Increased Risk of Incident Chronic Obstructive Pulmonary Disease and Related Hospitalizations in Tuberculosis Survivors: A Population-Based Matched Cohort Study

Kim Taehee,Choi Hayoung,Kim Sang Hyuk,Yang Bumhee,Han Kyungdo,Jung Jin-Hyung,Kim Bo-Guen,Park Dong Won,Moon Ji Yong,Kim Sang-Heon,Kim Tae-Hyung,Yoon Ho Joo,Shin Dong Wook,Lee Hyun 대한의학회 2024 Journal of Korean medical science Vol.39 No.11

Background: Tuberculosis (TB) survivors have an increased risk of developing chronic obstructive pulmonary disease (COPD). This study assessed the risk of COPD development and COPD-related hospitalization in TB survivors compared to controls. Methods: We conducted a population-based cohort study of TB survivors and 1:1 age- and sex-matched controls using data from the Korean National Health Insurance Service database collected from 2010 to 2017. We compared the risk of COPD development and COPD-related hospitalization between TB survivors and controls. Results: Of the subjects, 9.6% developed COPD, and 2.8% experienced COPD-related hospitalization. TB survivors had significantly higher COPD incidence rates (36.7/1,000 vs. 18.8/1,000 person-years, P < 0.001) and COPD-related hospitalization (10.7/1,000 vs. 4.3/1,000 person-years, P < 0.001) than controls. Multivariable Cox regression analyses revealed higher risks of COPD development (adjusted hazard ratio [aHR], 1.63; 95% confidence interval [CI], 1.54–1.73) and COPD-related hospitalization (aHR, 2.03; 95% CI, 1.81–2.27) in TB survivors. Among those who developed COPD, the hospitalization rate was higher in individuals with post-TB COPD compared to those with non-TB COPD (10.7/1,000 vs. 4.9/1,000 person-years, P < 0.001), showing an increased risk of COPD-related hospitalization (aHR, 1.84; 95% CI, 1.17–2.92). Conclusion: TB survivors had higher risks of incident COPD and COPD-related hospitalization compared to controls. These results suggest that previous TB is an important COPD etiology associated with COPD-related hospitalization.

Corn Silk Extract Prevents Carrageenan-Induced Inflammatory Edema

Kim Yonghwan,Han Na Choi,Kim Taehee,Kim Su Jin,Kim Yuna,Kim Jin Soo,Lee Sang-Hoon,Goo Young-Tae,Kim Dong Woon,Do Lee Sang 건강기능식품미래포럼 2022 건강기능식품미래포럼 학술지 Vol.2 No.1

Corn silk extract (CSE) has been used as a traditional medicine for edema, cystitis, gout, kidney stones, nephritis, and prostatitis. Although CSE has been shown to be effective against oxidative stress and diabetes, the effects of CSE on peripheral edema are unclear. Therefore, in this study, the effects of CSE on carrageenan-induced peripheral edema in the hind paw of mice were examined. CSE administered orally for a week suppressed the formation of edema and inhibited the swelling of epidermis and the infiltration of inflammatory cells into the dermis. To explore the mechanism of the anti-inflammatory action, CSE was tested on the adhesion between monocytes and endothelial cells using THP-1 cells (a monocyte cell line) and human umbilical vein endothelial cells (HUVECs). CSE inhibited the adhesion only when THP-1 cells were treated with CSE but not HUVECs. This finding suggests that CSE possibly influences the expressions of the membrane proteins of the monocyte involved in the adhesion with endothelial cells. Thus, CSE was treated for 24 hours and the expressions of CD11a, CD11b, CD18, CD49d and CD162 using its respective antibody and flowcytometry. Of these proteins, CD162, also known as P-selectin glycoprotein ligand-1 (PSGL-1), was shown to be reduced in its expression. PSGL-1 is known to be required for the binding of inflammatory cells to intercellular adhesion molecules of endothelial cells. In conclusion, CSE may suppress inflammatory edema by inhibiting the binding of inflammatory cells to the vascular endothelium.

