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박원대(Won Dae Park),박승국(Soong Kook Park),곽춘식(Choon Sik Kwak) 대한내과학회 1987 대한내과학회지 Vol.32 No.4
N/A This study was carried out to investigate the metabolic alteration of plasma and CSF amino acids in patients with liver cirrhosis only and liver cirrhosis with hepatic encephalopathy. Plasma amino acids were measured in 20 cases of liver cirrhosis only, 17 cases of patients with hepatic encephalopathy and 20 cases of normal person as a control. Among above groups of patients, CSF amino acid concentrations were measured in 15 cases of liver cirrhosis only, 17 cases of patients with hepatic ence-phalopathy and 15 cases of normal person. The plasma amino acid concentrations were determined by high performance liquid chromatography. The results were as follow: The plasma concentrations of branched chain amino acids (valine, leucine, isoleucine) were lower in cirrhotic patients and patients with hepatic encephalopathy (p<0.05) than control group and more decreased in patients with hepatic encephalopathy than cirrhotic patients. The plasma concentrations of phenylalanine in aromatic amino acids increased in hepatic encephalopathy (p<0.05), but tyrosine increased in both group of patients (p<0.05). 1n the study of CSF, there were no significant changes in branched chain amino acid concentrations, but in aromatic amino acid concentrations (phenylalanine, tyrosine) increased (p<0.05). In hepatic encephalopathy compare to liver cirrhosis only, phenylalanine concentration was higher (p<0.05) in CSF. The molar ratio between branched chain amino acids and aromatic amino acids (Val.+Leu.+Isoleu./Phen.+Tyr,) of plasma and CSF were lower in both groups of patients than control. In hepatic encephalopathy com-pare to liver cirrhosis only, the molar ratio was lower in hepatic encephalopthy.
박승국,전영준,송홍석,윤덕구,박원대 啓明大學校 醫科大學 1985 계명의대학술지 Vol.4 No.2
저자들은 상대정맥증후군을 동반한 Behcet증후군 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Behcet's syndrome consists of the clinical triad of relapsing uveitis, oral andeg nital ulcers. This syndrome is now recognized as a multisystem disease involving mucocutaneous, ocular, intes-tinal, articular, urogenital, vascular and nervous system. Four types of vascular lesions are recognized : arterial occlusion; aneurysms: venous occlusion; and development of varices. Venous lesions are more common than arterial lesions. Venous occlusions are frequently observed, most commonly in the inferior or superior vena cava. Thus, when superior vena caval obstruction is present in a patient, a careful historical review of other lesions associated with Behcet syndrome may prove rewarding. As far as we know, there is no case record of Behcet's syndrome with superior vena cava syndrome in Korea. We report a case of Behcet's syndrome accompanied by superior vena cava syndrome with a review of literature.
오영철,박승국,전영준,송홍석,박원대,남상숭 대한내과학회 1986 대한내과학회지 Vol.31 No.6
Herein we reported a case of acute copper sulfate intoxication which was the second in our nation. The patient was 23-year old woman, and complained of severe vomiting, upper abdominal pain and jaundice after ingestion of copper sulfate (about 60 gm) for suicidal attempt. The clinical and laboratory findings were consistent with the pictures of intravascular hemolytic anemia. Liver biopsy performed on fifth hospital day showed normal histology in light microscopy. Serial measurements of serum copper and ceruloplasmin concentration during hospital days correlated significantly with clinical course. The symptoms improved all after treatment with the penicillamine and BAL, and the patient discharged oneleventh day of admission.
