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천연가용화제인 스테비오사이드를 활용한 수용성 루틴 생성의 최적화
고진아 ( Jin-a Ko ),남승희 ( Seung-hee Nam ),김영민 ( Youngmin Kim ) 한국키틴키토산학회 2016 한국키틴키토산학회지 Vol.21 No.3
천연물 유래의 성분들은 좋은 생리활성에도 불구하고 낮은 수용성으로 인해 산업적으로 제약이 있거나 경제적 비용이 많이 소요되고 있는 실정이다. 최근, 합성계면활성제를 불신하는 소비자의 심리와 유해성 논란이 증폭되면서 산업화의 장벽을 해결하고 물성개선을 위한 새로운 방법이 절실하다. 본 연구에서의 천연유래의 스테비오사이드와 마이크로웨이브를 활용한 반응표면 분석에 의해 수용성 루틴을 최적화할 수 있는 조건을 최적화하였다. 중심합성계획에 따라 스테비오사이드의 농도(10, 20, 50, 100 mg/mL), 루틴의 농도(10, 20, 50 mg/mL), 마이크로웨이브 파워(50, 100, 150, 200 Watt) 그리고 처리시간(1, 3, 5분)로 실험하였다. 반응표면분석 결과는 스테비오사이드의 농도 146.05 mg/mL, 루틴의 농도 5.87 mg/mL, 마이크로웨이브 파워 50 Watt, 5분간 처리조건을 얻었고, 상기의 조건으로 100%의 수율의 수용화된 루틴을 얻을 수 있다. Rutin, naturally phenolic bioactive compound, is a potent antioxidant and anti-inflammatory activity having poor water-solubility as a weak point. The rapid and simple soluble rutin successfully formed using microwave treatments with stevioside as a natural solubilizer. Soluble rutin was optimized by the Box-Behnken design according to the independent four factors such as stevioside concentration, rutin concentration, microwave power, and microwave treated time, respectively. Finally optimal soluble rutin was obtained around 100% yield at a conditions as 146 mg/mL of stevioside, 5.9 mg/mL of rutin, 50 W of microwave power, and 5 min of treated time. These study illustrated that the soluble rutin formed by stevioside and microwave treatment can be applicable for functional foods and cosmetic materials in pharmaceutical areas.
오명운 ( Myoungoon Oh ),고경보 ( Kyoung Bo Ko ),조성철 ( Seong Cheol Cho ),고진아 ( Jin-a Ko ),류연철 ( Younchul Ryu ) 한국동물위생학회 2021 韓國家畜衛生學會誌 Vol.44 No.4
This study investigated the status and analyzed of stray dogs, stray cats admitted to the Jeju Animal Shelter during the year of 2015 to 2019, and the infection rates of specific diseases for abandoned dogs. In addition, in 2017 to 2019, the collected intake and outcome data were reviewed to analyze shelter capacity in terms of housing capacity (monthly daily average intake, required holding capacity, and adoption-driven capacity), staff capacity (staff hours required for daily care). Out of 24,557 dogs admitted to the shelter, owners of 1,808 dogs (7.4%) visited the shelter and found their lost dogs, while 3,612 dogs (14.7%) were adopted to new families. However, the number of puppies that were euthanized was the highest at 12,266 (49.9%), and 6,876 (28%) died either death from disease or natural causes because they were detained in shelters. The monthly daily average (MDA), which is one of the indicators for efficient population management of Jeju Animal Shelter, was found to be 17.4 for abandoned dogs and 1.7 for abandoned cats. Seasonal variations were observed for MDA, RHC, MDA adoptions, ADC, and RSDC, indicating that various strategies are needed for shelter management. This study was performed to analyze and interpret meaningful statistics for improving the efficiency of animal shelters in Jeju. However, inconsistent collection of animal statistics limited data compilation. Creation of a basic animal statistics matrix with reference to well-designed matrices from recognized professional animal shelters is essential.
