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      • A case of twin results of allergic test in twin with atopic dermatitis

        ( Hyun Yi Lee ),( Ji Seon Kim ),( Yu Jin Jeon ),( Dae Young Oh ),( Joong Sun Lee ),( Dae Won Koo ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

        Atopic dermatitis is a chronic inflammatory skin disease associated with genes, the environment, defective skin barrier function, and allergy. The risk of developing atopic dermatitis is much higher in those whose family members are affected. It can be thought that atopic dermatitis is associated with genetic influence. However, there are many cases where the skin symptom or test result is not similar even in twins, because environmental and developmental factors must play a role too. A 19-year-old men came to our hospital to do allergic tests. They were twin who both had an atopic dermatitis. They underwent a skin prick test, specific immunoglobulin E(MAST) and a blood test including serum total immunoglobulin E(Ig E). In specific Ig E, the brothers showed identical results, showing positive responses to ticks, animal hair, and nuts such as walnuts. The skin prick test also showed very similar responses, positive reactions with cockroach, walnuts, mugwort, and ticks. And their total Ig E level was 591.6IU/mL and 528.4 IU/mL, respectively. Many studies showed that genetic factors play an important role in the development of this disease. Also, there have been many studies on twins. However, as far as we know there are no studies showing identical positive reactions to multiple allergens in skin prick tests, specific Ig E, and similar level in total Ig E. In that sense, our case report is interesting.

      • KCI등재후보

        Skin Prick Test Reactivity in Patients with Chronic Eczematous External Otitis

        Ozlem Celebi Erdivanli,K. Cagdas Kazikdas,Zerrin Ozergin Coskun,Munir Demirci 대한이비인후과학회 2011 Clinical and Experimental Otorhinolaryngology Vol.4 No.4

        Objectives. To investigate the incidence of skin prick test (SPT) positivity in patients with eczematous external otitis. Methods. Forty-six patients with eczematous external otitis and forty-four healthy volunteers were included in the study. All the patients were skin-tested by prick test. Reactions were assessed by the degree of redness and swelling and the size of the wheal produced. Results. According to SPT positivity and total immunoglobulin E values, the difference between the study and the control groups was statistically significant (P<0.05). The most common skin reactions were against to mites and grasses in this study. Conclusion. Eczematous external otitis is perhaps the most difficult to treat of all forms of external otitis because the provocative agents usually remain undiagnosed. Patients suffering from eczematous external otitis symptoms should be investigated for allergens and be informed for prevention of the causative agents. SPT might be performed in cases of prolonged or treatment-resistant external otitis.

      • KCI등재

        Immediate Hypersensitivity Reactions Induced by Triamcinolone in a Patient with Atopic Dermatitis

        Son, Jee Hee,Park, Sook Young,Cho, Yong Se,Chung, Bo Young,Kim, Hye One,Park, Chun Wook KOREAN ACADEMY OF MEDICAL SCIENCE 2018 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.33 No.12

        <P>Corticosteroids are potent anti-inflammatory and anti-allergic agents used in the treatment of various inflammatory diseases, including allergic disease. They are frequently considered the therapy-of-choice for many skin diseases. However, allergic reactions caused by corticosteroids have been reported. Among these, delayed reactions to topical steroids are more common, whereas immediate reactions to systemic steroids are rare. Herein, we report the case of a 32-year-old woman with triamcinolone-induced immediate hypersensitivity reaction, in which the patient had a positive prick test result with triamcinolone. She has had atopic dermatitis (AD) for three years. She had used systemic steroid, cyclosporine, and antihistamine with topical steroids for AD. In clinic, approximately 10 minutes after intralesional injection of triamcinolone, she complained of erythematous patches with slight elevation and itching on the face, trunk, and both hands. After intravenous injection of dexamethasone, her symptoms got worse. After treatment with epinephrine, all symptoms resolved within two hours. We performed an open test and skin prick test. She had a positive result only from the prick test with triamcinolone; all other steroids showed negative results from the open tests. Dermatologists should be aware of the possibility of anaphylaxis or other allergic hypersensitivity in response to corticosteroids.</P>

      • KCI등재

        Immediate Hypersensitivity Reactions Induced by Triamcinolone in a Patient with Atopic Dermatitis