방병기,윤영석,이정상,한대석,이호영,김형규,박한철,강종명,김명재,이희발,류석희,윤견일,고행일,오하영,유병희,정영,정석호,나하연,이시래,김기현,원대식,전건웅,조동규,윤경우,김현철,최일균,강영준,채종구,임중규,구완서,최의진,김문재,전성주,송정균,이광훈,성낙억,최영주,최창필,강성귀,나영호,김문중,신영태,김석영,이영규,남궁견 대한신장학회 1988 Kidney Research and Clinical Practice Vol.7 No.2
Since 1981, the Korean Society of Nephrology started annual report on renal replacement therapy in Korea. The annual number of new patients receiving dialysis treatment in 1986, compared with 1985, rose from 825 patients (20.4 per million population) to 957 patitents (23. 3 per million population) and the total number of patients on replacement therapy rose from 1,508 patients (37.3 per million population) to 2,534 patients (61.7 per million population). 1,335 patients (32.6 per million population) of these patients were living on hemodialysis, 573 patients (13.9 per million population) on continuous ambulatory peritoneal dialysis (CAPD) and 621 patients (15.1 per million population) on fun- ctioning renal graft as of December 31, 1986 The common causes of renal failure of new patients were chronic glomerulonephritis (41,6%), followed by diabetic nephropathy (12.6%), hypertensive nephroscler- osis (7.8%), chronic pyelonephritis (2.5%) and others. The annual mortality rate fell from 21.9% in 1981 to 13. 5% in 1986. The common causes of death in patients on dialysis therapy in order were cardiac (32.8%), vascular (14.7%), infective (14.7%) social problems (11.2%). Recently, the number of patients requiring dialysis is rapidly increasing due to expanded medical insurance support for dialysis and improved economic status of our country. Therefore, it is necessary to draw up counterplan for a rapid growth of the number of new patients.
간질환 환자에서 α- D- Mannosidase 와 β- D- Mannosidase 의 활성도
곽춘식,안성훈,박승국,황재석,허정욱,박원대 대한소화기학회 1999 대한소화기학회지 Vol.33 No.2
Background/Aims: We studied the activities of α- and β-D-mannosidase to evaluate their diagnostic significance in liver diseases. Methods: One hundred fifty one patients with liver diseases were en rolled. The activities of the enzymes were measured by microquantitative spectrophotometry. Results: The activities of α-D-mannosidase isozymes (neutral and intermediate α-D-mannosidase) were signif icantly high in patients with icteric acute hepatitis (IAH)(48.4 ±25.4, 17.6 ±12.9, 12.2 ±6.2), anicteric acute hepatitis (AAH)(29.9 ±16.0, 11.9 ±5.3, 10.2 ±3.1), cholestatic hepatitis (ChH) (118.3 ±20.6, 50.3 ±12.2, 37.0 ±5.5), icteric liver cirrhosis (ILC)(36.6 ±13.5, 12.0 ±7.8, 9.6 ±4.3), ILC with hepa tocellular carcinoma (HCC)(39.0 ±16.5, 15.1 ±9.4, 11.1 ±5.8). The activity of β-D- mannosidase was also significantly high in patients with IAH (212 ±36), icteric chronic hepatitis (ICH)(193 ±25), ACH (196 ±25), ChH (252 ±38), ILC (188 ±21), ILC with HCC (217 ±55), and ALC with HCC (203 ± 34). Conclusion: The activitiesof α- and β- D-mannosidase were significantly increased in liver diseases with jaundice, which was related to the increased permeability of the liver cell membrane and the leakage of the enzymes into the blood in large quantities. Serial measurement of these enzymes will be helpful to diagnose liver diseases and to understand the clinical conditions of the patients. (Kor J Gastroenterol 1999;33:211 - 221)
간경변증환자에서 고농도 분지형 아미노산제제 투여후 혈중 아미노산과 간기능 검사상의 변화 - 일반 아미노산제제와 비교조사 -
안성훈 ( Sung Hoon Ahn ),박승국 ( Soong Kook Park ),박원대 ( Won Dae Park ),한승범 ( Seung Beum Han ),이수형 ( Soo Hyeong Lee ),허정욱 ( Jeug Wook Hur ) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
N/A This study was done to compare the therapeutic effect of enriched branched chain amino acid (BCAA) infusion to regular amino acid infusion for the decompensated liver cirrhosis. Enriched BCAA solution (Pamisol) was given to 30 patients and regular amino acid solution (Salviamine) was given to 8 patints. The changes of plasma amino acid concentrations and liver profiles in before and 7 days after amino acid infusion daily 1,000 ml were compared. The results were as follow. 1) In the group of patients given enriched BCAA infusion, the plasma concentrations of valine, leucine, isoleucine (BCAA) increased (p<0.001), while the phenylalanine, tyrosine (aromatic amino acid: AAA) decreased (p<0.001). 2) In the group of patients given regular amino acid infusion, both BCAA and AAA concentrations increased (p+0.001). 3) In the group of patients given enriched BCAA infusion, total protein increased (p<=0.01), total bilirubin decreased (p<=0.01), prothrombin time shortened (p<0.05), and blood ammonia decreased (p< 0.01). 4) In the group of patients given regular amino acid infusion, only total protein increased (p < 0.01) but, bilirubin, prothromoin time and blood ammonia remained no significant changes. 5) The molar ratio of BCAA/AAA more improved in the enriched BCAA infusion than regular amino acid.
