만성 기류폐쇄 환자에서 가역성 예측 지표로서의 아토피

최인선,고영일,박석채,강유호,정익주,이신석 (In Seon Choi,Young Il Koh,Seog Chea Park,Yoo Ho Kang,Ik Joo Chung,Shin Seok Lee) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.2

Background: Smoking-related chronic obstructive pulmonary disease and chronic asthmatic bronchitis, which are the most important causes of chronic airflow obstruction (CAO), can occur together in a pat,ient and the prognoses of these two diseases are different each other.Objective and method: To estimate the extent of asthmatic component in patients with CAO and to evaluate the role of atopy as a predictable index for reversibility of airflow obstruction, 89 CAO patients who were older than 40 years were examined retrospectively. Result: Only 15 patients (16.8%) showed an increase of >15% in FEV20 to inhaled salbutamol (short-term responder). However, 18 out of 32 patients (56.3%), who were not responded significantly to inhaled bronchodilator and performed a follow-up lung function study, showed an increase of ) 15% in FEV20 to anti-asthmatic therapy including corticosteroid for 3-4 weeks (long-term responder). Peripheral blood eosinophil count only was different between short-term responder and short-term nonresponder, and there was no difference in all of the measurements between short-term responder and long-term responder. However, there were significant differences in smoking, wheezing on auscultation, peripheral blood eosinophil counts, serum total IgE levels, and MAST atopy score between long- term responder and long-term nonresponder. The increase in FEV, following shortor long -term therapy was related to peripheral blood eosinophil counts and MAST atopy score, and it was significantly great,er in patients with high eosinophil counts or high atopy score.Conclusion .: About 2/3 of patients with CAO who were older than 40 years had an asthmatic component ap atopy may be useful to predict good bronchodilator response to anti-asthmatic therapy.

보중익기탕(補中益氣湯) 및 그 가미방(加味方)을 투여한 중풍환자에 대한 임상적 고찰

최인선,민성순,김종환,서상호,박상은,김영균,권정남,Choi, In-Seon,Min, Sung-Soon,Kim, Jong-Hwan,Seo, Sang-Ho,Park, Sang-Eun,Kim, Young-Kyun,Kwon, Jung-Nam 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3

Object: This study was designed to investigate the clinical and practical characteristics of stroke patients treated with the age-old herbal medicines, Bojungikki-tang and Bojungikki-tang-gamibang. Methods: The 80 patients studied were all diagnosed with stroke by neurological examination, B-CT and B-MRI scan. They were treated with Bojungikki-tang and Bojungikki-tang-gamibang over 5 days and symptoms were observed. There were inpatients and outpatients at the Oriental Medical hospital of Dong-eui University from January in 2000 to June in 2003. All patients were interviewed and medical charts examined. Result and Conclusion: The results were found: 1.Many were in their sixties. Average age was 64.54. 2.Cerebral infarction was diagnosed in 86.25% of all cases. 3.30% of stroke cases occurred in spring. 4.Average blood pressure was 129/84mmHg on the fifth day of treatment with Bojungikki-tang and Bojungikki-tang-gamibang and 135/86mmHg on the first day. 5.The white color were best in facial color about 85.29%. 6.There were many who returned for treatment within 6 to 10 days. 7.Bojungikki-tang and Bojungikki-tang-gamibang were used Rt. hemiplegia more than for Lt. hemiplegia.

이동컴퓨팅 환경에서 사용자의 선호도를 고려한 프리페칭

최인선,조기환,Choi, In-Seon,Cho, Gi-Hwan 한국정보처리학회 2006 정보처리학회논문지 C : 정보통신,정보보안 Vol.13 No.5

