나노복합재료의 전기/역학적 특성과 예측을 위한 멀티스케일 모델링의 최신 연구 분석

길태건,배진호,윤현노,이행기,Taegeon Kil,Jin-Ho Bae,Hyun-No Yoon,Haeng-Ki Lee 한국전산구조공학회 2023 전산구조공학 Vol.36 No.2

Nanocomposites have been considered innovative composite materials that have multi-functionality and high performance. Because the incorporation of nanoscale fillers may significantly improve the electrical, mechanical, and thermal properties of composites, numerous extensive studies on the characterization of nanocomposites with nanoscale fillers have been performed. In particular, the development of nanocomposites using carbon-based nanoscale fillers (e.g., carbon nanotubes, carbon black, graphene nanoplates) have attracted much interest in the composite field. This paper provides a review of recent advances in the electrical/mechanical characteristics of nanocomposites, which are essential for their practical applications. Furthermore, this paper revisits the recent research on multi-scale modeling, which is a promising approach for predicting the characteristics of nanocomposites. The current challenges and future development potentials for multi-scale modeling are also discussed.

나노복합재료의 전기/역학적 특성과 예측을 위한 멀티스케일 모델링의 최신 연구 분석

길태건,배진호,윤현노,이행기 한국전산구조공학회 2023 한국전산구조공학회논문집 Vol.36 No.2

Nanocomposites have been considered innovative composite materials that have multi-functionality and high performance. Because the incorporation of nanoscale fillers may significantly improve the electrical, mechanical, and thermal properties of composites, numerous extensive studies on the characterization of nanocomposites with nanoscale fillers have been performed. In particular, the development of nanocomposites using carbon-based nanoscale fillers (e.g., carbon nanotubes, carbon black, graphene nanoplates) have attracted much interest in the composite field. This paper provides a review of recent advances in the electrical/mechanical characteristics of nanocomposites, which are essential for their practical applications. Furthermore, this paper revisits the recent research on multi-scale modeling, which is a promising approach for predicting the characteristics of nanocomposites. The current challenges and future development potentials for multi-scale modeling are also discussed.

혈장분획제제 제조공정에서 크로마토그래피 세척 검증을 위한 모델바이러스로서의 Porcine Parvovirus 정량

길태건,김원중,이동혁,강용,성학모,유시형,박순희,김인섭,Kil Tae Gun,Kim Won Jung,Lee Dong Hyuk,Kang Yong,Sung Hark Mo,Yoo Si Hyung,Park Sue-Nie,Kim In Seop 한국미생물학회 2005 미생물학회지 Vol.41 No.3

혈장분획제제 중 혈액응공인자제제와 일부 면역글로불린제제는 혈장에 존재하는 다양한 단백질로부터 유효한 단백성분만을 선택적으로 분리 정제하기 위해 크로마토그래피 방법을 사용하여 생산된다. 효율적인 세척(cleaning) 공정이 이루어지지 않는다면 크로마토그래피는 다양한 종류의 불순물뿐만 아니라 혈액 중 내재 또는 오염 가능성이 있는 위해인자가 오염될 가능성이 있다. 본 연구에서는 혈장분획제제 제조공정에 사용되는 크로마토그래피의 세척 공정에서 혈장유래 바이러스의 제거 및 불활화 공정의 검토 강화로 혈장분획제제의 안전성을 확보하기 위해 크로마토그래피 세척 검증 시스템을 구축하고자 하였다. 크로마토그래피 세척 공정 중 바이러스 제거 검증을 위해 혈장유래 바이러스 중 물리${\cdot}$화학적 처리에 가장 큰 저항성을 갖는 human parvovirus B19의 모델 바이러스의 porcine parvovirus(PPV)를 대상으로 real-time PCR 정량법을 확립하였다. PPV에 특이적인 primer를 선별하였으며 형광염료 SYBR Green I을 사용하여 PPV DNA를 정량하였다. 세포배양법에 의한 감염 역가와 비교한 결과 PCR 민감도는 1.5 $TCID_{50}/ml$이었다. 확립된 검증법의 신뢰성(reliability)을 보증하기 위해 실험법의 특이성(specificity), 재현성(reproducibility) 등을 검증하였다. 구축된 검증시스템을 thrombin 분리${\cdot}$정제를 위한 SP-Sepharose 양이온 크로마토그래피 공정과 factor VIII 분리${\cdot}$정제를 위한 Q-Sepharose 음이온 크로마토그래피 공정에 적용하여 크로마토그래피 세척 검증을 실시하고, 세척 검증 시스템의 적합성을 확인하였다. Chromatography has now been used successfully to provide the requisite purity for human plasma-derived biop-harmaceuticals such as coagulation factors and immunoglobulins. Recently, increasing attention has been focused on establishing efficient cleaning procedures to prevent potential contamination by microorganisms as well as carry-over contamination from batch to batch. The purpose of present study was to develop a cleaning validation system for the assurance of virus removal and/or inactivation during chromatography process. In order to establish an assay system for the validation of virus clearance during chromatography cleaning process, a quantitative real-time PCR method for porcine parvovirus(PPV) was developed, since PPV, a model virus for human parvovirus B19, has a high resistance to a range of physico-chemical treatment. Specific primers for amplification of PPV DNA was selected, and PPV DNA was quantified by use of SYBR Green I. The sensitivity of the assay was calculated to be 1.5 $TCID_{50}/ml$. The established real-time PCR assay was successfully applied to the validation of PPV removal and cleaning during SP-Sepharose cation chromatography for thrombin purification and Q-Sepharose anion chromatography for factor VIII purification. The comparative results obtained by real-time PCR assay and infectivity titrations suggested that the real-time PCR assay could be a useful method for chromatography cleaning validation and that it could have an additive effect on the interpretation and evaluation of virus clearance during the virus removal process.

