S-298 Recurrent stroke in relation to the grade of patent foramen ovale

( Yoonjung Jang ),( Woo Jin Jang ),( Woo Jung Chun ),( Ju Hyeon Oh ),( Mirae Lee ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Purpose: Previous studies have demonstrated a strong association between the presence of patent foramen ovale (PFO) and cryptogenic stroke. We aimed to investigate the relationship between the grade of PFO and recurrent stroke.?Methods: Consecutive 120 patients who underwent transesophageal echocardiography (TEE) for evaluation of cryptogenic stroke were retrospectively collected. Each stoke in all patients was classified as an index stroke and a recurrent stroke; the recurrent stoke was defined as a case which had definite history of previous stroke and/or showed old ischemic lesion on brain MR in addition to acute lesion. PFO was diagnosed by a cardiologist based on TEE using agitated-saline contrast and Valsalva maneuver. Quanti?cation of PFO was graded as 0 (no microbubbles), I (1-5 microbubbles), II (6-20 microbubbles), or III (>20 microbubbles). We also reviewed conventional risk factors of ischemic stroke in all patients.?Results: A total of 96 patients (55±13 years, 66 men) were analyzed after excluding 34 patients who showed extracardiac shunt, interatrial septal defect, or nondiagnostic TEE. PFO was observed in 88 (92%) patients; 8 patients with grade 0, 16 with grade I, 35 with grade II, and 37 with grade III. Index stokes and recurrent strokes were observed in 59 and 37 patients, respectively. Risk factors of hypertension (n=43), diabetes (n=12), dyslipidemia (n=25) and smoking (n=30) were observed. Increasing grades of PFO was not related to the presence of recurrent stroke in the study patients (p=0.118). In multivariate analysis including age, sex, PFO grading, and the risk factors, PFO grading was still not a significant predictor for recurrent stroke (odds ratio=0.68, 95% confidence interval [CI]=0.42-1.11). In the multivariate analysis, age, sex, and the risk factors were also not significant predictors for recurrent stroke (data not shown).?Conclusions: Despite a well-known association between the presence of PFO and cryptogenic stroke, the amount of shunt through PFO was not related to recurrent strokes in this study. The relationship between the grade of PFO and the recurrence of stroke needs large prospective study.

기계적 평가와 이미지를 이용한 얼굴의 번들거림과 윤기의 분류 기준의 연구

장윤정 ( Yoonjung Jang ),김보라 ( Bora Kim ),문태기 ( Tae Kee Moon ),김남수 ( Nam Soo Kim ),이선화 ( Sun Hwa Lee ),이혜지 ( Hye-ji Lee ) 대한화장품학회 2018 대한화장품학회지 Vol.44 No.3

얼굴 피부는 신체 건강을 표현할 뿐만 아니라 매력을 결정하는 요소 중 하나이다. 특히 윤기 나는 피부는 대부분의 사람들이 선호하며 윤기 나는 피부 표현을 위해 다양한 화장품들이 만들어져왔다. 하지만 윤기 있는 피부는 주관적 평가이기 때문에 기름진 피부의 경우 기존의 피부 윤기 평가 방법으로는 명확한 윤기 있는 피부로 평가하기가 어렵다. 더욱이 윤기와 유사하게 광이 있지만 부정적으로 평가되는 번들거리는 피부와 명확한 분류 기준 또한 없는 상황이다. 본 연구에서는 피부측정 파라미터 5개[피부 광채, 피부 보습, 피부 투명도, 피부 피지, 안면 이미지]를 측정하였고, 연구대상자들이 촬영된 안면 이미지를 근거하여 각각의 윤기 있는 피부와 번들거리는 피부의 이미지를 선별하여 피부 측정의 정량화를 통해 비교 분석하였다. 그 결과 번들거리는 피부에서 피부 광채 및 피지 증가, 투명도 감소, 보습 감소를 확인하였다. 그러나 윤기 있는 피부의 경우 피부 광채, 피지, 투명도는 유사한 패턴을 보였지만 보습이 유의차 있게 증가하는 결과를 보였다. 본 연구에서는 기기측정 및 정량적 평가를 통해서 윤기 있는 피부와 번들거리는 피부를 분류하는 객관적 평가 기준을 제시하고자 한다. The facial skin condition expresses physical healthy as well as is considered one of important factors for attractiveness. Especially, most people prefer shiny skin. So various cosmetics has been manufactured for expression of shiny skin. However, shiny skin is subjectively evaluated, and difficult to evaluate clear shininess using the existing method in oily skin. Moreover, there is no clear classification criteria between shininess and glossiness, which is assessed negatively in the skin. So there has not been a reference value by mechanical measurement to define and classify shiny skin from greasy skin. In this study, we measured skin biophysical parameters (gloss, hydration, translucency and sebum) and facial images which are selected by volunteers using sensory evaluation. According to the measurement results, the values of gloss, sebum, and translucency were similar in both shiny and greasy skin; the values of sebum and gloss increased, whereas those of translucency decreased. However only skin moisture values statistically increased in shiny skin. In conclusion, we propose objective assessment criteria for classifying shiny and greasy skin using device measurement and quantitative assessment.

