The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65

Xichang Wang,Haoyu Wang,Li Yan,Lihui Yang,Yuanming Xue,Jing Yang,Yongli Yao,Xulei Tang,Nanwei Tong,Guixia Wang,Jinan Zhang,Youmin Wang,Jianming Ba,Bing Chen,Jianling Du,Lanjie He,Xiaoyang Lai,Yanbo Li 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.4

Background: Subclinical hypothyroidism (SCH) is the most common thyroid dysfunction, and its relationship with blood pressure(BP) has been controversial. The aim of the study was to analyze the association between SCH and newly-diagnosed hypertension. Methods: Based on data from the Thyroid disease, Iodine nutrition and Diabetes Epidemiology (TIDE) study, 49,433 euthyroid individuals and 7,719 SCH patients aged ≥18 years were enrolled. Patients with a history of hypertension or thyroid disease were excluded. SCH was determined by manufacturer reference range. Overall hypertension and stage 1 and 2 hypertension were diagnosedaccording to the guidelines issued by the American College of Cardiology/American Heart Association in 2017. Results: The prevalence of overall hypertension (48.7%), including stage 1 (28.9%) and 2 (19.8%) hypertension, increased significantly in SCH patients compared with euthyroid subjects. With elevated serum thyroid stimulating hormone (TSH) level, the hypertension prevalence also increased significantly from the euthyroid to different SCH subgroups, which was more profound in femalesor subjects aged <65 years. The age- and sex-specific regression analysis further demonstrated the same trends in the general population and in the 1:1 propensity matched population. Similarly, several BP components (i.e., systolic, diastolic, and mean arterial BP)were positively associated with TSH elevation, and regression analysis also confirmed that all BP components were closely relatedwith SCH in female subjects aged <65 years. Conclusion: The prevalence of hypertension increases for patients with SCH. SCH tends to be associated with hypertension and BPcomponents in females younger than 65 years.

A rapid modeling method and accuracy criteria for common-cause failures in Risk Monitor PSA model

Zhang, Bing,Chen, Shanqi,Lin, Zhixian,Wang, Shaoxuan,Wang, Zhen,Ge, Daochuan,Guo, Dingqing,Lin, Jian,Wang, Fang,Wang, Jin Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.1

In the development of a Risk Monitor probabilistic safety assessment (PSA) model from the basic PSA model of a nuclear power plant, the modeling of common-cause failure (CCF) is very important. At present, some approximate modeling methods are widely used, but there lacks criterion of modeling accuracy and error analysis. In this paper, aiming at ensuring the accuracy of risk assessment and minimizing the Risk Monitor PSA models size, we present three basic issues of CCF model resulted from the changes of a nuclear power plant configuration, put forward corresponding modeling methods, and derive accuracy criteria of CCF modeling based on minimum cut sets and risk indicators according to the requirements of risk monitoring. Finally, a nuclear power plant Risk Monitor PSA model is taken as an example to demonstrate the effectiveness of the proposed modeling method and accuracy criteria, and the application scope of the idea of this paper is also discussed.

Activation of JNK/p38 Pathway is Responsible for α-Methyl-n-butylshikonin Induced Mitochondria-Dependent Apoptosis in SW620 Human Colorectal Cancer Cells

Wang, Hai-Bing,Ma, Xiao-Qiong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

${\alpha}$-Methyl-n-butylshikonin (MBS), one of the active components in the root extracts of Lithospermum erythrorhizon, posses antitumor activity. In this study, we assess the molecular mechanisms of MBS in causing apoptosis of SW620 cells. MBS reduced the cell viability of SW620 cells in a dose-and time-dependent manner and induced cell apoptosis. Treatment of SW620 cells with MBS down-regulated the expression of Bcl-2 and up-regulated the expression of Bak and caused the loss of mitochondrial membrane potential. Additionally, MBS treatment led to activation of caspase-9, caspase-8 and caspase-3, and cleavage of PARP, which was abolished by pretreatment with the pan-caspase inhibitor Z-VAD-FMK. MBS also induced significant elevation in the phosphorylation of JNK and p38. Pretreatment of SW620 cells with specific inhibitors of JNK (SP600125) and p38 (SB203580) abrogated MBS-induced apoptosis. Our results demonstrated that MBS inhibited growth of colorectal cancer SW620 cells by inducing JNK and p38 signaling pathway, and provided a clue for preclinical and clinical evaluation of MBS for colorectal cancer therapy.