사용자의 이동성으로 인하여 이동컴퓨팅 환경에서 안정된 서비스 품질(QoS)로 사용자가 원하는 정보를 제공받는데 많은 한계점이 있다. 이동성과 더불어 무선 네트워크의 낮은 대역폭, 높은 전송지연 등의 고유 특성을 부분적으로 보완하기 위해서 유효 데이터의 캐슁 혹은 프리페칭 기법의 적용이 심도 있게 연구되고 있다. 본 논문은 사용자의 선호도(Preference) 즉, 관심도(Interest)와 인기도(Popularity)를 고려한 IP기반 프리페칭 기법을 제안한다. IP기반 프리페칭은 사용자의 선호도를 사용자별 특정 정보에 대한 개인적인 성향을 관심도로, 특정 정보의 일반적인 성향을 인기도로 분리, 적용함으로써 프리페칭의 유효성을 높인다. 제안된 방법은 기존의 방법들보다 높은 정보의 활용률과 정보검색 실패율을 최소화시키는 성능을 보이고 있다. Mobile computing environment is known to be quite difficult to provide user with a stable QoS(Qualify of Service) due to its mobility nature. In order to protect the inherent characteristics of wireless network such as low bandwidth and high transmission delay along with the user's mobility, many works are conducted to apply caching and prefetching methods. This paper presents a novel prefetching technique which is based on user's preference, that is, interest and Uuかity. It tries to improves the effectiveness of prefetching by separating and appling the interest with personal tendency of a given information, and the popularity with general tendency of the information. The proposed scheme shown relatively superior performance in terms of the utilization ratio of prefetched information and the failure ratio of information retrieval than the existing methods.

음악 · 무용을 전공하는 여고생의 식생활 습관과 골 밀도에 관한 연구

최인선(Choi, In-Seon),황민경(Hwang, Min-Kyong),노희경(Ro, Hee-Kyong) 전남대학교 생활과학연구소 2007 生活科學硏究 Vol.17 No.-

Bone mass is accumulated at growth period and women can reach about 90% of maximum bone mass by 18 and bone growth is very important. Thus examination of bone density of girls' high school students is needed, but materials of bone density are lacking. This study examines health conditions, living habits, eating behaviors, measures bone density and obtains the following results in order to evaluate influence of eating habits of girls' high school students majoring music and dance on their bone density. As a result of examining general items with subjects, average height and weight were 162.3 cm and 53.9 kg in music students and 165.5 cm and 51.0 kg in dance students and their weight was showed significant difference. Body Mass Index (BMI) was 20.4 kg/㎡ in music students and as 18.6 kg/㎡ in dance students and music students were significantly higher than dance students. As a result of examining health conditions and living habits, dizziness and vertigo were 15.4% in music students and 53.8% in dance students and dance students were significantly higher. Daily average sleeping hours were highest at ‘6~7 hours' as 34.6% and 38.5% in music and dance students respectively, but 61.5% of music students responded it was sufficient and 65.4% of dance students responded it was insufficient. 88.5% of music students didn't perform regular exercise and 84.6% of dance students did regular exercise and there was significant difference between two groups. As a result of examining their eating behaviors, 71.2% of subjects have breakfast. Bone density was 705.0 g/㎤ at music students and 715.3 g/㎤ at dance students and that of dance students was higher than that of music students. In the relationship between BMI and bone density, ‘16~19.9' of BMI corresponded to 712.4 g/㎤ of bone density, ‘20~24.9' of BMI to 709.8 g/㎤ of bone density and ‘over 25' of BMI was 741.5 g/㎤ of bone density and there was significant difference. In sum, since dance students who did regular exercise had higher bone density, it was known that exercise is profitable factor to increase bone density and more researches on promoting bone health of youth are needed in future.

단순 Methacholine 흡입법에 의한 비특이성 기도과민반응검사

최인선(In Seon Choi),장희성(Hee Seoung Chang),허윤(Yun Hur),박경옥(Kyung Ok Park) 대한내과학회 1987 대한내과학회지 Vol.32 No.4

N/A The usual methacholine challenge procedures are quite time consuming. So the presumptive estimation of the provocation concentration from the percent changes of spirometric measurements was performed in 22 asthmatics, 17 allergic rhinitis pathents and 40 normal subjects. In asthmatics inhalation of 2mg/ml methacholine resulted in a 19.3% diminution in FEV1 and PC20 was estimated approximately as 2 mg/ml. But in allergic rhinitis patients and normal subjects PC20, were higher than 20 mg/ml because their responses to 20 mg/ml methacholine were -5.9% and -1.8%, respectively. The baseline lung function of responders (asthmatics in whom FEV, decreased by more than 15%) was lower than nonresponders (p<0.001), and a significant correlation was present between the baseline FEV, and % change FEV1 (r=0.46, p<0,05). These results suggested that PC20 is different according to the severity of the bronchial obstruction and it indicate the bronchial hyperreactivity of the present time. This simple, rapid method using the solutions of 2 mg/ ml and 20 mg/ml methacholine may give a rough but clinically useful information about the bronchial hyper- reactivity like as reactive to 2mg/ml, intermediate response, or nonreactive even to 20 mg/ml.

