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[논문]보육실습에서 프로젝트접근법에 대한 예비보육교사의 관심수준 변화 연구
유병민,박수홍,강문숙,박철수,정경훈 교육혁신학술위원회 2011 교육혁신연구 Vol.21 No.1
본 연구는 예비보육교사가 보육실습이라는 과정에서 프로젝트 접근법에 대한 관심은 어떠하며, 관심변화 여부를 사례중심으로 살펴보는 것을 목적으로 하였다. 이를 위하여 예비보육교사를 대상으로 보육실습 사전과 사후검사를 실시하였으며, 자세하고 구체적인 사실과 연구의 질적인 부분을 찾아보고자 인터뷰하였다. 그 결과, 첫째, 프로젝트에 대한 예비보육교사들의 관심은 전반적으로 무관심으로 나타났다. 둘째, 사전․사후검사 결과, 프로젝트 접근법에 대한 관심수준의 변화가 있었던 사례에서는 관심변화의 패턴도 다양하게 나타났으며, 관심변화가 크게 없었던 사례에서는 개인, 정보관심이 높게 나타났다. 이러한 결과는 프로젝트에 대한 예비보육교사의 관심수준은 보육환경, 보육과정, 실습지도 교사, 예비보육교사의 지각력, 프로젝트에 대한 사전지식이나 교육정도에 따라 다양하게 변할 수 있음을 알게 되었다. The purpose of this study is to analyze the case in which we can identify how the SoC of prospective child care teachers about the project approach changes and why these change appears during the child care practice when we assumpt that for prospective child care teachers to implement the project approach is that they participate in change during child care practice. In Case K, the SoC of the prospective child care teacher moves from Stage 0 awareness to Stage 2, Stage 3, Stage 4, and In Case M, the SoC moves from Stage 0 to Stage 1. In Case P, the SoC moves from Stage 1 to Stage 2, Stage 3, and in Case S, the SoC isn't changed. Above this, we identify the SoC of prospective child care teachers. Case K, M, and P changes SoC after child care practice, but Case S doesn't change. the reason why there is a difference is the mindset of prospective child care teachers. Anyone who wants to accomplish specific purposes can deal with diverse changes with flexibility, but others can easily have an effect on the changes. We suggest that instructor in organization for prospective child care teachers’ education need to have a class for prospective child care teachers to put theory into practice, give direct facilitation and intervention in the field to prospective child care teachers, make a learning environment for prospective child care teachers to make good use of teaching materials and instrument, develop guidebook for project approach and give support to prospective child care teachers.
마우스 대장암 모델 구축 및 항암제 활성 평가를 위한 예비 연구
김예솔,강봉석,이상은,이은주,이경록,정상헌,박정숙 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-
Abstract – Aberrant crypt foci (ACF) are early imorphological changes observed in rodents after administration of colon-specific carcinogen such as azoxymethane (AOM). ACF are considered to be putative preneoplastic lesions and are widely used as a surrogate biomarker to rapidly evaluate chemopreventive potential of compounds. The size of colorectal cancer was evaluated after administration of three anticancer drugs, 1 parent drug and 2 prodrugs. The body weights of mice were measured daily and considered as a surrogate for evaluation of general wellbeing. Colons were removed, cut along the longitudinal axis and flushed with phosphate-buffered saline. Each colon was cut into three equal lengths and fixed flat between filter papers. The fixed colon sections were stained with methylene blue. The number of ACF per colon, the number of aberrant crypts observed in each focus and the location of each focus were recorded. After single administration of AOM and multiple doses of anticancer drugs, no significant changes in the body weights of the mice was observed which was recorded for 52 days. However, an expected ACF was not observed in any treated groups. These findings suggest the induction of ACF in mice requires the promotion by dextran sulfate sodium as well as the initiation by AOM.
