아세톤-물 혼합용매에서 trans-[Co(en)_2Cl_2]^+, trans-[Co(N-eten)_2Cl_2]^+, trans-[Co(N-meen)_2Cl_2]^+, trans-[Co(tn)_2Cl_2]^+ 착이온의 가용매 분해반응에 대한 압력과 용매조성의 영향 : 반응메카니즘과 자유에너지 변화사이클 및 Excess 자유에너지 Excess Free Energy & Free Energy Cycle and Reaction Mechanism

朴裕哲,趙靈濟 慶北大學校 物理化學硏究所 1986 硏究論文集 Vol.7 No.-

아세톤-물 혼합용매에서 trans-[Co(AA)_2Cl_2]^+ 착이온의 가용매분해반응속도를 전도도법과 분광광도법을 사용하여 1∼2000 bar의 압력범위에서 측정하였다. 여기서 AA는 에틸렌디아민(en), N-에틸에틸렌디아민(N-eten), N-메틸에틸렌디아민(N-meen)과 트리메틸렌디아민(tn)을 각각 의미한다. 속도상수에 대한 압력의 영향으로부터 구한 활성화 체적은 AA가 en, N-eten, N-meen 및 tn 일때 각각 -0.2∼0.9㎤mole^-1, -0.2∼0.6㎤mole^-1, -0.8∼6.0㎤mole^-1, 0.7∼7.0㎤mole^-1이었다. 이들 착이온의 가용매분해반응성은 excess 자유에너지와 자유에너지 사이클로부터 얻은 결과를 비교하여 검토하였다. 가용매분해반응성은 압력이 감소할수록, 그리고 아세톤의 함량이 증가할수록 S_N1 경향성이 증가하였다. 또한 가용매 분해반응의 메카니즘에 미치는 하전분리 효과도 고찰하였다. The rates of solvolysis of trans-[Co(AA)_2Cl_2]^+ in which AA indicates ethylenediamine(en), N-ethylethylenediamine(N-eten), N-methylethylenediamino(N-meen) and trimethylenediamine(tn) respectively have been investigated using conductometric and spectrophotometric methods at various pressure up to 2,000 bar in acetone-water mixture. The activation volumes(ΔV^≠) obtained from the pressure effect on rate constants were -0.2∼0.9㎤mole^-1 for en, -0.2∼0.6㎤mole^-1 for N-eten, -0.8∼6.0㎤mole^-1 for N-meen and 0.7∼7.0㎤mole^-1 for tn. The rates of solvolysis of these complexes were analyzed by comparing with the results obtained from excess free energy(G^E) and free energy cycle. It was found that S_N1 character was increased with decreasing the pressure and increasing the content of acetone in the mixture solvent. In addition to that, the effect of charge separation on the mechanism of solvolysis was discussed.

남성화 암쥐의 모리스 수중 미로 수행력 : 성에 따른 공간기억력과 테스토르테론 효과의 차이

신성현,박제민,정우영,박문일,서유나,김성곤,강철중 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5

Objectives : It is widely accepted that gonadal steroids are involved in organization and activation of sexual dimorphism in the brain areas related with spatial leaming. This study aimed to test the following hypothesis : 1) spatial memory is affected by sex, 2) this difference is related with brain differentiation by exposure to testosterone in the neonatal period, and/or 3) the sexual difference of spatial memory is the result of the interaction between organization of sexual dimorphism in the brain and the circulating testosterone after growing up. Methods : Testosterone enanthate 100 ㎍, ('androgenized') orvehicle ('control') was randomly administered to 28 female and 25 male rat pups within 24 hour of birth. The escape latencies (EL) in Morris water maze were measured in 15 and 16 week of age with vehicle ('baseline') and with 10 μmol/kg of testosterone ('with testosterone'), respectively. Each session Consis-ted of 10 trials, and means of the last 5 trials were analyzed. Results : The baseline EL of the males were significantly shorter than females regardless ofneonatal exposure to testosterone. With testosterone, EL of the androgenized females were significantly shorter than control females and comparable to those of males. Conclusion : Neonatal exposure to testosterone in female rats may develop a tesosterone-dependent male-like spatial leaming system.

