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Cheon, Kyeong-Jun,Cho, Seoung-Won,Jang, Won-Seok,Kim, Ju-Won,Yang, Byoung-Eun Korean Association of Maxillofacial Plastic and Re 2020 Maxillofacial Plastic Reconstructive Surgery Vol.42 No.-
Background: Various types of miniplates have been developed and used for the reduction of facial bone fractures. We introduced Yang's Keyhole (YK) plate, and reported on its short-term stability. The purpose of this study was to evaluate the long-term stability of the YK plate, as a follow-up study, by examining the patients who had used the YK plate among the patients with the reduction of mandible fractures and who visited for plate removal. Methods: We reviewed the medical records of 16 patients who underwent mandibular fracture fixation using a YK plate (group I) and 17 patients who underwent mandibular fracture fixation using a conventional plate (group II). Assessment was then made on malunion, occlusal stability, discomfort during the application, and clinical symptoms. Results: From January 2015 to December 2017, a total of 36 patients underwent mandibular fracture surgery using a YK plate. A total of 16 patients received plate removal. Among them, 15 were male and 1 female. The average age was 26 years. The applied surgical sites were the 12 on mandibular angle, 4 on mandibular symphysis, and 2 on subcondyle. The application period of YK plate was an average of 335 days. During the same period, 45 people underwent surgery on the conventional plate. A total of 17 patients received plate removal. Among them, 15 were male and 2 females. The average age was 36 years. The applied surgical sites were the 8 on mandibular angle, 4 on mandibular symphysis, and 2 on subcondyle. The application period of the conventional plate was an average of 349 days. No malocclusion occurred at the time of removal, and occlusion was stable. No patient complained of joint disease or discomfort. Conclusion: The YK plate system, in which the screw was first inserted and the plate was applied, for clinical convenience did not cause any particular problem and no significant difference from the conventional plate.
Economic Operation of a Data Backup Scheme for Computer Systems under Disastrous Information Threats
Won Seok Yang,Nam K. Kim 대한산업공학회 2017 Industrial Engineeering & Management Systems Vol.16 No.3
In this paper, we deal with the economic operation of a data backup scheme for various computer systems under disastrous information threats. To this end, we introduce a queueing model that combines disasters and two-stage queues. Making use of the matrix-geometric approach, we obtain its steady-state probabilities. From these results, we compute the average total cost with a recovery cost and a backup cost taken into account. With sample numerical results, we investigate the optimal backup operation that minimizes the average total cost.
( Won Seok Yang ),( Xiang Zi Han ),( Kyoung Soon Lee ),( Kyung Min Lee ),( Ji Hyun Ju ),( In Cheol Shin ) 한국환경생물학회 2011 환경생물 : 환경생물학회지 Vol.29 No.1
In this study we present a mammalian cell culture model that allows to study the effect of endocrine disruptors (EDCs) on aromatase activity of aquatic amphibian, Bombina orientalis. Bombina orientalis aromatase gene was subcloned into a mammalian expression vector and subsequently transfected to mammalian cells. Although the protein expression level of Bombina orientalis aromatase was low, it had a significant aromatase activity. When EDCs were added to aromatase transfected cells, aromatase activity was significantly decreased. We report here that this system may be used to monitor the effect of EDCs on aromatase activity of aquatic organisms.
