인접한 고층건물의 豊荷重 상호간섭에 관한 연구

조강표,정진택,정명채,김윤석 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

Wind load is evaluated based on Standard Design Loads for Building of AIK(Architectural Institute of Korea), which was obtained from wind-tunnel experiment for an isolated building in open country, actual wind load can be different from the code because of terrain, building geometry, wind direction, separation distance between the buildings. Among them. separation distance is the most important factor. This paper presents the interference factor for sqaue section high-rise building structure, focusing on the separation distance. Interference factor was obtain from the force balance test in a wind tunnel.

Clostridium difficile 장염에 의한 속발성 유전분증에서 발현된 독성 장염

조형원,정혜경,강현주,이윤표,강혜원,심기남,정성애 Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1

Amyloidosis is characterized by extracellular deposition of protein fibrils in one or multiple organs. AA amyloidosis is secondarily occurred to be related with chronic infections or inflammatory diseases. We report a 67-year-old man suffered from secondary AA amyloidosis related with chronic Clostridium difficile colitis after repeated total hip replacement surgery. Infection control is the most important treatment of AA amyloidosis secondary to chronic infection. However, the patient’s C. difficile colitis was not controlled well, eventually toxic megacolon with sepsis was developed. Consequently, he had to take total colectomy, but he expired with multi-organ failures. We suggested that early surgical procedure might be one option for intractable C. difficile colitis complicated with secondary amyloidosis.

Comparison of DNA hypermethylation patterns in different types of uterine cancer: Cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma

Kang, Sokbom,Kim, Jae Weon,Kang, Gyeong Hoon,Lee, Sun,Park, Noh Hyun,Song, Yong Sang,Park, Sang Yoon,Kang, Soon Beom,Lee, Hyo Pyo Alan R. Liss, Inc 2006 International journal of cancer Vol.118 No.9

<P>The incidence of cervical adenocarcinoma (CA) is rising, whereas the incidence of cervical squamous cell carcinoma (CSCC) continues to decrease. However, it is still unclear whether different molecular characteristics underlie these 2 types of cervical carcinoma. To better understand the epigenetic characteristics of cervical carcinoma, we investigated the DNA promoter hypermethylation profiles in CA and CSCC. In addition, we investigated whether DNA hypermethylation patterns might be used for the molecular diagnosis of CA and endometrial adenocarcinoma (EA). Using the bisulfite-modification technique and methylation-specific PCR, we examined the aberrant promoter hypermethylation patterns of 9 tumor suppressor genes (APC, DAPK, CDH1, HLTF, hMLH1, p16, RASSF1A, THBS1 and TIMP3) in 62 CSCCs, 30 CAs and 21 EAs. After Bonferroni correction adjustment (statistically significant at p < 0.0055), we found that the aberrant hypermethylations of CDH1 and DAPK were more frequent in CSCCs than in CAs (80.6% vs. 43.3%, p = 0.001; 77.4% vs. 46.7%, p = 0.005), whereas HLTF and TIMP3 were more frequently methylated in CAs (3.2% vs. 43.3%, p < 0.001; 8.1% vs. 53.3%, p = 0.001). The hypermethylations of RASSF1A and APC were more frequent in CAs than in CSCCs, but this was not significant (9.7% vs. 33.3%, p = 0.008; and 14.5% vs. 40.0%, respectively, p = 0.009). In addition, RASSF1A hypermethylation was significantly more frequent in EAs than in CAs (81.0% vs. 33.3%, p = 0.001). In conclusion, the existence of these unique methylation patterns in these cancers suggests that their tumorigenesis may involve different epigenetic mechanisms. © 2005 Wiley-Liss, Inc.</P>

Measurement of Fractional Exhaled Nitric Oxide in Adults: Comparison of Two Different Analyzers

