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Jeon, Boram,Kim, Hangeun,Chung, Dae Kyun The Korean Society for Microbiology and Biotechnol 2022 한국미생물·생명공학회지 Vol.50 No.2
Lipoteichoic acid (LTA) regulates the immune system, including inflammatory responses, through TLR2-mediated signaling pathways. LTA isolated from Staphylococcus aureus (aLTA) has been shown to induce apoptosis, but the detailed mechanism has not been identified. We found that aLTA induced apoptosis through an autocrine mechanism in the human monocyte-like cell line, THP-1. We observed that the expression level of the anti-apoptosis protein, Bcl2, was suppressed in LTA-treated THP-1 cells. In addition, the cytokines, TNF-α and IFN-γ, which have been shown to induce apoptosis in some cell lines, were involved in THP-1 cell death via the modulation of Bcl2. The suppression of Bcl2 by aLTA was recovered when the negative regulator, SOCS-1, was knocked down. Taken together, these results showed that aLTA induced apoptosis in THP-1 cells through an autocrine mechanism of cytokines and SOCS-1-mediated Bcl2 inhibition.
휴대폰 패키지를 활용한 비즈니스 전략 및 앱세서리 제안
전혜미(Hyemi Jeon),강동민(Dongmin Kang),김화랑(Hwalang Kim),안영미(Youngmi An),황민정(Minjeong Hwang),진보람(Boram Jin),신창범(Changbeom Shin),전기석(Kisuk Jeon) 한국HCI학회 2014 한국HCI학회 학술대회 Vol.2014 No.2
최근 디자인 장르에서 감성디자인이 대두되기 시작했다. 이는 20세기 전반에 영향을 미친 기능주의 디자인의 이성적, 논리적 한계를 극복하고 그 후 포스트모던 상황 하에서도 도외시되어 온 인간의 감성적 측면까지를 포함하는 종합적 디자인이 요구되기 때문이다. 본 연구에서 제안하는 앱세서리는 보통의 소셜 네트워크의 소통방법과는 다르게 자신을 반영한 피규어라는 매개체를 통하여 커뮤니케이션을 할 수 있고, 기업들에게는 홍보의 기회를 나아가서 관련매출 상승이라는 결과를 얻게 할 것이다. 다양한 컨텐츠들로 구성된 피규어 기반의 소셜 네트워크는 사용자들에게는 새로운 경험을, 기업에게는 다양한 이득을 취하게 할 것으로 기대된다. 본 컨셉 내용은 특허 출원 중에 있으며 프로토타입으로 제작하여 사용자 경험측면에서 가능성을 검증 중이다. Recently emotional design emerged as a important subject. It passed the logical and rational limit of functionalism design. Then under post modernism situation it was required for overall design that included emotional sides of people. Appcessory proposed this experiment is able to communicate with someone through a figure reflected oneself, in contrast with existing social network s ystems. and it w ill give companies chance o f promotion a nd upward in sales. Social network system based on figure combined various contents will give people new experiments and company various benefits. This concept is in the process of a patent application and verifies possibility of user experience side by making a prototype.
Jeon Youngsic,Yoo Jeong Eun,Rhee Hyungjin,Kim Young-Joo,Il Kim Gwang,Chung Taek,Yoon Sarah,Shin Boram,Woo Hyun Goo,Park Young Nyun 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
The expression of estrogen receptor alpha (ERα, encoded by ESR1 ) has been shown to be associated with the prognostic outcomes of patients in various cancers; however, its prognostic and mechanistic significance in hepatocellular carcinoma (HCC) remain unclear. Here, we evaluated the expression of ERα and its association with clinicopathological features in 339 HCC patients. ERα was expressed in 9.4% (32/339) of HCCs and was related to better overall survival (OS; hazard ratio [HR] = 0.11, p = 0.009, 95% C.I. = 0.016–0.82) and disease-free survival (DFS, HR = 0.4, p = 0.013, 95% C.I. = 0.18–0.85). ERα expression was also associated with features related to more favorable prognosis, such as older age, lower serum alpha-fetoprotein level, and less microvascular invasion ( p < 0.05). In addition, to obtain mechanistic insights into the role of ERα in HCC progression, we performed integrative transcriptome data analyses, which revealed that yes-associated protein (YAP) pathway was significantly suppressed in ESR1 -expressing HCCs. By performing cell culture experiments, we validated that ERα expression enhanced YAP phosphorylation, attenuating its nuclear translocation, which in turn suppressed the downstream signaling pathways and cancer cell growth. In conclusion, we suggest that ERα expression is an indicator of more favorable prognosis in HCC and that this effect is mediated by inactivation of YAP signaling. Our results provide new clinical and pathobiological insights into ERα and YAP signaling in HCC.
