Sodium Alginate와 Cellulose 가 흰쥐의 공복 혈장 Lipoportein 조성과 콜레스테롤 대사에 미치는 영향 (I)

강희정,서명자,김은희,송영선 한국식품영양과학회 1994 한국식품영양과학회지 Vol.23 No.6

This study was carried out to determine, the effects of sodium alginate and cellulose on the plasma lipoportein composition and cholesterol metabolism inrats.Each experimental diet contained 105 sodium alginate and cellulose by weight, respectivley and rats were fed fro 4 weeks. The results obtained were as follows : The feeding of sodium alginate and cellulose decreased total plasma cholesterol slightly . total cholesterol of Chylomicron /VLDL- , LDL-fraction and liver were decreased significantly insodium alginate group. HDL-cholesterol was slightly increased in soidum alginate group. The feeding of sodium alginate significantly lowered plasma , Chylomicron VLDL-, LDL-fraction and liver TG concentrations compared with those fed fiber-free diet . The HMG-CoA reductase activity was not different among diet groups but the lowest activity was observed in sodium alginate group. The feeding of sodium alginate significantly increased fecal cholesterol , TG, and bile acid excretion . In summary , the ingestion of sodium alginate decreased cholesterol and TG concentrations of plasma and liver. This may be explained by the facts that fecal cholesterol, bile acid and TG level were increased significantly in sodium alginate group.

Sodium Alginate의 항돌연변이 및 암세포 성장억제 효과

이숙희,박건영,조은주 대한암예방학회 2006 Journal of cancer prevention Vol.11 No.2

Antimutagenic and anticarcinogenic effects of sodium alginate were studied under Ames assay and cell culture system. Sodium alginate showed strong antimutagenicity against aflatoxin B1 (AFB1) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium TA100. At 5.0% concentration, sodium alginate exhibited 65 and 58% antimutagenicity against AFB1 and MNNG, respectively. In addition, sodium alginate inhibited the growth of AGS human gastric adenocarcinoma cells and HT-29 human colon carcinoma cells. The cancer cell growth inhibitory effect of sodium alginate was stronger than that of fucoidan, the well-known anticancer compound from seaweed. In particular, the growth inhibitory effect of AGS cells was stronger than that of HT-29 cells. The growth of AGS and HT-29 cells was inhibited to 77 and 66%, respectively, by the treatment of sodium alginate 0.01%. On the other hands, sodium alginate did not affect the growth of Ac2F normal cells. It suggests that sodium alginate inhibits the growth of cancer cells selectively. The present study indicates that sodium alginate shows not only antimutagenic activity but also growth inhibitory effect on human cancer cells. (Cancer Prevention Res 11, 123-128, 2006)

용액 농도에 따른 항균성 알긴산 아연 필름의 제조 및 그 특성

이주현(Ju Hyun Lee),서혜진(Hye Jin Seo),손태원(Tae Won Son),임학상(Hak Sang Lim) 한국고분자학회 2013 폴리머 Vol.37 No.6

Alginate를 농도 별로 용액상태로 제조한 후 필름 메이커를 이용하여 필름 형태로 만든 후 3 wt%의 ZnCl2 수용액에 필름을 고화시킨 후 수세하여 60 oC의 건조기에서 약 20분 동안 건조시켜 zinc alginate 필름을 제조하였다. 필름의 특성을 조사하기 위하여 항균성 및 점도와 FTIR, TGA, SEM, EDS 및 접촉각, 인장측정, 용해도분석 등을측정하였다. 항균성 시험 결과, zinc alginate 필름에서는 두 균주(포도상구균, 폐렴간균) 모두 우수한 항균력이 나타나는 것을 확인하였다. 9 wt%의 sodium alginate로 제조한 zinc alginate 필름의 표면은 다른 농도별 필름보다 균일한 형태를 나타내었으며, ZnCl2 응고액에 잘 고화될 때 단단하고 거친 느낌의 단면 형태를 확인하였다. Zinc alginate 필름의 인장강도는 가교결합에 의해 sodium alginate 용액의 농도가 증가함에 따라 증가하였으며, 초기 열 분해 온도가 점차적으로 높아지고 있는 형태를 보였다. Zinc alginate films were prepared by a film maker from sodium alginate solutions of different weight ratios and then they solidified into 3 wt% content ZnCl2 coagulation solution and washed and dried at a 60 oC oven for 20 min. The characteristics were measured by several methods (antimicrobial activity, viscosity, FTIR, TGA, SEM, EDS, contact angle, tensile strength and solubility) and the film properties were investigated. The antimicrobial test showed that the zinc alginate films result in excellent antimicrobial activity in the two strains (Klebsiella pneumonia, Staphylococcus). The surface of zinc alginate film from the solution of 9 wt% sodium alginate showed more uniform shape than any other films and the cross-section were hard and rough when the films were well-solidified by the ZnCl2 solution. The tensile strength of zinc alginate films increased along with the concentration of sodium alginate solution due to the cross-linking,and the initial thermal decomposition temperature increased gradually.

