초·중·고등학교 학생, 학부모, 일반교사의 보건교육 요구

윤순녕,김영임,최정명,조희순,김영희,박영남,오경순,이분옥,조선녀,조소영,한선희,하영미 韓國學校保健學會 2004 韓國學校保健學會誌 Vol.17 No.2

Purpose : The purpose of this study was to identify needs of health education of the students, parents, general teachers, and health teacher of the elementary, middle, and high schools. Method : 279 schools of elementary, middle, and high school were sampled nonproportionally during the period from June 28 to July 26, 2004 . The data were collected by the questionnaire from 1,888 students, 1,876 parents, 1,695 general teachers, 279 health teachers. A frequency, % and χ2-test were used to analysis by SAS program. Result : 1. It showed that 98.1% of elementary school students, 92.3% of middle school students, 89.6% of high school students answered that they need health education. The most of students, parents, and general teachers had high interests in health education. 2. In the case of students, main causes of needs of health education was 'to prevent diseases or accidents''. But parents answered that it was 'to build up a healthier behavior'. General teachers answered that it was 'more effective systematic and continuous health education'. 3. Over 80% of students, parents, and general teachers about the question of who qualified person is to teach health education as a regular class responded that health teacher is available. Especially 93% of elementary school students answered like that. 4. The most of students, parents, and general teachers answered that health education in the classroom is favorable 1 to 2 hours per week. Conclusion : As results of the study , the majority of students, parents, general teachers agreed needs of health education. Therefore, on the basis of this study, systematic and continuous health education is necessary. Additionally the establishment of independent health subject is required certainly.

초·중·고등학교 학생·학부모·일반교사의 보건교육 영역별 요구도와 보건교육

윤순녕,김영임,최정명,조희순,김영희,박영남,오경순,이분옥,조선녀,조소영,한선희,하영미 韓國學校保健學會 2005 韓國學校保健學會誌 Vol.18 No.1

Purpose: The purpose of this study was to identify the needs of health education in students, their parents and teachers in the elementary, middle and high schools and the current situation of health education class. Method: The subjects of this study were a total of 9450 persons including students, their parents and teachers from 279 schools throughout the country. They were selected through convenient sampling. Data were analyzed through x^(2)­test and ANOVA. Result: Students, their parents and teachers replied that 18 dimensions of health education class (DHEC) are necessary. The four DHEC - healthier life style, sex education, mental health and safety education - showed high educational needs in students, their parents, and teacher. High school students had higher educational need of 'symptom management for daily living' than elementary and middle school students. Students, their parents and teachers in elementary school had higher educational needs of 17 DHEC that those in middle and high school. The percentages of schools with health education class taught by health teachers were 99.2%, 75.5% and 66.0% respectively in elementary, middle and high schools. Health education was given mainly using physical education classes at elementary schools, and creative class hours at middle and high schools. In general, health education took 1-3 hours per week at elementary schools, and less than an hour at middle and high schools. Conclusion: Therefore, based on the results, systematic health education class should begin from elementary school to meet the need of health education in students, their parents and teachers, and further study should be made on the number of hours required and the amount of contents of 18 DHEC.

파노라마 방사선사진과 cone beam CT에서 하악 제3대구치와 하악관의 관계 평가

정연화,나경수,조봉혜 대한구강악안면방사선학회 2008 Imaging Science in Dentistry Vol.38 No.3

Purpose : The purpose of this study is to evaluate the position of the mandibular canal in relation to the mandibular third molar by cone beam CT in cases showing a close relationship between the third molar and the mandibular canal on the panoramic radiograph. Materials and Methods : The panoramic images and cone beam CT scans of 87 impacted mandibular third molars in 60 patients were evaluated to assess the tooth relationship to the mandibular canal. The clearness of the canal wall and the vertical depth of the lower third molar were evaluated on panoramic radiographs. The lower third molars were assessed using cone beam CT to determine the proximity and position of the canal relative to the roots. Results : In the 66 cases where the canal wall was unclear on the panoramic radiographs, 58 (87.9%) of the third molars had contact between the canal and root; 34 (51.5%) canals were showed an inferior position and 22 (33.3%) showed a linguoinferior position on cone beam CT. Conclusion : Interruption of the canal wall on panoramic radiographs was highly predictive of contact between the mandibular canal and the third molar. Cross sectional CT may be indicated for localization of the mandibular canal in such cases.

