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Kim, Kook Hwan,Jeong, Yeon Taek,Oh, Hyunhee,Kim, Seong Hun,Cho, Jae Min,Kim, Yo-Na,Kim, Su Sung,Kim, Do Hoon,Hur, Kyu Yeon,Kim, Hyoung Kyu,Ko, TaeHee,Han, Jin,Kim, Hong Lim,Kim, Jin,Back, Sung Hoon,Ko Nature Publishing Group, a division of Macmillan P 2013 Nature medicine Vol.19 No.1
Despite growing interest and a recent surge in papers, the role of autophagy in glucose and lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of Atg7 (encoding autophagy-related 7). Unexpectedly, these mice showed decreased fat mass and were protected from diet-induced obesity and insulin resistance; this phenotype was accompanied by increased fatty acid oxidation and browning of white adipose tissue (WAT) owing to induction of fibroblast growth factor 21 (Fgf21). Mitochondrial dysfunction induced by autophagy deficiency increased Fgf21 expression through induction of Atf4, a master regulator of the integrated stress response. Mitochondrial respiratory chain inhibitors also induced Fgf21 in an Atf4-dependent manner. We also observed induction of Fgf21, resistance to diet-induced obesity and amelioration of insulin resistance in mice with autophagy deficiency in the liver, another insulin target tissue. These findings suggest that autophagy deficiency and subsequent mitochondrial dysfunction promote Fgf21 expression, a hormone we consequently term a 'mitokine', and together these processes promote protection from diet-induced obesity and insulin resistance.
Corn Silk Extract Prevents Carrageenan-Induced Inflammatory Edema
Kim Yonghwan,Han Na Choi,Kim Taehee,Kim Su Jin,Kim Yuna,Kim Jin Soo,Lee Sang-Hoon,Goo Young-Tae,Kim Dong Woon,Do Lee Sang 건강기능식품미래포럼 2022 건강기능식품미래포럼 학술지 Vol.2 No.1
Corn silk extract (CSE) has been used as a traditional medicine for edema, cystitis, gout, kidney stones, nephritis, and prostatitis. Although CSE has been shown to be effective against oxidative stress and diabetes, the effects of CSE on peripheral edema are unclear. Therefore, in this study, the effects of CSE on carrageenan-induced peripheral edema in the hind paw of mice were examined. CSE administered orally for a week suppressed the formation of edema and inhibited the swelling of epidermis and the infiltration of inflammatory cells into the dermis. To explore the mechanism of the anti-inflammatory action, CSE was tested on the adhesion between monocytes and endothelial cells using THP-1 cells (a monocyte cell line) and human umbilical vein endothelial cells (HUVECs). CSE inhibited the adhesion only when THP-1 cells were treated with CSE but not HUVECs. This finding suggests that CSE possibly influences the expressions of the membrane proteins of the monocyte involved in the adhesion with endothelial cells. Thus, CSE was treated for 24 hours and the expressions of CD11a, CD11b, CD18, CD49d and CD162 using its respective antibody and flowcytometry. Of these proteins, CD162, also known as P-selectin glycoprotein ligand-1 (PSGL-1), was shown to be reduced in its expression. PSGL-1 is known to be required for the binding of inflammatory cells to intercellular adhesion molecules of endothelial cells. In conclusion, CSE may suppress inflammatory edema by inhibiting the binding of inflammatory cells to the vascular endothelium.
Kim Taehee,Choi Hayoung,Kim Sang Hyuk,Yang Bumhee,Han Kyungdo,Jung Jin-Hyung,Kim Bo-Guen,Park Dong Won,Moon Ji Yong,Kim Sang-Heon,Kim Tae-Hyung,Yoon Ho Joo,Shin Dong Wook,Lee Hyun 대한의학회 2024 Journal of Korean medical science Vol.39 No.11
Background: Tuberculosis (TB) survivors have an increased risk of developing chronic obstructive pulmonary disease (COPD). This study assessed the risk of COPD development and COPD-related hospitalization in TB survivors compared to controls. Methods: We conducted a population-based cohort study of TB survivors and 1:1 age- and sex-matched controls using data from the Korean National Health Insurance Service database collected from 2010 to 2017. We compared the risk of COPD development and COPD-related hospitalization between TB survivors and controls. Results: Of the subjects, 9.6% developed COPD, and 2.8% experienced COPD-related hospitalization. TB survivors had significantly higher COPD incidence rates (36.7/1,000 vs. 18.8/1,000 person-years, P < 0.001) and COPD-related hospitalization (10.7/1,000 vs. 4.3/1,000 person-years, P < 0.001) than controls. Multivariable Cox regression analyses revealed higher risks of COPD development (adjusted hazard ratio [aHR], 1.63; 95% confidence interval [CI], 1.54–1.73) and COPD-related hospitalization (aHR, 2.03; 95% CI, 1.81–2.27) in TB survivors. Among those who developed COPD, the hospitalization rate was higher in individuals with post-TB COPD compared to those with non-TB COPD (10.7/1,000 vs. 4.9/1,000 person-years, P < 0.001), showing an increased risk of COPD-related hospitalization (aHR, 1.84; 95% CI, 1.17–2.92). Conclusion: TB survivors had higher risks of incident COPD and COPD-related hospitalization compared to controls. These results suggest that previous TB is an important COPD etiology associated with COPD-related hospitalization.