중증 만성정신질환자 수의 추산 : Through Two Community Surveys 두 지역사회 조사를 중심으로

홍진표,김윤,배재남,정유진,강영호,양병국,김용익,김병후,이철,조맹제 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.2

국내 중증 만성정신질환자 수를 추정하기 위하여 일 농촌 및 대도시 지역의 지역의료보험 및 의료보호 대상자 중 1993년 1년간 의료기관에서 정신증 상병(ICD-9 code 상 290-299) 및 알콜 남용/중독, 성격장애 및 정신박약 진단하에 치료를 받은 적이 있는 사람에 대해 설문조사를 실시하였다. 연구자들이 개발한 진단도구를 이용하여 진단을 평가하고, Strauss-Carpenter scale 등을 이용하여 기능 장애를 평가하고 유병기간 등을 조사하였다. 결과를 요약하면 다음과 같다. 1) 진단평가상 정신분열병군(61.1%)이 가장 많았으며, 정동장애군(23.7%), 알콜장애군(11.2%), 기질성 정신장애군(4.0%)의 순서이었다. 2) 직업활동정도는 진단군별로 차이가 많았다. 지난 1년간 직업활동이 6개월 미만이거나 전혀 없는 환자 비율이 정신분열병군은 67.2%, 알콜장애군 52.0%, 정동장애20.8%의 순으로 정신분열병군이 가장 불량하였다. 3) 사회활동도 진단군별로 차이가 많아서 지난 1년간 의도적, 사회활동이 없는 비율이 정신분열병군이 가장 높았고(72.3%), 알콜장애군(32.0%), 정동장애군(20.7%)의 순이었다. 4) 국내 의료보험 및 사회복지시설 이용 자료 등을 토대로 본 조사 결과를 적용한 결과 국내중증 만성 정신질환자의 수는 약 8만 7천명으로 추산되었다. Objectives: The purpose of this study was to estimate the number of serious and persistent mentally ill patients in Korea. Methods : Study populations were recruited from medical insurance data of two district areas ; one rural and the other urban areas. Subject were all mentally ill who had ever visited any hospital in 1993 and were diagnosed as having psychosis, personality disorder and drug abuse. We conducted a home visiting survey applying semi-structured diagnostic interview, assessing the level of social adjustment with Strauss-Carpenter Scale, and past psychiatric history by the trained researchers, in October and November,1994. Results : According to diagnostic assessment schizophrenic patients constituted the major portion(61.1%) of study subjects. The distribution of occupational functions and social contacts was variable according to diagnosis. Most schizophrenic patients were unemployed or worked less than 6 months in the previous year(67.2%), and showed poor social contact(72.3%). But affective disorder patients were relatively independent in job maintenance and social relationship. Alcoholic patients lay between those of schizophrenic and affective disorder groups. It was estimated that about 87,000 adult Koreans were suffering from chronic mental disorders which seriously interfere with their daily life. Conclusions : Serious and persistent mentally ill patients were common in Korea. Community support program should be provided for them.

3-MCPD의 생식˙발생독성에 관한 연구

곽승준(Seung Jun Kwack),김순선(Soon Sun Kim),최요우(Yo Woo Choi),이규식(Gyu Seek Rhee),손경희(Kyung Hee Sohn),이이다(Rhee Da Lee),채수영(Soo Young Chae),정용현(Yong-Hyun Chung1),유일재(Il Je Yu1),박귀례(Kui Lea Park) 한국독성학회 2004 Toxicological Research Vol.20 No.2

3-Monochloro-1,2-propanediol(3-MCPD) is a toxic compound, often present in different foods containing acid hydrolyzed(AH) protein, like seasonings and savory food products. The purpose of the present study was to investigate the effects of 3-MCPD on male fertility, sperm and testosterone secretion. In vivo male fertility test was performed for observing the adverse effects of 3-MCPD on the function of male reproductive system and pregnancy outcome. 0.01, 0.05, 0.25, 1 and 5 mg/kg b.w. of 3-MCPD was given daily by gavage to groups of 15 adult male SD rats for 4 weeks. At the end of pre-treatment period, males were mated overnight with normal females. Following morning, males demonstrating successful induction of pregnancy were sacrificed on that day to assess sperm parameters and histopathology of reproductive organs. The resulting pregnant females were sacrificed on day 20 of gestation to evaluate pregnancy outcome. As a result, four-week paternal administration with 3-MCPD resulted in adverse effects on male fertility and pregnancy outcome without remarkable histopathological changes in testes and epididymides; sperm motility, copulation index and fertility index were markedly decreased in the treated group and numbers of live fetuses showed steep dose-response curves. Also, spermatogenesis was investigated in this experiment. However, no<br/> effect was observed on production of sperm in testes treated with 3-MCPD for 4 weeks. Hormone assay was performed for observing the effects of 3-MCPD on testosterone and luteinizing hormone (LH) in blood and testes of male SD rats and cultured primary Leydig cell. In result, significant changes of related hormones did not observed by treatment of 3-MCPD. These results indicated that paternal treatment with 3-MCPD induced spermatotoxic effect, which caused an antifertility on male.

