정신지체아 두발 중 중금속 함량 IV - 구리와의 관련성 -

김두희,남상숭,박순우,Kim, Doo-Hie,Nam, Sang-Soong,Park, Soon-Woo 대한예방의학회 1989 Journal of Preventive Medicine and Public Health Vol.22 No.4

The relationship between copper content in scalp hair and mental retardation was investigated. Samples of scalp hair were collected from 297 mentally retarded children who were students in one of two schools providing special educational services, one, consisted of children living in an orphan home, the other, children living with parents. For comparison, 117 scalp hair samples were collected from the children who had got average or above average academic achivement in a regular elementary school. Hair samples were taken from the nape of the neck and the copper content was determined by an atomic absorption spectrophotometer (IL 551). There was no statistically significant difference in scalp copper levels across different age groups except female orphan group, but no trend or correlation between copper conents and age was found. The hair copper contents of the mentally retarded children groups were significantly lower than that of control groups. But there was no dose-response relationship between degree of mental retardation and hair copper level. The hair copper contents of the group accompanied by Down's syndrome and unknown group were significantly lower than that of control group in both sex, and in the case of accompanied by epilepsy or autism, lower than control group in male. Although the results of this study show no evidence that mental retardation has owed to copper deficiency, the possibility of copper deficiciency in their fetal or infant age could not be ruled out. Thus further study is needed to determine whether mental retardation could be attributed to copper deficiency, through the examinations about their living environments, dietary pattern, eating habit and the impact of copper deficiency on brain development.

장티푸스와 파라티푸스 30 예에 대한 임상적 고찰 및 Thiamphenicol 의 치료효과

박창호(Chang Ho Park),김종서(Zong Suh Kim),남상숭(Sang Soong Nam),기세길(Se Kil Kee),윤덕구(Duk Koo Yun),송홍석(Hong Suck Song) 대한내과학회 1986 대한내과학회지 Vol.31 No.1

N/A We reviewed 30 cases of bacteriologically con- firmed salmonellosis which performed hone marrow culture from March I984 to August 1985 at the Keimyung University. The results of study were as follows: Among 30 cases, paratyphoid A was 13 cases and group D typhoid fever was 17 case. Age distribution was from 16 to 63 years and most frequent in 2nd decade. Male to female ratio was 1: 3.3 in group A and 1: 1.4 in group D with female predominance. Clinical symptoms were fever, chill, general weakness, headache, anorexia, eneral ache in order of frequency and there was no difference in both group. Physical findings revealed abdominal tenderness in 14 cases(47%) and most common in right lower quadrant area. Splenomegaly was 3 cases(10%) and hepatomegaly was 4 cases(13%). Laboratory findings revealed anemia in 13%, leukopenia in 30%, thrombocytopenis in 10%, positive stool occult blood in 27%, proteinuria in 33% and hypoalbuminemia in 20%. Increased alkaline phosphatase was 20%, increased was 73%, increased SGPT was 80% and positive SGOT widal test above 1: 160 titer was 43%. With blood culture 73% was isolated, 20% with stool culture, 0% with urine culture, 77% with bone marrow culture and 20% isolated with bone marinrow culture only. Mean duration of defervescence was 4.1 days in chloramphenicol-treated group and 5.5 days in thiamphenicol-treated group. Neutropenia after drug therapy was occurred 62% in CP-treated group and 67% in TP-treated group. Complications occurred in 5 cases of typhoid fever: Intestinal hemorrhage in 2 cases and intestinal perforation, pleurisy, 1st degree AU block in 1 case respectively.

전자의무기록의 도입과 관리

南相崇 대한의사협회 1999 대한의사협회지 Vol.42 No.1

미만성 조직구성 림프종의 임상적고찰

남상숭,천종욱,조진환,김종서,강영우,송홍석 啓明大學校 醫科大學 1987 계명의대학술지 Vol.6 No.1

A retrospective review is presented for 70 previously untreated adult patients with diffuse histiocytic lymphoma between March 1980 through March 1986 at the Keimyung University. The mean age was 51.4 years with a male to female ratio of 1.7:1. On admission, neck mass was the most frequent symptom in 31 cases(44%) and abdominal pain, fever, weight loss, dysphagia, anorexia, sore throat and abdominal distension were commonly presented. Physical findings revealed peripheral lymph node enlargement in 47 cases (67%) with cervical, inguinal, axillary in order of frequency. Abdominal mass was observed in 12 cases, hepatomegaly 12 cases and intussusception 2 cases and SVC syndrome, exophthalmos, scrotal mass in 1 case respetively. Extra-nodal involvement was 49 cases (70%) and GIT was most frequent site of involvement (15 cases). Laboratory findings revealed anemia in 33%, leukocytosis in 30%, leukopenia in 16%, thrombocytopenia in 7%, hypoproteinemia in 17%, increased alkaline phosphatase in 9% and increased SGOT in 20%. Local-regional involvement (stage Ⅰ-Ⅱ) occurred in 49% and advanced stage (stage Ⅲ-Ⅳ) in 51% and constitutional symptoms were associated with stage Ⅰ-Ⅱ in 15% stage Ⅲ-Ⅳ in 44%. Treatment was performed with radiotherapy in 12 cases, combination chemotherapy in 23 cases and combined modality therapy in 3 cases. Three year survival rate of complete responder is 92% and 3 year survival rate of local-regional disease was 82% and advanced disease was 33%.