연구논문 : 소디움 알지네이트 농도에 따른 감 칼슘 알지네이트 비드의 물리적 및 관능적 특성

용동희 ( Dong Hee Yong ),송민경 ( Min Kyung Song ),윤혜현 ( Hye Hyun Yoon ) 한국식품조리과학회(구.한국조리과학회) 2011 한국식품조리과학회지 Vol.27 No.5

The purpose of this study was to apply molecular gastronomy and spherification methodology to persimmon deserts. We prepared ``persimmon calcium alginate beads`` and investigated their physical and sensory characteristics by adding different concentrations of sodium alginate (0.4, 0.6, 0.8, and 1.0%). Lightness and yellowness decreased significantly as the concentration of sodium alginate increased. However hardness, springiness, chewiness, cohesiveness, and resilience but not adhesiveness tended to increase as the concentration of sodium alginate increased. The thickness of the beads increased as the concentration of sodium alginate increased. In contrast, the thickness of the membrane decreased as the concentration of alginate increased from 0.8 to 1.0% suggesting that the amount of sodium alginate had reached a critical point. Quantitative descriptive analysis showed that voluminosity, springiness, hardness, chewiness, and residue tended to increase as the concentration of sodium alginate increased. Overall preference reached a peak at 0.4% sodium alginate.

Chemically bound Prussian blue in sodium alginate hydrogel for enhanced removal of Cs ions

Cho, Eunbee,Kim, Jongho,Park, Chan Woo,Lee, Kune-Woo,Lee, Taek Seung Elsevier 2018 Journal of hazardous materials Vol.360 No.-

<P><B>Abstract</B></P> <P>A new approach for efficient removal of radioactive <SUP>137</SUP>Cs was developed using a sodium alginate hydrogel beads-based adsorbent containing chemically bound Prussian blue (PB). Sodium alginate was crosslinked with Fe (III) ions to form hydrogel beads, in which Fe (III) had a dual function; it served as a crosslinking agent and also led to PB formation via reaction with hexacyanoferrate. Fe (III) ions, an unusual crosslinking agent for sodium alginate gel, led to stable, homogeneous distribution of PB inside the beads. The amount of embedded PB in the composite beads was more than two times larger than in the conventional sodium alginate-PB composite beads, resulting in an adsorption capacity for Cs ions that was two to five times higher, mainly because of a higher PB contents and because of the microporosity of the sodium alginate hydrogel.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Sodium alginate beads containing chemically bound PB beads were prepared. </LI> <LI> The beads showed improved adsorption of Cs ions compared to conventional sodium alginate beads containing PB. </LI> <LI> The beads showed efficient adsorption in a fixed bed column as well as in a batch with good stability. </LI> <LI> The beads exhibited high removal efficiency toward radioactive <SUP>137</SUP>Cs. </LI> </UL> </P>

Sodium alginate–arabinoxylan composite microbeads: preparation and characterization

Munish Ahuja,Meenakshi Bhatia,Komal Saini 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.7

The objective of present study was to prepare composite microbeads of psyllium arabinoxylan and sodium alginate by ionotropic gelation method using calcium chloride as a cross linker and was further evaluated for release study. The effect of concentration of sodium alginate/arabinoxylan and concentration of calcium chloride on the entrapment efficiency and on % release were studied employing 2-factor, 3-level central composite experimental design. The results of the study revealed that interaction effect of the concentration of sodium alginate/ arabinoxylan and calcium chloride influenced the entrapment efficiency and release of diclofenac sodium significantly. The optimal calculated parameters were found to be concentration of sodium alginate/arabinoxylan-5 and concentration of calcium chloride-0.75 M, that provided microbeads with entrapment efficiency-64.4 % and release of 28.5 % of the drug over 8 h period of study. Further, arabinoxylan–sodium alginate mucoadhesive microbeads were found to sustain the release of diclofenac sodium over a period of 8 h following zero order kinetics with the mechanism of release being diffusion.

