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- 저자 : 금민수(Min Soo Kum) (검색결과 1 건)
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한금주(Kum Joo Han),안병철(Byeong Cheol Ahn),권중구(Joong Goo Kweon),김영탁(Young Tak Kim),금민수(Min Soo Kum),권영오(Young Oh Kweon),김성국(Seong Kook Kim),최용환(Yong Whan Choi),정준모(Joon Mo Chung) 대한내과학회 1995 대한내과학회지 Vol.48 No.5
N/A Objectives: In order to examine for one of the genetic predisposition to alcohol related liver disease, and for evaluation of their immunologic status, we studied HLA and delayed skin test in patients with alcoholic liver disease. Methods: A study of HLA in 50 patients with alcoholic liver disease(including 38 patients with liver cirrhosis) was conducted and delayed skin hyper-sensitivity to ubiquitous antigens was also tested in 46 patients with alcoholic liver disease. Results: 1) The comparison of the frequency of HLA-A2, A26, A34, B8, B48, B51, B60, B62 and DR3 between the patient group with alcoholic liver disease(N=50) and control group(N=196) showed higher values for the patients group, 78% vs 49%(p<0.0001), 18% vs 7.7% (p<0.05), 10% vs 0% (p<0.0001), 4% vs 0.5%(p,0.05), 10% vs 2%(p<0.01), 40% vs 7.7%(p<0.0001), 28% vs 9.7%(p<0.001), 34% vs 16.3%(p<0.01) and 24% vs 2.9%(p<0.0001) respectively. 2) The comparison of the frequency of HLA-A2, A26, A34, B8, B51, B60, B62 and DR3 between the patient group with aloholic liver cirrhosis(N=38) and control group(N=196) showed higher values in the patients group, 76.3% vs 43%(p<0.001), 21.1% vs 7,7%(p<0.01), 10.5% vs 0%(p<0.0001), 5.3% vs 0.5%(p<0.001), 36.8% vs 7.7%(p<0.0001), 28.9% vs 9.7%(p<0.001), 34.2% vs 16.3%(p<0.01) and 21.1% vs 2.9%(p<0.0001). 3) The data of delayed skin test with ubiquitous antigens did not show significant difference between the group of alcoholic liver disease(N=46) and that of normal control(N=20). Conclusion: Theses results suggest that genetic factor would be involved in the progression of the alcoholic liver disease but further studies are needed to evaluate the immunologic status in alcohnlic liver disease.
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