperate to solve this problem, and standardization should be carried out by considering existing health/functional products and claims/indications from other countries.
Yb<sub>2</sub>O<sub>3</sub>가 첨가된 (Ba<sub>1</sub>Sr<sub>1</sub>Ca)TiO<sub>3</sub>후막의 치밀화와 유전특성
박상만,이영희,남성필,이성갑,Park, Sang-Man,Lee, Young-Hie,Nam, Sung-Pil,Lee, Sung-Gap 한국전기전자재료학회 2007 전기전자재료학회논문지 Vol.20 No.7
[ $(Ba_{0.57}Sr_{0.33}Ca_{0.10})TiO_3$ ] (BSCT) powders, prepared by sol-gel method, were mixed with organic vehicle and the BSCT thick films were fabricated by the screen printing method. The structural and dielectric properties were investigated as a function of the $Yb_2O_3$ doping contents. As a result of the TG-DTA, exothermic peak was observed at around $670^{\circ}C$ due to the formation of the polycrystalline perovskite phase. All BSCT thick films showed the typical XRD patterns of a cubic polycrystalline structure. The average thickness of all BSCT thick films was about $70{\mu}m$. The grain size of the BSCT thick film doped with 0.7 mol% $Yb_2O_3$ was approximately $6.2{\mu}m$. The Curie temperature and relative dielectric constant at room temperature decreased with increasing $Yb_2O_3$ amount. Relative dielectric constant and dielectric loss of the specimen doped with 0.1 mol% $Yb_2O_3$ were 4637 and 19 % at Curie temperature, respectively.