Projection of Waste Generation Rates and Assessment of Applicability of Waste-to-Energy Technologies in Korea

( Jang-soo Lee ),( Sung-jin Cho ),( Ki-bae Lee ),( Yong-chil Seo ),( Yoonjung Seo ),( Nickolas Themelis ) 한국폐기물자원순환학회 2011 ISWA Vol.2011 No.0

Cost-Effectiveness Analysis of Germline and Somatic BRCA Testing in Patients With Advanced Ovarian Cancer

Jang Jaehyeok,Kim Yoonjung,Kim Jae-Hoon,Cho Sun-Mi,Lee Kyung-A 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.1

=Background: BRCA testing is necessary for establishing a management strategy for ovarian cancer. Several BRCA testing strategies, including germline and somatic testing, are implemented in clinical practice in Korea. We aimed to comparatively evaluate their cost-effectiveness from patients’ perspective. Methods: We developed a decision model comprising five BRCA testing strategies implemented in Korea: (1) germline testing first, followed by somatic tumor testing for patients without a germline variant; (2) somatic testing first, followed by germline testing for patients with a variant detected by somatic testing; (3) both germline and somatic testing; (4) germline testing alone; and (5) somatic testing alone, with no testing as the comparator. One-way sensitivity analysis was conducted to test the uncertainty of key parameters. Results: Assuming a willingness-to-pay of $20,000 per progression-free life-year gain (PF-LYG), all five strategies were considered cost-effective. Strategy 4 was the most cost-effective option, with an incremental cost-effectiveness ratio (ICER) of $2,547.7 per PF-LYG, followed by strategy 1, with an ICER of $3,978.4 per PF-LYG. Even when the parameter values were varied within the possible range, the ICERs of all strategies did not exceed the willingness-to-pay threshold. Conclusions: Considering the importance of knowing a patient’s BRCA gene status, germline testing first, followed by somatic testing, may be a reasonable option. Background: BRCA testing is necessary for establishing a management strategy for ovarian cancer. Several BRCA testing strategies, including germline and somatic testing, are implemented in clinical practice in Korea. We aimed to comparatively evaluate their cost-effectiveness from patients’ perspective. Methods: We developed a decision model comprising five BRCA testing strategies implemented in Korea: (1) germline testing first, followed by somatic tumor testing for patients without a germline variant; (2) somatic testing first, followed by germline testing for patients with a variant detected by somatic testing; (3) both germline and somatic testing; (4) germline testing alone; and (5) somatic testing alone, with no testing as the comparator. One-way sensitivity analysis was conducted to test the uncertainty of key parameters. Results: Assuming a willingness-to-pay of $20,000 per progression-free life-year gain (PF-LYG), all five strategies were considered cost-effective. Strategy 4 was the most cost-effective option, with an incremental cost-effectiveness ratio (ICER) of $2,547.7 per PF-LYG, followed by strategy 1, with an ICER of $3,978.4 per PF-LYG. Even when the parameter values were varied within the possible range, the ICERs of all strategies did not exceed the willingness-to-pay threshold. Conclusions: Considering the importance of knowing a patient’s BRCA gene status, germline testing first, followed by somatic testing, may be a reasonable option.