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

Kim, Kook Hwan,Jeong, Yeon Taek,Oh, Hyunhee,Kim, Seong Hun,Cho, Jae Min,Kim, Yo-Na,Kim, Su Sung,Kim, Do Hoon,Hur, Kyu Yeon,Kim, Hyoung Kyu,Ko, TaeHee,Han, Jin,Kim, Hong Lim,Kim, Jin,Back, Sung Hoon,Ko Nature Publishing Group, a division of Macmillan P 2013 Nature medicine Vol.19 No.1

Despite growing interest and a recent surge in papers, the role of autophagy in glucose and lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of Atg7 (encoding autophagy-related 7). Unexpectedly, these mice showed decreased fat mass and were protected from diet-induced obesity and insulin resistance; this phenotype was accompanied by increased fatty acid oxidation and browning of white adipose tissue (WAT) owing to induction of fibroblast growth factor 21 (Fgf21). Mitochondrial dysfunction induced by autophagy deficiency increased Fgf21 expression through induction of Atf4, a master regulator of the integrated stress response. Mitochondrial respiratory chain inhibitors also induced Fgf21 in an Atf4-dependent manner. We also observed induction of Fgf21, resistance to diet-induced obesity and amelioration of insulin resistance in mice with autophagy deficiency in the liver, another insulin target tissue. These findings suggest that autophagy deficiency and subsequent mitochondrial dysfunction promote Fgf21 expression, a hormone we consequently term a 'mitokine', and together these processes promote protection from diet-induced obesity and insulin resistance.

A Study on Symbolic and Behavioural Hybrid Approach to Robotic Agent

Kim, Taehee 영산대학교 2001 영산논총 Vol.8 No.-

본 논문은 전통적인 기호주의적 접근방식과 목표 지향적인 행동기반 접근방식을 접합하는 방식의 에이전트를 제안한다. 에이전트는 시스템의 하부에 세세한 정보를 다루는 루틴과 함께 상부의 추론과 같은 추상화된 기능들을 가질 필요가 있다. 중앙집중식의 전통적인 기호주의적 접근방식은 하부의 세세함을 다루는데 있어서 적함하지 않을 것을 본 논문에서 주장한다. 대신에, 세세한 정보를 처리하는 하부의 행동기반에 의한 반응적인 기구를 채택한 방법론을 제안한다. 상부의 기호주의적 부분은 최소한의 크기를 가지고 작업 순서와 같은 전체적인 작업계획만을 생성하도록 한다. 이러한 방식은 비교적 단순하고 편리하게 복잡한 에이전트를 디자인할 수 있도록 한다. This paper proposes an approach to agent that hybridises classical symbolic approach and the goal directed behaviour-based approach. An agent is a system that usually requires detailed low level information handling routines, at the same time high level abstract functions such as reasoning. We argue that a centralised methodology based on the classical symbolic approach is inappropriate in managing low level details. Rather, we propose a methodology that employs behaviour-based reactive low level mechanism which deals with detailed information processing. High level classical symbolic component can be kept as its minimal size and generates global job plans such as job orders. This feature would provide a relatively simple and convenient methodology in designing a complex agent.

Switchable Composite Right/Left-Handed (S-CRLH) Transmission Line Using MEMS Switches

Taehee Jang,Sung-Hyun Hwang,Yong-Seung Bang,Jong-Man Kim,Yong-Kweon Kim,Chang-Wook Baek,Sungjoon Lim IEEE 2009 IEEE microwave and wireless components letters Vol.19 No.12

<P>This letter presents a novel switchable composite right/left-handed (S-CRLH) metamaterial transmission line (TL) using MEMS switches. The proposed TL is based on a general CRLH TL with switchable capacitors and switchable shunt inductive stubs. The LH mode of the S-CRLH TL ranges from 7.5 GHz to 10.4 GHz. In these frequencies, the S-CRLH TL is able to switch from a negative phase response (phase lag) to a positive phase response (phase lead), or vice versa. This phase modulation can be obtained through a voltage, due to the use of MEMS switches. The size of the fabricated S-CRLH TL, including bias networks, is 4941 mum times 2076 mum and is compact thanks to the LH mode.</P>

Classification of springs of Jeju Island using cluster analysis of annual fluctuations in discharge variables: investigation of the regional groundwater system

