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지속성 복막투석의 동물 모델에서 복막휴식이 용질 수송과 복막 섬유화에 미치는 영향
김석재(Seog Jae Kim),김용림(Yong Lim Kim),조동규(Dong Kyu Cho),김용진(Yong Jin Kim),김준홍(Jun Hong Kim),김성호(Sung Ho Kim),김찬덕(Chan Duck Kim),남직화(Jick Hwa Nam) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.3
N/A Ultrafiltration failure has been known as a major cause of dropout from long-term peritoneal dialysis and is often related to peritoneal hyperpermeability. This can be explained in part by progressive peritoneal fibrosis. The present experiment has been under- taken to evaluate the effects of peritoneal rest on peritoneal transport and morphology in rat model of peritoneal dialysis. Twenty-four male rats(Sprague-Dawley, 250-300g) were used and divided into three groups : group 1 (control, n=6) without dialysis, group 2(n=9) sacrificed immediately after 3 weeks of dialysis, and group 3 (n=9) sacrificed after 4 weeks of peritoneal rest after 3 weeks of dialysis. Peritoneal dialysis was performed twice a day with 25mL of 3.86% dextrose solution for 3 weeks. Peritonitis was induced by supplementing lipopolysaccharide(5μg/mL) in the dialysis fluid on days 8, 10 and 12 of peritoneal dialysis. Peritoneal equilibration tests were performed before dialysis and repeated on the 4th and 8th week of dialysis. Mor-phometric analysis of the peritoneal membrane and immunohistochemistry for collagen type I and type III were done in tissue specimens obtained at the time of sacrifice. The D/Do ratio for glucose at two hours in groups 2 and 3 at the beginning of week 4 were signifi-cantly lower than baseline value, indicating increase in the peritoneal penneability to glucose after 3 weeks of dialysis. D/Do in group 3 at the beginning of week 8, after 4 weeks of peritoneal rest, was significantly higher than at week 4. The drained dialysate volumes in groups 2 and 3 at week 4 were significantly lower than at baseline; however, The drained dialysate volume in group 3 at week 8 was significantly greater than at week 4. The thickness of the parietal peritoneal membraoe in group 2 and 3 were significantly greater than in group 1. Severity of the thickness of the parietal peritoneal membrane in group 3 was not much than that of group 2(group 1, 11.4±7.6; group 2, 37.5±18.4; group 3, 21.4±12.1 pm). Histologically, the thickened peritoneum in group 2 showed a monolayer of mesothelial cells and under-lying multilayer of curled collagen bundles. Mononu-ciear cells and fibroblasts were embedded in these collagen layers and capillary proliferation was present. Immunohistochemistry for collagen type I and Z demonstrated that the distribution of collagen type llI was richer than that of collagen l in group 2 at fibrotic area of submesothelial region. These findings were decreased in group 3. Ultrastructural examination of the peritoneum showed thicker fibrotic zone and the activated fibro-blasts in group 2 compared to group 1 and 3. Meso-thelial cells were plump and the number of meso-thelial microvilli was decreased in group 2. Nucleus was enlarged and irregular. Intracytoplasmic orga-nelles were also richer than those of group I or 3. In conclusion, peritoneal rest improves ultrafil- tration in rats by decreasing the hyperpermeability of glucose and also reduces the degree of peritoneal fibrosis. These data suggest that dialysis-induced changes in peritoneal transport and morphology are reversible under the condition of peritoneal rest in this experimental model.
김직수(Jick-Soo Kim),박도영(Do-Young Park),나민영(Min-Young Ra) 한국정보과학회 2000 한국정보과학회 학술발표논문집 Vol.27 No.2Ⅰ
최근 들어 모빌 데이타베이스에 대한 관심이 높아가고 있다. 모빌 데이타베이스란 모빌 컴퓨팅 기기에 사용되는 데이타베이스를 말한다. 그러나 모빌 기기의 특성상 노트북은 너무 크고 불편하므로 최근 들어서는 대부분 소형 모빌 기기를 그 대상으로 하고 있다. 따라서 규모가 작고 응용성이 강하며 Open된 구조의 DBMS가 필요하게 되었다. 본 논문에서는 무선 클라이언트-서버 환경에서 사용될 수 있을 뿐만 아니라 독자적으로도 데이타베이스를 구축 관리할 수 있는 모빌 기기 전용 DBMS의 개발을 다루었다. 우선 1차적으로 모빌 기기에 내장되어 Stand alone 형으로 사용될 수 있는 소형 DBMS를 개발하였고 앞으로는 무선 클라이언트/서버 환경에서 활용 가능토록 데이타 동기화 기능 등이 확장될 것이다. 이러한 시스템 개발은 모빌 데이타베이스 산업 분야 활성화에 매우 긍정적으로 작용할 것이다.
선박 안전운항 지원을 위한 선교운용 단말장치 및 경보시스템 구현 및 설계
김옥수,유병직,이명원,김영길,Kim, Ok-Soo,Yoo, Byung-Jick,Lee, Myung-Won,Kim, Young-Kil 한국정보통신학회 2011 한국정보통신학회논문지 Vol.15 No.7
해양에서의 선박의 사고는 교통량의 증가와 더불어 끊임없이 증가하는 추세에 있으며, 해상에서의 안전운항을 확보하기 위하여 사고 발생 후의 대처도 중요하지만 해양사고를 미연에 방지하는 운항 안전을 위한 사전 감시기술이 부각되고 있는 실정이다. 따라서, 본 논문에서는 안전운항을 위한 통합적인 안전관리 플랫폼 기반의 시스템을 제안하였고, 항해 근무상태 감시 및 항해/추진/기관/발전 등 이상상태 및 오동작 상태 감시를 위한 선교운용 단말장치 및 경보시스템을 구현하였으며, 선박 탑재를 위하여 선급 표준에 근거한 성능 평가를 수행하여 실증화를 위한 기반을 갖추었다. Since the marine accidents increase with the increased volume of traffic, preventive surveillance technology for safety navigation of the ships before the accident is being emphasized to secure the safety at sea along with post-accident measures. This paper aims to suggest a design based on an integrated safety management platform systems to support nautical safety, implements of bridge operation terminal equipments and alarm system for bridge watch monitoring and abnormal state of navigation/propulsion/machinery/power, and performs a quality evaluation for the actual boarding on the ship based on the classification standards.