Comparisons of the pharmacokinetics and tolerability of fixed-dose combinations of amlodipine besylate/losartan and amlodipine camsylate/losartan in healthy subjects: a randomized, open-label, single-dose, two-period, two-sequence crossover study

Choi, YoonJung,Lee, SeungHwan,Cho, Sang-Min,Kang, Won-Ho,Nam, Kyu-Yeol,Jang, In-Jin,Yu, Kyung-Sang Dove Medical Press 2016 Drug design, development and therapy Vol.10 No.-

<P><B>Background</B></P><P>A fixed-dose combination (FDC) of amlodipine and losartan has been used to reduce blood pressure in patients whose hypertension is not sufficiently controlled with either drug alone. The aim of this study was to evaluate the pharmacokinetic (PK) characteristics and tolerability of an FDC of 6.94 mg amlodipine besylate (5 mg as amlodipine)/50 mg losartan potassium compared to an FDC of 5 mg amlodipine camsylate/50 mg losartan potassium in healthy subjects.</P><P><B>Subjects and methods</B></P><P>A randomized, open-label, single-dose, two-period, two-sequence crossover study was conducted on 46 healthy male subjects. Blood concentrations were measured by liquid chromatography–tandem mass spectrometry. Blood samples were collected up to 144 hours post dose for each period. PK parameters were calculated in each treatment group using a noncompartmental method. The 90% confidence intervals (CIs) of the geometric mean ratios of the two treatments for the maximum plasma concentration (<I>C</I><SUB>max</SUB>) and the area under the concentration curve from time zero to the last quantifiable time point (AUC<SUB>0–t</SUB>) were estimated. Tolerability assessments were performed for all subjects who received the drug at least once.</P><P><B>Results</B></P><P>The PK profiles of the two treatments were similar. For amlodipine, the geometric mean ratios (90% CIs) of amlodipine besylate to amlodipine camsylate for the <I>C</I><SUB>max</SUB> and AUC<SUB>0–t</SUB> were 0.98 (0.94−1.01) and 0.97 (0.93−1.01), respectively. The corresponding values for losartan were 0.91 (0.81−1.02) and 1.05 (0.98−1.12), respectively. The incidence of adverse events was not significantly different between the two treatments, and both were well tolerated.</P><P><B>Conclusion</B></P><P>An FDC of 6.94 mg amlodipine besylate (5 mg as amlodipine)/50 mg losartan potassium produced similar results to an FDC of 5 mg amlodipine camsylate/50 mg losartan potassium treatment with respect to the PK parameters of amlodipine and losartan based on <I>C</I><SUB>max</SUB> and AUC<SUB>0–t</SUB> values. The amlodipine besylate/losartan potassium combination was well tolerated by healthy male subjects.</P>

패키지 소프트웨어 인증을 위한 테스트 프로세스

이윤정(Yoonjung Lee),최병주(Byoungju Choi),장우현(Woohyun Jang) 한국정보과학회 2001 정보과학회지 Vol.19 No.11

Intravenous albumin for the prevention of contrast-induced nephropathy in patients with Liver cirrhosis and chronic kidney disease undergoing contrast-enhanced CT

( Heejung Choi ),( Yoonjung Kim ),( Soo Min Kim ),( Junam Shin ),( Hye Ryoun Jang ),( Jung Eun Lee ),( Woo Seong Huh ),( Yoon Goo Kim ),( Ha Young Oh ),( Dae Joong Kim ) 대한신장학회 2012 Kidney Research and Clinical Practice Vol.31 No.2

Background: The purpose of this study was to evaluate the incidence of contrastinduced nephropathy (CIN), and the effect of intravenous albumin for prophylaxis of CIN in patients with liver cirrhosis (LC) and chronic kidney disease (CKD). Methods: We conducted a retrospective study of 81 subjects with LC and CKD (estimated glomerular filtration rate (eGFR)o60 mL/min/1.73 m2) who underwent contrast-enhanced computed tomography (CT). Patients received either isotonic sodium bicarbonate solution (3 mL/kg for 1 h before CT and 1 mL/kg/h for 6 h after CT) or albumin (20% albumin, 25 mL for 1 h before CT and 75 mL for 6 h after CT). CIN was defined as an increase of Z25% or Z0.5 mg/dL in serum creatinine level. Results: Overall, CIN developed in three patients (3.7%). Of the 81 subjects, 43 received sodium bicarbonate solution and 38 received albumin. Both groups were comparable with regard to age, sex, diabetes mellitus, and baseline eGFR. The albumin group showed a significantly poorer liver function profile. CIN incidence did not differ significantly between the groups: it occurred in one (2.3%) of the 43 subjects receiving sodium bicarbonate and two (5.3%) of the 38 subjects receiving albumin (P¼0.6). However, the albumin group showed a significantly smaller increase in body weight (P¼0.03). Conclusion: The incidence of CIN in patients with LC and CKD undergoing contrast-enhanced CT after preventive measures was relatively low. The incidence of CIN was not significantly different between sodium bicarbonate and albumin groups.