Perspectives of Integrative Cancer Genomics in Next Generation Sequencing Era

Kwon, So-Mee,Cho, Hyun-Woo,Choi, Ji-Hye,Jee, Byul-A,Jo, Yun-A,Woo, Hyun-Goo Korea Genome Organization 2012 Genomics & informatics Vol.10 No.2

The explosive development of genomics technologies including microarrays and next generation sequencing (NGS) has provided comprehensive maps of cancer genomes, including the expression of mRNAs and microRNAs, DNA copy numbers, sequence variations, and epigenetic changes. These genome-wide profiles of the genetic aberrations could reveal the candidates for diagnostic and/or prognostic biomarkers as well as mechanistic insights into tumor development and progression. Recent efforts to establish the huge cancer genome compendium and integrative omics analyses, so-called "integromics", have extended our understanding on the cancer genome, showing its daunting complexity and heterogeneity. However, the challenges of the structured integration, sharing, and interpretation of the big omics data still remain to be resolved. Here, we review several issues raised in cancer omics data analysis, including NGS, focusing particularly on the study design and analysis strategies. This might be helpful to understand the current trends and strategies of the rapidly evolving cancer genomics research.

아토피 피부염의 중증도에 작용하는 중요인자

장가연,조소연,강호정,함정희 梨花女子大學校 醫科大學 醫科學硏究所 1998 EMJ (Ewha medical journal) Vol.21 No.3

목적: 아토피 피부염의 중증도나 동반 알러지 질환 유무에 따른 임상 및 검사실 소견의 차이와 그 의의를 알아보고자 하였다. 방법: 1995년 8월부터 1996년 7월까지 1년동안 본원 피부과 외래를 방문한 환자를 대상으로 피부과 의사의 직접적인 면담, 신체검사, 세균배양검사, 단자 검사 및 면역학적 검사를 시행하였다. 결과: 1) 피부 건조증, 이개 균열, hyperlinear paim의 동반이 중증도에 따른 유의성을 보였다. 2) 땀, 음식, 흡입항원이 중증군에서 통계학적으로 유의하게 악화요인으로 작용하였다. 3) 아토피 피부염의 가족력 도압ㄴ율이 중증군에서 57.9%, 경증군에서 26.3%로 중증도에 따른 유의성을 보였다. 4) 호흡기 아토피 질환 유무에 따른 집먼지 진드기에 대한 피부단자검사 양성율이 통계학적인 유의성을 보였다. 5) 총 혈청 IgE가 중증군에서 938.3±601.8IU/mL, 경증군에서 526.7±352.1IU/mL로 통계학적인 유의성을 보였다.(p<0.05) 6) 호흡기 아토피 질환이 동반된 아토피 피부염환자의 혈청 IgE는 1025.8±713.2IU/mL, 호흡기 아토피 질환이 동반되지 않은 군은 403.3±273.4IU/mL 로 유의한 차이를 보였다(p<0.05). 7) 혈청 호산구 값은 중증군에서는 509.9±398.4/㎣, 경증군에서는 340.5±219.4/㎣로 중증군에 따른 유의성을 보였다(p<0.05). 결론: 1) 아토피 피부염의 임상적 중증도와 연관있는 것은 피부 건조증, 이개균열, hyperlinear palm 같은 피부 보조증상, 땀, 음식, 흡입항원같은 악화요인이며, 혈청 IgE 증가 및 혈중 호산구증가같은 거사실 소견이었다. 2) 호흡기 아토피 질환이 있는 아토피 피부염 환자에서 높은 혈청 IgE치와 집먼지 진드기에 대한 높은 단자 검사 양성율을 보였다. Objectives : This study was performed to investigate the clinical manifestations and labora-tory findings, and to see whether the severity of atopic dermatitis(AD) implies a relationship to the clinical and laboratory findings. Methods : Our study was designed by analyzing outpatients with AD via physical examinat-ion, questionnaires and laboratory investigations such as prick test to house dust mites, bacterial cultures, total IgE, IgA, IgG, IgG_4, IgM, and peripheral eosinophil count. Results : 1) Xerosis, ear fissuring and hyperlinear palms were related to the severity of AD(p<0.05). 2) Sweating, foods and aeroallrgen were related to the severity of AD(p<0.05). 3) The presence of family history of AD differed significantly(p<0.05) between the severe group(57.9%) & the mild group(26.3%). 4) The positivity of the prick test to Dermatophagoides pteronyssinus and D.farinae was found in 90.0% of respiratory group and in 30.0% of AD only(p<0.05%). 5) Serum IgE level was higher in the severe group(938.3±601.8 IU/mL) than the mild group(526.7±352.1IU/mL)(p<0.05). 6) Serum IgE level in AD patients with respiratory disease(1025.8±713.2IU/mL) was higher than AD only(403.3±273.4IU/mL)(p<0.05). 7) Peripheral eosinophil counts were higher in the severe group(509.9±389.4/㎣) than the mild group(340.5±219.4/㎣)(p<0.05). Conclusion : The factors related to severity of AD were xerosis, ear fissuring, hyperlinear palms, sweating, food, aeroallergen, serum IgE and peripheral eosinophil count. The AD pati-ents with respiratory allergic disease had higher IgE levels and higher positive rates of prick test with house dust mite.

