Determinants of Compliance of Travelers with Vaccination and Malaria Prophylaxis at a Travel Clinic

권혜윤,이혜진,임재형,박신구,이연지,백지현,이진수 대한의학회 2019 Journal of Korean medical science Vol.34 No.33

Background: Pre-travel medical consultation is essential to reduce health impairment during travel. Yellow fever vaccination (YFV) is mandatory to enter some endemic countries. In this study, we evaluated the factors that affect compliance with appropriate prevention of infectious diseases in travelers who visited clinic for YFV. Methods: For this retrospective study, chart reviews for 658 patients who visited a travel clinic for YFV before travel were conducted. The period of this study was from January 2016 to September 2018. The associations between appropriate vaccination and factors such as travel duration, destination, time of visiting clinic before departure, and purpose of travel were analyzed. Results: Among 658 patients who got YFV during the study period, 344 patients (52.3%) received additional vaccination or malaria prophylaxis following a physician's recommendation. Travelers who visited the clinic more than 21 days before departure were more compliant than those who visited 14 days or fewer before departure (odds ratio [OR], 1.90; 95% confidence interval [CI], 1.23–2.93; P = 0.004). Travelers visiting Africa were more compliant than were those traveling to South and Central America (OR, 1.97; 95% CI, 1.34–2.90; P = 0.001). Travelers in age groups of 40-49 years and over 70 years were less compliant than the 18–29 years old population (OR, 0.51; 95% CI, 0.28–0.93; P = 0.027 and OR, 0.19; 95% CI, 0.04–0.84; P = 0.03, respectively). Also, those who traveled for tour or to visit friends or relatives were more compliant than those who departed for business (OR, 0.77; 95% CI, 1.03–3.56; P = 0.04). Conclusion: For appropriate vaccination, pre-travel consultation at least 3 weeks before departure is crucial. Travelers should be aware of required vaccination and malaria prophylaxis before visiting South and Central America and Asia. Plans to enhance compliance of the elderly and business travelers should be contrived.

A Case of Chronic Cough Caused by Achalasia Misconceived as Gastroesophageal Reflux Disease

권혜윤,임준혁,신용운,김철우 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.6

Cough is one of the most common symptoms that causes patients to seek outpatient medical care. If cough persists longer than 8 weeks, common causes of chronic cough, such as upper airway cough syndrome, asthma, and gastroesophageal reflux disease (GERD), should be considered. Although not a common cause of chronic cough, achalasia may cause symptoms very similar to reflux that can lead to its misdiagnosis as GERD. In this report, a 40-year-old woman presenting with chronic cough was initially diagnosed with GERD; however, her symptoms were refractory to conventional GERD treatment. Finally, she was diagnosed with achalasia. Her cough improved completely after pneumatic dilatation. Achalasia is a rare disease accompanied by dysphagia or regurgitation. If cough presumably due to GERD does not respond to treatment, or if the cause of chronic cough is uncertain, physicians should suspect achalasia.

중학교 수학 영재 교실 담화 분석 -교사와 학생 간의 대화를 중심으로

권혜윤 한국수학교육학회 2014 뉴스레터 Vol.30 No.5

영재수학수업에서교사는학생들의수학적사고를확장시키고,창의성을발현할수있는수업의장을마련해야한다.특히,교사와학생은수업에참여하는학습공동체로서서로의수학적사고과정,개념적이해둥을공유하고수학적지식을창출할수있는수준높은담화를형성할필요가있다. 그러나 수학영재교사 7명의 22차시 수엽의 통영상을 촬영하여 담화를 분석한 결과 교사는 학생틀에게 높은 수준의 수학 지식을 정확하게 전달하는 일방적 담화를 주로 수업을 진행했으며, 학생들의 견해와 사고를 반영하여 그들의 목소리에 관심을 기울이는 대화적 담화가 부족하였다. 본 연구는 7명 의 22차시 수업 나옹 대화적 담화가 어떤 맥락에서 발생하는지 살펴보고, 그 때의 대화적 담화에서 나타나는 교사의 발문과 피드백의 유형을 분석하여 수학영재교실에서 균형 잡힌 담화 유지를 위한 교사의 담화 전략을 알 아보고자한다.

중학교 수학 영재 교실 담화 분석 - 교사와 학생 간의 담화를 중심으로

권혜윤,신인선 한국수학교육학회 2014 수학교육 학술지 Vol.2014 No.2

교육학적 구조를 적용한 고등학교 수학적 모델링 수업 설계 구체화

권혜윤(Hye Yoon Kwon),장영재(Young Jae Jang),조아라(Ah Ra Cho),권오남(Oh Nam Kwon) 학습자중심교과교육학회 2022 학습자중심교과교육연구 Vol.22 No.21

