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RISS 인기검색어
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- 저자 : 권중구(Joong Goo Kweon) (검색결과 3 건)
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한금주(Kum Joo Han),안병철(Byeong Cheol Ahn),권중구(Joong Goo Kweon),김영탁(Young Tak Kim),금민수(Min Soo Kum),권영오(Young Oh Kweon),김성국(Seong Kook Kim),최용환(Yong Whan Choi),정준모(Joon Mo Chung) 대한내과학회 1995 대한내과학회지 Vol.48 No.5
N/A Objectives: In order to examine for one of the genetic predisposition to alcohol related liver disease, and for evaluation of their immunologic status, we studied HLA and delayed skin test in patients with alcoholic liver disease. Methods: A study of HLA in 50 patients with alcoholic liver disease(including 38 patients with liver cirrhosis) was conducted and delayed skin hyper-sensitivity to ubiquitous antigens was also tested in 46 patients with alcoholic liver disease. Results: 1) The comparison of the frequency of HLA-A2, A26, A34, B8, B48, B51, B60, B62 and DR3 between the patient group with alcoholic liver disease(N=50) and control group(N=196) showed higher values for the patients group, 78% vs 49%(p<0.0001), 18% vs 7.7% (p<0.05), 10% vs 0% (p<0.0001), 4% vs 0.5%(p,0.05), 10% vs 2%(p<0.01), 40% vs 7.7%(p<0.0001), 28% vs 9.7%(p<0.001), 34% vs 16.3%(p<0.01) and 24% vs 2.9%(p<0.0001) respectively. 2) The comparison of the frequency of HLA-A2, A26, A34, B8, B51, B60, B62 and DR3 between the patient group with aloholic liver cirrhosis(N=38) and control group(N=196) showed higher values in the patients group, 76.3% vs 43%(p<0.001), 21.1% vs 7,7%(p<0.01), 10.5% vs 0%(p<0.0001), 5.3% vs 0.5%(p<0.001), 36.8% vs 7.7%(p<0.0001), 28.9% vs 9.7%(p<0.001), 34.2% vs 16.3%(p<0.01) and 21.1% vs 2.9%(p<0.0001). 3) The data of delayed skin test with ubiquitous antigens did not show significant difference between the group of alcoholic liver disease(N=46) and that of normal control(N=20). Conclusion: Theses results suggest that genetic factor would be involved in the progression of the alcoholic liver disease but further studies are needed to evaluate the immunologic status in alcohnlic liver disease.
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소화성궤양 환자에 있어서 Omeprazole(오엠피®)의 치료효과
권중구,이창형,김영탁,금민수,권영오,김성국,최용환,정준모 慶北大學校 醫科大學 1995 慶北醫大誌 Vol.36 No.1
목적 : 소화성궤양 환자의 치료제중 하나인 benzimidazole유도체인 Omeprazole은 강력한 위산분비억제기능을 가지고 있는 것으로 알려져 있다. Omeprazole의 소화성궤양에 대한 치료효과를 관찰하기 위하여 본 연구를 실시하였다. 대상 및 방법 : 1994년 8월부터 12월까지 경북대학교병원 내과를 방문한 환자중 상부소화관내시경 검사로 확진된 위궤양 및 십이지장궤양 15예를 대상으로 omeprazole(OMP®) 20㎎을 1일 1회 투여하고, 4주후에 내시경검사를 실시하고 그 치유효과를 관찰하였다. 결과 : 소화성궤양에 대한 4주후의 내시경상의 치유율이 93.4%(8예 중 8예)였고 완전치유율은 62.5%(8예 중 5예)였다. 소화성궤양에 대한 4주후의 증상의 변화를 보면 저명개선이 66.7%(15예중 10예)였고 개선이 33.3%(15예 중 5예)였다. 4주후에 임상적으로 특기할만한 부작용이 관찰되지 않았다. 결론 : Omeprazole이 소화성궤양에 뚜렷한 효과가 있고 비교적 안전하게 사용할 수 있는 약물로 생각된다. For the evaluation of clinical efficacy of omeprazole in the treatment of patient with gastric and duodenal ulcer, 15 patients with upper GI endoscopically proved active gastric ulcer(14 patients) and duodenal ulcer(1 patient) were admitted to this trial. Omeprazole was administered 20㎎ daily for 4 weeks and then follow up was done by endoscopy. The observed results were as follows: (1) Overall improvement of peptic ulcers by endoscopy was noted in 93.4% of the patients. 7 out of 8 cases of peptic ulcers had been healed up in 4 weeks. The complete healing rates of peptic ulcer by endoscopic examination at 4 weeks were 62.5% of the patients. (2) Clinical manifestations of peptic ulcer had been markedly improved in 10 out of 15 cases (66.7%) after 4 weeks medication with omeprazole and had been improved in 5 out of 15 cases (33.3%) (3) No significant clinical side effects had been noticed with 4 weeks medication. According to this study, omeprazole appears to be fairly effective and safe for the treatment of patient with peptic ulcer-diseases.
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