임상 유형에 따른 백반증의 분류

조소연,강형철 ( So Yun Cho,Hyung Chul Kang ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4

Background: Vitiligo is a distressing skin condition in which acquired destruction of melanocytes causes depigmented patches of various shapes & sizes by as yet unclear mechanisms. Its classification is as varied and unresolved as the theories on its pathogenesis, the most plausible of which are autoimmune, neurohumoral and self-destruction theories. Objective . Our purpose was to devise a classification scheme which would correlate well with the disease course and prognosis. Method: We classified vitiligo into 3 types(symmetric: type 1, segmental; type 2, localized; type 3) based on different proposed pathogenetic mechanisms and analyzed the differences between these types in the clinical manifestations of 502 Korean cases. Results : 1. There were 203 males(40.4% ) and 299 females(59.6%). 2. The most frequent clinical type was the symmetric type(49.8%), followed by the localized type(34.1%) and the segmental type(16.1%). 3, The male-to-female ratio was highest in type 2, but not significantly so. 4. Poliosis and halo nevus were associated in 22.3% and 3.8%, respectiuely. 5. The mean age at the first visit was 32.7 years(male, 29.2 years, female; 27.5 years), and there was a significant difference between the clinical types(type 1; 41.0 years, type 2; 20.5 years, type 3; 26.2 years). 6. The mean age of onset was 25.6 years(male; 23.0 years, female; 27.5 years), and there was a significant difference between the clinical types(type 1; 31.3 years, type 2; 15.7 years, type 3; 22.1 years). 7. A family history of vitiligo was observed in 11.2% of patients, whose sisters were most frequently affected, and there was no significant difference between the clinical types. 8. Associated diseases were seen in 12.1% of the patients, the frequency of which was significantly higher in type 1 vitiligo. 9. Abnormal laboratory findings were found in 14.7% and were significantly more common in type 1 vitiligo. Conclusions . The 3 types differ significantly in the mean age at the first visit, the mean age of onset, disease association and abnormal laboratory findings. Type 1 develops by autoimmune mechanisms, as shown by the continuous progression and the close association with other diseases and abnormal laboratory findings, Types 2 and 3 have a different disease course, becoming stationary after initial progression, Thus, the 3 clinical types classified by the authors are thought to be useful in predicting the course and prognosis of vitiligo and in determining the appropriate therapy. For a more optimal classification, further study on the pathogenesis of vitiligo seems to be in order. (Kor J Dermatol 1997;35(4): 827-637)

