Incidence and risk factors of hepatitis C virus infection among human immunodeficiency virus (HIV) patients in a large HIV clinic in South Korea

( Shinwon Lee ),( Sun Hee Lee ),( Su Jin Lee ),( Kye Hyung Kim ),( Jeong Eun Lee ),( Heerim Cho ),( Seung Geun Lee ),( Joo Seop Chung ),( Ihm Soo Kwak ) 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.4

Background/Aims: Increasing incidences of hepatitis C virus (HCV) infection in human immunodeficiency virus (HIV)-infected men who have sex were reported in the United States and Europe. However, few studies regarding the epidemiology of HCV infection in HIV-infected patients in Asian countries have been reported. Methods: To determine the prevalence and incidence of HCV infection in HIV-infected patients, a retrospective cohort study was conducted. All HIV-infected patients who visited a tertiary care hospital in Korea from 2000 to 2013 were identified. Patients with ≥ 1 HCV antibody (Ab) test were included and observed until December 2014. Results: Among 996 HIV-infected patients, 790 patients (79%) had baseline HCV Ab tests and 41 (5.2%) were positive at baseline and four at follow-up. Experience of injecting drug use (IDU; adjusted odds ratio, 16.20; 95% confidence interval [CI], 1.56 to 167.89; p < 0.01) was significantly associated with prevalent HCV infection. Conversion to HCV Ab positivity was observed in four of 384 included patients, with an incidence rate of 2.22 (95% CI, 0.60 to 5.80)/1,000 person-years (PYs); 164.89 (95% CI, 34.00 to 481.88)/1,000 PYs in patients with IDU, and 1.40 (95% CI, 0.35 to 7.79)/1,000 PYs in men who have sex with men who denied IDU. There was no significant increase in incidence rate of HCV in HIV-infected patients from 2009 to 2014 (p = 0.119). Among 19 patients who were positive for HCV RNA, genotype 1b (73%) was the most common following 2a/2c (20%). Conclusions: IDU was an independent risk factor for prevalent HCV infection. Prevalence of HCV infection was low and incidence of HCV infection was not significantly increased in HIV-infected patients in South Korea.

Ten-Year Trends of Hepatitis A Seroprevalence in People Living with HIV in Korea

Lee Shinwon,Lee Jeong Eun,Lee Soon Ok,Sim Yong Ki,Lee Sun Hee 대한감염학회 2022 Infection and Chemotherapy Vol.54 No.3

Epidemiological information on hepatitis A among people living with HIV (PLHIV) in Korea is scarce. This retrospective study was performed at a tertiary care hospital and included 756 PLHIV with anti- hepatitis A virus (HAV) IgG tests. Between 2012 and 2021, the age at anti-HAV IgG seroconversion is gradually delayed, and the proportion of individuals susceptible to HAV infection increased among adult PLHIV in Korea. The independent risk factors for HAV seropositivity were female sex and HBs antigen (Ag) positivity. Therefore, HAV vaccination is highly recommended for young PLHIV, especially for women or HBsAg-positive individuals.

Trends in Malignancies among Korean Patients Infected with Human Immunodeficiency Virus in the Highly Active Antiretroviral Therapy Era

Lee, Shinwon,Lee, Sun Hee,Lee, Jeong Eun,Kang, Jin Suk,Lee, Seung Geun,Chung, Joo Seop,Kwak, Ihm Soo KOREAN ACADEMY OF MEDICAL SCIENCE 2017 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.32 No.9

<P>Since the introduction of highly active antiretroviral therapy, the life span of people with human immunodeficiency virus (HIV) or AIDS (PWHA) has been extended significantly. Therefore, the importance of non-AIDS-defining cancers (NADCs), as well as AIDS-defining cancers (ADCs) has increased. There is little information concerning the epidemiology of malignancies in PWHA in Korea. A descriptive epidemiologic study was conducted at a tertiary care hospital in Korea. PWHA who visited Pusan National University Hospital from January 2000 to October 2014 were included. Demographics and clinical data were obtained from the medical records and analyzed. A total of 950 PWHA were observed for 4,439.71 person-years. Forty-eight episodes (5.05%) of cancers were diagnosed in 47 patients. Mean age of the enrolled patients was 40.66 ± 12.15 years and 88% were male. Among the 48 cancer episodes, 20 (42%) were ADCs and 28 were NADCs. The most common ADCs was non-Hodgkin's lymphoma (53.6%), followed by Kaposi's sarcoma (17.9%). The most common NADCs were lung cancer (25%) and hepatocellular carcinoma (25%). The overall incidence of total cancers, ADCs, and NADCs was 10.8 (95% confidence interval [CI], 8.0–14.3), 4.5 (95% CI, 2.8–7.0), and 6.3 (95% CI, 4.2–9.1)/1,000 person-years, respectively. NADCs accounted for 12/15 (80%) of cancers among PWHA with good adherence to care. The 5-year survival rate of PWHA and NADC was 26.3%. NADCs have become the main type of malignancy among Korean PWHA with good adherence to care. Effective strategies to improve screening of NADCs among PWHA are required in Korea.</P>

