마우스모델을 이용한 황산아연 및 염화아연의 발모 효과

민명자,최문희,신현재 대한피부미용학회 2015 대한피부미용학회지 Vol.13 No.4

Hair medically helps to protect scalp, maintain body temperature, emit heavy metals and so on. Aesthetically, while, it is important to express ones confidence through beautiful decoration of its style. Recently, therefore, hair loss and/or alopecia have received a lot of attention from the public as well as medical doctors and scientists. In order to treat alopecia and to improve the hair loss symptoms, many compounds have been tried to be included in hair tonics and remedy. This study considers if there are any connection between the zinc known as essential trace elements and the hair growth. through mouse experiments (C57BL/6). The effect of zinc sulfate and zinc chloride on the hair growth of mouse model has been investigated by visual observation (in terms of hair growth score) and histological section analysis. The experiment was conducted over a total of 6 weeks after depilating the dorsum of the C57BL/6 mice hair. No treatment and tonic water groups were negative controls and 3% minoxidil a positive control. Zinc solutions were mixed by the final concentration of 20 ppm ZnSO4 and ZnCl2 with a tonic water. Comparison of hair growth in C57BL/6 mice dorsum was done after application of 2 mL zinc solutions. Experimental results were as follows: 3% minoxidil > ZnSO4 > tonic water > no treatment > ZnCl2 groups. Experimental skin tissue was cut in a transverse plane in order to analyze a morphological change in five weeks. As the result, the hair follicles and hair growth condition, hair papilla and hair root well-developed were observed. This result showed that the coated zinc solution on the skin has been absorbed in hair follicles, induces the production of the capillary, and increases in the melanin pigment cells related to enable the hair-growth by having influence on growth hormones around the hair follicle. If the experiment were carried out with a further more in-depth research such as the additional clinical trial, the potential of zinc would be considered as a therapeutic agent for alopecia.

샴푸의 모발 손상에 대한 코아세르베이트 시스템의 영향

손성길 ( Seong Kil Son ),김시원 ( See Won Kim ),박무경 ( Moo Kyung Park ),송상훈 ( Sang-hun Song ),박수진 ( Su Jin Park ),황성록 ( Seong-lok Hwang ),이상민 ( Sang Min Lee ) 대한화장품학회 2018 대한화장품학회지 Vol.44 No.2

코아세르베이트의 구조는 모발의 침착에 매우 큰 영향을 줄 수 있다. 본 연구의 목적은 모발의 표면 성질과 모발 손상에 미치는 영향에 대해 상대적으로 미세하고 균일한 구조를 갖는 코아세르베이트의 효과를 조사하였다. 본 연구에서는 10% 농도로 희석한 샴푸 용액에서 크기가 다른 코아세르베이트를 탐구하였다. 하나의 용액은 입자의 크기가 균일하지 않은 코아세르베이트(평균 10 - 300 μm)를 함유하고, 다른 용액은 미세하고 균일 한 구조(평균 1 - 3 μm)의 코아세르베이트를 형성하였다. 샴푸가 모발의 물리적 성질과 모발 손상에 미치는 영향을 연구하기 위해 두 종류의 샴푸를 사용하여 모발 파괴 특성, 색 변화, 마찰 특성, 지질 함량 및 모발 표면을 조사하였다. 결과는 상대적으로 미세하고 균일한 크기의 코아세르베이트가 모발 표면에 고르게 침착되었음을 명확하게 보여주었다. 결과적으로, 코아세르베이트 계는 모발 마찰, 파손 특성 및 색상과 같은 모발의 표면 성질에 실질적으로 영향을 미칠 수 있다. 마찰력 역시 크게 감소하였다. 미세하고 균일 한 크기의 코아세르베이트의 사용은 현저하게 모발 표면 특성을 향상시킬 수 있다. 결론적으로, 모발 파괴가 감소하였고 코아세르베이트의 모발 손상에 대한 영향은 현저하게 높았다. The structure of the coacervate can dramatically influence deposition on the hair. The purpose of this study was to investigate the effect of coacervate with a relatively fine and uniform structure on the surface properties of hair and its influence on hair damage. In this study, coacervates of different sizes were explored in 10% shampoo solutions; one solution contained coacervates with non-uniform sizes (10 - 300 μm average), and the other solution formed a coacervate with a fine and uniform (1 - 3 μm) structure. To study the effect of shampoo on the physical properties of hair and damage to the hair, the hair breakage characteristics, color changes, friction properties, lipid contents and hair surface were examined after using two different types of shampoo. The results clearly show that the relatively fine and uniformly sized coacervate was evenly deposited over the surface of the hair. As a result, the coacervate system can substantially influence the surface properties of the hair such as hair friction, breakage characteristics, and color. The frictional force was dramatically reduced. The use of a fine and uniformly sized coacervate can notably improve hair surface properties. Consequently, hair breakage decreased, and the effect of the coacervate on hair damage was remarkably high.

