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      • KCI우수등재

        개선된 Mode Acceleration Method에 의한 해양(海洋) 구조물(構造物)의 동적(動的) 해석(解析)

        김태남,Kim, Tae Nam 대한토목학회 1994 대한토목학회논문집 Vol.14 No.1

        동적(動的) 해석(解析)에 널리 사용되는 Mode Superposition Method(MSM)에 있어서 몇개의 모우드를 포함하여 해석(解析) 하느냐 하는 문제는 공학적(工學的) 판단에 의지할 수 밖에 없는 문제이다. 합리적(合理的)이고 알맞은 모우드수를 결정(決定)하기란 어려운 과제이고, 또 대단히 중요(重要)한 문제이다. 이러한 문제점을 보완할 수 있는 한 방법으로 Mode Acceleration Method(MAM)가 발표(發表)되었으나 주파수(周波數) 영역(領域)에서는 그 수식(數式)이 너무 복잡(複雜)하고, 까다로와서 또 다른 단점(短點)이 대두되었다. 본(本) 연구(硏究)에서는 이 단점을 극복할 수 있는 실용적(實用的)으로 간편화된 Advanced Mode Acceleration Method(AMAM)을 유도하였다. 예제(例題) 해석(解析)을 통하여 AMAM이 MSM 및 MAM보다 우수한 해법(解法)이 됨을 입증할 수 있었다. Determination of the number of modes to be included in the mode superposition method(MSM) is very important and difficult. Mode acceleration method(MAM) is recommended recently with the intention to overcome the problem. But the solution of the MAM is complex and complicate in frequency domain analysis. In this paper, advanced mode acceleration method(AMAM) is formulated and examined. The results from example analyses show that AMAM is a simple, accurate and reliable method compared with the MSM and the MAM.

      • KCI등재

        복강경하 경복막 부신절제술의 임상경험

        김태남,이정주,정문기,인주,용기,이완 대한비뇨의학회 2005 Investigative and Clinical Urology Vol.46 No.9

        Purpose: A laparoscopic procedure is considered the treatment of choice for an adrenalectomy. We report our experience of a laparoscopic transperitoneal adrenalectomy in a series of 41 patients. Materials and Methods: Between February 1999 and September 2004, 41 consecutive patients underwent a laparoscopic transperitoneal adrenalectomy. The indications for a adrenalectomy were primary aldosteronism in 16 patients, Cushing's syndrome in 7, pheochromocytoma in 6, nonfunctional adenoma in 5, adrenal cyst in 3, benign cystic teratoma in 2, myelolipoma in 1 and metastatic renal cell carcinoma in 1. The author analyzed the results of each operation. Results: The affected adrenal gland was successfully removed, with the exception of 3 cases. Conversion to open surgery was necessary in 3 of the pheochromocytoma patients due to massive intraoperative bleeding and severe adhesion to retroperitoneal fat. The mean operative time was 245.3 minutes(125-420). The mean intraoperative blood loss and adrenal mass size were 189.6ml(20-2100) and 3.6cm(1.0-10.4), respectively. The mean post-operative hospital stay was 10.4 days(5-29). The mean times to oral intake and ambulation were 1.4(1-3) and 1.0 days(1-2) after the operation, respectively. The mean number of days of analgesic administration was 2.1(0-6). The conversion and major complication rates were 7.3 and 10.5%, respectively. Conclusions: A laparoscopic adrenalectomy is safe and effective in nearly all adrenal pathologies, with early oral intake, ambulation and a low number of days of pain control.