탄닌 투여시 인체의 혈청 지질개선 효과에 미치는 영향

최인선(In-Seon Choi),이경화(Kyung-Hwa Lee),이성숙(Sung-Sug Lee),오승호(Seung-Ho Oh) 한국식품영양과학회 1997 한국식품영양과학회지 Vol.26 No.5

본 연구는 인체실험을 통해 혈청 지질 개선효과에 영향을 미칠 수 있는 탄닌이 인체의 혈청 지질 저하효과를 나타내는지를 밝히기 위하여 여자 대학생에게 탄닌 양을 달리하여 1주간씩 섭취시켜 분중 담즙산 및 혈청 지질 성분에 미치는 영향을 측정하여 다음과 같은 결과를 얻었다. 혈장 총 지질 농도는 대조기간에서 평균 671.1±55.1㎎/dl이었고, 탄닌 0.5g/day, 1.0g/day 및 2.5g/day 투여량별로 각각 346.9±70.7㎎/dl, 652.4±25.2㎎/dl 및 585.4±40.1㎎/dl로 탄닌 0.5g/day를 줄 때 유의적으로 낮았으나 여타 실험기간은 대조기간과 유사한 경향이었다. 탄닌의 투여 시기별 혈청 지질 개선효과는 뚜렷한 결과를 보이지 않았으나 탄닌의 첨가 급식초기에 분중 담즙산 배설량의 증가와 혈장 총 지질 함량이 현저하게 감소하는 경향을 나타낸 것으로 미루어 보아, 투여 수준 및 기간에 따라 탄닌은 혈청 지질 개선 효과를 나타낼 것으로 추측되어지나 이에 대하여는 추후 더 많은 연구가 요구된다. In order to observe the effect of tannin on plasma lipid status in human, tannin was supplemented with increasing amounts from 0 to 0.5, 1.0, 2.5g/d early week until 4th week. The results obtained from this research are as follows. Concentration of total lipid in plasma was significantly lower compared to the control group when the level of tannin supplementation was 0.5g/day while the level of tannin 1.0g/day and 2.5g/day did not affect to change the total lipid level. There seems to be no obvious improvement of the plasma lipid status respect to different tannin levels. Despite the result, the excretion of total bile acids in feces was increased and total lipid in plasma was reduced significantly during first time supplementation compared the control.

Airway Hyperresponsiveness to Hypertonic Saline as a Predictive Index of Exercise-Induced Bronchoconstriction

최인선 ( In Seon Choi ),( Se Woong Chung ),( Young Il Koh ),( Myoung Ki Sim ),( Seo Na Hong ),( Jang Sik Moon ) 대한내과학회 2005 The Korean Journal of Internal Medicine Vol.20 No.4

Background : Changes in airway mucosal osmolarity are an underlying mechanism of bronchoconstrictive responses to exercise and hypertonic saline (HS). The purpose of this study was to examine whether an osmotic challenge test using HS can predict exercise-induced bronchospasm (EIB) in asthma patients. Methods : Thirty-six young male asthmatic patients underwent bronchial challenge tests based on 4.5% HS, exercise (> 24h later), and methacholine (MCh) at the Chonnam National University Hospital. The relationships between responses to HS and exercise, and between MCh and exercise were evaluated. Results : The maximal fall in forced expiratory volume in one second following exercise was significantly higher in the HS-responders (n=19) than in the HS-nonresponders (n=17, 35.9±4.1% vs. 17.9±2.7%, ρ<0.001), and there was a significant correlation between the severity of EIB and HS-airway hyperresponsiveness (AHR). When compared with the MCh-AHR test in terms of predicting EIB, the HS-AHR test showed higher specificity (71.4% vs. 42.9%), but a lower sensitivity (58.6% vs. 89.7%) and negative predictive value (29.4% vs. 50.0%). At the moderate AHR cutoff value, the MCh-AHR test had a specificity that was comparable with and predictive values that were higher than those of the HS-AHR test. Conclusions : The HS-AHR test was more specific than the MCh-AHR test, but was less sensitive and had a poorer negative predictive value, which in combination preclude the use of the HS-AHR test as a screening tool for EIB. The MCh-AHR test had a cutoff value for moderate AHR that may be more useful for predicting EIB in asthmatic patients.