신체적 헤어스타일 결정요인과 유행하는 헤어스타일 모방수준의 관련성 연구

홍성희,당수민 한국피부과학연구원 2013 대한피부미용학회지 Vol.11 No.6

This article aims at introducing the need to the most impressive hair-style and offering research dataof preparing the basis of customer satisfaction and a business strategy, as finding the way to decideher hair-style depending on her body type and the effect on it for adult female. The subject of studywere 400 adult-females who are in Daegu-gyeongbuk, it was examined from the 1st of May to 30thof June, 2010 through the self-administered questionnaire. The results of study are as follows: Therewere the effect of the hair form on the decision of hair-style in the 5factors such as how much sheconcern herself about a trendy hair-style, how much frequency she follows a trendy hair-style generally,how much effect of a trendy hair-style there are in the decision of her own hair-style, how much shetalks to others about a trendy hair-style and how much she will imitate a trendy hair-style in the future. When put together the results above, this article found that women select their own hair-style depending ontheir hair form, and there were a wide range in the decision level of a hair-style, considering their various hairform and they were into it as well. So it needs to offer the information for deciding a hair-style to learn a basicknowledge that needs to decide the most idealistic hair-style, and to offer a service including the cheap pricesand the systematic hair management system considering women’s attributes.

탈색모발에 콜드 펌 시술 시 케라틴 전처리 적용이 모발 손상 개선에 미치는 효과

곽은주,이재남 대한미용학회 2022 대한미용학회지 Vol.18 No.3

Hair bleaching and permanent wave (perm) have been popular as methods for making women look more beautiful. However, repeated chemical treatments result in hair damage. Therefore, this study attempted to examine the effects of keratin pretreatment on damaged hair before performing a cysteamine cold perm on bleached hair. Hair was divided into three groups: DKC (no keratin pretreatment applied), DKC1(50% keratin pretreatment applied), and DKC2 (100% keratin pretreatment applied). Analysis of the collected data was based on hair gloss, tensile strength, wave formation efficiency, methylene blue absorbance, hair thickness measurement (FE-SEM), and cuticle thickness measurement (FE-SEM); the results were as follows: In the DKC1 and DKC2 groups, hair gloss, tensile strength, and hair thickness (top, bottom) showed a statistically significant increase while methylene blue absorbance was significantly decreased, demonstrating damaged hair-repairing effects. On the contrary, wave formation efficiency decreased in the DKC1 and DKC2 groups, however an elastic wave was formed. In sum, it would be reasonable to conclude that keratin pretreatment is helpful in repairing damaged hair with hair protection effects.

8 레벨 탈색모에 대한 블루베리 추출물의 염색과 모발보호 효과

장미여 ( Mi-year Jang ),박은준 ( Eun-jun Park ),김기영 ( Ki-young Kim ) 한국미용학회 2017 한국미용학회지 Vol.23 No.5

Hair dyes are used to change hair color. In this study, the effect of coloring and hair protection from blueberry extract were investigated in 5 and 8 level bleached hair. The virgin hair was collected and divided into 9 pieces. 8 Pieces were bleached, and 7 pieces of them were dyed with oxidized hairdye, blueberry under acid or alkali condition. The hair was measured color (lightness, redness, yellowness), thickness and tensile strength, and morphological change of hair cuticles was observed before and after shampoo. In the results, 8 level bleached hair is better the dyeing effect than 5 level bleached hair. The oxidized hairdye treated hair was red violet, the blueberry acid was deep violet and the blueberry alkali was dark bluish violet in 8 level. The oxidized hairdye, the blueberry acid, and the blueberry alkali had weak change of the similar lightness, redness, and yellowness after 30 times shampoo in compared with before shampoo. The lowest color change had observed in the blueberry alkali treated hair pieces after 30 times shampoo so it had the excellent dyeing sustainability. Thicker hair diameter and stronger tensile strength were in the blueberry acid and the blueberry alkali treated hair than in oxidized hairdye treated hair. The damage of hair cuticle such as chipped off, floating was weaker in the blueberry acid and alkali treated hair than in the oxidized hairdye treated hair. In conclusion, the blueberry extract has a good effect of hair coloring and protection and may be useful for natural hairdye.