      • KCI등재

        흰쥐 방광출구 단기부분폐색에 의한 방광혈류 변화와 허혈에 관여하는 유전자 발현 변화

        김태남,박영수,이정주 대한비뇨의학회 2005 Investigative and Clinical Urology Vol.46 No.9

        Purpose: This study was aimed at evaluating the expressions of types I and III collagen, inducible nitric oxide synthase(iNOS), hypoxic inducible factor-1α(HIF-1α), vascular endothelial growth factor(VEGF) and the hemodynamic changes of the bladder during the acute stages of a partial bladder outlet obstruction(PBOO) in adult rats. Materials and Methods: Bladder specimens were aseptically removed from 35 Sprague-Dawley adult rats(8 week old, weight 250-300gm) of both sham and experimental groups at 6, 12 and 24 hours, and 2, 3, 5 and 7 days after establishing a partial bladder outlet obstruction. Bladder blood flow was measured at the left vesicular artery using a laser flowmeter. The expressions of types I and III collagen, iNOS, HIF-1α and VEGF in relation to changes of the bladder wall were evaluated by immunohistochemical staining and Western blot assay. Results: There was a significant difference in the vesical blood flow between the sham and experimental groups after the establishment of a PBOO. The bladder blood flow of the experimental groups was significantly decreased after establishing a PBOO of 3 days duration. The expressions of type III collagen and iNOS from the immunohistochemical staining of the bladder were markedly increased during the acute stages of a PBOO. The expressions of HIF-1α and VEGF from the Western blot of the bladder increased with duration of the obstruction. Conclusions: A decreased bladder blood flow during the acute stages of PBOO generally enhanced the expressions of iNOS and type III collagen. This study suggests that hypoxia of the bladder after establishing a PBOO induces the expression of HIF-1α, and then enhances the production of nitric oxide(NO) due to activation of iNOS, which finally results in bladder growth and a decrease in bladder wall compliance

      • KCI등재

        Short rare minisatellite variant of BORIS-MS2 is related to bladder cancer susceptibility

        김태남,원태,정미소,문미혜,민혜,이정주,임선희 한국유전학회 2019 Genes & Genomics Vol.41 No.2

        Background BORIS/CTCFL, a paralog of CTCF and member of the cancer-testicular antigen family, is abnormally activated in multiple cancers. Objective We investigated the relationship between polymorphic variants of the BORIS minisatellite 2 (BORIS-MS2), located within the 5′ upstream promoter region of BORIS, and bladder cancer. Methods We used case-control study with 516 controls and 113 bladder cancer patients. To evaluate whether minisatellite variants play a role in BORIS expression, we examined the transcript levels of a reporter gene linked to these minisatellites in cell lines. We also examined BORIS expression in cancerous and non-cancerous bladder tissue. Results A statistically significant association was identified between the short rare allele (13-repeat) and bladder cancer incidence (odds ratio (OR) 2.97, 95% confidence interval (CI) [1.14, 7.74]; P = 0.020). In particular, short rare alleles in the younger group (aged < 65) were associated with statistically significant increase in bladder cancer risk (OR 5.38, CI [1.32, 21.87]; P = 0.01). The BORIS-MS2 region acted as a negative regulator, and the expression level of the luciferase reporter in bladder cancer cells was less effectively inhibited than in normal cells. Furthermore, the expression of BORIS mRNA significantly differed (P < 0.05) between normal and cancerous muscle-invasive bladder cancer tissues, and relationship to clinical parameters was observed. Conclusions The short rare allele of BORIS-MS2 could be used to identify bladder cancer risk. BORIS expression levels have been shown to increase with the progression of bladder cancer, could be used as a biomarker for its progression.

      • 축소모형을 이용한 사장교의 자유진동해석

        김태남 尙志大學校 生産技術硏究所 2000 生産技術論叢 Vol.8 No.-

        Analytic solutions are the most common method for free vibration analysis of structures. In general some idealization of structure is always present in the mathematical model, so it is recommend to compare the results another methods. Experimental tests are useful in order to compare the analytic solutions and to improve the results. In this study, a free vibration analysis of cable-stayed bridge by small scale model tests have been carried out in order to understand their dynamic characteristics. The determined dynamic characteristics are more shapes, natural frequencies and damping ratios. The example of cable-stayed bridge is Dolsan bridge and the basic scale factor for the model is 1/150.

      • 현수교의 확율론적 동적 解析 : 수직 진동 해석

        김태남 尙志大學校 生産技術硏究所 1997 生産技術論叢 Vol.- No.1

        A method of stochastic dynamic analysis of suspension bridge(vertical vibration analysis) has been developed in this paper. Example analyses are carried out by mode superposition method(MSM), mode acceleration method(MAM) and advanced mode acceleration method(AMAM) in frequency domain for the Nam-Hae Bridge. Damping ratio which applied to each mode is 2 %. The analyses are achieved by steps, in which the number of modes included are from one to ten. The considered structural response quanties are displacements, shearforces and bending moments. The mean extreme responses are approximately calculated by three times of standard deviations. From the results of this study the numerical results are agree reasonably well when the numbers of modes increase and AMAM is simple, accurate, economic and reliable compared with the other method.

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