        손지희,박숙영,조용세,정보영,김혜원,박천욱 대한의학회 2018 Journal of Korean medical science Vol.33 No.12

        Corticosteroids are potent anti-inflammatory and anti-allergic agents used in the treatment of various inflammatory diseases, including allergic disease. They are frequently considered the therapy-of-choice for many skin diseases. However, allergic reactions caused by corticosteroids have been reported. Among these, delayed reactions to topical steroids are more common, whereas immediate reactions to systemic steroids are rare. Herein, we report the case of a 32-year-old woman with triamcinolone-induced immediate hypersensitivity reaction, in which the patient had a positive prick test result with triamcinolone. She has had atopic dermatitis (AD) for three years. She had used systemic steroid, cyclosporine, and antihistamine with topical steroids for AD. In clinic, approximately 10 minutes after intralesional injection of triamcinolone, she complained of erythematous patches with slight elevation and itching on the face, trunk, and both hands. After intravenous injection of dexamethasone, her symptoms got worse. After treatment with epinephrine, all symptoms resolved within two hours. We performed an open test and skin prick test. She had a positive result only from the prick test with triamcinolone; all other steroids showed negative results from the open tests. Dermatologists should be aware of the possibility of anaphylaxis or other allergic hypersensitivity in response to corticosteroids.

      • KCI등재후보

        알레르기 질환 환자에서 고양이털 항원에 대한 감작을 및 고양이털의 항원성에 관한 연구

        라선영(Sun Young Rha),남동호(Dong Ho Nam),김범수(Bum Soo Kim),안중배(Joong Bae Ahn),원욱희(Wook Hee Won),송현용(Hyun Yong Song),조홍근(Hong Keun Cho),전동운(Dong Woon Jun),홍천수(Chein Soo Hong) 대한내과학회 1995 대한내과학회지 Vol.48 No.3

        N/A Objectives: The cat fur allergen used in skin prick test was known to be contaminated with housedust mites. So we intended to evaluate the clinical importance of cat fur as a causative allergen in patients with allergic diseases. Methods: We performed skin prick tests with cat allergen of Torii company(Japan), Bencard company (England) and home made extracts in 387 patients, We detected specific IgE by 3M FAST-plus and ELISA method using home made cat fur allergen, developed at this class. To characterize the allergenic components, cat fur extracts were fractionated by 12 % sodium dodecyl sulfate polyacrylamide gel electrophoresis(SDS-PAGE) and then transferred onto nitrocellulose membrane and probed with sera of cat fur sensitive patients Results: 1) Out of 387 patients, 77(19.9%) showed more than 1+results on skin prick test. There were no significant differences in the rates of positive results ac- cording to the allergic diseases, but the age groups were correlated with the positive results(younger than 30: 34.5%, between 30 and 50: 14.4%, older than 50: 6.8%). 2) Cat ELISA showed specific inhibition to cat fur allergen and Cat ELISA inhibition test revealed the linear dose response curve on the added amounts of cat allergn into pooled sera. 67.7% out of Torii cat fur sensitive patients(A/H ratio≥1) showed positive results in Cat ELISA for specific IgE antibody. 3) Cat fur extracts showed 15 protein bands by SDS-PAGE, then they were transferred onto nitrocellulose membrane and probed with sera of 16 cat-fur sensitive patients, one sera pool of patients with RAST class 3, and three negative controls and with biotin-conjugated anti IgE-avidin peroxidase. Six IgE binding protein bands were detected at 94, 73, 56, 44, 28 and 21 kilodalton of molecular weight. Out of six IgE binding bands, MW 21KD concerned as major cat allergen, Fel d 1, were noted in five sera(31.3% ). Conclusion: It is suggested that cat fur can be regarded as an important allergenic fur and that we need further studies to st.andardize cat antigens for in vivo and in vitro tests.

