Implementation of functional expansion tally method and order selection strategy in Monte Carlo code RMC

Wang, Zhenyu,Liu, Shichang,She, Ding,Su, Yang,Chen, Yixue Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.2

The spatial distribution of neutron flux or reaction rate was calculated by cell or mesh tally in traditional Monte Carlo simulation. However, either cell or mesh tally leads to the increase of memory consumption and simulation time. In this paper, the function expansion tally (FET) method was developed in Reactor Monte Carlo code RMC to solve this problem. The FET method was applied to the tallies of neutron flux distributions of uranium block and PWR fuel rod models. Legendre polynomials were used in the axial direction, while Zernike polynomials were used in the radial direction. The results of flux, calculation time and memory consumption of different expansion orders were investigated, and compared with the mesh tally. Results showed that the continuous distribution of flux can be obtained by FET method. The flux distributions were consistent with that of mesh tally, while the memory consumption and simulation time can be effectively reduced. Finally, the convergence analysis of coefficients of polynomials were performed, and the selection strategy of FET order was proposed based on the statistics uncertainty of the coefficients. The proposed method can help to determine the order of FET, which was meaningful for the efficiency and accuracy of FET method.

Proteomic Analysis of Goat Longissimus dorsi Muscles with Different Drip Loss Values Related to Meat Quality Traits

Zhenyu Wang,Fan He,Weili Rao,Na Ni,Qingwu Shen,Dequan Zhang 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.2

Longissimus dorsi muscles from 3 goat species were assigned to high and low drip loss groups. Physio-chemical properties, sarcomere length, and proteome profiles were investigated. The high drip loss group had lower pH, higher brightness, and higher shear force values, and shorter sarcomere lengths than the low drip loss group. 22 differential proteins were identified between high and low loss groups. α-Enolase, NADH dehydrogenase, pyruvate dehydrogenase E1, HSP27, superoxide dismutase, peroxiredoxin-2, myosin, and the myosin light chain were among these proteins, which were metabolic enzymes, stress response factors, and structural proteins that affected glycolysis, oxidation, and muscle contraction. Drip loss was probably produced via proteins involved in glycolysis, oxidation, and muscle contraction.

Estrogen receptor β promotes bladder cancer growth and invasion via alteration of miR-92a/DAB2IP signals

Zhenyu Ou,Yongjie Wang,Jinbo Chen,Le Tao,Li Zuo,Deepak Sahasrabudhe,Jean Joseph,Long Wang,Shuyuan Yeh 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Although early studies suggested that bladder cancer (BCa) is more prevalent in men than in women, muscle-invasive rates are higher in women than in men, suggesting that sex hormones might play important roles in different stages of BCa progression. In this work, we found that estrogen receptor beta (ERβ) could increase BCa cell proliferation and invasion via alteration of miR-92a-mediated DAB2IP (DOC-2⁄DAB2 interacting protein) signals and that blocking miR- 92a expression with an inhibitor could partially reverse ERβ-enhanced BCa cell growth and invasion. Further mechanism dissection found that ERβ could increase miR-92a expression at the transcriptional level via binding to the estrogen-response-element (ERE) on the 5′ promoter region of its host gene C13orf25. The ERβ up-regulated miR-92a could decrease DAB2IP tumor suppressor expression via binding to the miR-92a binding site located on the DAB2IP 3′ UTR. Preclinical studies using an in vivo mouse model also confirmed that targeting this newly identified ERβ/miR-92a/ DAB2IP signal pathway with small molecules could suppress BCa progression. Together, these results might aid in the development of new therapies via targeting of this ERβ-mediated signal pathway to better suppress BCa progression.

Transiting Exoplanet Monitoring Project (TEMP). II. Refined System Parameters and Transit Timing Analysis of HAT-P-33b

Wang, Yong-Hao,Wang, Songhu,Liu, Hui-Gen,Hinse, Tobias C.,Laughlin, Gregory,Wu, Dong-Hong,Zhang, Xiaojia,Zhou, Xu,Wu, Zhenyu,Zhou, Ji-Lin,Wittenmyer, R. A.,Eastman, Jason,Zhang, Hui,Hori, Yasunori,Nar American Astronomical Society 2017 The Astronomical journal Vol.154 No.2

