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Interface Shear Strength at Joints of Ultra‑High Performance Concrete Structures
Young?Jin Kim,Won?Jong Chin,Se?Jin Jeon 한국콘크리트학회 2018 International Journal of Concrete Structures and M Vol.12 No.6
When ultra-high performance concrete (UHPC) is fabricated as precast members such as in a UHPC segmental bridge, the joint design between the precast members can significantly affect the overall integrity and safety of the structure. Therefore, the structural behavior of the UHPC joint was experimentally investigated in this study with test variables including joint type, number and height of shear keys, type of filler, curing temperature, and lateral compressive stress. The UHPC considered in this study is the K-UHPC developed in Korea with a specified compressive strength as high as 180 MPa and high flowability. The joint shear strengths affected by the test variables were investigated in detail. The test results were also compared with two representative predictive equations for interface shear strength to determine an appropriate equation for the joint design of UHPC. These equations did not match well with the test data because they were originally proposed for normal strength concrete. However, the JSCE equation could be improved by modifying a coefficient to show good agreement with the test especially in the case of the dry joint with epoxy application.
김웅철,이원철,손영석,오세윤,김부섭,유진호,김지환 한국보건의료인국가시험원 2005 보건의료교육평가 Vol.2 No.1
This study prepared a basic framework for the development and improvement of Korean Dental Technicians' Licensing Examination, based on actual test questions. A peer review was conducted to ensure relevance to current practices in dental technology. For the statistical analysis, 1000 dental laboratory technicians were selected; specialists in dental laboratory technology (laboratory owners, educators, etc.) were involved in creating valid and reliable questions. Results indicated that examination subjects should be divided into three categories: basic dental laboratory theory, dental laboratory specialties, and a practical examination. To ensure relevance to current practice, there should be less emphasis on basic dental laboratory theory, including health-related laws, and more emphasis on dental laboratory specialties. Introduction to dental anatomy should be separated from oral anatomy and tooth morphology; and fixed prosthodontics should be separated from crown and bridge technology and dental ceramics technology. Removable orthodontic appliance technology should be renamed 'orthodontic laboratory technology'. There should be less questions related to health related law, oral anatomy, dental hygiene, dental materials science and inlay, while the distribution ratio of questions related to tooth morphology should be maintained. There should be a decrease in the distribution ratio of questions related to crown and bridge technology, dental ceramics technology, complete dentures and removable partial dentures technology, and orthodontic laboratory technology. In the practical examination, the current multiple choice test should be replaced with tooth carving using wax or plaster. In dental laboratory specialties, subjects related to contemporary dental laboratory technology should be included in the test items.
제4형 가족성 고중성지방혈증 임산부에서 발생한 급성 췌장염 1례
박관응,윤채중,김영학,진영기,윤성호,권용은,김태원,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.2
Plasma levels of cholesterol (TC) and triglyceride(TG) physiologically increase during pregnancy. The lipid increment is 23-53% above the pregravidic level for TC and 2- to 3-fold of the prepregnancy level for TG. If the TC and TG are higher than normal values in pregnancy, the patient must be carefully monitored. Acute pancreatitis is the main consequence of hyperlipidemia and occurs either during pregnancy, in the third trimester, or in the puerperium. Mortality is high both for the mother (21%) and the fetus (20%). We report a case of 28 year-old pregnant woman at 29 weeks gestation with hypercholesterolemia (TC = 357 ㎎/dl) and severe hypertriglyceridemia (TG = 1300 ㎎/dl). The patient was admitted to the hospital because of severe epigastric pain, nausea and vomiting. Total serum cholesterol was increased and trigyleride was markedly increased. The electroporesis pattern of serum lipoprotein showed increase in pre-beta lipoprotein fraction, suggesting IV hypertriglyceridemia pattern. According to a review of the literature, the incidence of pancreatitis during pregnancy is 1 in 1000 to 3000 pregnancies. Severe hypertriglyceridemia in pregnancy should be treated with a careful restriction of calories and fat: for preventing acute pancreatitis, hospitalization for intravenous fluid therapy and plasma exchange must be required.
Studies on Medium-Term Carcinogenicity Tests Using Genetically Engineered Mice
Young-Suk Won,Hyo-Jung Kwon,Yang-Kyu Choi,Won-Kee Yoon,Ki-Hoan Nam,Oc-Sung Moon,Hyoung-Chin Kim(김형진) 한국실험동물학회 2008 한국실험동물학회 학술발표대회 논문집 Vol.2008 No.-
A long-term carcinogenicity study is required to assess the safety of new drug candidates. This classical toxicological method has been using rats and mice as animal systems. The International Conference on Harmonization of Technical Requirements of Pharmaceuticals for Human Use (ICH) have recommended a long-term rodent carcinogenicity test system using rat and a supplementary mouse test system such as an initiation-promotion model, a transgenic model or a neonatal model. This study was carried out to develop a new liver carcinogenicity model using HBx tg mice and disease model mice. The incidence of liver tumor was increased in treated group at 16, 20 or 26 weeks after carcinogen treatment. It was statistically significant compared with the control animals. We could suggest the possibilities of HBx mice and other disease model as a new carcinogenesis screening model system, and if we have more data about reference chemicals for these animals, it will be recommended as alternative test for carcinogenicity risk assessment and used for a rapid evaluation of hepatocarcinogenicity of several chemical.