      • KCI등재

        Prevalence of Allergic Rhinitis Among Adults in Urban and Rural Areas of China: A Population-Based Cross-Sectional Survey

        Ming Zheng,Xiangdong Wang,Mingyu Bo,Kuiji Wang,Yan Zhao,Fei He,Feifei Cao,Luo Zhang,Claus Bachert 대한천식알레르기학회 2015 Allergy, Asthma & Immunology Research Vol.7 No.2

        Purpose: The aim of the present study was to compare the prevalence of self-reported and confirmable allergic rhinitis (AR) with positive skin pricktest (SPT) results among adults living in urban and rural areas of China. Methods: Adults from a community in Beijing and a village in Baoding wereselected as representative urban and rural dwellers, respectively. All eligible residents were enrolled from the population register and received aface-to-face interview using modified validated questionnaires. Equal sets of randomly selected self-reporting AR-positive and AR-negative participantswho responded to the questionnaires were also investigated using skin prick tests. Results: A total of 803 participants in the rural area and atotal of 1,499 participants in the urban area completed the questionnaires, with response rates being 75.9% and 81.5% respectively. The prevalenceof self-reported AR of the rural area (19.1%) was significantly higher than that of the urban area (13.5%). The elementary school of educational levelincreased the risk of having AR (adjusted OR=2.198, 95% CI=1.072-2.236) .The positive SPT rates among subjects with self-reported AR in therural and urban areas were 32.5% and 53.3%, respectively; the confirmable AR prevalence of 6.2% and 7.2% among the rural and urban adults, respectively. Conclusions: The prevalence of confirmable AR is similar between rural and urban areas in China, although there is a higher prevalenceof self-reported AR in the former. Purpose: The aim of the present study was to compare the prevalence of self-reported and confirmable allergic rhinitis (AR) with positive skin prick test (SPT) results among adults living in urban and rural areas of China. Methods: Adults from a community in Beijing and a village in Baoding were selected as representative urban and rural dwellers, respectively. All eligible residents were enrolled from the population register and received a face-to-face interview using modified validated questionnaires. Equal sets of randomly selected self-reporting AR-positive and AR-negative participants who responded to the questionnaires were also investigated using skin prick tests. Results: A total of 803 participants in the rural area and a total of 1,499 participants in the urban area completed the questionnaires, with response rates being 75.9% and 81.5% respectively. The prevalence of self-reported AR of the rural area (19.1%) was significantly higher than that of the urban area (13.5%). The elementary school of educational level increased the risk of having AR (adjusted OR=2.198, 95% CI=1.072-2.236) .The positive SPT rates among subjects with self-reported AR in the rural and urban areas were 32.5% and 53.3%, respectively; the confirmable AR prevalence of 6.2% and 7.2% among the rural and urban adults, respectively. Conclusions: The prevalence of confirmable AR is similar between rural and urban areas in China, although there is a higher prevalence of self-reported AR in the former.

      • KCI등재

        Variability of Offending Allergens of Allergic Rhinitis According to Age: Optimization of Skin Prick Test Allergens

        이지은,안재철,한두희,김동영,김정훈,조상헌,박흥우,이재서 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.1

        Purpose: This study evaluates offending allergens in patients with allergic rhinitis (AR) according to age that establish a minimal panel for skin prick test (SPT) allergens required to identify if a patient is sensitized. Methods: We retrospectively analyzed SPT results according to age to determine the minimum test battery panel necessary to screen at least 93%-95% of AR patients. Allergic skin tests (common airborne indoor and outdoor allergens) were performed on 7,182 patients from January 2007 to June 2011. All patients were classified into 9 groups according to age; subsequently, we investigated offending allergens by age group. Results: A total of 5,032 (70.1%) patients were found sensitized to at least one of the 55 aeroallergen extracts tested. The annual ranking of offending allergens was not significantly different from each other over the past 5 years. House dust mites (HDM) were the most prevalent allergens ranked from first to third for all 5 years. The allergens in the minimum test panel differed slightly among all age groups; in addition, the types of sensitized allergen sources were more diverse in the older versus younger age group. HDM covered a larger proportion of the sensitized allergens in the younger age group versus the older age group. Testing with 5 allergens (Dermatophagoides farinae, Tetranychus urticae, oak, mugwort and cockroach) adequately identified over 90% of the sensitized patients. Conclusions: A SPT with around 5-7 allergens adequately detected most of the sensitization in the majority of the age groups in Korea. However, this study suggests that physicians perform the SPT with appropriately selected allergens in each age category for the screening of AR.

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