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박동립,전혜정,박정희,허태행,이창대,윤상애,김명규 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.7 No.-
Sclerosing Hemangioma of the Lung -a case report- Sclerosing hemangioma of the lung is a rare benign neoplasm of uncertain histogenesis, with characteristic histologic and radiologic appearance.. We experienced a case of histologically proven sclerosing hemangioma of the lung in a 30 year old woman who complained dyspnea on exertion and chest discomfort. Chest radiograph showed a 2x2.5 cm sized, well circumscribed, ovoid soft tissue nodule without calcification on the pericardiac area of the left lower lung zone. CT scan revealed a well defined and smooth marginated, avoid mass with marked enhancement on the lingular division of the left upper lobe. An enucleation fo the nodule for diagnosis and treatment was performed, then histologically confirmed as sclerosing hemangioma of the lung.
박동재 ( Park Dong Jae ),박지영 ( Park Ji Yeong ),이석종 ( Lee Seog Jong ),김도원 ( Kim Do Won ),정상립 ( Jeong Sang Lib ),김선주 ( Kim Seon Ju ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.9
BCG(Bacillus Calmette-Guerin) is a vaccine from living attenuated Mycobacterium bovis which produces resistance to tuberculous infection. It induces specific and nonspecific dermatologic complications on the vaccination site or out of the site. The specif
백반증 환자에서 각질형성세포의 산화성 스트레스에 대한 생존률의 감소
박동재 ( Dong Jae Park ),나건영 ( Gun Yeon Na ),이석종 ( Seok Jong Lee ),김도원 ( Do Won Kim ),정상립 ( Sang Lip Chung ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.5
N/A Background : Vitiligo, a disease presenting as white patches on the skin, is caused by selective destruction of melanocytes, which are completely absent in established lesions. There are many theories about the etiology of vitiligo including the self-destruct, biochemical, neural, autoimmune and genetic hypotheses. Oxidative stress has been implicated in vitiligo as a causative factor. Objective : To examine the susceptibility of vitiligo keratinocytes to external oxidative stress, H_2O_2, we compared survival rates in cultured keratinocytes according to the different concentration and exposure time of H_2O_2. Methods : Keratinocytes were prepared from normal control volunteer, and the center of lesion and non-lesions skin of vitiligo patients. It was evaluated in cultures at the second and third passages. And, keratinocytes were exposed to various concentrations of hydrogen peroxide (H_2O_2) for10, 20 and 40 minutes. Finally, the 96 wells plate containing cells were performed MTT assay. Results : Compared to normal keratinocytes, vitiligo keratinocytes, both non-lesional and lesional, showed markedly lower survival rate. At the concentration of 0.01, 0.1 and 1 mM H_2O_2, survival rates did not significantly affect viability of keratinocytes after neither exposure times. On the contrary, vitiligo keratinocytes, both non-lesional and lesional, were more susceptible to the toxic effect of H_2O_2 after the Period of exposure at concentration of 10mM H_2O_2 compared with normal keratinocytes. The survival rate of at concentration of 10mM H_2O_2 inversely correlated with the exposure period in all experiments. Conclusions : Our results demonstrate the presence of an imbalance in the anti-oxidant system in vitiligo keratinocytes and provide further support for oxidative damage as a pathogenic event in vitiligo. (Korean J Dermatol 2003;41(5) : 592~596)
면도절제술 후 귀걸이 압박요법으로 자가 치료한 귓불 켈로이드 4예
박동재 ( Dong Jae Park ),차영창 ( Young Chang Cha ),이석종 ( Seok Jong Lee ),나건연 ( Gun Yoen Na ),김도원 ( Do Won Kim ),정상립 ( Sang Lip Chung ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.11
Keloid is a benign proliferative growth of dermal collagen which extends beyond the original wound. Although there are several available methods of treatment including intralesional corticosteroid injection, cryotherapy, surgical excision, laser therapy, pressure, radiotherapy, interferon-α injection and so on, no effective modality to prevent the recurrence of keloids may be present. We have done shaving excision of keloids on the earlobes of 4 patients and then recommended earring made to order for home compression over 4∼5 months therapy with no recurrence for 1∼3 years. It is suggested that compression therapy with earring following shaving excision may be proven to be not only a simple but effective method for prevention of recurrence after removal of keloid on the earlobe.
박동재 ( Dong Jae Park ),오병민 ( Byung Min Oh ),이석종 ( Seok Jong Lee ),나건연 ( Gun Yeon Na ),김도원 ( Do Won Kim ),정상립 ( Sang Lip Chung ),곽은경 ( Eun Kyung Kwak ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.4
Neuroendocrine carcinoma is known to have features of neuroendocrine and epithelial differentiation through immunochemical and biochemical investigation and Merkel cell carcinoma is a rare primary malignancy of the skin belonging to the broad spectrum of tumors of the neuroendocrine system. Small cell carcinoma of uterine cervix, also a kind of neuroenodcrine carcinoma, is rarely reported and it is much more exceptional in the world that cervical carcinoma metastases to distant skin. Further more this may be the first case of a uterine neuroendocrine carcinoma metastasizing to the skin in Korean medical literature. We report a case of 74-year-old woman who presented with a somewhat fixed subcutaneous nodule measuring 2.5 ㎝ × 0.8 ㎝ on the left side of forehead. A biopsy of the nodule revealed a poorly differentiated carcinoma under the muscle without involvement of upper structures and it showed neuroendocrine differentiation by immunohistologic studies. Before appearing as cutaneous manifestation 2 months ago, she had showed a history of abnormal vaginal bleeding and diagnosed as a cervical neuroendocrine carcinoma, especially small cell carcinoma histologically. (Korean J Dermatol 2003;41(4) : 484-488)
Arthroscopic Shaver를 이용한 지방종의 수술적 치료
박동재 ( Park Dong Jae ),박지영 ( Park Ji Yeong ),이석종 ( Lee Seog Jong ),나건연 ( Na Geon Yeon ),김도원 ( Kim Do Won ),정상립 ( Jeong Sang Lib ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.10
Lipoma is one of the most common benign tumors of soft tissue which tends to be left untreated due to unremarkable clinical features and its property of slow growth. It comes to clinical attention only when it causes concern of malignancy because of inordinate size or is perceived as faults in need of cosmetic removal and consequently the incision line is, frequently long and may result in high risk of intra- and postoperative complications such as hematoma and hypertropic scars. So it requires cosmetically acceptable and convenient methods for treatment of lipoma, especially located in the exposed area. The liposuction was tried to get less complications and smaller incision line. But for deep seated variants of lipoma they tend to be less well-circumscribed and often have thick fibrous septa around the lipoma, simple liposuction showed some limitations. So we tried the new liposuction method using arthroscopic shaver for 5 patients having lipomas larger than 5 cm in diameter. The surgery was performed with arthroscopic shaver system equipped with a motorized blade rotating in the suction cannula and emulsifying the lipoma tissue for easy aspiration. The aspirated material was collected and examined histopathologically to rule out the evidence of malignancy. Lipomas were removed completely without any remarkable complications, and no recurrence was seen till three years after surgery. The new method was easier to operate and took less operation time and left only small incision line.(Korean J Dermaton 2003;41(10) : 1347~1350)