갈조류 유래 알긴산이 HepG2 간세포 독성에 미치는 영향

강남성,표석능,정다혜,손은화,장기효 한국자원식물학회 2010 한국자원식물학회지 Vol.23 No.2

갈조류 유래 alginate 성분은 간이식술에 있어서 cell microencapsulation시키는 matrix로써 임상적인 응용이 시도되고 있다. 이에 본 연구에서는 alginate의 간세포에 대한 안전성을 평가하기 위하여, 간세포를 자극하는 NO, iNOS, TGF-b1, IL-1b의 분비 및 발현량을 측정하였으며, 실험 결과 모두 증가시켰다. Alginate가 간세포를 자극하여 이러한 요소들을 증가시키는 것은 간염 및 간섬유화 등의 간질환을 일으킬 수 있다는 가능성을 제시하고 있으며, 이러한 결과는 간에 적용하는 alginate를 사용시에는 안전성이 요구되는 농도 조절 및 alginate의 자극 효과를 억제할 수 있는 새로운 재료의 첨가 등에 대한 고려를 제시할 수 있을 것으로 사료된다. Alginates are polysaccharides isolated from brown algae with gel-forming properties composed of 1,4-linked beta-D-mannuronic acid (M), alpha-L-guluronic acid (G), and alternating (MG) blocks. In this study, we have examined the toxic effects of high M-alginate to activate HepG2 human liver cells. Alginate enhanced the NO production and iNOS protein expression in HepG2 cells. In addition, alginates stimulated the HepG2 to induce IL-1 release and expression of TGF-beta1, which could influence the liver inflammation and chirrhosis. These findings suggest that high M-alginate form brown algae may have toxic effects on liver cells.

이온 가교에 의한 수용성 알긴산나트륨의 경화와 염 수용액에 의한 이의 재용해에 관한 연구

이승한,이지헌,채하늘,민병길 한국섬유공학회 2021 한국섬유공학회지 Vol.58 No.2

In this work, the insolubilization of water-soluble sodium alginate, which is a representativebiomass natural polymer, was investigated for various purposes, including coatingson paper cups. It was observed that sodium alginate could be insolubilized well incalcium chloride by formation of ionic crosslinks through replacement of Na+ ions withCa2+ ions on a block of L-guluronic acid of alginate to form calcium alginate. Water-insolubilizationof alginate is a critical prerequisite for the coatings on cups to retain water. However,the calcium alginate coating needs to undergo re-dissolution in water to enablerecycling of the paper cups after use. It was observed that calcium alginate could be easilyre-dissolved in a specific aqueous salt solution containing disodium phosphate (Na2HPO4). The re-dissolution of calcium alginate was confirmed by scanning electron microscopy andenergy-dispersive X-ray spectroscopy (EDS). The process developed in this study isexpected to be used for various eco-friendly applications without the need to use organicsolvents.

Influence of hydrophilic polymers on functional properties and wound healing efficacy of hydrocolloid based wound dressings

( Sung Giu Jin ),( Abid Mehmood Yousaf ),( Kyeong Soo Kim ),( Dong Wuk Kim ),( Dong Shik Kim ),( Jin Ki Kim ),( Chul Soon Yong ),( Yu Seok Youn ),( Jong Oh Kim ),( Han Gon Choi ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-

