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Zhou, Luping,Chen, Lulu,Wang, Yaqin,Huang, Jie,Yang, Guoping,Tan, Zhirong,Wang, Yicheng,Liao, Jianwei,Zhou, Gan,Hu, Kai,Li, Zhenyu,Ouyang, Dongsheng The Korean Society of Ginseng 2019 Journal of Ginseng Research Vol.43 No.3
Background: Ginsenoside compound K (CK) is a promising drug candidate for rheumatoid arthritis. This study examined the impact of polymorphisms in NR1I2, adenosine triphosphate-binding cassette (ABC) transporter genes on the pharmacokinetics of CK in healthy Chinese individuals. Methods: Forty-two targeted variants in seven genes were genotyped in 54 participants using Sequenom MassARRAY system to investigate their association with major pharmacokinetic parameters of CK and its metabolite 20(S)-protopanaxadiol (PPD). Subsequently, molecular docking was simulated using the AutoDock Vina program. Results: ABCC4 rs1751034 TT and rs1189437 TT were associated with increased exposure of CK and decreased exposure of 20(S)-PPD, whereas CFTR rs4148688 heterozygous carriers had the lowest maximum concentration ($C_{max}$) of CK. The area under the curve from zero to the time of the last quantifiable concentration ($AUC_{last}$) of CK was decreased in NR1I2 rs1464602 and rs2472682 homozygous carriers, while $C_{max}$ was significantly reduced only in rs2472682. ABCC4 rs1151471 and CFTR rs2283054 influenced the pharmacokinetics of 20(S)-PPD. In addition, several variations in ABCC2, ABCC4, CFTR, and NR1I2 had minor effects on the pharmacokinetics of CK. Quality of the best homology model of multidrug resistance protein 4 (MRP4) was assessed, and the ligand interaction plot showed the mode of interaction of CK with different MRP4 residues. Conlusion: ABCC4 rs1751034 and rs1189437 affected the pharmacokinetics of both CK and 20(S)-PPD. NR1I2 rs1464602 and rs2472682 were only associated with the pharmacokinetics of CK. Thus, these hereditary variances could partly explain the interindividual differences in the pharmacokinetics of CK.
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Luping Zhou,Lulu Chen,Yaqin Wang,Jie Huang,Guo Ping Yang,Zhi-Rong Tang,Yicheng Wang,Jianwei Liao,Gan Zhou,Kai-hua Wei,Zhenyu Li,Dongsheng Ouyang 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.3
Background: Ginsenoside compound K (CK) is a promising drug candidate for rheumatoid arthritis. Thisstudy examined the impact of polymorphisms in NR1I2, adenosine triphosphateebinding cassette (ABC)transporter genes on the pharmacokinetics of CK in healthy Chinese individuals. Methods: Forty-two targeted variants in seven genes were genotyped in 54 participants using SequenomMassARRAY system to investigate their association with major pharmacokinetic parameters of CK and itsmetabolite 20(S)-protopanaxadiol (PPD). Subsequently, molecular docking was simulated using theAutoDock Vina program. Results: ABCC4 rs1751034 TT and rs1189437 TT were associated with increased exposure of CK anddecreased exposure of 20(S)-PPD, whereas CFTR rs4148688 heterozygous carriers had the lowestmaximum concentration (Cmax) of CK. The area under the curve from zero to the time of the lastquantifiable concentration (AUClast) of CK was decreased in NR1I2 rs1464602 and rs2472682 homozygouscarriers, while Cmax was significantly reduced only in rs2472682. ABCC4 rs1151471 and CFTR rs2283054influenced the pharmacokinetics of 20(S)-PPD. In addition, several variations in ABCC2, ABCC4, CFTR, andNR1I2 had minor effects on the pharmacokinetics of CK. Quality of the best homology model of multidrugresistance protein 4 (MRP4) was assessed, and the ligand interaction plot showed the mode of interactionof CK with different MRP4 residues. Conlusion: ABCC4 rs1751034 and rs1189437 affected the pharmacokinetics of both CK and 20(S)-PPD. NR1I2 rs1464602 and rs2472682 were only associated with the pharmacokinetics of CK. Thus, thesehereditary variances could partly explain the interindividual differences in the pharmacokinetics of CK.
