Letters to the Editor : Henoch-Sch?nlein Purpura during Isotretinoin Therapy

( Yilmaz Turan ),( Mutlu Cayirli ),( Mustafa Tunca ) 대한피부과학회 2013 Annals of Dermatology Vol.25 No.1

New metal connectors developed to improve the shear strength of stone masonry walls

Turan Karabork,Yilmaz Kocak 국제구조공학회 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.50 No.1

Stone masonry structures are widely used around the world, but they deteriorate easily, due to low shear strength capacity. Many techniques have been developed to increase the shear strength of stone masonry constructions. The aim of this experimental study was to investigate the performance of stone masonry walls strengthened by metal connectors as an alternative shear reinforcement technique. For this purpose, three new metal connector (clamp) types were developed. The shear strength of the walls was improved by applying these clamps to stone masonry walls. Ten stone masonry walls were structurally tested in diagonal compression. Various parameters regarding the in-plane behavior of strengthening stone masonry walls, including shear strength, failure modes, maximum drift, ductility, and shear modulus, were investigated. Experimentally obtained shear strengths were confirmed by empirical equations. The results of the study suggest that the new clamps developed for the study effectively increased the levels of shear strength and ductility of masonry constructions.

New metal connectors developed to improve the shear strength of stone masonry walls

Karabork, Turan,Kocak, Yilmaz Techno-Press 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.50 No.1

Stone masonry structures are widely used around the world, but they deteriorate easily, due to low shear strength capacity. Many techniques have been developed to increase the shear strength of stone masonry constructions. The aim of this experimental study was to investigate the performance of stone masonry walls strengthened by metal connectors as an alternative shear reinforcement technique. For this purpose, three new metal connector (clamp) types were developed. The shear strength of the walls was improved by applying these clamps to stone masonry walls. Ten stone masonry walls were structurally tested in diagonal compression. Various parameters regarding the in-plane behavior of strengthening stone masonry walls, including shear strength, failure modes, maximum drift, ductility, and shear modulus, were investigated. Experimentally obtained shear strengths were confirmed by empirical equations. The results of the study suggest that the new clamps developed for the study effectively increased the levels of shear strength and ductility of masonry constructions.

Intelligent Network Data Analytics Function in 5G Cellular Networks using Machine Learning

Salih Sevgican,Meriç Turan,Kerim Gökarslan,H. Birkan Yilmaz,Tuna Tugcu 한국통신학회 2020 Journal of communications and networks Vol.22 No.3

5G cellular networks come with many new features compared to the legacy cellular networks, such as network data analytics function (NWDAF), which enables the network operatorsto either implement their own machine learning (ML) based dataanalytics methodologies or integrate third-party solutions to theirnetworks. In this paper, the structure and the protocols of NWDAFthat are defined in the 3rd Generation Partnership Project (3GPP)standard documents are first described. Then, cell-based syntheticdata set for 5G networks based on the fields defined by the 3GPPspecifications is generated. Further, some anomalies are added tothis data set (e.g., suddenly increasing traffic in a particular cell),and then these anomalies within each cell, subscriber category,and user equipment are classified. Afterward, three ML models,namely, linear regression, long-short term memory, and recursiveneural networks are implemented to study behaviour informationestimation (e.g., anomalies in the network traffic) and network loadprediction capabilities of NWDAF. For the prediction of networkload, three different models are used to minimize the mean absoluteerror, which is calculated by subtracting the actual generated datafrom the model prediction value. For the classification of anomalies, two ML models are used to increase the area under the receiver operating characteristics curve, namely, logistic regressionand extreme gradient boosting. According to the simulation results, neural network algorithms outperform linear regression innetwork load prediction, whereas the tree-based gradient boosting algorithm outperforms logistic regression in anomaly detection. These estimations are expected to increase the performance of the5G network through NWDAF.

Slide Session : OS-NEP-06 ; Nephrology : Paraoxonase-1 Activity in Patients with Anemia with or Without Chronic Renal Failure

( Yildiz Okuturlar ),( Nilgul Akalin ),( Ozlem Harmankaya ),( Nurten Turan Guner ),( Deniz Yilmaz ),( Asuman Gedikbasi ),( Ozlem Soyluk ),( Meral Mert ),( Abaki Kumbasar ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Paraoxonase (PON)-1 is an antioxidant enzyme. It has three known activities, paraoxonase, arylesterase and diazoxonase. It has been reported that PON-1 defi ciency is related to increased susceptibility to development of atherosclerosis and cardiovascular disease. The aim of this study is to evaluate antioxidative status and carotid intima-media thickness (CIMT) in patients with anemia with/without chronic renal failure. Methods: 42 patients with anemia and a control group of 47 patients were enrolled in to the study. Patients were divided into two groups as Group 1 with iron defi ciency anemia and Group 2 with chronic renal failure and anemia of chronic disease and Group 3 as the healthy control group. In all three groups antioxidative status was evaluated by measuring free sulfhydryl groups (-SH = total thiol), paraoxonase and arylesterase levels. CIMT measurements were also performed at the same time. Results: In all three groups, age, weight, average height, gender, presence of diabetes and smoking habit were not signifi cantly different (p>0.05). Hemoglobin levels were 7.85 ± 1.25 in Group 1, 8.62 ± 1.09 in Group 2 and 13.45±1.63 in Group 3. We have found that Arylesterase and -SH levels were decreased both in Group 1 and 2 according to Group 3. Bilateral CIMT was increased only in Group 2. Between group 1 and group 2 the only difference was the the more signifi cant decrease in Arylesterase levels in group 2 (Table 1-2). Conclusion: PON-1 activity and -SH levels may be independently associated with the presence of atherosclerosis.