TiO2 혼입 시멘트 복합체의 물리∙화학적 특성 및 광촉매 반응을 이용한 오염물 제거 성능에 대한 개요

서준호,윤현노,김선혁,배상진,장대익,길태건,박솔뫼,이행기 한국복합재료학회 2020 Composites research Vol.33 No.2

Recently, the use of TiO2 as a phtocatalyst has been diversely investigated due to its excellent durability performance and high photocatalytic reaction efficiency. Active researches have particularly focused on the development of TiO2-incorporated cementitious composites in order to remove the atmospheric pollutants. Furthermore, the potential utilization of TiO2-incorporated cementitious composites as road accessories such as tunnels, road median separators and soundproof walls in the form of tiles, blocks and structural components has been widely examined. In this regard, a thorough understanding on the material characteristics of TiO2-incorporated cementitious composites should be preceded. The present overview article, therefore, revisits previous studies of TiO2- incorporated cementitious composites and summarizes their various physicochemical properties and atmospheric pollutants removal performance.

화재하중을 받는 이방향 프리스트레스트 콘크리트 패널부재의 실험적 평가

최지훈(Choi, Ji Hun),김태균(Kim, Tae Kyun),최승재(Choi, Seung Jai),길태건(Kil, Tae Gun),김장호(Kim, Jang Ho Jay) 한국콘크리트학회 2016 한국콘크리트학회 학술대회 논문집 Vol.28 No.1

폐수 슬러지에서 정제된 TiO₂를 혼입한 시멘트 페이스트의 수화특성 및 질소산화물 제거 성능 평가

윤현노(Yoon, Hyunno),서준호(Seo, Joonho),김선혁(Kim, Seonhyeok),배진호(Bae, Jinho),길태건(Kil, Taegeon),이행기(Lee, Haeng-Ki) 대한토목학회 2021 대한토목학회논문집 Vol.41 No.4

본 연구에서는 서로 다른 종류의 TiO₂ 혼입이 시멘트 페이스트의 수화특성 및 질소산화물 제거성능에 미치는 영향에 대해 조사하였다. 상용 제품인 P-25와 NP-400, 폐수 슬러지에서 제조된 GST, 총 세 종류의 TiO₂를 시멘트 무게대비 0, 5, 10, 20 % 첨가하여 시멘트 페이스트의 수화특성 및 질소산화물 제거성능을 분석하였다. 미소수화열 측정결과 TiO₂의 혼입은 시멘트 페이스트의 초기 수화반응에 큰 영향을 미치는 것이 확인되었으며, P-25, NP-400, GST 순으로 더 높은 누적 발열량을 나타내었다. 이로 인해 Rietveld 분석결과 TiO₂ 혼입 샘플에서 더 많은 C-S-H의 생성량이 관찰되었으며, 이는 TiO₂ 혼입 시멘트 페이스트의 28일 압축강도 증가에 영향을 미친 것으로 판단된다. SEM/EDS 분석결과 P-25, GST, NP-400순으로 페이스트 샘플 표면에 더 많은 Ti 원소의 함량이 관찰되었지만, NOx 제거 성능은 P-25, NP-400, GST 순으로 우수한 것으로 확인되었다. The present study investigated the hydration properties and NOx-removal performances of the cement pastes containing three different types of TiO₂. Two commercially available TiO₂ (P-25 and NP-400) and refined TiO₂ (GST) obtained from waste sludge were incorporated to cement paste at levels of 0, 5, 10, and 20 wt%. Isothermal calorimetry test results indicated that the TiO₂ incorporation induced a notable influence on the reaction kinetics of cement paste, showing the highest cumulative heat release in the samples containing P-25, followed by NP-400 and GST. Quantitative X-ray diffractometry as calculated by the Rietveld method identified that the incorporated TiO₂ promoted the formation of C-S-H, ultimately leading to the enhancement in the 28 day-compressive strength of cement pastes. As revealed by SEM/EDS analysis, the content of distributed Ti elements on the surface of the samples was in the order of P-25, GST, and NP-400. Regardless, the NOx-removal performance was the highest in the sample containing P-25, followed by NP-400 and GST.