<P>We present 10. R-band photometric observations of eight different transits of the hot Jupiter HAT-P-33b, which has been targeted by our Transiting Exoplanet Monitoring Project. The data were obtained by two telescopes at the Xinglong Station of National Astronomical Observatories of China (NAOC) from 2013 December through 2016 January, and exhibit photometric scatter of 1.6-3.0 mmag. After jointly analyzing the previously published photometric data, radial-velocity (RV) measurements, and our new light curves, we revisit the system parameters and orbital ephemeris for the HAT-P-33b system. Our results are consistent with the published values except for the planet to. star radius ratio (RP/R-*), the ingress/egress duration (tau) and the total duration (T-14), which together indicate a slightly shallower and shorter transit shape. Our results are based on more complete light curves, whereas the previously published work had only one complete transit light curve. No significant anomalies in Transit Timing Variations (TTVs) are found, and we place upper mass limits on potential perturbers, largely supplanting the loose constraints provided by the extant RV data. The TTV limits are stronger near mean-motion resonances, especially for the low-order commensurabilities. We can exclude the existence of a perturber with mass larger than 0.6, 0.3, 0.5, 0.5, and 0.3 M-circle plus near the 1: 3, 1: 2, 2: 3, 3: 2, and 2: 1 resonances, respectively.</P>

Comprehensive transcriptome analysis discovers novel candidate genes related to leaf color in a Lagerstroemia indica yellow leaf mutant

Ya Li,Zhenyu Zhang,Peng Wang,Shu’an Wang,Lingling Ma,Linfang Li,Rutong Yang,Yuzhu Ma,Qing Wang 한국유전학회 2015 Genes & Genomics Vol.37 No.10

Lagerstroemia indica is a popular woody ornamental plant throughout the world. However, relatively little is known about the molecular processes regulating leaf color in L. indica compared with other ornamental plants. Although yellow leaf mutants from various organisms have been well characterized, L. indica yellow leaf mutant has not yet been reported. In this study, a L. indica yellow leaf mutant, named YL03, was characterized and its leaf transcriptome was sequenced. A total of 30,712,752 reads were generated and assembled de novo into 45,308 unigenes with an average length of 987.51 bp. Among these unigenes, 21,339 (47.10 %) were identified as putative homologs of annotated sequences in public databases. A total of 79 unigenes involved in chlorophyll biosynthesis and degradation, photosynthesis and chloroplast development were identified. The expression levels of those genes were detected using quantitative real-time PCR in this study. Among those genes, 11 unigenes showed highly significant difference in the mutant compared to wild type plants. Conclusively, the leaf color formation is greatly affected by the activity of chloroplast development and chlorophyll metabolism. And the possible formation pathway of yellow leaf mutant is deduced based on our results.

Cloning and Functional Characterization of Putative Escherichia coli ABC Multidrug Efflux Transporter YddA

( Zhenyue Feng ),( Defu Liu ),( Ziwen Liu ),( Yimin Liang ),( Yanhong Wang ),( Qingpeng Liu ),( Zhenhua Liu ),( Zhongjing Zang ),( Yudong Cui ) 한국미생물 · 생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.7

A putative multidrug efflux gene, yddA, was cloned from the Escherichia coli K-12 strain. A drugsensitive strain of E. coli missing the main multidrug efflux pump AcrB was constructed as a host and the yddA gene was knocked out in wild-type (WT) and drug-sensitive E. coliΔacrB to study the yddA function. Sensitivity to different substrates of WT E.coli, E. coliΔyddA, E. coliΔacrB and E. coliΔacrBΔyddA strains was compared with minimal inhibitory concentration (MIC) assays and fluorescence tests. MIC assay and fluorescence test results showed that YddA protein was a multidrug efflux pump that exported multiple substrates. Three inhibitors, ortho-vanadate, carbonyl cyanide m-chlorophenylhydrazone (CCCP), and reserpine, were used in fluorescence tests. Ortho-vanadate and reserpine significantly inhibited the efflux and increased accumulation of ethidium bromide and norfloxacin, while CCCP had no significant effect on YddA-regulated efflux. The results indicated that YddA relies on energy released from ATP hydrolysis to transfer the substrates and YddA is an ABC-type multidrug exporter. Functional study of unknown ATP-binding cassette (ABC) superfamily transporters in the model organism E. coli is conducive to discovering new multidrug resistance-reversal targets and providing references for studying other ABC proteins of unknown function.