Remote Sensing Images Data Integration Based on the Agent Service

Binge Cui,Chuanmin Wang,Qiang Wang 보안공학연구지원센터(IJGDC) 2008 International Journal of Grid and Distributed Comp Vol.1 No.1

Time Trends of Ovarian Cancer Incidence in China

Wang, Bing,Liu, Shu-Zheng,Zheng, Rong-Shou,Zhang, Fang,Chen, Wan-Qing,Sun, Xi-Bin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

The aim of this study was to examine the trend of ovary cancer incidence from 1999 to 2010 in China and predict the burden up to 2020. Crude incidence, age specific incidence and age-adjusted incidence rates were calculated. Joinpoint regression was performed to obtain estimated annual percentages and Bayesian age-period-cohort modeling was used to predict the incidence rate until the year 2020. In China, the crude rate of ovary cancer was 7.91/100,000 and the age-adjusted rate was 5.35/100,000 overall during period 1999-2010. The rates in urban regions were higher than in rural regions. A significant rising trend during 1999-2006 was followed by a drop during 2006-2010 in age-adjusted rates for urban females. In contrast, constant rise was observed in rural women. The decrease in ovary cancer of urban areas tended to be restricted to women aged 50 years and younger. In contrast, increases of ovary cancer in rural areas appeared in virtually all age groups. Although the age-adjusted incidence rate for ovary cancer was predicted to be reduced after year 2011, the crude rate was likely to be relative stable up to 2020. The burden of ovary cancer in China will continue to be relative stable due to the aging population.

Study on stiffness deterioration in steel-concrete composite beams under fatigue loading

Bing Wang,Qiao Huang,Xiaoling Liu,Yong Ding 국제구조공학회 2020 Steel and Composite Structures, An International J Vol.34 No.4

The purpose of this paper is to investigate the degradation law of stiffness of steel-concrete composite beams after certain fatigue loads. First, six test beams with stud connectors were designed and fabricated for static and fatigue tests. The resultant failure modes under different fatigue loading cycles were compared. And an analysis was performed for the variations in the load-deflection curves, residual deflections and relative slips of the composite beams during fatigue loading. Then, the correlations among the stiffness degradation of each test beam, the residual deflection and relative slip growth during the fatigue test were investigated, in order to clarify the primary reasons for the stiffness degradation of the composite beams. Finally, based on the stiffness degradation function under fatigue loading, a calculation model for the residual stiffness of composite beams in response to fatigue loading cycles was established by parameter fitting. The results show that the stiffness of composite beams undergoes irreversible degradation under fatigue loading. And stiffness degradation is associated with the macrobehavior of material fatigue damage and shear connection degradation. In addition, the stiffness degradation of the composite beams exhibit S-shaped monotonic decreasing trends with fatigue cycles. The general agreement between the calculation model and experiment shows good applicability of the proposed model for specific beam size and fatigue load parameters. Moreover, the research results provide a method for establishing a stiffness degradation model for composite beams after fatigue loading.

AN ULTRA-LUMINOUS QUASAR AT <i>z</i> = 5.363 WITH A TEN BILLION SOLAR MASS BLACK HOLE AND A METAL-RICH DLA AT <i>z</i> ∼ 5

Wang, Feige,Wu, Xue-Bing,Fan, Xiaohui,Yang, Jinyi,Cai, Zheng,Yi, Weimin,Zuo, Wenwen,Wang, Ran,McGreer, Ian D.,Ho, Luis C.,Kim, Minjin,Yang, Qian,Bian, Fuyan,Jiang, Linhua IOP Publishing 2015 ASTROPHYSICAL JOURNAL LETTERS - Vol.807 No.1