( Sung-yoon Kang ),( Sang Pyo Lee ),( Taehyun Nam ),( Ui Won Ko ),( Sang Min Lee ),( Sun Young Kyung ),( Shin Myung Kang ),( Jeong-woong Park ),( Sung Hwan Jeong ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Background Fractional exhaled nitric oxide (FeNO) is a recognized marker for eosinophilic airway inflammation and treatment decisions for responses to corticosteroids. Our study evaluated the differences between two FeNO analyzers and derived a correction equation for adults. Methods A total of 99 participants with the chief complaint of cough and dyspnea, who attended the outpatient clinics, were selected. They underwent concurrent FeNO measurement in a random order using NIOX VERO^® (Circassia AB, Solna, Sweden) and NObreath^® (Bedfont, Kent, UK). Agreement between the devices was evaluated by Wilcoxon tests, Spearman’s tests, and Bland-Altman plots. Results: Of the recruited 99 participants, they had a middle-aged female predominant feature (mean age: 51.2 ± 17.1 years and female 58.6%). Patients with asthma were found in 58.6 % of all participants. The median FENO level measured with the NIOX VERO^® (27, interquartile range, 15-45) was significantly lower than that measured with NObreath^® (38, 22-58, p < 0.001 ). There was a strong positive correlation in the measurement of FENO level between the devices (r= 0.787, p < 0.001). Bland- Altman plots confirmed this agreement. The following conversion equation was derived using linear regression: Ln (NObreath^®) = 0.728 × Ln (NIOX VERO^®) + 1.244. Conclusions The present study demonstrated that the values of two FeNO analyzers were in good agreement and had positive correlations. The correction equation that we provided could help assess the data obtained by these two analyzers.

Genomic distribution of simple sequence repeats in Brassica rapa

Hong, Chang Pyo,Piao, Zhong Yun,Kang, Tae Wook,Batley, Jacqueline,Yang, Tae Jin,Hur, Yoon Kang,Bhak, Jong,Park, Beom Seok,Edwards, David,Lim, Yong Pyo Korean Society for Molecular and Cellular Biology 2007 Molecules and cells Vol.23 No.3

국화과 3종 지상부 유래 정유의 향기 강도, 패턴 및 성분에 대한 분석

표종일(Jong Il Pyo), 강윤임(Yoon Im Kang), 서정남(Jung Nam Suh), 서경혜(Kyung Hye Seo), 장혜숙(Hye Sook Jang), 안명숙(Myung-Suk Ahn) 인간식물환경학회 2023 인간식물환경학회 학술대회 Vol.2023 No.1

Alteration in Lipid and Protein Profiles of Ovarian Cancer: Similarity to Breast Cancer

Kang, Sokbom,Lee, Aera,Park, Young Seung,Lee, Seok Cheol,Park, Sang Yoon,Han, Sang Yun,Kim, Kwang Pyo,Kim, Young Hwan,Yoo, Chong Woo,Kim, Hark Kyun BMJ 2011 International journal of gynecological cancer Vol.21 No.9

<B>Abstract</B><P>This study was undertaken to evaluate protein and lipid profiles of ovarian cancer tissue samples. Twenty-three frozen ovarian cancer samples and 6 adjacent normal samples were analyzed using histology-directed, matrix-assisted laser desorption/ionization mass spectrometry. Sinapinic acid and 2, 5-dihydroxybenzoic acid/α-cyano-4-hydroxycinnamic acid were manually deposited on areas of each tissue section enriched in epithelial cells to identify protein and lipid profiles respectively, and mass spectra were acquired using a matrix-assisted laser desorption/ionization-time of flight instrument. Protein and lipid profiles classify 11 cancer and 3 adjacent normal samples in 100 random test sets with 92.9% median accuracy. Phosphatidylcholines {32:3} [M + Na]<SUP>+</SUP> (<I>m</I>/<I>z</I> = 750.66), {34:1} [M + K]<SUP>+</SUP> (<I>m</I>/<I>z</I> = 798.60), and {36:2} [M + K]<SUP>+</SUP> (<I>m</I>/<I>z</I> = 824.56) were found to be increased in ovarian cancer. Interestingly, breast cancer-associated changes in lipid and protein profiles were also found in ovarian cancer. Thus, protein and lipid profiles accurately distinguish ovarian cancer from adjacent normal tissue samples. Common cancer-associated alterations in lipid and protein profiles were identified between ovarian and breast cancers.</P>

PE-030 : Epidemiologic review of patients with chronic hepatitis B in the era of antiviral therapy: A single center experience at 2010