건강증진 중재프로그램 적용에 따른 두피와 모발건강 효과 분석

정인심 ( In-sim Jeong ),박길순 ( Kil-soon Park ) 한국미용학회 2017 한국미용학회지 Vol.23 No.4

Today, 1 out of 5 adults are suffering from hair loss and the number of patients getting treated for hair loss are on the rise. Hair loss requires steady interests and treatments but many people use wrong treatment method hoping for quick recovery and misses optimum treatment time. This research applied health promotion intervention program to such 24 male adults and the result are as follows. First, according to analysis on difference of health of scalp and hair perceived by intervention program, as the program progressed, they moved to stage of practice which were stage of action and stage of management and score on health of scalp(p=.000), health of hair(p=.047) and habit of management(p=.000) were high. Secondly, all scalps applied with intervention program were normal scalps but had strong skin oil level so they needed steady inner and outer management. After looking at hair density, 23 test subjects out of 24 gained normal density. and 23 had normal pore which meant healthy scalp. Also, in order to measure health of hair, damage level of hair was measured and it turned out that all test subjects gained healthy hair. The thickness of hair before and after intervention program were compared and measured and it was shown that hair became thicker after the program in effect with (p=.000) difference. As shown, health of scalp and hair improved after applying intervention program which also increased awareness and improved management habit for health of scalp and hair. This shows that intervention program was definitely effective. This conclusion is considered to provide aid to health of people all over the nation and contribute to marketing strategy and studies in beauty industry. However, there is a little sense of regret because all test subjects were male and we hope that the research will continue in the future with female subjects as well.

In vivo and In vitro hair growth promotion effects of extract from Glycine soja Siebold et Zucc

( Jae Chan Yang ),( Bo Ae Kim ) 한국응용생명화학회 2016 Journal of Applied Biological Chemistry (J. Appl. Vol.59 No.2

Hair is a dermal adjunctive organ that protects the body from external physical and chemical stimuli; hair undergoes anagen, catagen, and telogen phases, with hair-loss occurring during the telogen phase. Alopecia is a condition wherein a person undergoes hair-loss far exceeding the normal amount, owing to diverse external factors. Wild beans are rich in isoflavone and amino acids known to prevent hair-loss; compared to cultivated beans, many wild bean species have higher protein content. This study aimed to develop a hair growth promoting solution, with superior hair growth promoting effects and fewer side effects, using naturally obtained Glycine soja Siebold et Zucc (GSSZ) extracts. Sevenweek- old C57BL/6N male mice were classified into different experimental groups. Hair growth was observed in GSSZ-treated mice, and compared against that seen in 3 % minoxidil (MXD, positive control)-treated mice. Visual observations revealed a greater reduction in hair-loss in MXD and GSSZ application groups, compared to that in TXN group (hair loss induction using 1 % testosterone). Evaluation using an image analysis software revealed that compared to the positive control, TXN + GSSZ group showed the highest hair growth. TXN + MXD and control groups exhibited similar follicular cell growth, while the hair growth promotion patterns were similar in the negative control (normal), TXN + GSSZ, and TXN groups, as observed via histological analysis. GSSZ did not induce cytotoxicity (even at 2 mg/mL) in keratinocytes and dermal papilla cells; alternately, dermal papilla cell proliferation was activated in a (GSSZ) concentration-dependent manner. Therefore, the GSSZ extract promoted hair growth and increased hair growth-related cell activity, and could therefore be utilized in alopecia treatment.

염모제의 성분 특성 및 사용횟수에 따른 모발손상도 연구

김경진(Gyeung-Jin Kim),강민숙(Min-Sook Kang),문덕환(Deog-Hwan Moon) 한국인체미용예술학회 2011 한국인체미용예술학회지 Vol.12 No.4

This study was conducted to assess the level of hair damage according to type of hair dye components used and to prepare fundamental data for promoting healthy hair. Samples came from a 14-year-old girl whose hair had never been dyed. It was cut into 20cm lengths at a point 5㎝ away from the scalp. Each sample weighed 2g. The hair samples were dyed once, twice, and three times with eight kinds of hair dyes and dried naturally. The cuticles were observed with SEM to examine hair damage. To evaluate the damage of hair observed with SEM, 5 levels of damage were classified. Ten professors of hairdressing in the Department of Cosmetology evaluated the samples. There were significant differences in hair damage according to the number of times the hair was dyed. The level of damage was greatest in hair dyed with chemical henna and lowest in hair dyed with the squid ink.