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Zhenyu He,San-Gang Wu,Juan Zhou,Fengyan Li,Jiayan Sun,Qin Lin,Huanxin Lin,Xunxing Guan 한국유방암학회 2014 Journal of breast cancer Vol.17 No.3
Purpose: Several accelerated partial breast irradiation (APBI)techniques are being investigated in patients with early-stagebreast cancer. The present study evaluated the feasibility, earlytoxicity, initial efficacy, and cosmetic outcomes of acceleratedpartial breast intensity-modulated radiotherapy (IMRT) for Chinesefemale patients with early-stage breast cancer after breastconservingsurgery. Methods: A total of 38 patients met the inclusioncriteria and an accelerated partial breast intensity-modulatedradiotherapy (APBI-IMRT) plan was designed for each patient. The prescription dose was 34 Gy in 10 fractions, 3.4 Gy per fraction,twice a day, in intervals of more than 6 hours. Results: Of the38 patients, six patients did not meet the planning criteria. Theremaining 32 patients received APBI-IMRT with a mean targetvolume conformity index of 0.67 and a dose homogeneity indexof 1.06. The median follow-up time was 53 months and no localrecurrence or distant metastasis was detected. The most commonacute toxicities observed within 3 months after radiotherapywere erythema, breast edema, pigmentation, and pain in the irradiatedlocation, among which 43.8%, 12.5%, 31.3%, and28.1% were grade 1 toxicities, respectively. The most commonlate toxicities occurring after 3 months until the end of the followupperiod were breast edema, pigmentation, pain in the irradiatedlocation, and subcutaneous fibrosis, among which 6.2%,28.1%, 21.9%, and 37.5% were grade 1 toxicities, respectively. Thirty-one patients (96.8%) had fine or excellent cosmetic outcomes,and only one patient had a poor cosmetic outcome. Conclusion: It is feasible for Chinese females to receive APBIIMRTafter breast conserving surgery. The radiotherapeutic toxicityis acceptable, and both the initial efficacy and cosmeticoutcomes are good.
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Zhou, Wenhao,Leem, Jina,Park, Inhye,Li, Yinshi,Jin, Zhenyu,Min, Yo-Sep The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.45
<P>Organic–inorganic hybrid or alloy films have great potential as a functional material because they have structural flexibility owing to the presence of an organic moiety. Here organic–inorganic hybrid films were grown by molecular layer deposition (MLD) by using trimethylaluminum and <I>p</I>-phenylenediamine. Although the hybrid films could be grown <I>via</I> the self-limiting growth mechanism of MLD, the hybrid films were severely air sensitive. The stability problem of the hybrid films could be solved by alloying the hybrid layer with Al<SUB>2</SUB>O<SUB>3</SUB> layers. The alloy films, which were grown by repeating supercycles with one subcycle for the hybrid layer and four subcycles for the Al<SUB>2</SUB>O<SUB>3</SUB> layers, showed excellent dielectric properties: a leakage current density of ∼2.3 × 10<SUP>−8</SUP> A cm<SUP>−2</SUP> at 1 MV cm<SUP>−1</SUP>; a dielectric breakdown field at ∼2.9 MV cm<SUP>−1</SUP>; and a dielectric constant of ∼6.2. Interestingly, charge trapping behavior was clearly observed in the alloy film. The charge trapping ability of the alloy film was verified with a charge trapping memory capacitor in which the alloy film was inserted as a charge trapping layer.</P> <P>Graphic Abstract</P><P>Organic–inorganic hybrid or alloy films have great potential as a functional material because they have structural flexibility owing to the presence of an organic moiety. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm35553a'> </P>
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Zhenyu Xu,Ke Li,Kui Zhou,Shuiyuan Li,Hongwei Chen,Jiaqi Zeng,Rugang Hu 한국섬유공학회 2023 Fibers and polymers Vol.24 No.1
Silk Fibroin (SF) is a protein polymer with great biocompatibility, which can promote cell proliferation and differentiation,and enhance bone repair. In this paper, the effects of distinctive concentrations of SF solutions on the physicochemical andbiological properties of the SF-HA-SA scaffolds were investigated. The SF-HA-SA porous scaffolds were prepared utilizingthe pneumatic extrusion 3D printing technique, composed of hydroxyapatite (HA) and different concentrations of SF solution,and sodium alginate (SA) as a binder. The results shown the SF-HA-SA scaffolds can promote cell proliferation withthe increase of SF concentration in scaffolds, and the strength meets the necessities of trabecular bone defects of bone andcartilage repair. It provides an important reference for the application of SF in bone tissue engineering.