( Yang Won Min ),( So Young Bae ),( Geum Youn Gwak ),( Yong Han Paik ),( Moon Seok Choi ),( Joon Hyoek Lee ),( Seung Woon Paik ),( Byung Chul Yoo ),( Kwang Cheol Koh ) 대한간학회 2012 Clinical and Molecular Hepatology(대한간학회지) Vol.18 No.2
Background/Aims: The aim of this study was to identify the parameters that could noninvasively predict the presence of esophageal/gastric varices and portal hypertensive gastropathy (PHG) in patients with chronic liver disease (CLD), and to determine the accuracy of those parameters. Methods: We retrospectively analyzed 232 patients with CLD who underwent both upper endoscopy and liver CT within an interval of 3 months. The multidimensional index (M-Index) for spleen volume was obtained from the multiplication of splenic length, width, and thickness, as measured by computer tomography. Results: The multivariate analysis revealed that platelet, albumin, and M-Index were independently associated with the presence of varices and PHG. We combined three independent parameters, and developed a varices and portal hypertensive gastropathy (VAP) scoring system (=[platelet count (/mm3)×albumin (g/dL)]/[M-Index (cm3)]). The area under the receiver operating characteristic curve of the VAP score was 0.850 (95% confi dence interval, 0.801-0.899). The VAP cut-off value of 861 had a sensitivity of 85.3%, a positive likelihood ratio of 3.17, and a negative predictive value of 86.4%. For predicting high-risk lesions for bleeding, with a cut-off value of 861 the sensitivity was 92.0%, the positive likelihood ratio was 2.20, and the negative predictive value was 96.4%. Conclusions: The VAP score can predict the presence of varices and PHG in patients with CLD and may increase the costbenefi t of screening endoscopy in the clinical practice setting. A prospective validation study is necessary in the future.
Yang, Hae Kyung,Ham, Dong-Sik,Park, Heon-Seok,Rhee, Marie,You, Young Hye,Kim, Min Jung,Shin, Juyoung,Kim, On-You,Khang, Gilson,Hong, Tae Ho,Kim, Ji-Won,Lee, Seung-Hwan,Cho, Jae-Hyoung,Yoon, Kun-Ho Wolters Kluwer Health, Inc. All rights reserved. 2016 Transplantation Vol.100 No.2
<P>Background. Clinical application of encapsulated islet transplantation is hindered by low biocompatibility of capsules leading to pericapsular fibrosis and decreased islet viability. To improve biocompatibility, we designed a novel chitosan-coated alginate capsules and compared them to uncoated alginate capsules. Methods. Alginate capsules were formed by crosslinking with BaCl2, then they were suspended in chitosan solution for 10 minutes at pH 4.5. Xenogeneic islet transplantation, using encapsulated porcine islets in 1,3-galactosyltransferase knockout mice, and allogeneic islet transplantation, using encapsulated canine islets in beagles, were performed without immunosuppressants. Results. The chitosan-alginate capsules showed similar pore size, islet viability, and insulin secretory function compared to alginate capsules, in vitro. Xenogeneic transplantation of chitosan-alginate capsules demonstrated a trend toward superior graft survival (P = 0.07) with significantly less pericapsular fibrosis (cell adhesion score: 3.77 +/- 0.41 vs 8.08 +/- 0.05; P < 0.001) compared to that of alginate capsules up to 1 year after transplantation. Allogeneic transplantation of chitosan-alginate capsules normalized the blood glucose level up to 1 year with little evidence of pericapsular fibrotic overgrowth on graft explantation. Conclusions. The efficacy and biocompatibility of chitosan-alginate capsules were demonstrated in xenogeneic and allogeneic islet transplantations using small and large animal models of diabetes. This capsule might be a potential candidate applicable in the treatment of type 1 diabetes mellitus patients, and further studies in nonhuman primates are required.</P>
Diagnostic performance of on-site CT-derived fractional flow reserve versus CT perfusion