Na Gyeong Geum(Na Gyeong Geum),Ju Hyeong Yu(Ju Hyeong Yu),So Jung Park(So Jung Park),Min Yeong Choi(Min Yeong Choi),Jae Won Lee(Jae Won Lee),Gwang Hun Park(Gwang Hun Park),Hae-Yun Kwon(Hae-Yun Kwon),J 한국자원식물학회 2022 한국자원식물학회지 Vol.35 No.6
Under the COVID-19 pandemic, interest in immune enhancement is increasing. Although the immune-enhancing activity of plants of the genus Hibiscus has been reported, there is no study on the immune-enhancing activity of H. syriacus. Thus, in this study, we investigated the immune-enhancing activity of Hibiscus syriacus leaves (HSL) in mouse macrophages, RAW264.7 cells, and immunosuppressed mice. HSL increased the production of immunostimulatory factors such as nitric oxide (NO), inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) and activated the phagocytosis in RAW264.7 cells. The HSL-mediated production of immunostimulatory factors was dependent on toll-like receptor 4 (TLR4), p38, and c-Jun N-terminal kinase (JNK) in RAW264.7 cells. In the immunosuppressed mouse model, HSL increased the spleen index, the levels of the cytokines, and the numbers of lymphocytes, neutrophils, and monocytes. Taken together, HSL may be considered to have immune-enhancing activity and be expected to be used as a potential immune-enhancing agent.
Park, Beomjin,Park, Jaesung,Son, Jin Gyeong,Kim, Yong-Jin,Yu, Seong Uk,Park, Hyo Ju,Chae, Dong-Hun,Byun, Jinseok,Jeon, Gumhye,Huh, Sung,Lee, Seoung-Ki,Mishchenko, Artem,Hyun, Seung,Lee, Tae Geol,Han, American Chemical Society 2015 ACS NANO Vol.9 No.8
<P>Precise graphene patterning is of critical importance for tailor-made and sophisticated two-dimensional nanoelectronic and optical devices. However, graphene-based heterostructures have been grown by delicate multistep chemical vapor deposition methods, limiting preparation of versatile heterostructures. Here, we report one-pot synthesis of graphene/amorphous carbon (a-C) heterostructures from a solid source of polystyrene <I>via</I> selective photo-cross-linking process. Graphene is successfully grown from neat polystyrene regions, while patterned cross-linked polystyrene regions turn into a-C because of a large difference in their thermal stability. Since the electrical resistance of a-C is at least 2 orders of magnitude higher than that for graphene, the charge transport in graphene/a-C heterostructure occurs through the graphene region. Measurement of the quantum Hall effect in graphene/a-C lateral heterostructures clearly confirms the reliable quality of graphene and well-defined graphene/a-C interface. The direct synthesis of patterned graphene from polymer pattern could be further exploited to prepare versatile heterostructures.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-8/acsnano.5b03037/production/images/medium/nn-2015-03037u_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b03037'>ACS Electronic Supporting Info</A></P>
P056 : Psoriasis concurrent with inflammatory bowel disease
( Gyeong Yul Park ),( Eun Jung Hwang ),( Jin Yong Kim ),( So Young Yoon ),( Seong Joon Koh ),( Dong Hun Lee ),( Jai Il Youn ),( Hyun Sun Yoon ),( So Yun Cho ),( Hyun Sun Park ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Previous studies have indicated an association between psoriasis and inflammatory bowel disease (IBD), and its higher morbidity rate in Caucasian populations. However, reports on the concurrence of psoriasis with IBD in the Asian population are scarce. Objectives: To analyze the characteristics and the associated morbidities of psoriasis concurrent with IBD in the Asian population. Methods: We retrospectively examined the medical records of 15 patients diagnosedwith both psoriasis and IBD. Sixty age-, and gender-matched patients diagnosedwith psoriasis only were included as controls. The characteristics of psoriasis, presence of comorbidity, and laboratory parameters were compared. Results: Compared to controls with psoriasis only, cases of psoriasis concurrent with IBD had early onset and longer duration of psoriasis, and a higher Psoriasis Area Severity Index (PASI) score. However, these differenceswere not statistically significant. This case group showed higher erythrocyte sedimentation rate and C-reactive protein levels (both P = 0.000), as well as higher incidence of psoriatic arthritis and autoimmune disease as compared to the control group (P = 0.007 and 0.005, respectively). Conclusion: Asian patients having psoriasis concurrent with IBD exhibited different characteristics inpsoriasis severity, risk of psoriatic arthritis, systemic inflammatory parameters, and presence of autoimmune comorbidityas compared to those having psoriasis only.