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Effect of Dendritic Cells Treated with CpG ODN on Atopic Dermatitis of Nc/Nga mice
Park, Sang-Tae,Kim, Kyoung-Eun,Na, Kwang-Min,Kim, Young-Hwa,Kim, Tae-Yoon Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.4
Atopic dermatitis (AD) is a chronic inflammatory skin disease and the pathogenesis of AD is associated with the release of various cytokines/chemokines due to activated $Th_2$ immune responses. Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG dinucleotide in the context of particular base sequence (CpG motifs) are known to have the immunostimulatory activities in mice and to convert from Th2 to Th1 immune responses in AD. We aimed to investigate that CpG ODN, especially phosphodiester form, can stimulate the protective immunity in NC/Nga mice with AD. We isolated BMDCs from NC/Nga mice and then, cultured with GM-CSF and IL-4 for 6 days, and treated for 2 days by either phosphorothioate ODN or phosphodiester ODN. CpG ODN-treated DCs resulted in more production of IL-12. When CpG ODN-treated DCs were intravenously injected into the NC/Nga mice, the NC/Nga mice with CpG ODN-treated DCs showed significant improvement of AD symptoms and decrease of IgE level. Histopathologically, the NC/Nga mice skin with CpG ODN-treated DCs showed the decreased IL-4 and TARC expression comparing with non-injected mice. These results may suggest that phosphodiester CpG ODN-treated DCs might function as a potent adjuvant for AD in a mouse model.
The effects of essential oil of Chamaecyparis Obtuse impregnant fabric for atopic dermatitis
( Kwang Ho Yoo ),( Chang Kwun Hong ),( Tae Rin Kwon ),( Myeung Nam Kim ),( Hee Su Kim ),( Dong Sik Bang ),( Beom Joon Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: The essential oil of Chamaecyparis obtuse (EOCO) has been used as an alternative treatment modality for allergy-related diseases due to their immune modulating activity. Textiles have the longest and most intense con〓tact with the human skin, and functional textiles with intrinsic properties such as anti-oxidative and anti-microbial activities have been gaining importance in medical applications. Specially designed textiles may support AD treatment and may improve the quality of life of AD patients.Objectives: Here, the effect of EOCO delivered through fabric on AD was investigated using NC/Nga mice as animal models. Methods: The fabric was applied 6 hours a day for 14 days in the experimental group. Results: The EOCO group had a significantly reduced modified SCORAD score, TEWL and serum IgE. Amongthe inflammatory cytokines analyzed, only the mean values of RANTES (regulated on activation, normal T cell expressed and secreted) were detected as low compared with the other control groups. And histological analysis of the skin also revealed that EOCO group reducedepidermal hyperplasia (thickness measurement, p<0.05) with recovery of the protein expression of filaggrin, involucrin and loricrin. Conclusion: It was confirmed that EOCO fabric has anti-atopic and anti-inflammatory activity. Based on the study data, it is suggested that EOCO fabric may be useful as an alternative functional textile for people suffering from AD.