The purpose of this study was to investigate the influence of different hydrophilic polymers on the swelling, bioadhesion and mechanical strength of hydrocolloid wound dressings (HCDs) in order to provide an appropriate composition for a hydrocolloid wound dressing system. In this study, the HCDs were prepared with styrene-isoprene-styrene copolymer (SIS) and polyisobutylene (PIB) as the base using a hot melting method. Additionally, numerous SISIPIB-based HCDs were prepared with six hydrophilic polymers, and their wound dressing properties were assessed. Finally, the wound healing efficacy of the selected formulations was compared to a commercial wound dressing. The swelling ratio, bioadhesive force and mechanical strengths of HCDs were increased in the order of sodium alginate> sodium CMC = poloxamer = HPMC > PYA = PVP, sodium alginate> sodium CMC = poloxamer > PYA> HPMC = PVP and sodium alginate > PYA >PVP = HPMC = sodium CMC> poloxarmer, respectively. Among the hydrophilic polymers tested, sodium alginate most enhanced the swelling capacity, bioadhesive force and mechanical strengths. Thus, the hydrophilic polymers played great role in the swelling, bioadhesion and mechanical strength of SISIPIB-based HCDs. The HCD formulation composed of PIB, SIS, liquid paraffin and sodium alginate at the weight ratio of 20/25/12/43 gave better wound dressing properties and more excellent wound healing efficacy than the commercial wound dressing. Therefore, the novel HCD formulation could be a promising hydrocolloid system for wound dressings.

Sodium Alginate Bead-biochar 복합체 제조 및 수중의 납 이온 제거

박유진 ( Yu-jin Park ),이수림 ( Su-lim Lee ),이재훈 ( Jae-hoon Lee ),노준석 ( Jun-suk Rho ),최아영 ( Ah-young Choi ),김신실 ( Sin-sil Kim ),이슬린 ( Seul-rin Lee ),박종환 ( Jong-hwan Park ),서동철 ( Dong-cheol Seo ) 한국환경농학회 2022 한국환경농학회 학술대회집 Vol.2022 No.-

산업 폐수(배터리, 전기 도금, 염료 및 안료)를 통해 방류되는 중금속은 인간에게 각종 질병을 유발할 수 있으며, 특히 납은 생체 내에 쉽게 축적되고 저농도임에도 납 중독 등 치명적인 질병을 유발한다. 납과 같은 중금속을 제거하기 위한 다양한 공정들이 연구되어 왔으며, 이 중 흡착 공정이 중금속 제거에 효율적이고 경제적인 공정으로 알려졌다. 이에 최근 탄소소재인 Biochar를 활용한 중금속 처리가 대두되고 있지만, 비산이나 2차 오염 등의 문제가 있어 Alginate 등을 활용한 생물흡착 공정과 연계가 제시되고 있다. 따라서 본 연구에서는 Sodium alginate와 바이오매스 전소발전소에서 배출된 바이오차를 이용하여 흡착량과 회수율을 높인 Sodium alginate bead-biochar 복합체(SAB-B)를 제조하고 수중의 납 이온을 제거하는 흡착제로서 성능을 평가하고자 하였다. 바이오차 첨가량에 따른 SAB-B의 수중 납 이온 흡착량을 알아보기 위해 바이오차를 1, 2.5 및 5% 첨가하여 SAB-B를 제조하고 Pb 용액을 농도별로 주입하여 등온흡착실험을 진행하였다. Langmuir 흡착 모델과의 높은 적합성을 가졌으며, 최대 흡착능(a)은 28.736 mg/g(2.5% SAB-B), 26.667 mg/g(1% SAB-B), 21.692 mg/g(SAB), 19.920 mg/g(5% SAB-B) 순으로 높았다. SAB-B 투입량에 따른 수중 납 이온 제거효율을 알아보기 위해 0.1, 0.5 및 1g을 투입하여 흡착하였다. 1g을 투입하였을 때 가장 높은 제거효율을 보였다. 앞선 흡착실험에서 가장 높은 흡착능을 가졌던 2.5% SAB-B의 반응시간에 따른 수중 납 이온 흡착량을 알아보기 위해 동적흡착실험을 진행하였다. 반응시간 8시간까지 급격히 증가하였으며, Pseudo-second order 모델과의 적합성을 가졌다. 납 이온용액의 pH에 따른 2.5% SAB-B의 흡착량을 알아보고자 납 이온 용액을 pH 3, 4, 4.5, 5 및 5.5로 조절하여 흡착한 결과 pH 4에서 5.5까지 비슷한 흡착량을 보였다. 이와 같은 결과들을 통해 SAB-B는 수중의 납 이온을 제거하는 흡착제로서 활용할 수 있을 것이라고 판단된다. 하지만, 납을 흡착한 Sodium alginate bead-biochar 복합체를 지속적으로 사용하기 위해서는 추가적인 실험이 수행되어야 할 필요가 있다.