Habitat use by the Javan caecilian (Ichthyophis hypocyaneus)

Amaël Borzée,Yoonjung Yi,Mirza D. Kusrini,Yikweon Jang 한국양서·파충류학회 2017 한국양서·파충류학회지 Vol.8 No.1

Caecilians are the least known amphibians and most species are under threat due to urbanisation, habitat degradation and climate change. Here we report the fourth sighting of Ichthyophis hypocyaneus, in Gunung Halimun-Salak National Park. The individual was found in a flooded grassland and we described habitat and vegetation in the vicinity of the site. We hypothesized that it was either breeding or feeding as it was active at the site, and flooding had provided both breeding habitat and numerous preys. Although being a single sighting we would like to draw attention to the fact that no ecological preferences have been described for the species, and that such studies are urgently needed.

콘크리트 3D 프린팅에 적합한 레올로지 특성 분석

이윤정(Lee, YoonJung),송진수(Song, JinSoo),김민석(Kim, Min Seok),장범수(Jang, Beom Soo),김정환(Kim, Jung-Hwan),김강수(Kim, Kang Su) 한국콘크리트학회 2018 한국콘크리트학회 학술대회 논문집 Vol.30 No.2

농림업 분야 중점협력국별 국제개발협력 전략 수립

허장(Heo Jang),석현덕(Seok Hyundeok),차원규(Cha Wonkyu),이윤정(Lee Yoonjung),정동열(Jeong Dongyeol) 한국농촌경제연구원 2019 한국농촌경제연구원 기본연구보고서 Vol.- No.-

Background & Purpose of Research This is the first year report of multi-year research. It is to provide policy suggestions for enhancing ODA effectiveness in agriculture and forestry sectors, especially through focusing upon the private sector’s roles, and applying analytical tools of value chains and stakeholders. The main purpose of the research is, therefore, to provide in-depth strategic suggestions by analyzing current situations and challenges of carefully selected focus countries, and digging out key development cooperation areas. Research Method The first year, 2018, is devoted to developing research methodologies for the next years, and, from the second year, it is planned to establish strategic policy directions for the selected focus countries. With a comprehensive review of literature related with the research topics, statistical analysis process has been implemented to select focus countries. Out of databases, for instance, FAOSTAT, raw data on 143 developing countries were selected, weighted and aggregated. AHP analysis was adopted to decide weight of each category and indicator. Experts from domestic and international—Bangladesh and Azerbaijan—research institutes were requested to undertake researches on areas of cooperation and value chains. Face-to-face interviews were also used for in-depth understanding of situations of agriculture and forestry sectors of Paraguay and Bangladesh. Results and Implications By utilizing data from FAOSTAT of FAO, Databank of the World Bank, and others, related statistics were gathered on four categories, government policy, areas in which development cooperation is required, readiness of cooperation, and business conditions. AHP analysis produced weights for categories and indicators, and ultimately lists of focus countries were derived on the agriculture sector, forestry sector, and agriculture-forestry sector. For developing value chain analysis of the agricultural sector of developing countries, conceptual definition, points of difference from supply chain, methodology, analytical framework, and cases of USAID and the World Bank were reviewed and introduced. UNIDO’s five steps for value chain analysis were adopted to apply to agriculture and forestry sectors of developing countries: identification of objects, mapping, cost and benefit analysis, analysis on structural and dynamic factors, and strategy establishment. With regard to stakeholder analysis, methodological cases of British ODA and DFID, and KOICA were provided. In applying to the agriculture and forestry sector analysis, it is suggested to proceed the following phases: understanding project types and features, identifying and listing key stakeholders, grouping stakeholders and grasping their interests, checking possibilities of cooperation from stakeholders and their capacities, and forming a matrix to indicate influence and importance of stakeholders. Private sector development, PSD, is an emerging area for sustainable development cooperation and creation of new sources of fund. The level of support is classified as upper-stream (macro-level), mid-stream, and down-stream (micro-level), whereas areas of support are investment environment, infrastructure, and productive capacity. This research estimated current ODA budget assigned for PSD, which is 67 million USD in 2016 in terms of support level, and 81 million USD in terms of support areas; however, it was hard to find out any consistencies in yearly changes. The research also suggested potential areas of development projects for developing the private sector of partner countries. Development policy experiences and areas of comparative advantages of Korea were introduced as parts of guidelines for development cooperation strategy. Eight areas were figured out including rice productivity improvement, agricultural technology R&D and extension, forestation, and so forth. Tables of contents of strategic docu