Yang, Dong Hyun,Kim, Young-Hak,Roh, Jae Hyung,Kang, Joon-Won,Ahn, Jung-Min,Kweon, Jihoon,Lee, Jung Bok,Choi, Seong Hoon,Shin, Eun-Seok,Park, Duk-Woo,Kang, Soo-Jin,Lee, Seung-Whan,Lee, Cheol Whan,Park, Oxford University Press 2017 European heart journal cardiovascular Imaging Vol.18 No.4
Yang Daram,Kim Jong Won,Jeong Hyuneui,Kim Min Seok,Lim Chae Woong,Lee Kyuhong,Kim Bumseok 한국독성학회 2023 Toxicological Research Vol.39 No.1
Cigarette smoke (CS) is a dominant carcinogenic agent in a variety of human cancers. CS exposure during pregnancy can adversely affect the fetus. Non-alcoholic fatty liver disease (NAFLD) is considered as a hepatic manifestation of a metabolic disorder, and ranges from simple steatosis to cirrhosis leading to hepatocellular carcinoma. Non-alcoholic steatohepatitis (NASH) is a more severe phase of NAFLD. Recently, there is increasing apprehension about the CS-related chronic liver diseases. Therefore, we examined whether maternal CS exposure could affect the pathogenesis of NASH in offspring. Mainstream CS (MSCS) was exposed to pregnant C57BL/6 mice via nose-only inhalation for 2 h/day, 5 days/week for 2 weeks from day 6 to 17 of gestation at 0, 300, or 600 μg/L. Three-week-old male offspring mice were fed methionine and cholinesupplemented (MCS) diet or methionine and choline-deficient including high-fat (MCDHF) diet for 6 weeks to induce NASH. Maternal MSCS exposure increased the severity of NASH by increasing serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, hepatic total cholesterol (TC) and triglyceride (TG) levels, pro-inflammation, fibrosis, and steatosis in offspring mice. Especially, maternal MSCS exposure significantly downregulated the phosphorylation of AMPactivated protein kinase (AMPK) in MCDHF diet-fed offspring mice. Subsequently, the protein levels of sterol regulatory element-binding protein (SREBP)-1c and stearoyl-CoA desaturase-1 (SCD1) were upregulated by maternal MSCS exposure. In conclusion, maternal MSCS exposure exacerbates the progression of NASH by modulating lipogenesis on offspring mice.
Yang, In Seok,You, Ji Su,Sung, Sang Do,Chung, Chee Won,Kim, Jeongho,Lee, Wan In Elsevier 2016 Nano energy Vol.20 No.-
<P><B>Abstract</B></P> <P>Novel monodispersed spherical TiO<SUB>2</SUB> aggregate with a diameter of 100nm (SP100), which is the smallest TiO<SUB>2</SUB> spheres (or beads) reported thus far, has been prepared by a controlled hydrolysis and hydrothermal reaction. The obtained SP100 is a highly porous structure with an internal pore size of 12nm and a surface area of 112m<SUP>2</SUP>/g, and is shown to be an ideal building block of mesoporous TiO<SUB>2</SUB> layer for CH<SUB>3</SUB>NH<SUB>3</SUB>PbI<SUB>3</SUB>–based perovskite solar cells (PSCs). The optimized PSC employing SP100 exhibits photovoltaic conversion efficiency of 18.41% with <I>J</I> <SUB> <I>SC</I> </SUB> of 22.91mA/cm<SUP>2</SUP>, <I>V</I> <SUB> <I>OC</I> </SUB> of 1,049mV and <I>FF</I> of 0.759. Furthermore, fabricated PSCs exhibit reproducible PCE values with little hysteresis in their <I>J–V</I> curves. Time-resolved photoluminescence measurement indicates that the PSC with SP100 (PSC-SP100), compared to the devices with the nanoparticles of 30nm or 50nm size shows notably faster electron injection from CH<SUB>3</SUB>NH<SUB>3</SUB>PbI<SUB>3</SUB> to TiO<SUB>2</SUB> layer, resulting from the extended contact area between perovskite and mesoporous TiO<SUB>2</SUB> layer. Pulsed light-induced transient measurement of the photocurrent indicates that PSC-SP100 shows significantly longer electron lifetime, which is attributed to the suppression of electron recombination caused by the unique TiO<SUB>2</SUB> network.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Novel 100nm-sized spherical TiO<SUB>2</SUB> aggregate (SP100) was successfully prepared. </LI> <LI> SP100 is an outstanding building block of mesoporous TiO<SUB>2</SUB> layer for perovskite solar cells (PSCs). </LI> <LI> SP100 exhibits remarkable advantages in charge injection and electron transport. </LI> <LI> PSC employing SP100 shows photovoltaic conversion efficiency of 18.41%. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>