급성황산동중독증 1 예 보고

오영철,박승국,전영준,송홍석,박원대,남상숭 대한내과학회 1986 대한내과학회지 Vol.31 No.6

Herein we reported a case of acute copper sulfate intoxication which was the second in our nation. The patient was 23-year old woman, and complained of severe vomiting, upper abdominal pain and jaundice after ingestion of copper sulfate (about 60 gm) for suicidal attempt. The clinical and laboratory findings were consistent with the pictures of intravascular hemolytic anemia. Liver biopsy performed on fifth hospital day showed normal histology in light microscopy. Serial measurements of serum copper and ceruloplasmin concentration during hospital days correlated significantly with clinical course. The symptoms improved all after treatment with the penicillamine and BAL, and the patient discharged oneleventh day of admission.

컴퓨터를 활용한 정신운동기능 검사법의 개발 및 적용가능성 평가

이채용,손지연,이주영,김성아,박순우,남상숭,이종영 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.3

신경독성을 가장 민감하게 측정하는 도구로서 주목받고 있는 신경행동검사를 한국적 문화배경과 언어배경에 맞게 개발하기 위하여 시도된 연구에서 먼저 정신운동기능을 측정하는 3가지 검사영역의 4가지 검사를 구성하였다. 새로 개발된 신경행동검사는 컴퓨터를 이용하는 형태를 선택하여 하드웨어적인 부분에서 기존의 흔한 개인용 컴퓨터에 별다른 부가장치 없이 이용될 수 있는 소프트웨어로 접근하였다. 프로그램은 자기진행방식을 목표로 하였고, 피검자 개인별 결과뿐 아니라 집단의결과도 자동적으로 파일로 저장되도록 하여 선별검사에 바로 이용될 수 있도록 하였다. 프로그램은 NTOS(Neurobe-havioral Tests for Occupational Screening)로 이름 붙여졌다. NTOS는 단순반응시간 검사, 선택반응시간 검사, 수지타진검사의 3가지 하부영역으로 구성하였으며, 선택반응검사는 2가지 선택반응시간 검사와 4가지 선택반응시간 검사로 나뉘어진다. 신경독성물질에 폭로되지 않은 사람들을 대상으로 검사의 적용기능성을 확인하고자 시도되었다. 모두 120명의 의과대학생들을 대상으로 진행된 이 연구에서 수행능력을 측정하는데 있어서 결함이 발견되지 않았으므로, 프로그램의 안정성을 어느 정도 확인할 수 있었다. 2가지 선택반응시간 검사의 평균은 429.7 msec, 표준편차는 109.8이었으며, 4가지 선택반응시간은 평균이 493.6 msec이고 표준편차는 92.0으로 나타났다 단순반응시간의 평균은 254 msec 이며, 표준편차는 55 msec였다. 이 반응시간을 측정한 결과들은 모두 양의 방향으로 비대칭인 분포를 보였다. 수지타진검사는 주로 쓰는 손의 경우 평균이 77.2회였으며, 주로 쓰지 않는 손은 64.9회였다. 2가지 선택반응과 주로 쓰는 손의 수지타진검사에서 성별에 따른 유의한 차이를 보여 앞으로의 연구에서도 고려되어야 할 변수임을 나타내었다. 검사성적들의 인자 분석결과에서 수지타진 검사군과 반응시간 검사군으로 분류되었으며, 이것은 상관분석의 결과와도 일치하는 양상이어서 각 검사의 성적들이 통계적으로 유의한 상관성을 보이면서도 상관계수의 크기가 작아서 정신운동기능을 측정하는 상이한 검사들이란 간접적인 증거를 나타냈다. We tried to develop Korean computerized neurobehavioral tests to promote neurobehavioral research and screening in occupational setting in Korea. This program was designated Neurobehavioral Tests for Occupational Screening(NTOS). NTOS consisted of 3 test items, choice reaction time(2 choice and 4 choice), simple reaction time(visual and auditory stimulus), finger tapping test(both hands). NTOS was administered to 120 students of medical school and to evaluate applicability. The results of reaction time tests was positively skewed but finger tapping test was negatively skewed. The only data that was not skewed was the mean frequency of finger tapping of dominant hand. The means and standard deviations of choice reaction time were 429.7 msec and 109.8 msec(2 choice), 493.6 msec and 92.0 msec(4 choice). The results of simple reaction time were 254 msec(mean) and 55 msec(standard deviation). The mean frequency of finger tapping of dominant hand was 77.2 and that of nondominant hand was 64.9. The results of 2 choice reaction time test and finger tapping of dominant hand showed statistically significant sex difference. Factor analysis showed 2 factors, 1st reaction tests and 2nd tapping. The mean frequency of finger tapping had negative weak correlation with other reaction time test results. This computerized neurobehavioral tests may be widely applied in the other future studies, and is to be improved for the practical purpose of the occupational neurotoxicological area.