Accelerated Partial Breast Irradiation with Intensity-Modulated Radiotherapy Is Feasible for Chinese Breast Cancer Patients

Zhenyu He,San-Gang Wu,Juan Zhou,Fengyan Li,Jiayan Sun,Qin Lin,Huanxin Lin,Xunxing Guan 한국유방암학회 2014 Journal of breast cancer Vol.17 No.3

Purpose: Several accelerated partial breast irradiation (APBI)techniques are being investigated in patients with early-stagebreast cancer. The present study evaluated the feasibility, earlytoxicity, initial efficacy, and cosmetic outcomes of acceleratedpartial breast intensity-modulated radiotherapy (IMRT) for Chinesefemale patients with early-stage breast cancer after breastconservingsurgery. Methods: A total of 38 patients met the inclusioncriteria and an accelerated partial breast intensity-modulatedradiotherapy (APBI-IMRT) plan was designed for each patient. The prescription dose was 34 Gy in 10 fractions, 3.4 Gy per fraction,twice a day, in intervals of more than 6 hours. Results: Of the38 patients, six patients did not meet the planning criteria. Theremaining 32 patients received APBI-IMRT with a mean targetvolume conformity index of 0.67 and a dose homogeneity indexof 1.06. The median follow-up time was 53 months and no localrecurrence or distant metastasis was detected. The most commonacute toxicities observed within 3 months after radiotherapywere erythema, breast edema, pigmentation, and pain in the irradiatedlocation, among which 43.8%, 12.5%, 31.3%, and28.1% were grade 1 toxicities, respectively. The most commonlate toxicities occurring after 3 months until the end of the followupperiod were breast edema, pigmentation, pain in the irradiatedlocation, and subcutaneous fibrosis, among which 6.2%,28.1%, 21.9%, and 37.5% were grade 1 toxicities, respectively. Thirty-one patients (96.8%) had fine or excellent cosmetic outcomes,and only one patient had a poor cosmetic outcome. Conclusion: It is feasible for Chinese females to receive APBIIMRTafter breast conserving surgery. The radiotherapeutic toxicityis acceptable, and both the initial efficacy and cosmeticoutcomes are good.

Vertical uplift of suspension equipment due to hanger slackening: Experimental and numerical investigation

Zhenyu Yang,Chang He,Khalid M. Mosalam,Qiang Xie 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.82 No.6

The suspension thyristor valve can generate tremendous vertical acceleration responses in layers and large tension forces in hangers. A shaking table test of a scaled-down model of thyristor valves suspended on a hall building is performed to qualify the risk of vertical uplift of two representative types of valves, the chain valve and the rigid valve. Besides, an analytical model is established to investigate the source of the slackening of hangers. The test results show that the valves frequently experience a large vertical acceleration response. The soft spring joint can significantly reduce acceleration, but is still unable to prevent vertical uplift of the chain valve. The analytical model shows a stiffer roof and inter-story connection both contribute to a higher risk of vertical uplift for a rigid valve. In addition, the planar eccentricity and short hangers, which result in torsional motion of the valve, increase the possibility of vertical uplift for a chain valve. Therefore, spring joints with additional viscous dampers and symmetric layout in each layer are recommended for the rigid and chain valve, respectively, to prevent the uplift of valves.

Proteomic Analysis of Goat Longissimus dorsi Muscles with Different Drip Loss Values Related to Meat Quality Traits

Zhenyu Wang,Fan He,Weili Rao,Na Ni,Qingwu Shen,Dequan Zhang 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.2

Longissimus dorsi muscles from 3 goat species were assigned to high and low drip loss groups. Physio-chemical properties, sarcomere length, and proteome profiles were investigated. The high drip loss group had lower pH, higher brightness, and higher shear force values, and shorter sarcomere lengths than the low drip loss group. 22 differential proteins were identified between high and low loss groups. α-Enolase, NADH dehydrogenase, pyruvate dehydrogenase E1, HSP27, superoxide dismutase, peroxiredoxin-2, myosin, and the myosin light chain were among these proteins, which were metabolic enzymes, stress response factors, and structural proteins that affected glycolysis, oxidation, and muscle contraction. Drip loss was probably produced via proteins involved in glycolysis, oxidation, and muscle contraction.