( Kang Pyo Kim ),( Nam Woo Kwon ),( Beom Kyung Kim ),( Seung Up Kim ),( Do Young Kim ),( Sang Hoon Ahn ),( Kwang Hyub Han ),( Chae Yoon Chon ),( Jun Yong Park ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background: With wide use of vaccination and antiviral agents against hepatitis B virus (HBV) infection, epidemiologic characteristics of HBV-infected patients have changed substantially for several decades in South Korea, however, recent data are lacking. Hence, we reviewed the recent clinical characteristics of patients with chronic hepatitis B (CHB). Methods: From January 2010 to December 2010, we studied 5,262 consecutive HBV-infected patients who visited in Severance Hospital. Data concerning demographic profiles, laboratory findings about viral activity, and antiviral therapy were gathered. Results: Among the whole population, the median age was 51.0 and 66.0% were male. 1,788 (34.0%) had positive HBeAg and the median ALT level was 31.0 (2, 4700) IU/ml and 1,560 (29.6%) patients had family history of HBV-related liver disease. Regarding viral replication status, 297 (5%) patients were in immune tolerance phase, 2,195 (42%) in inactive phase, and the remaining 2,770 (53%) patients were in active CHB (eiher immune clearance or reactivation phase). Liver cirrhosis was diagnosed in 2,065 patients, among them, 611 (29.6%) patients had positive HBeAg, and 576 patients had experienced decompensation events including ascites, variceal bleeding, and hepatic encephalopathy. Hepatocellular carcinoma was diagnosed in 1,268 patients. Patients with HCC increased as they get older, especially after age of forty for male and after fifty for female. The male patients had a significantly higher ratio of the HCC than female patients did (78.7% vs. 21.3%, respectively, p<0.001). Conclusions: The study result shows that epidemiologic characteristics of CHB are male, elder, HBeAg negative dominant. The further studies are required to investigate the overall epidemiology of HBV infection in Korea.

다낭성 난소증후군 환자들에서 배란유도시 성장억제호르몬 유사체의 전처치가 난소 반응에 미치는 영향

강은희,장윤석,이종표,신혜진,채희동,김정훈,강병문,김홍권 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.3