<P>We report the discovery of an ultra-luminous quasar J030642.51+185315.8 (hereafter J0306+1853) at redshift 5.363, which hosts a supermassive black hole with M-BH = (1.07 +/- 0.27) x 10(10) M-circle dot. With an absolute magnitude M-1450 = -28.92 and a bolometric luminosity L-bol similar to 3.4 x 10(14) L-circle dot, J0306+1853 is one of the most luminous objects in the early universe. It is not likely to be a beamed source based on its small flux variability, low radio loudness, and normal broad emission lines. In addition, a z = 4.986 damped Ly alpha system (DLA) with [M/H] = -1.3 +/- 0.1, among the most metal-rich DLAs at z greater than or similar to 5, is detected in the absorption spectrum of this quasar. This ultra-luminous quasar puts strong constraints on the bright end of the quasar luminosity function and massive end of the black hole mass function. It will provide a unique laboratory for the study of BH growth and the co-evolution between a BH and the host galaxy with multi-wavelength follow-up observations. The future high-resolution spectra will give more insight into the DLA and other absorption systems along the line of sight of J0306+1853.</P>

Comparison of Static and Fatigue Behaviors between Stud and Perfobond Shear Connectors

Bing Wang,Qiao Huang,Xiaoling Liu 대한토목학회 2019 KSCE Journal of Civil Engineering Vol.23 No.1

This paper presents an experimental evaluation for comparison of the behaviors of stud and Perfobond shear connectors under static and fatigue loading based on 20 push-out tests. The push-out tests for each type of shear connectors including three series: static tests, fatigue endurance tests and residual mechanical properties test, respectively. In static tests, the failure modes of two types of connectors are different. The elastic stiffness and ultimate slip in the load-slip curves of the Perfobond are larger than that of stud. In fatigue endurance tests, the fatigue life of the studs is 2.68 million, while the Perfobond specimens do not fail after 3.0 million numbers of cycles under the same test conditions as studs'. Compared with the stud, the relative-slip of Perfobond increased sharply in the early period. In residual mechanical properties tests, the residual bearing capacity, shear stiffness and ductility are presented and discussed. The variation rules of these three indexes for two types of connectors are the same, while the indexes of Perfobond are much larger than stud’s throughout the process. The results indicate that Perfobond connector has good ductility, better fatigue resistance and higher safety reliability. However, the economy of Perfobond connectors is not as good as studs’.

Research on 3D Reconstruction Method ACL-based

Bing Wang,Chunlan Zhao 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.10

Anterior cruciate ligament (ACL) 3D reconstruction is a challenging problem for both orthopedic and sports surgeons. In this paper, to investigate the method of quickly establishing 3D digital model of ACL using 2D magnetic resonance images (MRI) and 2D computed tomography (CT) images, we propose an new scene-based segmentation 3D reconstruction method for anterior cruciate ligament. First, CCD camera is anglicized for 3D reconstruction method. Second, scene segmentation method is proposed to get image patch set. Third, the distance is calculated between the image patch and viewpoint of CCD camera. Finally, the proposed method is done for scene reconstruction. The performance of the proposed model is demonstrated on various 2D MRI and CT images. A relatively reliable ACL 3D reconstruction results indicate the validity of our method. The proposed method can provide a complete set of computer aided ACL operation system and realizing the individualized anatomical reconstruction of ACL.

Socio-economic Factors Influencing Tumor Presentation and Treatment Options in Chinese Breast Cancer Patients

Wang, Ke,Li, Xiao,Zhou, Can,Ren, Yu,Wang, Xian-Bing,He, Jian-Jun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1

The impact of income and education level on the clinical and pathologic characteristics, implementation of clinical breast examination (CBE), and treatment patterns of a small population of Chinese female breast cancer patients was studeied in order to provide a theoretical basis and statistical reference for further nationwide research. We included 484 pathologically confirmed female primary breast cancer inpatients of the First Affiliated Hospital of Medical College of Xi'an Jiaotong University from February 2003 to January 2004. All cases were reviewed and relevant information was collected using a designed case report form (CRF). Chisquare tests, rank-sum tests, and Fisher's exact tests were used in the analysis. Our analysis showed that: (1) women in different occupation groups had significant differences in tumor size, pre-operative mammography, surgical options, post-operative estrogen receptor (ER), progestin receptor (PR) and human epidermal growth factor receptor 2 (Her2) status, and post-operative radiotherapy and chemotherapy (P < 0.05); and (2) women with different education levels had statistically significant differences in tumor size, post-operative ER, PR and Her2 status, and post-operative chemotherapy, radiotherapy, and endocrine therapy (P < 0.05). In Xi'an, China, women in low-income occupations or with low education levels are more likely to have advanced tumor stages at presentation, lower implementation rate of clinical breast examination, and less treatment.