Clinical Practice Guideline of Acute Respiratory Distress Syndrome
( Young-jae Cho ),( Jae Young Moon ),( Ein-soon Shin ),( Je Hyeong Kim ),( Hoon Jung ),( So Young Park ),( Ho Cheol Kim ),( Yun Su Sim ),( Chin Kook Rhee ),( Jaemin Lim ),( Seok Jeong Lee ),( Won-yeon 대한결핵 및 호흡기학회 2016 Tuberculosis and Respiratory Diseases Vol.79 No.4
There is no well-stated practical guideline for mechanically ventilated patients with or without acute respiratory distress syndrome (ARDS). We generate strong (1) and weak (2) grade of recommendations based on high (A), moderate (B) and low (C) grade in the quality of evidence. In patients with ARDS, we recommend low tidal volume ventilation (1A) and prone position if it is not contraindicated (1B) to reduce their mortality. However, we did not support high-frequency oscillatory ventilation (1B) and inhaled nitric oxide (1A) as a standard treatment. We also suggest high positive end-expiratory pressure (2B), extracorporeal membrane oxygenation as a rescue therapy (2C), and neuromuscular blockage for 48 hours after starting mechanical ventilation (2B). The application of recruitment maneuver may reduce mortality (2B), however, the use of systemic steroids cannot reduce mortality (2B). In mechanically ventilated patients, we recommend light sedation (1B) and low tidal volume even without ARDS (1B) and suggest lung protective ventilation strategy during the operation to lower the incidence of lung complications including ARDS (2B). Early tracheostomy in mechanically ventilated patients can be performed only in limited patients (2A). In conclusion, of 12 recommendations, nine were in the management of ARDS, and three for mechanically ventilated patients.
Microbiological Contamination of Laboratory Mice and Rats in Korea from 2007 to 2008
Young-Suk Won,Hyo-Jung Kwon,Sang-Woon Kim,Jong-Tak Han,Sae-Bhom Lee,Ki-Hoan Nam,Won-Kee Yoon,Kang-Hyun Kim,Oc-Sung Moon,Hyoung-Chin Kim 한국실험동물학회 2010 Laboratory Animal Research Vol.26 No.3
In order to assess the microbiological contamination of laboratory mice and rats in Korea over the 2-year period from 2007 to 2008, we monitored animals housed in mouse and rat facilities equipped with barrier systems. In a barrier animal facility in Korea, the most important viruses in the identified pathogen were the mouse hepatitis virus (MHV) and Pasteurella (Pa.) pneumotropica, and Staphylococcus aureus was identified as the most common bacterial pathogen in Korea. The most commonly detected parasite in the identified pathogen was Trichomonas spp. in the mouse facilities and Entamoeba spp. in the rat facilities. In many cases, these pathogen-contaminated animals were genetically modified animals obtained from the university. Currently, consistent with the increased transfer of genetically modified animals between domestic and foreign animal facilities, the Pa. pneumotropica and parasites infection rates were shown to have increased as compared to those of the 2004-2006 period. Indeed, the MHV infection rate has been maintained at almost 20% in Korean animal facilities over the past 10 years. These results showed that effective quarantine programs for contaminated genetically engineered mutant mice and the monitoring of regular or irregular MHV monitoring in animal colonies should help to reduce pathogen contamination in Korean animal facilities.
Young-Suk Won,Hyo-Jung Kwon,Yang-Kyu Choi,Won-Kee Yoon,Sang-Woon Kim,Hae Jin Lee,Bon-Chul Koo,Sae-Bhom Lee,Ki-Hoan Nam,Oc-Sung Moon,Hyoung-Chin Kim 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.3
Dermatophytes are the most important dermatological zoonosis pathogen. Although it is well known as a transmittable disease from animal to human, control of dermatophyte is still difficult in conventionally housed animals. Laboratory New Zealand White rabbits and Hartley guinea pigs bred in conventional facility were sent to the Korea Research Institute of Biotechnology and Biology for health monitoring. Two of five rabbits and six of ten guinea-pigs had discrete, irregularly shaped and encrusted alopecia around eye, legs, mouth and thigh area. Histopathologically, epidermis showed hyperkeratosis, parakeratosis and acantosis. Dermis and hair follicle were infiltrated with numerous neutrophils, macrophages and lymphocytes. The PAS staining demonstrated large numbers of arthrospores and branched hyphae within stratum corneum and hair follicle. Fungal culture of the skin lesions revealed characteristic fungi colony and conidia of Trichophyton mentagrophyte. For rapid identification of this fungus using molecular method, we performed ITS gene specific PCR and sequenced the products. Results of ITS gene sequencing, our isolates have very similar sequence with previous reported Arthroderma vanbreuseghemii. These results suggest that our isolated fungi could be cause of these rabbits and guinea pigs dermal disease.