Taehee Kim,Deok-Cheol Moon,Won-Bae Park,Ki-Hwa Park,Gi-Won Ko 한국지질과학협의회 2007 Geosciences Journal Vol.11 No.4

Orientation Control of Block Copolymer Thin Films Placed on Ordered Nanoparticle Monolayers

Kim, Taehee,Wooh, Sanghyuk,Son, Jeong Gon,Char, Kookheon American Chemical Society 2013 Macromolecules Vol.46 No.20

<P>We investigate orientation and lateral ordering of poly(styrene-<I>block</I>-methyl methacrylate) (PS-<I>b</I>-PMMA) diblock copolymer (diBCP) thin films placed on ordered nanoparticle (NP) monolayers. The densely packed NP monolayers were prepared on silicon substrates with the Langmuir–Blodgett (LB) deposition technique. The perpendicular domain orientation of BCP thin films is obtained on the ordered NP monolayers due to the nanoscale regular roughness which exerts the elastic deformation on the BCP nanodomains and suppresses the substrate-induced parallel orientation. The effect of BCP film thickness as well as the NP size on the orientation of BCP nanodomains was systematically investigated. We also demonstrate the defect-tolerant ordering of the perpendicular orientation of BCP thin films on the NP-vacant sites.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/mamobx/2013/mamobx.2013.46.issue-20/ma401601f/production/images/medium/ma-2013-01601f_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ma401601f'>ACS Electronic Supporting Info</A></P>

A semi-analytical solution for groundwater responses to stream-stage variations and tidal fluctuations in a coastal aquifer

Kim, Kue-Young,Kim, Taehee,Kim, Yongje,Woo, Nam-Chil Wiley 2007 Hydrological processes Vol.21 No.5

<P>A two-dimensional semi-analytical solution to analyse stream–aquifer interactions in a coastal aquifer where groundwater level responds to tidal effects is presented. The conceptual model considered is a two-dimensional subsurface system with stream and coastline boundaries at right angles. The dimensional and non-dimensional boundary value problems were solved for water level in the aquifer by successive application of Laplace and Fourier transform techniques, and the results were obtained by numerical inversion of the transformed solution. The solution was then verified by reducing the solutions to one-dimensional known problems and comparing the results with those from previous studies. Hypothetical examples were used to examine the characteristics of water-level variations due to the variations in stream stage and the fluctuations in tide level. Sensitivity analysis indicated that streambed leakance has no influence over the amplitude of groundwater fluctuations, but that the effect of stream stage increases with increasing leakance. Little difference was observed in the water level for different aquifer penetration ratios with narrow stream width. Increases in streambed leakance caused increases in the effect of aquifer penetration by the stream on the water level. An increased specific yield value resulted in decreased amplitude of water fluctuations and mean water level, and showed that water-level variations due to stream and tidal boundaries are sensitive to specific yield. Copyright © 2006 John Wiley & Sons, Ltd.</P>

Reconstruction of a pathologic fracture following osteomyelitis of the mandible using a fibula osteocutaneous flap

Kim, Taeki,Kim, Junhyung,Choi, Jaehoon,Jo, Taehee,Shin, Hyeong Chan,Jeong, Woonhyeok Korean Cleft Palate-Craniofacial Association 2021 Archives of Craniofacial Surgery Vol.22 No.2

The use of a fibula osteocutaneous flap is currently the mainstay of segmental mandibular reconstruction. This type of flap is used to treat tumors, trauma, or osteoradionecrosis of the mandible. However, a fibula osteocutaneous flap may also be a good option for reconstructing the mandible to preserve oropharyngeal function and facial appearance in cases of pathological fracture requiring extensive segmental bone resection. Chronic osteomyelitis is one of the various causes of subsequent pathologic mandibular fractures; however, it is rare, and there have been few reports using free flaps in osteomyelitis of the mandible. We share our experience with a 76-year-old patient who presented with a pathologic fracture following osteomyelitis of the mandible that was reconstructed using a fibula osteocutaneous flap after wide segmental resection.

Predictors of happiness among older Korean women living alone

Kim, Jongim,Song, Youngshin,Kim, Taehee,Park, Keumok Blackwell Publishing Ltd. 2019 GERIATRICS AND GERONTOLOGY INTERNATIONAL Vol.19 No.4