박성배,김기현,김영호,김현철,김형규,이시래,한대석,이영규,강성구,이호영,정석호,홍관수,방병기,이희발,고행일,박한철,최의진,원대식,강종명,황승덕,전건웅,최창필,허용진 대한신장학회 1987 Kidney Research and Clinical Practice Vol.6 No.2
The Korean Society of Nephrology reports the Multicenter Study on CAPD in diabetics with ESRD. This report based on the analysis of the questionairs distributed to fourteen centers throughout the nation. The results were as follows; 1) As of September, 1987, 626 patients are on CAPD in Korea. Of these, 14.1 per cent of the patients are comprised of diabetics. 2) Diabetics with ESRD were older than non diabetic patients with ESRD, and it was most prevalent in the fifties. 3) Most of the centers considered CAPD as the treat- ment of choice for the diabetics with ESRD. 4) It takes 14.6 years on average for diabetics to get in end stage renal failure. 5) Most centers tend to start diabetics on dialysis earlier than in nondiabetics, that is, when their serum creatinine reach 9.83 mg/dl on average. 6) Blood sugar levels were reduced after 24 months of CAPD compared to pre CAPD level, but it was not statistically significant. 7) Various hematologic and biochemical indexes such as hemoglobin level, serum albumin level, Ca and phosphorus levels were improved after starting CAPD. 8) Peritonitis is still a major complication. Each patient experiences 1.9 episodes of peritonitis on average per year. 9) Sizable number of the patients suffered from gastrointestinal complications, particularly nausea and vomiting and cardiovascular complications. 10) 43 patients succumbed to death while on CAPD. Main cause of death were peritonitis and cardiovascular complications. 11) 26 patients stopped peritoneal dialsysis for various reasons other than death or lost to follow-up, and the major reason was peritonitis comprising of 15 patients. 12) Diabetics with ESRD are not doing well in terms of the rehabilitation. This is partly attributable to old age and to cardiovascular complications. 13) The actuarial survival rate were 95.4%, 90.2%, 79. 2% and 61.0% at 3 months, 6 months, 12 months and 24 months respectively. This is lower than that in non diabetics with ESRD. We conclude that continuous ambulatory peritoneal dialysis is a good alternative treatment for diabetics with end-stage renal disease.
방병기,구완서,윤영석,장윤식,최의진,김영우,김승수,임천규,김명재,김형규,이시래,김현철,이영규,정영,원대식,나하연,전건웅,이정상,황승덕,이희발,이호영,한대석,이광훈,윤경우,윤견일,고행일,강영준,강성귀,채종구,유석희,홍세용,박정식,한민희,강종명,박한철 대한신장학회 1987 Kidney Research and Clinical Practice Vol.6 No.1
In 1981, the Korean Society of Nephrology started annual report on dialysis therapy in Korea. Thereafter, the brief summary of Combined report on hemodialysis in Korea during the period 1981-1984 was reported in 1984. In 1985, the annual number of new patients rose from 17.4 to 20.4 per million, and also the total number of patients on dialysis theraphy rose from 20.7 to 29.1 per million. Total 808 patients (20.0 per million) were being on hemodialysis, 370 patients (9.1 per million) on CAPD and 330 patients (8.2 per million) with functioning renal graft on 31th Dec. 1985. The common causes of renal failure of new patients in order were chronic glomerulonephritis (40.0%), diabetic nephropathy (9.7%), hypertensive nephrosclerosis (6.3%) and so on. The common causes of death in dialytic patients were cardiac (33.7%), vascular (14.1%) and infection (9.8%), and social death due to refuse further treatment or suicide was 20.7% of all. Now the number of patients requiring dialysis therapy is increasing rapidly, largely due to expanded medical insurance coverage and improved economic status. But, dialysis equipment and personnel were increased rela- tively slower than explosion of number of patients requiring renal replacement therapy. Therefore we have to consider counterplan for this rapid growth of patients such as expansion of regular training for dialysis members, establishment of home and satellite dialysis system, and lawful background ready for cadaver renal transplantation.