Resveratrol-induced Depression of the Mechanical and Electrical Activities of the Rat Heart is Reversed by Glyburide: Evidence for Possible KATP Channels Activation

Mesut Buluc,Murat Ayaz,Belma Turan,Emine Demirel-Yilmaz 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.5

Resveratrol, a natural phytoalexin found in wine, has been suggested to have benefits in preventing cardiovascular diseases. However, the direct effects of resveratrol on the activity of cardiac tissues and its mechanism of action have not been determined. This study examined the effects of resveratrol on the right and left atrium and left papillary muscle isolated from the rat heart. The contractile responses of the right atrium and papillary muscle and the action potential from the left atrium were recorded and the effects of resveratrol on these responses were observed. The resting force of the isolated right atrium and the peak developed force of the left papillary muscle were depressed by resveratrol (0.1 nM - 0.1 mM). Exposure to the KATP channel blocker glyburide (3 µM) prevented significantly the resveratrol-induced decrease. Resveratrol (0.1 mM) shortened the repolarization phase of action potential recorded from the left atrium and this effect of resveratrol was reversed by glyburide (3 µM). These results indicated that resveratrol depressed cardiac muscle contraction and shortened action potential duration probably due to the activation of KATP channels in the rat heart.

Can Propofol Lead to an Increase in Seizure Threshold Over the Course of Electroconvulsive Therapy?

Hande Gurbuz Aytuluk,Tahsin Simsek,Mehmet Yilmaz,Ayse Zeynep Turan,Kemal Tolga Saracoglu 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.4

Objective: To evaluate the effects of 2 different dose regimens of propofol (low dose: < 1 mg/kg, high dose: ≥ 1 mg/kg) on the duration of the seizures, the required energy for the seizures, and the seizure threshold over the course of electroconvulsive therapy (ECT). Methods: The electronic medical records of 165 patients receiving 971 sessions of ECT were analyzed retrospectively. Patients were evaluated in two groups according to the according to propofol doses that they had received for ECT. Group LP (n = 91): patients who received low dose propofol (< 1 mg/kg). Group HP (n = 74): patients who received high dose propofol (≥ 1 mg/kg). Results: The required energy for seizures in Group HP were significantly higher than the Group LP in the 3rd, 4th, 5th, 6th, 7th, 8th, and 9th sessions (p < 0.05). The duration of seizures in the Group HP were significantly lower than the Group LP in the 1st, 2nd, 4th, 5th, 7th, and 8th sessions (p < 0.05). Higher electrical stimulus was needed to acquire a minimum length of seizure (> 25 sn) during the course of ECT in higher propofol doses. Although there was an increase in the seizure threshold over the course of ECT in both groups, this increase was found to be much more pronounced in the high-dose propofol group according to the low-dose propofol group. Longer duration of seizures was observed in the low-dose propofol group. Conclusion: Higher doses of propofol in induction of anesthesia can lead to a more progressive rise in seizure threshold than lower doses of propofol.

Comparison of the Effects of Electroacupuncture and Melatonin on Nerve Regeneration in Experimentally Nerve-Damaged Rats

Yasemin Özkan,Mehmet Turgut,Yasemin Turan,Mehmet Dinçer Bilgin,Sinem Sari,Mustafa Yilmaz,Yiğit Uyanikgil,Mahmut Alp Kiliç,Derya Tanriöver,Zehra Seznur Kasar 사단법인약침학회 2021 Journal of Acupuncture & Meridian Studies Vol.14 No.5

Background: Development of methods to accelerate nerve regeneration in peripheral nerve damage is important. Electroacupuncture is a new therapeutic method that combines traditional acupuncture with modern electrotherapy. Melatonin has been shown to reduce nerve damage. Objectives: In this study, we aimed to determine and compare the therapeutic effects of electroacupuncture and melatonin on rat sciatic nerve injury. Methods: A total of 56 adult male Wistar Albino rats were divided into four study groups with 14 animals in each group: intact control (group I), subcutaneous saline (group II), subcutaneous melatonin (group III), and electroacupuncture (group IV). Surgical procedure including unilateral (right) sciatic nerve injury was applied to groups II, III, and IV. Saline and melatonin started immediately after surgery for six weeks, while electroacupuncture was given two weeks after surgery for 3 weeks. Functional and histological assessments were used as outcome measurements. Results: Sciatic nerve damage caused a significant decrease in nerve conduction velocity. Both electroacupuncture treatment and melatonin treatment significantly increased the nerve conduction velocity. Both sciatic functional recovery and histological regeneration were faster in these treatment groups compared to the saline. However, no significant difference was observed between the two treatment groups. Conclusion: Electroacupuncture and melatonin are promising alternative treatment strategies for peripheral nerve damage and can be examined in detail in future studies.