Radiation impacts on morphological and qualitative properties in common buckwheat (Fagopyrum esculentum) and tatary buckwheat (Fagopyrum tataricum) seeds

Je-Hyeok Yu,Min-Heon Yun,Seon-Mo Yang,Dong-Seop Kim,Young-Ho Yun,Kyung-Ho Ma,Eun-Ho Son,Sok-Young Lee,Hong-Sig Kim,Sun-Hee Woo 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

Breeding and cultivation techniques are being treated very severely regarding ecological and physiological development in buckwheat. This study was conducted to focus on the diversity occurring in the cultivated and tartary buckwheat and provide an overview of the characteristics and genetic resources activities. Morphological results showed that the height of common buckwheat ranges from 82-90cm, common buckwheat induced by 200Gy ranges from 52-75cm, common buckwheat induced by 300Gy ranges from 43-56cm, common buckwheat induced by 400Gy ranges from 33-60cm whereas the tartary buckwheat hight ranges from 65-87cm, and while it exposed to various radiation (200Gy, 300Gy and 400Gy), the obtained height ranges from 73-92cm, 55-80cm and 60-75cm respectively. However, the stems from the both cultivar are hollow and that’s why, the plant is very prone to lodging. The leaf color of common buckwheat was green, 200Gray, 300Gy 400Gy common buckwheat light green and green, whereas the tartary buckwheat green and bottle-green, 200Gray 300Gy 400Gy tatary buckwheat bottle-green, common buckwheat (control, 200Gy, 300Gy, 400Gy) stem color is light green and pink, flower color is white, tartary buckwheat (control, 200Gy, 300Gy, 400Gy) flower color is light green. The stem color from tartary buckwheat showed (200Gy, 300Gy, 400Gy) light green and light red color. The results revealed that the two buckwheat cultivars showed diversified characteristics.

Epidemiological Characterization of Opportunistic Mycoses between the Years 2006 and 2010 in Korea

( Je Seop Park ),( Seung Hak Cho ),( Seung Ki Youn ),( Young Seok Bak ),( Young Bin Yu ),( Young Kwon Kim ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.1

In order to perform an epidemiological characterization of opportunistic mycosis infections, we collected health insurance data between the years 2006 and 2010 from the Health Insurance Corporation and analyzed the data to determine the prevalence of opportunistic mycoses and treatment management of opportunistic mycoses. The prevalence within the study increased consecutively by 0.02% to 0.12% every year. The annual prevalence of opportunistic mycoses increased from 2.437% in 2006 to 2.709% in 2010. The average annual prevalence was 2.605%. Candidiasis occurred the most frequently, followed by aspergillosis, zygomycosis, and cryptococcosis. The regions with the highest incidences were the capital areas, Gyeonggi and Seoul. By sex, the prevalence in females (4.851%) was 14 times higher than that in males (0.352%). Interestingly, the adults from the 20- to 49-year-old age group showed higher prevalence than children and the elderly. The average duration of hospitalized treatment was 17.31 days and of outpatient treatment was 2.21 days; 3,577 hundred million won was used in total for medical expenses. This study provides useful data to study trends of opportunistic mycoses.