Jeon, Seong Gyu,Oh, Sun-Young,Park, Hye-Kyung,Kim, You-Sun,Shim, Eun-Jin,Lee, Hyun-Seung,Oh, Min-Hee,Bang, Boram,Chun, Eun-Young,Kim, Sang-Heon,Gho, Yong Song,Zhu, Zhou,Kim, You-Young,Kim, Yoon-Keun Elsevier 2007 The Journal of allergy and clinical immunology Vol.120 No.4
<P><B>Background</B></P><P>Although respiratory viral infections in early childhood can enhance the development of airway allergen sensitization, the exact mechanisms of the effects of viral infections on the adaptive immune response to inhaled allergens are controversial.</P><P><B>Objective</B></P><P>We sought to evaluate the effects of double-stranded RNA (dsRNA) on airway sensitization to inhaled allergens.</P><P><B>Methods</B></P><P>Novel mouse models were created through simultaneous airway sensitization to an allergen and low or high doses of dsRNA. The mouse models were applied to Toll-like receptor 3–, IL-13–, IL-4–, signal transducer and activator of transcription (STAT) 6–, IFN-γ–, and T-box expressed in T cells (T-bet)–deficient mice to evaluate underlying pathophysiologic mechanisms in the development of allergic lung inflammation.</P><P><B>Results</B></P><P>We found that airway allergen sensitization with dsRNA induced lung inflammation that was not present in Toll-like receptor 3–deficient mice. Moreover, lung inflammation enhanced by low-dose dsRNA was impaired in IL-13–deficient mice, whereas lung inflammation by high-dose dsRNA was impaired in IFN-γ–deficient mice. The models also demonstrated that low-dose dsRNA enhanced IL-4 expression during allergen sensitization and that inflammation enhanced by low-dose dsRNA was not present in IL-4– or STAT6-deficient mice. In contrast, the present study showed that high-dose dsRNA enhanced IFN-γ expression during allergen sensitization and that the development of lung inflammation enhanced by high-dose dsRNA was impaired in T-bet–deficient mice.</P><P><B>Conclusion</B></P><P>These findings suggest that airway allergen exposure during respiratory viral infections might induce asthma induced by both T<SUB>H</SUB>1 and T<SUB>H</SUB>2 immune responses to inhaled allergens.</P><P><B>Clinical implications</B></P><P>Targeting both T<SUB>H</SUB>1 and T<SUB>H</SUB>2 lung inflammation might be important in the treatment of virus-associated asthma.</P>
Seo, Boram,Jeon, Woo Hyung,Kim, Chul‐,Eui,Kim, Sanghyuck,Kim, Sung Hong,Lee, Phil Ho WILEY‐VCH Verlag 2016 Advanced synthesis & catalysis Vol.358 No.7
<P><B>Abstract</B></P><P>Sequential copper‐catalyzed [3+2] cycloaddition, rhodium‐catalyzed OH insertion, intramolecular 1,8‐addition, and rearrangement starting from 1‐alkynes, <I>N</I>‐sulfonyl azides, and tropolones is demonstrated for the synthesis of the 2‐functionalized aminotropones in one pot. These results indicate that sequential functionalization of OH and C(<I>sp</I><SUP>2</SUP>)O bonds smoothly occurs in the C(<I>sp</I><SUP>2</SUP>)OH bonds of tropolone</P>
하둡 클러스터 환경에서 SCSI 타겟 모듈을 이용한 대용량 스토리지 제공 방법에 관한 연구
이보람(BoRam Lee),전기만(KiMan Jeon),김영환(YoungHwan Kim) 한국정보기술학회 2014 Proceedings of KIIT Conference Vol.2014 No.5
하둡은 클라우드 컴퓨팅과 빅데이터 등 분석 처리 및 대용량 데이터 처리 등의 연구에서 현재 가장 큰 이슈로 떠오르고 있다. 하둡은 데이터노드를 추가하는 방법으로 하둡 크기를 확장할 수 있지만, 새로운 서버 설치보다 기존 스토리지 시스템에 SCSI 타겟 모듈을 설치하여 크기를 확장하는 것도 좋은 방법이 될 수 있다. 본 연구에서는 SCSI 기반 Target Module을 이용하여 하둡 클러스터 환경에 대용량 스토리지를 제공하고 이에 대한 성능을 측정하여 SCSI 기반 타겟 모듈이 하둡 클러스터 환경에서 스토리지 크기를 확장하는데 이점을 갖는 것을 확인하였다. Hadoop has become the biggest issue in the study of Big Data Processing and Distributed Data Processing. When Hadoop system has encountered the shortage of storage space, it could enlarge Hadoop system by inserting data nodes. Installing up SCSI target module to existing storage system could be a good way to expand the size of Hadoop storage space. In this paper, by using SCSI-based Target Module we build a large cluster and measure it"s performance.