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RISS 인기검색어
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- 저자 : 전동운(Dong Woon Jun) (검색결과 5 건)
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알레르기 질환 환자에서 고양이털 항원에 대한 감작을 및 고양이털의 항원성에 관한 연구
라선영(Sun Young Rha),남동호(Dong Ho Nam),김범수(Bum Soo Kim),안중배(Joong Bae Ahn),원욱희(Wook Hee Won),송현용(Hyun Yong Song),조홍근(Hong Keun Cho),전동운(Dong Woon Jun),홍천수(Chein Soo Hong) 대한내과학회 1995 대한내과학회지 Vol.48 No.3
N/A Objectives: The cat fur allergen used in skin prick test was known to be contaminated with housedust mites. So we intended to evaluate the clinical importance of cat fur as a causative allergen in patients with allergic diseases. Methods: We performed skin prick tests with cat allergen of Torii company(Japan), Bencard company (England) and home made extracts in 387 patients, We detected specific IgE by 3M FAST-plus and ELISA method using home made cat fur allergen, developed at this class. To characterize the allergenic components, cat fur extracts were fractionated by 12 % sodium dodecyl sulfate polyacrylamide gel electrophoresis(SDS-PAGE) and then transferred onto nitrocellulose membrane and probed with sera of cat fur sensitive patients Results: 1) Out of 387 patients, 77(19.9%) showed more than 1+results on skin prick test. There were no significant differences in the rates of positive results ac- cording to the allergic diseases, but the age groups were correlated with the positive results(younger than 30: 34.5%, between 30 and 50: 14.4%, older than 50: 6.8%). 2) Cat ELISA showed specific inhibition to cat fur allergen and Cat ELISA inhibition test revealed the linear dose response curve on the added amounts of cat allergn into pooled sera. 67.7% out of Torii cat fur sensitive patients(A/H ratio≥1) showed positive results in Cat ELISA for specific IgE antibody. 3) Cat fur extracts showed 15 protein bands by SDS-PAGE, then they were transferred onto nitrocellulose membrane and probed with sera of 16 cat-fur sensitive patients, one sera pool of patients with RAST class 3, and three negative controls and with biotin-conjugated anti IgE-avidin peroxidase. Six IgE binding protein bands were detected at 94, 73, 56, 44, 28 and 21 kilodalton of molecular weight. Out of six IgE binding bands, MW 21KD concerned as major cat allergen, Fel d 1, were noted in five sera(31.3% ). Conclusion: It is suggested that cat fur can be regarded as an important allergenic fur and that we need further studies to st.andardize cat antigens for in vivo and in vitro tests.
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홍천수,장길진,김응,김준명,전동운 대한감염학회 1993 감염 Vol.25 No.3
Clinical Observations were made on 46 cases of group A streptococcal bacteremia, admitted in Severance Hospital from January 1900 to June 1992. Following results were obtained. 1) In age and sex distribution, mean age was 31.7 years old and all age groups were affected. The male to female ratio was 1:1. There was seasonal variation in the prevalence with fewer cases occuring in the summer months(July-October). 2) There were 30 cases (65%) of significant bacteremia, 9 cases (20%) of transient bactermia and 7 cases(15%) of nosocomial bacteremia. And there were 35 cases(76%) of monomicrobial bacteremia and 11 cases(24%) of polymicrobial bacteremia. S. aureus was the most commonly concomitant pathogen in polymicrobial bacteremia. 3) In the clinical symtoms and signs, fever and chilling were most common. The gastrointestinal symptoms were frequently noted. There were 4 cases (9%) of cataneous symptoms. 4) All of our patients had concomitant underlying conditions : Malignant disease was most common (14 case-30%). There were 10 cases (21%) of chronic heart disease, 7 cases (15%) of chronic lung disease, 3 cases(7%) of diabetes melitus. 3 cases(7%) of liver cirrhosis, 3 cases (7%) of pregnancy, 2 cases (4%) of puerperium, and 1 case (2%) of steroid immunosuppressive therapy. And among 14 cases of malignant disease, 9 cases(64%) had solid tumors. 5) The lower respiratory tract was the commonest portal of entry (22 case-48%). There were 6 cases (13%) of hepatobiliary-gastrointestinal tract, 5 cases (11%) of female genital tract, 4 cases (9%) of skin and 1 case of infective endocarditis. We observed 7 cases (15%) of primary (cryptogenic) septicemias and the patients with primary septicemia had a lower mean age (22.2 years old) but no sexual predisposition and no difference in mortality rate. Most patients of primary septicemia had concomitant underlying deseases. 6) The mortality rate was 17%(8 cases) and septic shock/hypotension and confusion were associated with higher rates of mortality.
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연하빈맥(Deglutational Arrhythmia)의 기전과 치료에 관한 고찰;증례보고를 통해
김성순,박종석,최동훈,이천균,전동운,홍범기 대한내과학회 1996 대한내과학회지 Vol.51 No.5
Deglutition arrhythmia is a rare disease entity. We experienced atrial tachyarrhythmia associated with degllutition in a 70 year old male patient who previously underwent DC modification of AV node for the treatment of AV nodal reentrant tachycardia. Electrophysiologic study was performed to delineate the mechanism of atrial tachyarrhythmia. Also the swallowing and the esophageal ballooning reproduced clinically documented atrial tachyarrhythmia and AV nodal reentrant tachycardia. Subsequentyl patient was successfully treated with oral flecainide.
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우심실 자유벽의 거대 우종을 동반한 감염성 심내막염 1예
김진배,오성진,이승철,김원호,문용화,전동운,양주영 대한내과학회 2004 대한내과학회지 Vol.66 No.6
저자 등은 20세 여자 환자로서 10일간의 발열 및 기침을 주소로 내원하여 지역 사회 획득 폐렴으로 진단 후 치료한 후 추적관찰 중 계속하여 재발하는 임상양상을 보여 경식도 심초음파 시행, 심중격 결손 및 우심실 자유벽의 우종을 동반한 감염성 심내막염 진단하에 경험적 항생제 요법으로 성공적으로 치유한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Infective endocarditis is still one of the important fatal diseases especially when it is accompanied with systemic embolic manifestations. So, this is often misdiagnosised because of a variability of systemic embolic manifestations. We experienced a case of infective endocarditis with pulmonic embolic manifestations whose illness was initially diagnosed as recurrent pneumonia. She was a 20-yrs-old girl with ventricular septal defect and treated as community acquired pneumonia. But transesophageal echocardiography revealed a vegetation on right ventricular free wall. Son she was diagnosed as having infective endocarditis and treated effectively with appropriate antibiotic therapy and discharged with improvement of symptoms. This a first case of infective endocarditis with ventricular septal defect who have a vegetation on right ventricular free wall in korea. Therefore, we report this case with brief review of related literatures.
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