Microbially induced calcium precipitation based anaerobic biosynthetic crystals for removal of F− and Ca2+ in groundwater: Performance optimization, kinetics, and reactor operation

Zhenyu Zhai,Amjad Ali,Junfeng Su,Zhenle Hao,Jiaran Liu,Zhao Wang 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.11

Anaerobic biosynthetic crystals (ANBC) were prepared based on microbially induced calcium precipitation (MICP) and their potential explored for groundwater defluoridation and decalcification. The preparation conditions of ANBC were optimized and the influence of key factors (initial fluoride ions (F−) concentration, pH, and initial calcium ions (Ca2+) concentration) on the crystals was investigated. During the operation of the reactor, at pH of 7.0, the hydraulic retention time (HRT) of 6 h, and Ca2+ concentration of 180 mg L−1, a maximum removal efficiency reached 93.31%, while 66.20% of Ca2+ could be removed. The adsorption dynamics study showed that the adsorption of ANBC was most in line with the pseudo-second-order model. The stability of ANBC operation was studied and failure reaction showed that the crystals maintained a stable removal ability after 35 times of repeated use. Further studies found that this was attributed to the continuous growth and synthesis of the crystals. The defluoridation and decalcification mechanism was further explored by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and X-ray diffraction spectra (XRD). This study innovatively proposes a method for biosynthesis of crystals under anaerobic conditions based on MICP, which can efficiently and stably remove F− and Ca2+ in groundwater, providing a valuable strategy for groundwater contaminant remediation and energy saving.

Generation Mechanism and Development Characteristics of Rail Corrugation of Cologne Egg Fastener Track in Metro

Zhenyu Lei,Zhiqiang Wang 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.6

By establishing vehicle-track space coupled model and rail corrugation evaluation model, the generation mechanism of rail corrugation was analyzed in frequency domain and time domain, and development characteristics of corrugation were studied by using corrugation growth rate. Analysis based on frequency domain: through modal analysis and frequency response analysis on the finite element model of track structure, it is found that there are natural frequencies of track structure close to measured corrugation passing frequencies. It shows that the vibration modes corresponding to these frequencies can be more easily excited, which can cause the resonance phenomenon of track structure and form the rail corrugation at corresponding frequencies. Analysis based on time domain: the time-history curves of rail vertical vibration acceleration and rail vertical displacement are calculated by using vehicle-track coupled model and the frequency domain transformation of the time-history data is carried out. It is found that there are characteristic frequencies close to the measured corrugation passing frequencies, which indicates that the vibration of track structure at corresponding frequencies is an important reason to promote the formation of corrugation. The change of vehicle speed has no effect on characteristic frequencies of corrugation growth rate curves, which reflects the fixed frequency characteristic of corrugation. With the increase of train operation times, the corrugation corresponding to characteristic frequencies will gradually form and develop, and the increase of vehicle speed will increase the wavelength range and development speed of rail corrugation.

Isogeometric analysis of functionally graded CNT-reinforced composite plates based on refined plate theory

Zhenyu Liu,Chuang Wang,Guifang Duan,Jianrong Tan 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.9

A simple and effective approach based on refined plate theory (RPT) is proposed to study the static and free vibration characteristics of functionally graded CNTreinforced composite (FG-CNTRC) plates. Compared to traditional higher order shear deformation theories (HSDTs), the proposed method shows more efficient for FG-CNTRC plates analysis. To solve the C1-continuity requirement of the RPT, we used isogeometric analysis (IGA) to approximate the displacement field, which shows more advantages than the FEA, since it can construct higher-order elements without additional variables. This is an advantage for plate structural analysis because more variables make the calculation cumbersome. Finally, four types of FG-CNTRC plates were investigated and the results show the accuracy and efficiency of the proposed method.

Fiber orientation distribution and rheological properties of fiber suspension in a turbulent jet

Zhenyu Ouyang,Jianzhong Lin,Yelong Wang,Fangyang Yuan 한국유변학회 2018 Korea-Australia rheology journal Vol.30 No.1

The fiber orientation distribution and rheological properties of fiber suspension in a turbulent jet are numerically studied. The results show that, as the flow develops, more fibers align themselves with the flow direction. Few fibers orient with the flow direction with the increase of the fiber volume fraction and the Reynolds numbers. The fibers with large aspect ratio tend much easier to align with the flow direction, and the fiber orientation distribution is not sensitive to the aspect ratio when it is larger than 5. The shear stress increases along the flow direction and decreases from the center to the outside. The addition of fibers makes an increase of the shear stress, and the magnitude of increase is directly proportional to the fiber volume fraction, Reynolds number and fiber aspect ratio. The first normal stress difference is much less than the shear stress, and increases along the flow direction and from the center to the outside. It increases with increasing the fiber volume fraction and aspect ratio, and decreasing Reynolds number. The differences in the shear stress and the first normal stress difference for different parameters are the most and the least obvious at the centerline and the outside, respectively.