Analysis of the Climate inside Multi-span Plastic Greenhouses under Different Shade Strategies and Wind Regimes

He, Keshi,Chen, Dayue,Sun, Lijuan,Huang, Zhenyu,Liu, Zhenglu Korean Society of Horticultural Science 2014 원예과학기술지 Vol.32 No.4

In this work, the effects of shade combination, shade height and wind regime on greenhouse climate were quantified. A two-dimensional (2-D) computational fluid dynamics (CFD) model was developed based on an 11-span plastic greenhouse in eastern China for wind almost normal to the greenhouse orientation. The model was first validated with air temperature profiles measured in a compartmentalized greenhouse cultivated with mature lettuce (Lactuca sativa L., 'Yang Shan'). Next, the model was employed to investigate the effect of shade combinations on greenhouse microclimate patterns. Simulations showed similar airflow patterns in the greenhouse under different shade combinations. The temperature pattern was a consequence of convection and radiation transfer and was not significantly influenced by shade combination. The use of shade screens reduced air velocity by $0.02-0.20m{\cdot}s^{-1}$, lowered air temperature by $0.2-0.8^{\circ}C$ and raised the humidity level by 0.9-2.0% in the greenhouse. Moreover, it improved the interior climate homogeneity. The assessment of shade performance revealed that the external shade had good cooling and homogeneity performance and thus can be recommended. Furthermore, the effects of external shade height and wind regime on greenhouse climate parameters showed that external shade screens are suitable for installation within 1 m above roof level. They also demonstrated that, under external shade conditions, greenhouse temperature was reduced relative to unshaded conditions by $1.3^{\circ}C$ under a wind speed of $0.5m{\cdot}s^{-1}$, whereas it was reduced by merely $0.5^{\circ}C$ under a wind speed of $2.0m{\cdot}s^{-1}$. Therefore, external shading is more useful during periods of low wind speed.

Analysis of the Climate inside Multi-span Plastic Greenhouses under Different Shade Strategies and Wind Regimes

Keshi He,Dayue Chen,Lijuan Sun,Zhenyu Huang,Zhenglu Liu 한국원예학회 2014 원예과학기술지 Vol.32 No.4

In this work, the effects of shade combination, shade height and wind regime on greenhouse climate were quantified. A two-dimensional (2-D) computational fluid dynamics (CFD) model was developed based on an 11-span plastic greenhouse in eastern China for wind almost normal to the greenhouse orientation. The model was first validated with air temperature profiles measured in a compartmentalized greenhouse cultivated with mature lettuce (Lactuca sativa L., ‘Yang Shan’). Next, the model was employed to investigate the effect of shade combinations on greenhouse microclimate patterns. Simulations showed similar airflow patterns in the greenhouse under different shade combinations. The temperature pattern was a consequence of convection and radiation transfer and was not significantly influenced by shade combination. The use of shade screens reduced air velocity by 0.02-0.20 m·s<SUP>-1</SUP>, lowered air temperature by 0.2-0.8℃ and raised the humidity level by 0.9-2.0% in the greenhouse. Moreover, it improved the interior climate homogeneity. The assessment of shade performance revealed that the external shade had good cooling and homogeneity performance and thus can be recommended. Furthermore, the effects of external shade height and wind regime on greenhouse climate parameters showed that external shade screens are suitable for installation within 1 m above roof level. They also demonstrated that, under external shade conditions, greenhouse temperature was reduced relative to unshaded conditions by 1.3℃ under a wind speed of 0.5 m·s<SUP>-1</SUP>, whereas it was reduced by merely 0.5℃ under a wind speed of 2.0 m·s<SUP>-1</SUP>. Therefore, external shading is more useful during periods of low wind speed.

Research on the Predictive Optimal PID Plus Second Order Derivative Method for AGC of Power System with High Penetration of Photovoltaic and Wind Power

Xilin Zhao,Zhenyu Lin,Bo Fu,Li He,Chaoshun Li 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.3

Because of the uncertainty of the external environment, high penetration of renewable energy such as wind power and solar energy in the modern power system renders the traditional automatic generation control (AGC) methods more challenging. An improved AGC method named predictive optimal proportional integral diff erential plus second order derivative (POPID + DD) for multi-area interconnected grid is proposed in this paper to reduce the negative impacts of the uncertainty which is caused by the high penetration of renewable energy. Firstly, the mathematical model of the AGC system of multiarea power grid with penetration of photovoltaic (PV) and wind power is built. Then, PO-PID + DD controller is presented to improve the system robustness with respect to system uncertainties. In order to obtain the predictive sequence of the integral system output, the characteristic of the controller is included in the system model. Thus, according to the predictive sequence and designed objective function, the input of the controller can be readjusted to obtain the optimal eff ect of AGC. An IEEE 39-bus system is introduced as an example to testify the feasibility and eff ectiveness of the proposed method. The simulation results indicate that the system controlled by the proposed controller has desired dynamic performances.