Evaluation of the Selection of the Initial Seeds for K-Means Algorithm

ShinWon Lee,WonHee Lee 보안공학연구지원센터 2013 International Journal of Database Theory and Appli Vol.6 No.5

Design and Analysis of Mobile Learning Management System based on Web App

Shinwon Lee 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.1

We can take the e-Learning using smart devices on information society is that well-formed internet environment. LMS (Learning Management System) supports mobile video lectures. The proposed system designs that instructors can set up lectures without the professional computer related technologies, and the interaction between instructors and learners becomes easy. This system focuses on helping the interaction between instructors and learners made easier by using a web browser in the mobile device based on web app, anytime and anywhere learners want to use the system.

Evaluation of Time Complexity Based on Max Average Distance for K-Means Clustering

ShinWon Lee,WonHee Lee 보안공학연구지원센터 2012 International Journal of Security and Its Applicat Vol.6 No.2

P105 Clinical and therapeutic window of dapsone in various skin diseases

( Shinwon Hwang ),( Howard Chu ),( Kwang Hoon Lee ),( Min-geol Lee ),( Chang Ook Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: In dermatology, we use dapsone on a number of dermatologic disorders including inflammatory disease, pruritus and bullous disease. Although hemolyitic anemia, which is a typical side-effect of dapsone, is well known, but the mechanism of dapsone is not fully understood. Objectives: To evaluate the response of dapsone on various inflammatory dermatologic disorders and observe the monitoring markers for outcome and side effects. Methods: 167 patients treated with dapsone on various diseases were retrospectively reviewed. Clinical profiles, response of dapsone treatment, glucose-6 phosphate dehydrogenease(G6PD), hemoglobin, reticulocyte count and percentage(Reti%) were analyzed. Results: 167 patients were divided into 11 groups and treatment effect was evaluated. Dapsone usually showed good response. Almost patients had normal value of G6PD without severe hemolytic anemia. Mean of Reti(%) was 2.572%. Patients whose Reti(%) was higher than 2.5% were 64, while patients with lower than 2.5% value were 103. 31% of patients whose Reti(%) was higher than 2.5, had no effect or aggravation, while 19% of the patients with lower than 2.5% value had no effect or aggravation. Conclusion: Dapsone is very effective various dermatologic disorders. All patients showed mild to moderate hemolytic anemia and patients who have mild hemolytic anemia, need to check the possibility of insufficient use of dapsone and consider the increase in quantity or continue the use of dapsone with periodic monitoring.

[P016] Successful treatment of angiofibroma with 10,600-nm carbon dioxide fractional laser

( Shinwon Hwang ),( Young In Lee ),( Jihee Kim ),( Ju Hee Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Facial angiofibromas occur in 70% to 80% of patients with tuberous sclerosis(TS). Current treatment options include dermabrasion, surgical excision and laser therapy. However, such treatment can cause significant scarring and recurrent lesions. Nowadays, mTOR inhibitor (rapamycin) has changed the paradigm. With topical application, existing angiofibroma papules show decrease without significant side effect. However, for longstanding larger lesions, topical application alone does not seem enough. We report a case of successful treatment of angiofibroma by using ablative fractional CO₂ laser with topical rapamycin occlusive dressing. A 19-years-old male diagnosed with TS came to our clinic for angiofibromas on the face. At first, we prescribed topical rapamycin to the patient for one year since November 2015. Erythema and overall size of the lesions showed improvement but larger ones persisted especially on the perinasal area and forehead. When he was scheduled for excision of parietal scalp mass under general anesthesia in cooperation with the department of Plastic Surgery, ablative fractional CO₂ laser on the face was done with rapamycin occlusive dressing afterwards. By using ablative fractional CO2 laser and point ablation, nodularity of angiofibroma was much improved and there is no significant recurrence or post-treatment scar. Therefore, combination treatment with laser can be a useful treatment options for angiofibroma in TS

