http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Guidelines for Infection Control and Burnout Prevention in Healthcare Workers Responding to COVID-19
Park Se Yoon,Cheong Hae Suk,Kwon Ki Tae,Sohn Kyung Mok,Heo Sang Taek,Lee Shinwon,Chung Un Sun,Lee So Hee 대한감염학회 2023 Infection and Chemotherapy Vol.55 No.1
During the coronavirus disease 2019 (COVID-19) pandemic, frontline healthcare workers (HCWs) suffered more distress from the possibility of contracting the virus, quarantine, social stigma, and prejudice against their families. Many studies have investigated the impact of the pandemic on HCWs; however, studies or guidelines presenting strategies to overcome these challenges are lacking. As part of a 2020 research project supported by the Ministry of Health and Welfare, titled “Health impact assessment of healthcare workers undertaking coronavirus disease 2019 treatment and management in Korea: Identifying problems and researching effective solutions” (HC20C0003), we created guidelines to respond to serious problems posed by infection control. and burnout among HCWs during COVID-19 response measures throughout the extended pandemic period. We formulated the guidelines by means of a systematic review and collated them with the latest literature. The guidelines will highlight the gravity and impact of infection control and burnout among HCWs responding to COVID-19 and include potential prevention strategies, and they can be used as a reference in the event of another emerging infectious disease outbreak in the future.
각종 만성 간질환들에서 B형간염 바이러스의 잠재성 감염에 대한 관찰
정정명,강석우,윤철,채두근,김성목,설상훈,조환진,조경임,박영홍,모혜경 인제대학교 백병원 2001 仁濟醫學 Vol.22 No.2
Objectives: Occult Hepatitis B virus infection is defined as HBV DNA positivity without HBsAg by serologic test. It has been thought to be caused by the escape mutant which do not express HBsAg or prouduce S protein with altered antigenicity. But the precise mechanism and pathophysiology of this phenomenon is still unclear despite of numerous previous reports. We investigated occult hepatitis B infection and their clinical characteristics in the patients with various chronic liver diseases. Methods and Materials: Thirty eight patients with chronic liver diseases with positive HBsAb or negative HBsAg were included. After confirmation of HBV DNA, we performed entire base pair sequence analysis on the C region of HBV genome. Results: 1. HBV DNA was detected 29 cases among 38 patients(76.3%) they had 12 chronic toxic hepatitis(41.4%), 7 liver cirrhosis(24.1%), 7 cases of simultaneous hepatocellular carcinoma with liver cirrhosis(24.1%), 1 chronic C hepatitis(3.4%), 1 alcoholic liver disease(3.4%), and 1 uncertified cause(3.4%). 2. The mutation at core promoter region were found in 24 patients(83.1%), of which 15 showed simultaneous mutations in both nucleotide 1762 and 1764, and 1 patients in 1764 single mutation. 3. Twenty four of 29 patients(83.1%) have mutations at precore region, of which the nucleotide 1896(codon 28) was the most frequent site(9 patients- 37.5%). 4. The mutations were found at whole length of core gene, but were the most frequent at epitope regions. For cytotoxic T cell epitope region, the mutation in codon 27 and 31 were from 9(31.0%) and 19(65.5%) patients, respectively. For CD4 epitope region, the mutations in codon 49, 60 and 76 were from 12(41.4%), 9(31.0%) and 16 patients(55.2%), respectively. And for B cell epitope region, those in codon 130 and 143 were from 19(65.5%) and 15 patients(52.0%), respectively. 5. S gene mutations were observed in only 3 patients, 2 liver cirrhosis and 1 hepatocellular carcinoma patients. Point mutation was frequently observed in codon 51, 67, 68, 91 of pre-S1, codon 38, 39, 40, 46 of pre-S2, and codon 3, 27, 82, 92 of S gene. In the case of hepatocellular carcinoma, the 120bp deletion from pre-S1 to pre-S2 was observed. Conclusion: From the above results, we may conclude that the occult hepatitis B virus infection is highly prevalent in epidemic area of HBV infection, and may be related with severe liver diseases. Escape mutant may be an important mechanism of this phenomenon.
Cloning and Characterization of Two catA Genes in Acinetobacter lwoffii K24
CHUNG, YOUNG HO,HA, KWON-SOO,LEE, YUNG NOK,KIM, SEUNG IL,PARK, YOUNG-MOK,KIM, SOOHYUN,CHOI, JONG SOON,LEEM, SUN HEE,PARK, YONG KEUN 東亞大學校附設遺傳工學硏究所 1997 遺傳工學硏究 Vol.- No.6
Two novel type I catechol 1,2-dioxygenases inducible on aniline media were isolated from Acinetobacter lwoffii K24. Although the two purified enzymes, CDI₁and CDI₂, had similar intradiol cleavage activities, they showed different substrate specificities for catechol analogs, physicochemical properties, and amino acid sequences. Two catA genes, catA₁and catA₂, encoding by CDI₁ and CD I₂, respectively, were isolated from the A. lwoffii K24 genomic library by using colony hybridization and PCR. Two DNA fragments containing the catA1 and catA₂ genes were located on separate regions of the chromosome. They contained open reading frames encoding 33.4-and 30.4-kDa proteins. The amino acid sequences of the two proteins matched well with previously determined sequences. Interestingly, further analysis of the two DNA fragments revealed the locations of the catB and catC genes as well. Moreover, the DNA fragment containing catA₁ had a cluster of genes in the order catB₁-catC₁-catA₁ while the catB₂-catA₂-catC₂ arrangement was found in the catA₂ DNA fragment. These results may provide an explanation of the different substrate specificities and physicochemical properties of CDI₁ and CDI₂.
Chung, Sang Mok,Yoon, Eun Jeong,Kim, So Hee,Lee, Myung Gull,Lee, Heejoo,Park, Man Ki,Kim, Chong Kook 德成女子大學校 藥學硏究所 1992 藥學論文誌 Vol.3 No.1
The pharmacokinetics of 5-fluorouracil(5-FU)was compared after 30 min intravenous infusion of the same dose (20 mg/kg as 5-FU)of 5-FU(treatment Ⅰ),5-FU-acetic acid(5-FU-AA, treatment Ⅱ)and 5-FU-AA-human serum albumin conjugates (5-FU-AA-HSA, treatment Ⅲ)to rabbits. After post-infusion, plasma levels of 5-FU declined rapidly with a mean half-life of 8.0 min from treatment Ⅰ, however, they were not detected until 10-50 min and the mean plasma concentration of 1㎍/ml was maintained from 3 to 24 h for treatment Ⅲ. It might be possible to maintain constant plasma concentration s of 5-FU for a long period of time by 30min infusion of 5-FU-AA-HSA conjugates instead of tedious time-consuming infusion of 5-FU, The mean values of 24 h AUC(623 vs 1290㎍ min ml^-1)were significantly higher from treatment Ⅲ than that from treatment Ⅰ.5-FU was not detected from treatment Ⅱ nor 5-FU-AA from treatment Ⅲ in both plasma and urine samples. In treatment Ⅱ, 5-FU-AA was eliminated rapidly with a mean apparent terminal half-life of 18.7 min based on urinary excretion rate data. 5-FU was not detected in brain after 30 min intravenous infusion of both 5-FU and 5-FU-AA, however, significan amounts of 5-FU were found in brain after administration of 5-FU-AA-HSA conjugates. The in vitro release of 5-FU from 5-FU-AA-HSA conjugates was increased in the presence of protease or liver homogenates, however, 5-FU was not detected for up to 24 h incubation of 5-FU-AA with the various solutions.