메시지 기반 인터페이스 공동 개발을 위한 메시지 관리 시스템

유제영(Je-young Yu),박진희(Jinhee Park) 한국정보과학회 2008 정보과학회 컴퓨팅의 실제 논문지 Vol.14 No.6

대형 시스템은 각 컴포넌트가 여러 다른 개발자에 의하여 개발된다. 개발 과정에서 컴포넌트 간의 인터페이스 관리의 효율성은 전체 개발 효율에 큰 영향을 미친다. 특히, 개발 초기 과정에서는 컴포넌트가 새롭게 정의되거나 변경되는 경우가 많다. 컴포넌트의 새로운 정의나 변경은 컴포넌트 간의 인터페이스의 생성이나 변경을 필요로 한다. 이러한 인터페이스의 변경에 대한 관리가 효율적으로 이루어지지 않는 경우, 관련된 컴포넌트를 개발하는 서로 다른 개발자들이 서로 다른 인터페이스를 기반으로 개발을 진행하는 경우가 발생한다. 이는 개발의 효율이 저하되는 문제를 일으킨다. 이러한 문제를 해결하기 위하여 메시지 관리시스템은 메시지 기반의 인터페이스 관리를 위한 수단을 제공한다. 또한, 메시지에 대한 코드 생성을 통하여 구현의 편의성을 제공해 주며, 메시지 관리 시스템 내에 정의된 메시지 정보를 이용하여 인터페이스 설계 명세서(IDD)를 자동으로 생성해 준다. 문서 자동 생성은 메시지 변경으로 인한 실제 인터페이스와 문서와의 불일치를 방지한다. 또한, 메시지 관리 시스템은 전체 시스템의 각 컴포넌트 간 메시지를 관리함으로써 각 컴포넌트 간 메시지 흐름에 대한 종합적인 정보를 수집하는 것이 가능하다. 이러한 정보는 컴포넌트간 메시지 흐름의 병목 현상의 발생을 미리 방지하거나, 전체 시스템 성능의 조율을 지원하는데 응용할 수도 있다. In Large scale system, components are developed by many different developers. In such a development environment, efficiency of the development depends largely on effectiveness of interface management. In the early stage of development, many components are newly defined or modified quite often. These definitions and modifications of components cause the change of interfaces between components. If changes of interfaces are not properly managed, many developers may implement components based on different version of interfaces. This causes decrease in efficiency of development. “Message Definition and Management System (MDMS)” provides the means to cope with the inefficiency of unmanaged interface definitions and changes. MDMS automatically generates source code and Interface Design Description (IDD). The automatic generation of source code and IDD prevents the disagreement between code and documents. Furthermore, MDMS shows the overall view of message flow for a system. Based on this information, we can optimize the system identifying message bottleneck and apply to support for the performance tuning of the system.

개회충 유충 감염에서 발생되는 호산구성 폐질환의 특성

김유진 ( Yu Jin Kim ),경선영 ( Sun Young Kyung ),안창혁 ( Chang Hyeok An ),임영희 ( Young Hee Lim ),박정웅 ( Jung Woong Park ),정성환 ( Seong Hwan Jeong ),이상표 ( Sang Pyo Lee ),최동철 ( Dong Chull Choi ),정영배 ( Young Bae Je 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.62 No.1

연구배경: 개흡충증은 한국에서 호산구증다증과 호산구성 폐질환을 일으키는 흔한 원인의 하나이다. 우리는 개흡충증에 의한 호산구성 폐질환의 특장을 분석하였다. 방법: 2001년 9월 1일부터 2006년 3월 30일까지 개회충 2기유충에 의한 호산구증다증으로 진단 받은 141명의 환자들을 대상으로 하였다. 본 연구를 위해 단순 흉부 방사선 촬영. 흉부 컴퓨터단층촬영, 기관지내시경, 기관지폐포세척술과 각종 혈액학적 검사를 시행하였다. 개회충증의 진단은 개회충 2기유충의 순수 분비배설 항원을 사용하였다. 결과: 141명의 환자 중 32명이 개회충에 의한 호산구성 폐질환으로 진단되었다. 젖빛유리양상이 컴퓨터단층촬영에서 지배적으로 23/32명(71.9%)이었다. 13/32명(40.6%)은 무작위적 구역적 분포를 보였다. 흉수액이 9/32명(28.1%)에서 관찰되었다. 28/32명(87.5%)이 호흡기 증상을 호소하였다. 11/32명(34.4%)은 호흡기 증상과 소화기 증상을 동시에 호소하였다. 12/32명(37.5%)에서 간에 국소의 저음영의 침윤을 보였다. 결론: 개회충에 의한 호산구성폐질환의 임상적, 방사선적 특성은 다발성의 결절성 또는 경화성의 젖빛유리음영이 양폐 상하엽에 무작위적 분포를 하는 것이다. 앞으로 우리나라에서 호산구 증다증과 폐침윤을 보이는 성인에서 감별진단을 위해 개회충증의 가능성을 고려해야 할 것으로 판단된다. Background: Toxocariasis is a common cause of eosinophilia and eosinophilic lung disease in Korea. We analyzed the characteristics of eosinophilic lung disease in toxocariasis. Method: One hundred and forty one patients with eosinophilia caused by a toxocara larval infection were evaluated from September 1, 2001 through March 30, 2006. The plain chest x-ray, chest CT(computed tomography), and bronchoalveolar larvage(BAL) were examined. A diagnosis of toxocariasis was made by ELISA using that secretory-excretory antigen from the T. canis larvae. Results: Toxocarial eosinophilic lung diseases was diagnosed in 32 out of 141 patients. Ground glass attenuation was the main feature on the CT scans in 23 out of 141 patients (71.9%). Thirteen patients (40.6%) had a random in zonal distribution on CT. Pleural effusion was observed in 9 patients (28.1%). Twenty eight patients (87.5%) complained of respiratory symptoms. Eleven patients (34.4%) had gastrointestinal symptoms and 12 patients (37.5%) had liver infiltration. Conclusions: The most common findings of the chest CT in patients with toxocariasis was a randomly distributed ground grass attenuation. A toxocara infection should be considered in a differential diagnosis of patients who exhibit pulmonary infiltration with eosinophilia in Korea. (Tuberc Respir Dis 2007; 62: 19-26)