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Li Zhenyu,Zhou Zhihua,Wang Qun,Lu Songtao 한국물리학회 2023 Current Applied Physics Vol.55 No.-
It is still challenging to prepare an anti-static and anti-stray astigmatism coating on the high silicon aluminum alloy (>50 wt% Si, Al-50Si) for space material under extreme environments. To address these issues, the black anti-stray light coating with enhanced conductivity on the chemical etching surface of high-silicon Al-70Si alloy were successfully fabricated by the combination of plasma electrolytic oxidation (PEO) technology and deposited aluminum doped zinc oxide (AZO) transparent conductive film by magnetron sputtering technology. The microstructures, phase, elemental compositions, light absorption performance and electrical resistivity of coatings were tested and analyzed by SEM, EDS, XRD and XPS spectroscopy. The effects of process parameters including current density and AZO sputtering times on the structure, optical and electrical properties of the film layer were systematically studied. Convection through the fixation effect in the etched Al-70Si alloy porous layer promoted the internal heat and mass transfer during PEO process which is similar to previous reported mechanism of filling of cracks and pores by nanoparticles leading to the layer densification. The PEO coating had the highest absorptivity of 0.946 and it only decreased to 0.939 after AZO sputtering, at the same time the coating has the lowest resistivity of 1.04 × 107 Ω/sq, indicating excellent anti-stray light and antistatic ability. This two-step route pave the way to improve the conductivity without compromising optical properties of PEO coating on the high silicon aluminum alloy (>50 wt% Si, Al-50Si) for space material.
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The Flexural Capacity of 7A04-T6 Aluminum Alloy Rectangular Hollow Section Beams
Li Zhenyu,Zhou Yangfeng,Rong Bin 한국강구조학회 2022 International Journal of Steel Structures Vol.22 No.1
This paper presents a particular experimental research on rectangular hollow section (RHS) and square hollow section (SHS) beams made of 7A04-T6 aluminum alloys. A total of 18 in-plane bending specimens four-point confi gurations have been investigated. The infl uence of length, cross-section slenderness was investigated. Full load–rotation and load–displacement histories were derived, containing into the post-ultimate stage. Material parameters of each member was acquired from tensile experiments. The experimental results were duplicated by means of non-linear numerical modelling. Based on careful validation of the models, a total of 96 parametric studies were performed to assess the structural response of RHS/SHS over a wider range of cross-section slenderness. Following analysis of the data, the correctness of the fl exural capacity provisions in the present design specifi cations EN 1999-1-1 (Europe) and GB 50429 (China) was assessed. The results showed that the design rules provided conservative predictions of the ultimate fl exural capacities. In this study, modifi ed design rules based on Eurocode 9 (Europe) are proposed, which are shown to improve the accuracy of these design rules in a reliable manner.
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Feng Zhou,Jinjin Cai,Xiaoning Mao,Zhenyu Wu,Yong Nie 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.9
As a green plasticizer, the industrial production of dioctyl terephthalate (DOTP) is still facing the problemof high energy consumption. To optimize the production process and reactor, it is essential to understand the kineticbehavior of reaction system. In this work, the two-step consecutive esterification of solid terephthalic acid (PTA) and 2-ethylhexanol (2-EH) catalyzed by tetrabutyl titanate was studied. First, the equilibrium constants and enthalpies of thetwo-step reaction were experimentally determined and validated by the group contribution methods. Then, a pseudohomogeneouskinetic model was developed, and the reaction order of PTA was corrected to reflect its solid phase characteristic. Non-isothermal kinetic experiments were carried out under different initial feed molar ratios and catalystconcentrations, and the kinetic parameters in the model were estimated by mathematical regression. The model predicteddata agreed well with the experimental data. Finally, the analyses of reaction rate showed that the first-step reactionwas the rate-controlling step of the whole esterification process.
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