강완철 ( Wan Choul Kang ),양형석 ( Hyoung Seok Yang ),고진아 ( Jin A Ko ),이두식 ( Du Sik Lee ),손원근 ( Won Geun Son ) 한국동물위생학회 2015 韓國家畜衛生學會誌 Vol.38 No.4
The bacterium causing Johne’s disease (JD), Mycobacterium avium subspecies paratuberculosis (MAP), is distributed worldwide and causes progressive intestinal disease, also known as paratuberculosis, in domestic and exotic ruminants, including cattle. The subclinical form of this disease results in progressive weight loss, reduced milk production, lower slaughter value, and premature culling, with possible impacts on fertility and udder health. Eventually, infection can lead to the clinical form that manifests chronic diarrhea, emaciation, debilitation, and eventual death. JD is a major cause of economic loss in cattle industry. In this study, serological testing was conducted by ELISA to determine the prevalence of MAP in Korean native cattle of Jeju during the duration of 2010 to 2013. A total of 5,150 blood sera were collected in 111 farms and the samples were classified into four different age groups for MAP; group 1 (2 years or less), group 2 (2∼4 years), group 3 (5∼7 years), and group 4 (over 8 years). Overall seroprevalence of MAP was 5.2% (269/5,150), and annually from 2010 to 2013, they were 11.6% (106/915), 2.1% (10/474), 5.5% (89/1,627), and 3.0% (64/2,134), respectively. Also, the prevalence rates was determined by age groups: 48 of group 1 (17.8%), 154 of group 2 (57.3%), 48 of group 3 (17.8%), and 19 of group 4 (7.1%) were seropositive for MAP. Although seropositive samples were found in all age groups, the highest seroprevalence was found in group 2. This study showed that during the investigation the seroprevalence of MAP tended to decrease.
제주지역 돼지에서 Salmonella Typhimurium 항체가 조사
양형석 ( Hyoung Seok Yang ),강완철 ( Wan Choul Kang ),고진아 ( Jin A Ko ),배종희 ( Jong Hee Bae ),김재훈 ( Jae Hoon Kim ) 한국동물위생학회 2015 韓國家畜衛生學會誌 Vol.38 No.2
Porcine salmonellosis is an economically important disease affecting the global pig industry today. Salmonella (S.) Typhimurium is highly contagious and may rapidly spread within pig populations of herd. To investigate the prevalence of porcine salmonellosis in Jeju, a total of 12,885 blood sera of 96 pig farms from 2009 to 2012 were analyzed by microplate agglutination test. Antibodies to S. Typhimurium were detected in all of pig farms tested in Jeju Province, and the mean of seropositive rate of individual pig was 18.8%. The mean seropositive rate of S. Typhimurium in sows (46.7%) was 7 times higher than that of weaned or growing pigs (6.7%). The lowest seropositive rate (3.0%) was detected in 40 day-old pigs, and this result might be closely associated with the marked decrease of maternal passive immunity. The seropositive rate in winter (42.7%) was higher than in other seasons.
제주지역 흑염소에서 뇌염형 리스테리아증 발생 증례 보고
송경옥 ( Kyoung Ok Song ),양형석 ( Hyoung Seok Yang ),정수교 ( Soo Kyo Jung ),강완철 ( Wan Choul Kang ),고진아 ( Jin A Ko ),이철휴 ( Chul Hue Lee ),김재훈 ( Jae Hoon Kim ) 한국가축위생학회 2014 韓國家畜衛生學會誌 Vol.37 No.1
In February 2013, two Korean native goats with circling, dysphagia, sialorrhea, and death were submitted for necropsy to the Jeju Self-Governing Provincial Veterinary Research Institute. Histopathologically,multifocal to confluent micro-abscess composed of neutrophils and macrophages and severe mulifocal perivascular cuffing were observed in pons, medulla oblongata, and cerebellum. Isolated bacteria from the brain sample were Gram-positive coccobacilli and were confirmed as Listeria (L.) monocytogenes by VITEK and PCR analysis. Based on clinical sign, histopathology and bacterial isolation,this case was diagnosed as encephalitic listeriosis. In our best knowledge, this is the first report of encephalitic listeriosis caused by L. monocytogenes in Korean native goats in Jeju.