정상 혈청 총 IgE치를 보이는 알레르기 천식환자의 임상적 특성

최인선 ( In Seon S. Choi ),김옥기 ( Ok Ki Kim ),정성훈 ( Seong Hoon Jeong ),이우진 ( Won Jin Lee ),이성지 ( Seong Ji Lee ),신홍준 ( Hong Joon Sin ),한의령 ( Eui Ryoung Han ),정지민 ( Ji Min Jeong ) 대한천식알레르기학회 2009 천식 및 알레르기 Vol.29 No.2

Background: Although allergic diseases occur through IgE-mediated reaction, about 20% of allergic asthmatics have normal total serum IgE levels. Objective: To characterize the allergic asthmatics with normal total serum IgE levels. Method: Medical records of 430 consecutive allergic asthmatics, who received the tests for both total IgE and allergen-specific IgE in the serum or on the skin, were reviewed. According to the total and specific IgE levels, the subjects were classified to 4 groups (I, increased/strong; II, normal/strong; III, increased/weak; IV, normal/weak). Result: The Dermatophagoides farinae-specific IgE level in the serum was significantly related to the total serum IgE level (r=0.322, P<0.001). The D. farinae-specific IgE levels were significantly lower in the group II than in the group I (3.27±0.14 vs. 1.83±0.30, P<0.01) and the group IV than in the group III (0.79±0.05 vs. 0.44±0.13, P<0.01). The results for D. pteronyssinus and sum of checked allergens were similar. The proportion of the patients sensitized to single allergen to total subjects was 7.5%/13.5%/33.0%/40.0% for I/II/III/IV groups (χ2=44.5, P<0.001). Conclusion: The allergic asthmatics with normal total serum IgE levels had lower allergen-specific IgE levels and a higher proportion of the patients sensitized to single allergen. The levels of total serum IgE may be determined by the degree of sensitization in allergic asthma. (Korean J Asthma Allergy Clin Immunol 2009;29:96-104)

