Tissue-specific expression of the NOD-like receptor protein 3 in BALB/c mice

Zhiqiang Huang,Meng Yu,Shuang Tong,Kun Jia,Rongchang Liu,Heng Wang,Shou-Jun Li,Zhang-Yong Ning 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.2

Activation of the innate immune system requires recognitionof pathogen-associated molecular patterns, such as NOD-likereceptors. The NOD-like receptor protein 3 (NLRP3)inflammasome is involved in induction of the proinflammatorycytokine, IL-1β, and subsequent inflammatoryresponses. NLRP3 inflammasome plays important roles in theinflammatory and innate immune responses associated withautoimmune/inflammatory syndrome. However, analysis of thetissue distribution and expression profiles in BALB/c mice is stillincomplete. In this study, we investigated the tissue distributionand expression pattern of NLRP3 in BALB/c mice to furtherelucidate its function in innate immunity in this commonly usedlaboratory animal model. NLRP3 mRNA expression levels andtissue distribution of the protein were investigated by real-timequantitative PCR and immunohistochemical analyses,respectively. NLRP3 mRNA expression was higher in thekidney and inguinal lymph nodes than in other tissues. Cytoplasmic expression of NLRP3 was detected in the epithelialreticular cells of the spleen and thymus, lymphocytes in theinguinal lymph nodes, cardiac muscle cells, cerebral cortexneurons, alveolar macrophages, renal tubule cells and liversinusoidal endothelial cells. The results of this study will assistinvestigators in interpreting site-specific functions and roles ofNLRP3 in inflammatory responses.

Risk Factors of Postoperative Cerebrospinal Fluid Leak After Craniovertebral Junction Anomalies Surgery: A Case-Control Study

Yu Xiao,Bing Wang,Yulian Chen,Lingqiang Chen,Zhenkai Lou,Zhiqiang Gong 대한척추신경외과학회 2023 Neurospine Vol.20 No.1

Objective: To identify potential risk factors for cerebrospinal fluid (CSF) leakage after craniovertebral junction (CVJ) anomaly surgery and to provide a reference for clinical practice. Methods: Sixty-six patients who underwent elective CVJ anomaly surgery during a 6-year period (April 2013 to September 2019) were retrospectively included. Research data were collected from the patients’ medical records and imaging systems. Patients were divided into CSF leak and no CSF leak groups. Univariate tests were performed to identify potential risk factors. For statistically significant variables in the univariate tests, a logistic regression test was used to identify independent risk factors for CSF leakage. Results: The overall prevalence of CSF leakage was 13.64%. Univariate tests showed that a basion-dental interval (BDI) > 10 mm and occipitalized atlas had significant intergroup differences (p < 0.05). Multivariate analysis indicated that a BDI > 10 mm was an independent risk factor for CSF leakage, and patients with CVJ anomalies with a BDI > 10 mm were more likely to have postoperative CSF leaks (odds ratio, 14.67; 95% confidence interval, 1.48–30.88; p = 0.004). Conclusion: It is necessary to maintain vigilance during CVJ anomaly surgery in patients with a preoperative BDI > 10 mm to avoid postoperative CSF leaks.

Damaged and failure characterization of 7075-T6 Al alloy based on GISSMO model

Zhiqiang Zhang,Yuejie Cui,Ge Yu 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.3

Failure simulation of 7075-T6 Al alloy is very important due to its relatively low ductility compared to conventional steel. A hybrid numerical-experimental method was developed to determine plastic strains at fracture as a function of triaxiality. The uniaxial tension tests were performed by using the specimens including pure shear, 45° shear, smooth, R5 notch and R15 notch. The fracture locus was established by calibrating the parameters of the Hosford-Coulomb fracture model and was implemented into the GISSMO damage model. The results showed that the predicted force-displacement data were in good agreement with the experimental results. The results of the mesh dependence showed that the mesh size in the range of 0.5-5 mm did not have much influence on the damage results. To assess the accuracy of the damage model, three-point bending tests of the anti-collision beam were performed. The calibrated GISSMO damage model could accurately predict the load-displacement data.