[P015] Allogenic collagen filler for facial lipodystrophy due to lupus erythematosus panniculitis

( Shinwon Hwang ),( Young In Lee ),( Jihee Kim ),( Ju Hee Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Many patients with lipodystrophy, have cosmetic problem, especially occurring on the face. These deformities are treated with surgical techniques such as injectable fillers, transplanted or autologous fat grafting or extensive resection of the lesion. We report a case of extensive lipodystrophy by lupus panniculitis resistant to classic treatment, successfully treated by allogenic collagen filler. A 27-years-old female with lipodystrophy come to scar clinic due to extensive atrophic and depressed lesions on the face. She got three times of autologous fat transplant but clinical outcome was unsatisfactory both to the patient and physician. For more sustainable approach, allogenic collagen filler was used. After 10 days from injection, collagen injected areas were well maintained without any side effects such as bruising or infection. On last visit, contour of the face was well maintained and patient was satisfied with the results. Depressive and atrophic lesion due to lipodystrophy is hard to treat due to rapid absorption or other side effect. In our case, allogenic collagen filler maintained over 2 months without recurrence. It maintained longer time than other way like autologous fat transplant. Therefore, allogenic collagen fiber can be an alternative treatment option for the lipodystrophy caused by systemic autoimmune disease. Nonetheless, selecting appropriate candidate who shows clinically stable lesions should be preceded

Expert Consensus on Measures to Promote Physical and Psychological Health among COVID-19-Related Healthcare Workers in Korea using Delphi Technique

Lee So Hee,Noh Jin-Won,Kim Yeonjae,Ryoo Hyun Wook,Park Kyung-Hwa,Park Kyung-Hwa,Lee Shinwon,Cheong Hae Suk,Heo Sang Taek,Hong Ki Jeong,Kim Kyoung-Beom,Kwon Ki Tae 대한감염학회 2022 Infection and Chemotherapy Vol.54 No.2

Background The coronavirus disease 2019 (COVID-19) pandemic has caused health problems and distress among healthcare workers (HCWs), so supportive measures to promote their health and relieve distress are needed. Materials and Methods We conducted two rounds of Delphi surveys with 20 COVID-19-related frontline healthcare professionals and public officials. The surveys evaluated means of supporting HCWs’ health by improving health care systems and working environments in terms of effectiveness and urgency. The validity of the measures was assessed by calculating the content validity ratio. Results The top-priority measures to support HCWs were “secure isolation units capable of treating severe cases” in the facility infrastructure category, “secure nursing staff dedicated for patients in the intensive care units” in the personnel infrastructure category, “improve communication between central office and frontline field” in the cooperation system category, “support personal protective equipment and infection control supplies” in the aid supplies category, and “realization of hazard pay” in the physical/mental health and compensation category. Conclusion There was consensus among the experts on the validity and priorities of policies in the facility, personnel, cooperation, supplies, and compensation categories regarding measures to promote COVID-19 related HCWs’ health. Background The coronavirus disease 2019 (COVID-19) pandemic has caused health problems and distress among healthcare workers (HCWs), so supportive measures to promote their health and relieve distress are needed. Materials and Methods We conducted two rounds of Delphi surveys with 20 COVID-19-related frontline healthcare professionals and public officials. The surveys evaluated means of supporting HCWs’ health by improving health care systems and working environments in terms of effectiveness and urgency. The validity of the measures was assessed by calculating the content validity ratio. Results The top-priority measures to support HCWs were “secure isolation units capable of treating severe cases” in the facility infrastructure category, “secure nursing staff dedicated for patients in the intensive care units” in the personnel infrastructure category, “improve communication between central office and frontline field” in the cooperation system category, “support personal protective equipment and infection control supplies” in the aid supplies category, and “realization of hazard pay” in the physical/mental health and compensation category. Conclusion There was consensus among the experts on the validity and priorities of policies in the facility, personnel, cooperation, supplies, and compensation categories regarding measures to promote COVID-19 related HCWs’ health.