목적 수학적 모델링 과제 설계 및 실행에 대한 이론적 틀인 DIFMT 중 수업 설계에 관한 교육학적 구조를 적용하여 수학적 모델링 수업 설계를 구체화함으로써, 우리나라에서 수학적 모델링 수업을 지원하고자 한다. 방법 연구자 3인이 수업 예상 활동을 통해 교육학적 구조를 적용하여 1차로 구체화한 수업 설계안과 학습지를 개발한 후, 수학적 모델링에 대한 사전 지식이 있는 교사 11명에게 우리나라 학교 수학 맥락에서의 구체화에 대한 의견을 수렴하였다. 교사들의 수업 예상 활동을 통해 제시된 다양한 의견들을 반영하여 2차로 교육학적 구조를 적용한 구체화한 수업 설계안 및 학습지를 구성하였다. 결과 DIFMT의 교육학적 구조를 우리나라 고등학교 학교 현장에서 적용하여 수학적 모델링 수업 설계를 구체화할 수 있음을 확인하였다. 결론 본 연구는 교육학적 구조를 적용하여 구체화한 수업 설계를 연구참여자의 의견 반영을 통해서 발전, 개선 가능함을 확인하였다. 또한 모델링 수업의 구체화 과정에서 교육학적 구조의 각 단계 사이의 관계성이 확인되었으며, 개념적, 구조적 연결성을 포함한 다양한 요소를 반영한 수업 설계가 가능함을 보였다. Objectives This study aims at confirming the embodiment of instruction design by applying the pedagogical architecture in DIFMT, a theoretical framework for design and implementation of mathematical modeling tasks to support the promotion of mathematical modeling in Korea. Methods First, 3 researchers applied the pedagogical architecture to mathematical modeling task to construct the specific instruction design and handout. Then, we asked 11 teachers their opinions about implementing it in the context of Korean high school, by doing ‘implemented anticipation’. Lastly, the pedagogical architecture of instruction design and handout were revised by reflecting the various opinions. Results It was confirmed that the pedagogical architecture of DIFMT could support the mathematical modeling instruction design to be specified in the context of Korean high school. Conclusions To adapt pedagogical architecture of DIFMT, comments of researchers and participants through ‘implemented anticipation’ were collected. The study confirmed that it is possible to design instruction that reflect various factors beyond the theoretical framework including conceptual and structural connection. Through this process, conceptual and structural connection is refined. In addition, it was confirmed that the instruction design reflecting the pedagogical architecture can be continuously developed and improved by reflecting the opinions of researchers and teachers.

머신 러닝을 이용한 악성코드의 분류

권혜윤(Hye-yun Kwon) 한국정보과학회 2017 한국정보과학회 학술발표논문집 Vol.2017 No.12

관점지향 프로그래밍을 이용한 크로스 사이트 스크립팅(XSS) 취약점 제거

권혜윤(Hyeyun Kwon) 한국정보과학회 2016 한국정보과학회 학술발표논문집 Vol.2016 No.12

오픈 소스 보안 프레임워크를 활용한 어플리케이션의 보안 강화

권혜윤(Hyeyun Kwon) 한국정보과학회 2016 한국정보과학회 학술발표논문집 Vol.2016 No.6

Identification of Outer Membrane Vesicles Derived from Orientia tsutsugamushi

이선명,권혜윤,임재형,백지현,강재승,이진수 대한의학회 2015 Journal of Korean medical science Vol.30 No.7

Orientia tsutsugamushi, a causative pathogen of Scrub typhus, is a gram-negative intracellular bacterium. Outer membrane vesicles (OMVs) are produced from the membrane of bacteria and play many roles related to the survival of the pathogen. However, there have been no reports confirming whether O. tsutsugamushi indeed produce OMVs. O. tsutsugamushi boryong was cultured in ECV-304 cells for the purification of OMVs. Western blot analysis and immunoenrichment using anti-O. tsutsugamushi monoclonal antibody and electron microscopy were employed for identification and characterization of OMVs. We confirm the presence of OMVs derived from O. tsutsugamushi, and also found that those OMVs contain a major surface antigen of 56-kDa protein and variant immunogenic antigens.

GC/MS analysis and anti-inflammatory effect of leaf extracts from Hibiscus syriacus through inhibition of NF-κB and MAPKs signaling in LPS-stimulated RAW264.7 macrophages

어현지,권혜윤,Som Da Kim,Kang Yeongyeong,Park Youngki,박광훈 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.5

Hibiscus syriacus (H. syriacus), which belongs to Malvaceae, is a perennial herb widely distributed in East Asia. In this study, we investigated the anti-infammatory efects and its potential molecular mechanisms of leaves extracted with 70% ethanol of H. syriacus (HS-L) at the mRNA and protein level when RAW264.7 macrophages were stimulated by LPS. HS-L dose dependently (0, 25, 50, 100 μg/mL) reduced NO production by inhibiting iNOS, COX-2, and IL-β expression in LPS�induced RAW264.7 macrophages. HS-L decreased the LPS-stimulated degradation and phosphorylation of IkB-a. Moreover, treatment with HS-L suppressed LPS-induced DNA binding of NF-kB and nuclear translocation of p65. Furthermore, HS-L suppressed the phosphorylation of ERK1/2 and p38. HS-L was analyzed to contain compounds such as 2-pentadecanone, methyl palmitate, and ethyl palmitate in GC/MS analysis. These results suggested that HS-L could utilize anti-infammatory activity by inhibiting NF-κB and MAPKs signaling pathways and that HS-L could be used as a natural anti-infammatory agent.