CFC-101 ( 녹농균 백신 ) 의 능동 및 수동면역 효과

김영지(Young Gi Kim),김제학(Je Hak Kim),박완제(Wan Je Park),김유삼(Yu Sam Kim),함경수(Kyung Soo Hahm),조양제(Yang Je cho),박관하(Kwan Ha Park) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.4

The treatment of pseudomonal infection is a perplexed problem because of its modest susceptibility to most of the major antibiotics. A novel Pseudomonas vaccine(CFC-101) was prepared from the outer membrane protein fractions of several Pseudomonas strains. In this study, we examined CFC-101`s effectiveness in both active and passive immunization models. CFC-101 in mice at 0.2 mg/kg, i.p., given three times at two-day intervals, completely prevented the death caused by Pseudomonas aeruginosa. Antibody titer, in accordance with the protective effect in this active immunization, was elevated to its peak level following three consecutive administrations of CFC-101. Thereafter, antibody titer stayed at a constantly high level. Each outer membrane protein fraction from the four CFC-101 producers, exhibited good cross-protective effects in mouse infection models against different Fisher types of P. aeruginosa. In the passive immunization model, 21∼336 ㎍/㎏ of anti-rabbit IgG to CFC-101, when mice being infected with a challenge strain, prevented the Pseudomonas-induced death up to 60%. Therefore, the preventive effect of CFC-101 was verified in both the active and passive immunization models.

Physicochemical Property of Polygonum multiflorum by Acetic Acid Bacteria Fermentation

Kyung-Je Kim,Seong-Woo Jin,Hae-Shin Je,Young-Woo Koh,Seung-Bin Im,Sang-Wook Jeong,Yu-Seon Kim,Junseok Oh,Jae-Heoi Hong,Tae-Young Park,Kyoungsun Seo 한국버섯학회 2017 버섯 Vol.21 No.2

Polygonum multiflorum (Polygonaceae family) is effective to cholesterol lowering effect, increased immunity effect and whitening effect. P. multiflorum root is used for medicinal herb that can be used as raw material for food. In this study, acetic acid fermentation was adding extracts of P. multiflorum root(0%, 1%, 3%, 5%) for the developing healthy beverage. In this study, we investigated the contents of free sugars, organic acids and inorganic components of P. multiflorum root. As a result of free sugars from P. multiflorum root analysis, three kind of free sugars were determined the glucose, sucrose and lactose by HPLC. Four kind of organic acids were found in lactic acid fermented P. multiflorum root. And oxalic acid, lactic acid and succinic acid were detected in organic acids. The content of lactose and lactic acid in lactic acid fermented P. multiflorum root was the highest among the free sugars and organic acids. The content of minerals were in high orders of sodium> calcium> magnesium in P. multiflorum by acetic acid fermentation. The content of inorganic components was highest in lactic acid fermented solution with 5% and proportional to the content of P. multiflorum