목적: Clomiphene citrate(CC)에 난소 반응을 보이지 않았던 다낭성난소증후군 환자에서 human menopausal gonadotropin(hMG)을 사용한 배란유도시 성장억제호르몬 유사체인 octreotide의 배란유도전 전처치가 난소 반응 및 배란유도 결과에 미치는 영향을 알아보고자 하였다. 연구 대상 및 방법: 1998년 11월부터 1999년 6월까지 불임을 동반한 다낭성난소증후군 환자들중 CC에 반응을 보이지 않았던 30명을 대상으로 하였다. 대상 환자들은 배란유도전 octreotide의 전처치 유무에 따라 무작위로 치료군(n = 15)과 대조군(n = 15)으로 분류되었다. 모든 환자들에게 월경을 유도하기 위하여 progesterone in oil 200 mg을 근주하였고 치료군의 경우에는 progesterone in oil을 근주하는 날로부터 hMG를 투여하기 전까지 7일간 매일 오전 octreotide를 하루 100μg씩 투여받았다. 연구 결과: 양 군간에 hMG의 총 투여 용량과 투여 기간은 차이가 없었으나, hCG 투여일의 혈중 E2의 농도, 질식초음파로 관찰되는 평균 직경 10-14 mm 크기의 중간 난포의 총 수는 치료군에서 유의하게 낮았다(579.2 ± 421.0 pg/ml vs. 2120.3 ± 512.7 pg/ml, 4.3 ± 2.5 vs. 9.6 ± 4.4, p $lt; 0.001, p $lt; 0.001). 뿐만 아니라 혈중 헤마토크리트(hematocrit)도 치료군에서 유의하게 낮았다(36.9 ± 2.1% vs. 40.8 ± 2.9%, p $lt; 0.05). 중증 난소과자극증후군이 발생한 환자는 치료군의 경우 1예(6.7%), 대조군의 경우 3예(20.0%)로 치료군에서의 발생률이 낮은 것으로 나타났으나 통계학적 의미는 없었다. 양 군간 임상적 임신율, 자연유산율, 그리고 다태임신율은 유사하였다. 한편, 치료군에서는 octreotide 투여 전후의 혈중 난포자극호르몬, 테스토스테론, 그리고 dehydroepiandrosterone sulfate (DHEA-S)의 농도는 유의한 차이를 나타내지 않았으나 황체화호르몬, 에스트라디올, 인슐린유사성장인자-I, 인슐린의 농도는 octreotide의 투여 후에 유의하게 감소되었다. 결론: CC에 반응을 보이지 않았던 다낭성난소증후군 환자에서 hMG를 이용한 배란유도시 octreotide 전처치는 뚜렷한 부작용의 유발없이 임신율에는 크게 영향을 주지 않으면서 난포 성장 및 내분비 환경을 개선하여 과다한 난포성장을 억제할 수 있는 효과적인 치료 방법이라고 사료된다. Objective: To determine whether the somatostain analogue, octreotide, pretreatment before ovulation induction with human menopausal gonadotropin (hMG) affects ovarian response, and ovulation induction outcome in infertile patients with polycystic ovarian syndrome (PCOS) resistant to clomiphene citrate (CC) Methods: From November 1998 to June 1999, 30 infertile patients with PCOS unresponsive to CC were randomly allocated either octreotide pretreatment (treatment group) (n = 15) or hMG alone (control group) (n = 15) groups. In the treatment group, 100 g of octreotide were administered daily for 7 days after progesterone injection for withdrawal bleeding, and then hMG was administered for ovulation induction. Results: There were no differences in the total number of hMG ampules required and the duration of hMG administration between the two groups. The number of follicles of 10-14 mm diameter on the day of hCG injection was significantly less in the treatment group than that in the control group (4.3 ± 2.5 vs. 9.6 ± 4.4, p $lt; 0.001). The serum estradiol (E2) level on the day of hCG injection was significantly lower in the treatment group, with 1579.2 ± 421.0 pg/ml compared with 2120.3 ± 512.7 pg/ml in the control group (p $lt; 0.001). The hematocrit level on the day of hCG injection was also significantly lower in the treatment group than that in the control group (36.9 ± 2.1% vs. 40.8 ± 2.9%, p $lt; 0.05). The incidence of severe ovarian hyperstimulation syndrome (OHSS) seemed to be lower in the treatment group, but the difference did not achieve significance (6.7% vs 20.0%). Conclusion: This study suggests that octreotide pretreatment before ovulation induction could improve hormonal milieu compared to hMG alone, and therefore may be effective in ovulation induction for patients with PCOS resistant to CC.

<i>In situ</i> Identification and Localization of IGHA2 in the Breast Tumor Microenvironment by Mass Spectrometry

Kang, Suki,Maeng, Heysun,Kim, Baek Gil,Qing, Gao Ming,Choi, Yoon Pyo,Kim, Hak Yong,Kim, Pan Soo,Kim, Yangsun,Kim, Young Hwan,Choi, Young Deuk,Cho, Nam Hoon American Chemical Society 2012 JOURNAL OF PROTEOME RESEARCH Vol.11 No.9

<P>Modifications in the tumor microenvironment (TME) play a major role in the establishment, progression, and metastasis of cancer. Matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) is a powerful technique that enables the simultaneous identification and localization of biological compounds within tissues. To detect markers of early TME remodeling in invasive breast cancer, we used MALDI-MSI to compare the molecular profiles of tissues from the breast cancer interface zone, tumor zone, and normal-tissue zone. Using direct-tissue MALDI tandem mass spectrometry (MS/MS), we identified immunoglobulin heavy constant alpha 2 (IGHA2) as a new, zone-specific protein in the breast TME. The zone-specific expression of IGHA2 was verified by immunoblotting and immunohistochemical analysis. IGHA2 expression was consistently positive in tumor cells that were metastatic to regional nodes, with intense expression along the cytoplasmic borders. As a factor related to an increased percentage of nodes with tumor metastasis, IGHA2 expression was upregulated 3.745-fold in cases with an increased number of cancerous nodes (<I>p</I> = 0.0468). Our results provide the first evidence of IGHA2 as a marker of the early process of TME remodeling in invasive breast cancer. Furthermore, IGHA2 may be a novel marker for regional metastases in the lymph nodes of patients with breast cancer.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jprobs/2012/jprobs.2012.11.issue-9/pr3003672/production/images/medium/pr-2012-003672_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/pr3003672'>ACS Electronic Supporting Info</A></P>