고진(Ko Jin),오승훈(Oh Seung Hwoon),이종호(Rhee Jongho) 대한토목학회 2012 대한토목학회논문집 D Vol.32 No.2D
교차로 주변의 주차공간할당과 불법주차행위는 도로점유로 인한 도로용량의 감소는 물론 교차로에 접근하는 운전아제 혼란을 주어 교차로 교통소통에 지체를 유발시킨다. 현재 주·정차금지구역은 교차로 가장자리 또는 모퉁이로부터 5미터 이내의 곳으로 지정되어 있다. 그러나 현실적으로 5미터 이상의 곳에 주차허가가 되어 있는 교차로에서도 주차로 인한 소통방해가 심한 경우를 종종 볼 수 있다. 또한 주차가 교차로의 지체에 미치는 영향은 교차로의 유형, 규모, 서비스수준 등의 많은 변수에 다라 차이가 존재할 것이라고 추측하고 있지만 이데 대한 공학적인 접근의 연구는 미비한 실정이다. 본 연구에서는 교차로 부근 주·정차 시, 교차로 교통에 가장 영향이 클 것으로 판단되는 변수인 통과 교통량과의 우회전 비율을 선정하여, 이들의 변화에 따른 교차로 지체의 변화를 추적하였다. 이를 위하여 실제 교차로의 교통량과 우회전비율을 조사한 후 시뮬레이션 프로그램을 이용하여, 각 시나리오의 효과척도 및 서비스수진(LOS)의 변화를 비교/분석 하였다. 이 연구결과는 향후 교통여건이 다른 교차로 부근 주·정차금지구역 또는 주·정차허가지점의 설정 시 중요한 기준을 제시 할 것으로 판단된다. One of the traffic problems has been caused by the illegal parking because of the lack of parking space. Especially, the illegal occupancy of the road near an intersection makes an serious reduction of road capacity. The current illegal parking and stop-prohibited areas have been designated for less than 5meters from the edge or the corner of the 4-leg intersection. However, in reality, the cars parked at the place over 5 meters have had a significant impact on the intersection traffic. In addition, many variables such as intersection type, size, and service levels should be considered as factors which influence on the traffic condition at the intersection. It was assumed that through and right-turn traffic rate have a significant impact on the 4-leg inter section with the illegal parking or stop near it. This study tried to verify the impact through the simulation implementation with MOE and LOS. It shows a guideline to designate the parking or stop-prohibited area near the 4-leg intersection under various traffic conditions.
뒷좌석 승객 보호를 위한 성능 평가 및 개선 방안에 대한 연구
최현진(Hyun-jin Choi),고진(Jin Ko),권성은(Sung-Eun Kwon) 한국자동차공학회 2005 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2005 No.5_2
The seat submarine phenomenon is considered as one of the important causes increasing the front-seat occupant injury in the frontal impact crash. So, anti-submarine bar or anti-sliding airbag has been implemented to prevent the seat-submarine. However, due to lack of the regulation and requirement, the study and development of the submarine effect was not well studied for a rear-seat. The rear-seat occupant protection device almost has been using 2-point or 3-point a seat belt. When the rear-seat occupant protection performance is evaluated in frontal impact sled test using all dummies, especially the injury value of a small size dummies is not good. The reason is a seat submarine, which would bring rupture of the abdomen. There are some major factors affecting seat submarine such as the seat belt webbing length & elongation, the buckle guide line angle and the seat cushion materials etc. In this paper, we will discuss the evaluation method. And also, discuss the submarine improvement, controlling antisubmarine bar and buckle line route etc., in a sled test with FMVSS 208 generic corridor.