서울 시내 4년제 남자 대학생의 우울과 흡연량, 흡연기간, 니코틴 의존도와의 관계

박지영,박소영,이미숙,백수진,신의경,예혜련,오승진,장윤정,조혜진,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

Background: With reports on the relation between smoking and depression appearing since 1980, it has become clear that depression is one of the psychodynamics of smoking, though there has been little or no progress made in the study of whether or not there is indeed a relation between depression and nicotine dependence. Purpose: The purpose of the study was to investigate the effects of depression on the amount and period of smoking and nicotine dependence among university man student smokers. Method: In periodical examination between 14 and 21, May, 2003, using 170 university male. The CES-D(Center for Epidemiologic Studies Depression) Scale and the FTQ(Fagerstrom Tolerance Qustionnaire) were utilized to measure the level of depression and nicotine dependency. The amount of smoking was calculated based on the number of cigarette used. Result: Results indicated that depression had something to do with amount of smoking. Nicotine dependence also was related to depression but total value was relatively low. finally the period of smoking had nothing to do with depression. Conclusion: The results of this study revealed that the amount of smoking of university man student smokers was very high. Both the amount of smoking and nicotine dependence were affected by levels of depression. Accordingly psychiatric nursing access such as emotional support is needed to manage depression and decrease smoking.

Quinlolone 유도체 국소도포에 의한 좌창치료의 임상적 연구

권철욱,노영석,김재홍,조소연,강형철,함정희 大韓臨床藥理學會 1994 臨床藥理學會誌 Vol.2 No.2

크론병에 대한 CoPPLX의 방어효과에 대한 연구

이호학,김유림,문창기,이재일,양병윤,김종수,이정민,정재혁,안석진,박상준,김윤권,김소연,김영중,조민구,최영자,장성조 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

Original Articles : Clinical significance of occult hepatitis B virus infection in chronic hepatitis C patients

( Jae Young Jang ),( Soung Won Jeong ),( Sung Ran Cheon1 ),( Sae Hwan Lee1 ),( Sang Gyune Kim ),( Young Koog Cheon ),( Young Seok Kim1 ),( Young Deok Cho1 ),( Hong Soo Kim ),( So Young Jin ),( Yun Soo 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3

Background/Aims: We investigated the frequency of occult hepatitis B virus (HBV) infection in anti-hepatitis C virus (HCV)-positive individuals and the effects of occult HBV infection on the severity of liver disease. Methods: Seventy-one hepatitis B virus surface-antigen (HBsAg)-negative patients were divided according to their HBV serological status into groups A (anti-HBc positive, anti-HBs negative; n=18), B (anti-HBc positive, anti-HBs positive; n=34), and C (anti-HBc negative, anti-HBs positive/negative; n=19), and by anti-HCV positivity (anti-HCV positive; n=32 vs. anti-HCV negative; n=39). Liver biopsy samples were taken, and HBV DNA was quantified by real-time PCR. Results: Intrahepatic HBV DNA was detected in 32.4% (23/71) of the entire cohort, and HBV DNA levels were invariably low in the different groups. Occult HBV infection was detected more frequently in the anti-HBc-positive patients. Intrahepatic HBV DNA was detected in 28.1% (9/32) of the anti-HCV-positive and 35.9% (14/39) of the anti-HCV-negative subjects. The HCV genotype did not affect the detection rate of intrahepatic HBV DNA. In anti-HCV-positive cases, occult HBV infection did not affect liver disease severity. Conclusions: Low levels of intrahepatic HBV DNA were detected frequently in both HBsAg-negative and anti-HCV-positive cases. However, the frequency of occult HBV infection was not affected by the presence of hepatitis C, and occult HBV infection did not have a significant effect on the disease severity of hepatitis C. (Korean J Hepatol 2011;17:206-212)