한국인 머리채 평가

박진 ( Jin Park ),임철완 ( Chull Wan Ihm ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.1

Background: Hair researchers in medical science have focused on the biology of a hair, but the general population and the patients with alopecia are concerned about their total external hair mass or the hair volume of the head. There have been many reported papers on hair, yet it is difficult to find papers that have evaluated the total hair mass of the head of normal persons. Objective: We wanted to assess the total scalp hair mass and its parameters by which the hair mass is made. Methods: For 42 volunteers (22 males and 20 females, age range: 23 to 31 years old), the volume of total scalp hair mass was assessed by its total number of hairs, its density and the diameter of the hair via a unit area trichogram with performing dermoscopy and light microscopy. The proportions of terminal/intermediate/vellus hair, the anagen/non-anagen ratio and the growth rate of the scalp hairs were also assessed. The correlations of the hair length and the diameter were measured for 603 hairs taken from 14 alopecia areata patients only when they showed regrowth of normal hair. Results: The results are summarized as follows. The total number of scalp hairs was 112,000 (males: 116,000, females: 106,000) with no statistical difference between genders. The average size of the scalp was 694.4 cm2 (727.4 cm2 in males and 658.0 cm2 in females) with a statistically larger size for the males. The average scalp hair density of the males and females was 159.7/cm2 (153.0/cm2 at the temporal area (T) and 166.5/cm2 at the parieto-occipital area (PO)) with no statistical difference according to gender. The average diameter of the scalp hair was 87.0μm: 84.9μm (86.0μm in males and 83.6μm in females) in the T and 89.0μm (89.4μm in males and 88.5μm in females) in the PO with no statistical difference according to the area of the scalp area or gender. The proportions of terminal/intermediate/vellus hair (%) were 86.5/8.8/4.7 and the proportions of anagen/non-anagen (%) hairs were 89.6%/10.4% with no statistical difference according to the area of the scalp area or gender. The time for new hair to emerge on the surface of the scalp after epilation was about 68.5 days with no statistical difference according to the area of the scalp or gender. After the hair emerged on the skin surface, the average growth rate for the first 1 month was 0.172 mm/day and 0.248 mm/day during the following month, and 0.35 mm/day thereafter. It took about 4 months for the newly emerging hair to reach 1 cm from the scalp surface. The correlation between the length and diameter of hair with assessing 603 hairs of the 14 alopecia areata patients in their recovery phase was as follows: the hair less than 10 mm in length showed a diameter of 20∼40μm. It reached 60μm when the hair grew up to 18 mm in length. The diameter reached around 87μm when the length of the hair exceeded 35 mm and then the diameter kept its value. Conclusion: We numerically measured the various parameters of the hair mass of the head of normal Koreans in their twenties. (Korean J Dermatol 2010;48(1):17∼25)

반복 염색 시 케라틴 콜라겐 전처리와 헤어클리닉 후처리의 모발 성상 변화에 대한 연구

김종선 ( Jong-sun Kim ),박은준 ( Eun-jun Pack ) 한국미용학회 2019 한국미용학회지 Vol.25 No.3

The hair color maximizes the image of an individual by emphasizing the characteristics and personality of the individual. But the chemical treatment such as perm and dyeing damages the hair. In this study, keratin and collagen were pretreated before dyeing hair to reduce the hair damage when applying the chemical treatment applying the hair clinic as a post-treatment after dyeing, the hair was dyed from once to three times; and in order to check out the residual amount for the pre- and post-treatments, after conducing 30 Shampoos, the hair thickness, amino acid, and cuticles in the groups of pre- and post-treatments were histologically analyzed. In case of the pretreatment group, due to the addition of protein, the hair thickness became thicker and the total amount of amino acids increased. However, as the damage progressed through the repetitive dyeing, the difference became larger and the elution quality of the total amount of amino acid became eluted about 10 times more; and the difference in the number of the cuticle layer from the post-treatment group was identified. In the post-treatment group, the hair thickness and total amount of amino acids did not increase. However, as the damage progressed repeatedly, the total amount of amino acids in the pre-treatment group were eluted about 10 times less than that in the post-treatment. Therefore, pre- treatment helps to recover the inside of the hair, and post - treatment helps to prevent internal damage.