Insertional mutations exhibiting high cell-culture density HCD phenotypes are enriched through continuous subcultures in Chlamydomonas reinhardtii

Thung, Leena,He, Jing,Zhu, Qingling,Xu, Zhenyu,Liu, Jianhua,Chow, Yvonne The Korean Society of Phycology 2018 ALGAE Vol.33 No.1

Low efficiency in microalgal biomass production was largely attributed to the low density of algal cell cultures. Though mutations that reduced the level of chlorophyll or pigment content increased efficiency of photon usage and thus the cell-culture density under high-illumination growth conditions (e.g., >$500{\mu}mol\;photon\;m^{-2}\;s^{-1}$), it was unclear whether algae could increase cell-culture density under low-illumination conditions (e.g., ${\sim}50{\mu}mol\;photon\;m^{-2}\;s^{-1}$). To address this question, we performed forward genetic screening in Chlamydomonas reinhardtii. A pool of >1,000 insertional mutants was constructed and subjected to continuous subcultures in shaking flasks under low-illumination conditions. Complexity of restriction fragment length polymorphism (RFLP) pattern in cultures indicated the degree of heterogeneity of mutant populations. We showed that the levels of RFLP complexity decreased when cycles of subculture increased, suggesting that cultures were gradually populated by high cell-culture density (HCD) strains. Analysis of the 3 isolated HCD mutants after 30 cycles of subcultures confirmed that their maximal biomass production was 50-100% higher than that of wild type under low-illumination. Furthermore, levels of chlorophyll content in HCD mutant strains were similar to that of wild type. Inverse polymerase chain reaction analysis identified the locus of insertion in two of three HCD strains. Molecular and transcriptomic analyses suggested that two HCD mutants were a result of the gain-of-function phenotype, both linking to the abnormality of mitochondrial functions. Taken together, our results demonstrate that HCD strains can be obtained through continuous subcultures under low illumination conditions.

Reduction of Sodium Chloride Levels in Emulsified Lamb Sausages: The Effect of Lamb Plasma Protein on the Gel Properties, Sensory Characteristics, and Microstructure

Na Ni,Zhenyu Wang,Linchen Wang,Fan He,Jinkai Liu,Yuan Gao,Dequan Zhang 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.4

Reduced sodium emulsified lamb sausagesproduced using addition of lamb plasma protein wereevaluated for gel properties, sensory attributes, and microstructures. Hardness, cohesiveness, chewiness, redness,yellowness, juiciness, and overall acceptability values ofthe emulsified lamb sausages containing 1.5% sodiumchloride and more than 3% lamb plasma protein weresignificantly (p<0.05) higher than values for sausages with3.5% sodium chloride and no plasma protein. Sensoryattributes indicated that lamb sausages with addition of 4%plasma protein and 1.5% sodium chloride had the greatestoverall acceptability. Matrix morphological characteristicsof sausages were affected by addition of plasma proteinand sodium chloride. Lamb plasma protein enhanced thegel properties of emulsified lamb sausages and improvedthe sensory quality, providing a method to reduce thesodium chloride content of emulsified sausage.

The compositon, microstructure and mechanical properties of NiCrC nanocomposite films by filtered cathodic vacuum arc deposition

Bo Zhang,Zhenyu He 한국표면공학회 2023 한국표면공학회 학술발표회 초록집 Vol.2023 No.11-1

Insertional mutations exhibiting high cell-culture density HCD phenotypes are enriched through continuous subcultures in Chlamydomonas reinhardtii

Leena Thung,Jing He,Qingling Zhu,Zhenyu Xu,Jianhua Liu,Yvonne Chow 한국조류학회I 2018 ALGAE Vol.33 No.1

Low efficiency in microalgal biomass production was largely attributed to the low density of algal cell cultures. Though mutations that reduced the level of chlorophyll or pigment content increased efficiency of photon usage and thus the cell-culture density under high-illumination growth conditions (e.g., >500 µmol photon m-2 s-1), it was unclear whether algae could increase cell-culture density under low-illumination conditions (e.g., ~50 µmol photon m-2 s-1). To address this question, we performed forward genetic screening in Chlamydomonas reinhardtii. A pool of >1,000 insertional mutants was constructed and subjected to continuous subcultures in shaking flasks under low-illumination conditions. Complexity of restriction fragment length polymorphism (RFLP) pattern in cultures indicated the degree of heterogeneity of mutant populations. We showed that the levels of RFLP complexity decreased when cycles of subculture increased, suggesting that cultures were gradually populated by high cell-culture density (HCD) strains. Analysis of the 3 isolated HCD mutants after 30 cycles of subcultures confirmed that their maximal biomass production was 50-100% higher than that of wild type under low-illumination. Furthermore, levels of chlorophyll content in HCD mutant strains were similar to that of wild type. Inverse polymerase chain reaction analysis identified the locus of insertion in two of three HCD strains. Molecular and transcriptomic analyses suggested that two HCD mutants were a result of the gain-of-function phenotype, both linking to the abnormality of mitochondrial functions. Taken together, our results demonstrate that HCD strains can be obtained through continuous subcultures under low illumination conditions.