광주ㆍ전남 일부 지역 중학생들의 BMI 수준에 따른 식행동, 체형인식 및 체중조절 양상에 관한 연구

최인선(In-Seon Choi),노희경(Hee-Kyong Ro) 한국식품영양과학회 2010 한국식품영양과학회지 Vol.39 No.3

본 연구는 광주?전남지역 중학생 732명을 대상으로 BMI 수준에 따른 식습관, 식행동, 체형인식 및 체중조절 실태에 대해 조사하였으며 이에 대한 연구 결과를 요약하면 다음과 같다. BMI 수준에 따른 조사대상자의 분포는 남학생이 저체중군 27.8%, 정상체중군 45.9%, 과체중군 26.3%이었으며, 여학생은 저체중군이 26.2%, 정상체중군 53.6%, 과체중군 20.2%이었다. 남녀 중학생의 평균 BMI는 각각 20.7±1.0과 20.6±0.2이었다. 점수로 평가한 식습관과 식행동에서 남자중학생은 과체중군이 저체중군에 비해 빨리 먹는 점수가 높으며, 저녁식사의 양과 야식섭취 및 식품선택 시 기호보다 영양을 고려하는 점수는 낮았다. 여자 중학생은 과체중군이과식과 스트레스 시의 음식 섭취와 식품선택 시 가격보다 영양을 고려하는 점수는 높았고, 야식 점수가 낮았다. 조사대상자의 신장은 남자 중학생 저체중군이 정상체중군과 과체중군에 비해 유의적으로 낮았으나, 여자 중학생은 그룹 간 차이가 없었으며, 남녀 중학생 모두 실측한 신장보다 더 크기를 원하였다. 조사대장자의 체중은 남녀 중학생 모두 그룹간의 차이가 유의적이었다. 남자 중학생은 과체중군에서만 체중감소를 희망한 반면, 여자 중학생은 과체중군뿐아니라 정상체중군에도 체중의 감소를 희망하였는데, BMI가 클수록 원하는 체중과 실측체중간의 차이가 컸다. 본 연구대상자들의 인지체형은 남녀 중학생 모두 해당 군별 체형에 근접하였으나, 정상체중군에서 인지체형에 대한 왜곡경향이 높았으며, 희망체형과 인지체형의 차이가 과체중군에서 가장 컸다. BMI가 높을수록 체중조절에 대한 관심과 경험이 높았는데, 남자 중학생은 건강을 위해서, 여자 중학생은 날씬한 외모를 갖고 싶어서가 체중감량의 이유로 가장 많았다. BMI가 클수록 체형만족도가 낮으며, 희망체형과 인지체형간의 차이 값이 컸으나 스트레스는 BMI가 낮을수록 컸다. 또한 희망체중과 체형에서 실측체중 및 인지체형을 뺀 값이 클수록 체형만족도가 낮았다. 본 연구의 결과, 과체중군은 정상체중군과 저체중군에 비해 과식, 스트레스 시의 음식섭취에서 보다 바람직하지 않았으며, 스트레스와 체중조절관심도 및 경험이 더 많아, BMI 수준에 따라 식생활 양상에 차이를 보였는데, 과체중군의 식행동과 태도가 보다 바람직하지 못하였다. 따라서 남녀 중학생을 대상으로 올바른 체형인식과 더불어 체계적인 영양교육의 필요성을 제시하는 바이다. This study was performed to investigate the food habits, eating behaviors, perception of body shape, statuses of body weight control by BMI (Body Mass Index) of 732 middle school students in Gwangju and Jeonnam. The results of this study were compared among under weight (UW), normal weight (NW), and overweight (OW) groups according to BMI levels. In the OW group, female students had low scores in eating at night only, while male students had low scores in eating at night, eating speed, and food selection. All subjects wanted more height than measured. Only male students in the UW group wanted weight loss, whereas female students in the OW and NW groups did. Higher BMI in female students resulted in more weight difference between measured and wanted. All subjects responded properly themselves in perception of body shape but the OW groups showed a big difference between their present weight and wanted weights. Higher BMI in all students corresponded to more interest in concern and experience of weight management. In the male students, the reason for weight management showed high tendency in being healthy, whereas the female students had high tendency in having a slender figure. Higher BMI in all students corresponded to bigger difference between wanted and perceived body shape. In contrast, lower BMI in all students meant more stress. Greater difference between wanted and measured weight and greater difference between wanted and perceived body shape corresponded to less satisfaction in body shape. In conclusion, compared to the NW and UW groups, the OW group had overeating habits highly linked to stress. Also the OW group didn't have desirable eating behaviors and attitudes because of their greater interest in concern and experience of weight control and stress accumulation, and finally there was difference in food habits and behaviors according to the BMI level. Therefore these results suggest that effective nutritional programs should be developed including correct body image and good dietary habits.

메타콜린 유발검사 때 폐 천명과 flow volume loop 검사의 가치

최인선(In Seon Choi),강광원(Kwang Won Kang),임호(Ho Lim) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.5

N/A Background: In methacholine bronchoprovocation test, lung function is traditionally measured by using forced vital capacity maneuver which depends on patient's effort. And insufficient breath may result in a false positive test. Objective : To evaluate the additional indices of airflow obstruction in the interpretation of methacholine bronchoprovocation test. Method: FEV1/FVC, canfiguration index of flow-volume loop(Slope-Ratio), modified Borg dyspnea score, and wheezing in addition to FEV1 were measured before and after methacholine challenge. Results : The changes of the measurements after methacholine challenge were significantly greater in patients with airway hyperresponsiveness(AHR). However, only 9 out of 29(31.0%) patients with AHR developed all of indices and 6.9/o did not show any evidence of obstruction except dyspnea. On the contrary, 40% of patients without AHR showed positive in two or more indices and 2 of them were hyperresponsive to histamine. Among patients with AHR, those without dyspnea and wheezing on challenge showed significantly lower baseline Borg score. FEV1, FEV1/FVC, and PC20, and were older than those with them(p<0.05). Conclusion Methacholine-induced △FEV1 is related to, but not concordant with other indices of airflow obstruction. Development of dyspnea and wheezing depends on age, etc. For an accurate interpretation of methacholine bronchoprovocation test, it maybe necessary to consider these variables. (J Asthma Allergy Clin Immunol 20: 717-724, 200G)