Improved Method for Calculating Armature-Reaction Field of Surface-Mounted Permanent Magnet Machines Accounting for Opening Slots

Yu Zhou,Huaishu Li,Qingyu Wang,Zhiqiang Xue,Qing Cao,Shi Zhou 대한전기학회 2015 Journal of Electrical Engineering & Technology Vol.10 No.4

This paper presented an improved analytical method for calculating armature-reaction field in the surface-mounted permanent magnet machines accounting for opening slots. The analytical model is divided into two types of subdomains. The current of the armature is centralized in the center of the slots. The field solution of each subdomain is obtained by applying the interface and boundary conditions of the model. Two 30-pole/36-slot prototype machines with different slot-opening width are used for validation. The FE (finite element) results confirm the validity of the analytical results with the proposed model. The investigation shows that the wider the slot-opening width is, the smaller the peak value of radial and circumferential components of flux density, and the analytical armaturereaction field produced by centralized current in the slots is similar with the armature-reaction field produced by distributed current in the slots in the FE.

Improved Method for Calculating Armature-Reaction Field of Surface-Mounted Permanent Magnet Machines Accounting for Opening Slots

Zhou, Yu,Li, Huaishu,Wang, Qingyu,Xue, Zhiqiang,Cao, Qing,Zhou, Shi The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.4

This paper presented an improved analytical method for calculating armature-reaction field in the surface-mounted permanent magnet machines accounting for opening slots. The analytical model is divided into two types of subdomains. The current of the armature is centralized in the center of the slots. The field solution of each subdomain is obtained by applying the interface and boundary conditions of the model. Two 30-pole/36-slot prototype machines with different slot-opening width are used for validation. The FE (finite element) results confirm the validity of the analytical results with the proposed model. The investigation shows that the wider the slot-opening width is, the smaller the peak value of radial and circumferential components of flux density, and the analytical armature-reaction field produced by centralized current in the slots is similar with the armature-reaction field produced by distributed current in the slots in the FE.

A wireless decentralized control experimental platform for vibration control of civil structures

Yan Yu,Luyu Li,Xiaozhi Leng,Gangbing Song,Zhiqiang Liu,Jinping Ou 국제구조공학회 2017 Smart Structures and Systems, An International Jou Vol.19 No.1

Considerable achievements in developing structural regulators as an important method for vibration control have been made over the last few decades. The use of large quantities of cables in traditional wired control systems to connect sensors, controllers, and actuators makes the structural regulators complicated and expensive. A wireless decentralized control experimental platform based on Wi-Fi unit is designed and implemented in this study. Centralized and decentralized control strategies as sample controllers are employed in this control system. An optimal control algorithm based on Kalman estimator is embedded in the dSPACE controller and the DSP controller. To examine the performance of this control scheme, a three-story steel structure is developed with active mass dampers installed on each floor as the wireless communication platform. Experimental results show that the wireless decentralized control exhibits good control performance and has various potential applications in industrial control systems. The proposed experimental system may become a benchmark platform for the validation of the corresponding wireless control algorithm.

Research on Dynamic Pressure of Hydrostatic Thrust Bearing Under the Different Recess Depth and Rotating Velocity

Xiaodong Yu,Zhiqiang Wang,Xiuli Meng,Huanhuan Li,Dan Liu,Xu Fu,Bo Wu,Li Tan,Bai Qin,Xuezhe Dong 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.2

Thickness-dependent reversible hydrogenation of graphene layers.