TonEBP suppresses adipocyte differentiation via modulation of early signaling in 3T3-L1 cells
Kim, Soo Jin,Kim, Taehee,Choi, Han Na,Cho, Eun Jung,Park, Jin Bong,Jeon, Byeong Hwa,Lee, Sang Do The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.6
TonEBP belongs to the Rel family of transcription factors and plays important roles in inflammation as well as kidney homeostasis. Recent studies suggest that TonEBP expression is also involved in differentiation of several cell types such as myocytes, chondrocytes, and osteocytes. In this study, we investigated the roles of TonEBP during adipocyte differentiation in 3T3-L1 cells. TonEBP mRNA and protein expression was dramatically reduced during adipocyte differentiation. Sustained expression of TonEBP using an adenovirus suppressed the formation of lipid droplets as well as the expression of FABP4, a marker of differentiated adipocytes. TonEBP also inhibited the expression of $PPAR{\gamma}$, a known master regulator of adipocytes. RNAi-mediated knock down of TonEBP promoted adipocyte differentiation. However, overexpression of TonEBP did not affect adipogenesis after the initiation of differentiation. Furthermore, TonEBP expression suppressed mitotic clonal expansion and insulin signaling, which are required early for adipocyte differentiation of 3T3-L1 cells. These results suggest that TonEBP may be an important regulatory factor in the early phase of adipocyte differentiation.
Relationship between Structure and Optical Properties in the CdO-B2O3-SiO2 Glass System
Taehee Kim,Donggun Gwoo,김종환,Wongyu Choi,Kyungseok Han,Kyungbum Kee,황차원,류봉기 대한금속·재료학회 2012 ELECTRONIC MATERIALS LETTERS Vol.8 No.6
To study the compositional dependence of the optical properties and atomic structure of glasses, the CdOB2O3-SiO2 ternary glasses, which are known as highly photoconductive glasses, have been investigated. The photoconductivity of glasses containing CdO was investigated in a previous study, because of their potential applications in photoelectronic devices. The thermo-mechanical analysis and the Fourier transform infrared (FT-IR) spectra of the glass samples were measured to determine the structural variation of these glasses. Using transmittance measurements, we calculated the optical energy band gap. This paper presents results for control of the optical energy band gap 3.8 ~ 3.2 eV in cadmium-borosilicate glass system while the structural properties undergo monotonic changes.
Survey on Time-Series Human Motion Information Processing using Machine Learning Approach
Taehee Kim,Cheulwoo Ro,Hoyung Lee 한국정보통신학회 2018 2016 INTERNATIONAL CONFERENCE Vol.10 No.1
Humans have an ability to convey information using their body motions. Strong research activities in recognition and generation of body motions can be found in the machine learning research community. Recently, as deep learning solves many difficult problems, researchers apply deep learning approaches to human body motion information processing as well. We summarize and discuss human body motion information processing and generation that use machine learning approaches with a focus on deep learning. We find it interesting that highly abstract human behavior using body motions could be tackled using deep learning approaches.
( Taehee Kim ),( Yoon Jin Cha ),( Yoon Soo Chang ) 대한결핵 및 호흡기학회 2020 Tuberculosis and Respiratory Diseases Vol.83 No.1
Background: Programmed death-ligand 1 (PD-L1) expression is tested by immunohistochemistry (IHC)―22C3, SP263, and SP142. The aim of this study is to evaluate the correlation among the three methods of PD-L1 IHC in non-small cell lung cancer (NSCLC) and clinical significance of PD-L1 expression in lung adenocarcinoma with an epidermal growth factor receptor (EGFR)-tyrosine kinase domain mutation. Methods: The results of 230 patients who were pathologically confirmed as having NSCLC; tested using PD-L1 IHC 22C3, SP263, and SP142 methods; and evaluated via the peptide nucleic acid clamping method to confirm EGFR mutation, were analyzed in this study. Results: 164 patients underwent both the SP263 and 22C3 tests. There was a significant positive correlation between the outcomes of the two tests (Spearman correlation coefficient=0.912, p<0.001), with a derived regression equation as follows: 22C3=15.2+0.884×SP263 (R<sup>2</sup>=0.792, p<0.001). There was no relationship between the expression of PD-L1 and clinical parameters, including EGFR-tyrosine kinase inhibitor (TKI) mutation. The PD-L1 expression in patients treated with EGFR-TKI yielded a 2-month-shorter progression period than that in the PD-L1-negative group. However, this did not reach statistical significance (PD-L1<1% vs. PD-L1≥1%, 10 months vs. 8 months). Conclusion: The results of the 22C3 and those of SP263 methods were in good correlation with one another. Since the PD-L1 expression is not influenced by the EGFR mutation, it is necessary to perform a PD-L1 test to set the treatment direction in the patients with EGFR-mutant NSCLC.