Luo, Zhiqiang,Yu, Ting,Kim, Ki-Jeong,Ni, Zhenhua,You, Yumeng,Lim, Sanhua,Shen, Zexiang,Wang, Shanzhong,Lin, Jianyi American Chemical Society 2009 ACS NANO Vol.3 No.7

<P>In this work, graphene layers on SiO(2)/Si substrate have been chemically decorated by radio frequency hydrogen plasma. Hydrogen coverage investigation by Raman spectroscopy and micro-X-ray photoelectron spectroscopy characterization demonstrates that the hydrogenation of single layer graphene on SiO(2)/Si substrate is much less feasible than that of bilayer and multilayer graphene. Both the hydrogenation and dehydrogenation process of the graphene layers are controlled by the corresponding energy barriers, which show significant dependence on the number of layers. The extent of decorated carbon atoms in graphene layers can be manipulated reversibly up to the saturation coverage, which facilitates engineering of chemically decorated graphene with various functional groups via plasma techniques.</P>

Using SiNx double-layer deposition to reduce electrode incidence of short circuits due to impurity particles in thin film transistor preparation

Zhao Shuo,Yu Xiang,Pei Jingxuan,Yang Lei,Zhang Zhiqiang,Zhang Pingping 한국물리학회 2023 Current Applied Physics Vol.48 No.-

Aviation safety relies on accurate scope presentation of air navigation displays, and lack of display information due to poor dot line may cause the pilot to misjudge the air conditions. Impurity particles occurred during preparing thin film transistor (TFT) circuit may be a leading reason for poor dot line. This work attempts to replace existing SiNx single-layer deposition with double-layer, so that the incidence risk can be lower through reducing number and size of the impurity particles. Double-layer deposition approach has the dot line structures and performances to that of single-layer, and can meet the requirements of display usage. Results of field test demonstrate that double-layer deposition reduces defect rate of display more efficient than single-layer. Proposed mechanism of double-layer deposition illuminates that 2nd-SiNx can cover holes generated by falling impurity particles to avoid short circuits in both indium tin oxide (ITO) and source-drain (SD) contact.

Lactic acid bacterial inoculant effects on the vitamin content of alfalfa and Chinese leymus silage

Tingting Jia,Zhiqiang Sun,Run Gao,Zhu Yu 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.12

Objective: Information regarding the vitamin content of silage is limited. This study investigated the changes in the vitamin content of alfalfa and Chinese leymus silages with or without a lactic acid bacterial inoculant. Methods: Alfalfa at the early flowering stage and Chinese leymus at the full-bloom stage were harvested. The treatments for each forage type were control (deionized water only) and 1×106 colony-forming units Lactobacillus plantarum (LP)/g fresh matter. After 45 days of ensiling, all silages were sampled for evaluating the vitamin content, fermentation quality and chemical composition. Results: The LP inoculant decreased the pH value and ammonia nitrogen content of the alfalfa and Chinese leymus silages and significantly (p<0.05) increased the lactic acid, acetic acid concentrations and Flieg’s points. Prior to ensiling, the levels of five B-group vitamins (thiamin, riboflavin, niacin, pantothenic acid, and pyridoxine) and α-tocopherol in alfalfa were significantly (p<0.01) higher than those in Chinese leymus. Ensiling decreased the levels of the five B-group vitamins in both alfalfa and Chinese leymus while increasing the α-tocopherol content of Chinese leymus. The thiamin, riboflavin, niacin and pantothenic acid levels in the LP-treated silage were significantly (p<0.05) lower than those in the untreated silage for the alfalfa and Chinese leymus. The α-tocopherol content in the LP-treated alfalfa silage was significantly (p<0.05) higher than that in the untreated alfalfa silage. There was no significant (p>0.05) difference in pyridoxine content between the untreated and LP-treated silages for both forages. Conclusion: With or without LP inoculation, the levels of the five B-group vitamins (thiamin, riboflavin, niacin, pantothenic acid, and pyridoxine) in alfalfa and Chinese leymus decreased after 45 days of ensiling, while the α-tocopherol content of Chinese leymus increased. The LP inoculant improved the fermentation quality of both the alfalfa and Chinese leymus silages but increased the thiamin, riboflavin, niacin, and pantothenic acid loss in the two forages after fermentation.