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HBx형질전환 생쥐에서 발생한 간세포암종에서 H-ras 및 c-myc의 발현에 관한 연구
문형배,소병준,김학철,윤기중,한원철,조향정,유대열,정영진 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2
<연구목적> HBx형질전환 생쥐에서 발생한 간세포암종의 발암과정에 종양유전자(H-rgs, c-myc)의 발현 정도를 조사하고자 하였다. <연구방법> 정상생쥐 12마리(4-18개월) 및 HBx 형질전환 생쥐 44마리(4-18개월)를 대상으로 포르말린에 고정하고 파라핀에 포매한 간 조직을 이용하여 면역조직화학적염색을 실시하였다. 실험군은 정상 부위, 이형성 부위 및 종양 부위로 구분하였으며, 종양 부위는 소결절성병변 부위와 간세 포암종 부위로 구분하였고, 이형성병변 부위는 이형성병변만 발견되는 부위, 소결절성병변과 동반된 이형성병변 부위 및 간세포암종과 동반된 이형성병변 부위로 구분하였다. <연구결과> H-rgs의 발현은 정상 간조직에 비하여 이형성병변 부위(P<0.05) 및 종양 부위(P<0.01)에서 증가하였으며, 소결절성병변 부위과 간세포암종 부위 사이에서는 간세포암종 부위에서 증가된 경향이었으나 통계학적으로 유의한 차이가 없었으며, 각 이형성병변 부위 사이에서도 유의한 차이는 없었다. c-myc의 발현은 정상 간조직 및 이형성병변 부위에 비해 종양 부위에서 증가하였으며(P<0.001), 소결절성병변 부위와 간세포암종 부위에서는 비슷하였고, 각 이형성병변부위 사이에서도 비슷하였다. <결론> HBx형질전환 생쥐에서 발생하는 간세포암종의 발생에 H-rgs는 이형성 변화를 일으키는 시기에 관여하며, c-myc은 이형성병변에서 암으로 이행하는 시기에 관여할 것으로 생각한다. Background: This experiment was designed for the expression of H-ras and c-myc in hepatocarcinogenesis of the HBx transgenic mice. Methods: Immunohistochemical stains in the paraffin embedded tissue of the liver were used for the detection of H-ras and c-myc in the 12 normal mice and 44 HBx transgenic mice of the 4-18 month old. Results: Expression of the H-ras was significantly increased in the dysplastic area (P<0.05) and tumor area (P<0.01) than in the normal liver. But there were no differences of H-ras expression between areas of microscopically identified hepatocellular carcinoma (MI-HCC) and grossly identified hepatocellular carcinoma (GI-HCC) and dysplastic areas among the only dysplastic areas, dysplastic areas with MI-HCC and GI-HCC. Expression of the c-myc was significantly increased in the tumor area (P<0.001) than in the normal liver and dysplastic area. But there were no differences of c-myc expression between areas of MI-HCC and GI-HCC, and dysplastic areas among only dysplastic areas, dysplastic areas with MI-HCC and GI-HCC. Conclusions: Our study suggests that H-ras is related to the dysplastic change and c-myc is related to the neoplastic change in the hepatocarcinogenesis of the HBx transgenic mice.
결핵성 육아종에서 Thioredoxin peroxidase-2 의 발현
박근호,유형륜,정영진,윤기중,한원철,유대열,문형배 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2
Background: Thioredoxin peroxidase(TPX) is a kind of recently discovered antioxidant enzyme which react as rapid hydrogen ion donor for the removal of hydroperoxide. The action and distribution of the TPX was poorly understood in the human diseases. This experiments were designed for the study about the distribution of the TPX in the chronic granulomatous inflammation and about the correlation between the expression of TPX and the site of inflammation, histological activities of tuberculous inflammation or existence of mycobacterium in the inflammatory foci. Methods: The immunohistochemical stains were performed for the localization of the TPX-2 in the epithelioid cells, giant cells and lymphocytes in the chronic granulomatous inflammation. The tissue sections were obtained from the paraffin blocks of the 54 cases of tuberculosis (lung 21 cases, lymph node 12 cases, bone and soft tissue 12 cases, kidney 9 cases; active 33 cases, inactive 21 cases by the histologic classification; presence of mycobacterium 15 cases, no mycobacterium 39 cases by PCR reaction). Results: The expression of TPX-2 was 16.7% in the giant cells, 27.8% in the epithelioid cells and 100% in the lymphocytes of tuberculous inflammations. The expression of TPX-2 in the giant cells and epithelioid cells of the tuberculosis were 28.6% and 57.1% of the pulmonary tuberculosis; 33.3% in each cells of the renal tuberculosis; 0% in each cells of the lymph node or bone and soft tissue tuberculosis. The expression of TPX-2 in the giant cells and epithelioid cells were 9.1% in each cells of the active tuberculosis and were 28.6% and 57.1% in each cells of the inactive tuberculosis by histologic classification. The expression of TPX-2 in the giant cells and epithelioid cells was 40% in each cells of tuberculosis which mycobacteria were detected and the expression of TPX-2 was 7.7% and 23.1% in each cells which mycobacteria were not detected by PCR reaction in the paraffin embedded tissue. Conclusions: The above results were summarized that the TPX-2 in the giant cells and epithelioid cells were more frequently expressed in the inactive tuberculosis than in the active tuberculosis. These results suggest that the TPX-2 is a kind of regulating or suppressing factors in the activity of the tuberculosis.
고속철도KTX(Korea Train Express)의 역구내진입 제동시 브레이크슈 사이의 마찰소음에 관한 연구
배원식(Bae Won-Sik),정인수(Chung In-Soo),이동훈(Lee Dong-Hoon),유원희(Yu Won-Hee) 한국철도학회 2007 한국철도학회 학술발표대회논문집 Vol.- No.-
The noises which occurs from the rolling stock can be divided largely into three classes and they are Rolling noise, Traction noise and Aerodynamic noise. In the event of braking the rolling stock which enter into the station, Brake shoes cause Fraction noise (braking noise) and excessive braking noise makes passengers and operators uncomfortable. This study is to reduce squeal noise and minimize displeasure by measuring the braking noise and defining the major noise sources and noise mechanism,
일반연제 발표 : 복막투석환자에서 C반응단백, 혈액응고인자, apolipoprotein 및 Cardiac Troponin-T(cTnT)의 상관성
김유미 ( Kim Yu Mi ),서장원 ( Seo Jang Won ),장재원 ( Jang Jae Won ),양원석 ( Yang Won Seog ),김순배 ( Kim Sun Bae ),박수길 ( Park Su Gil ),이상구 ( Lee Sang Gu ),박정식 ( Park Jeong Sig ),홍창기 ( Hong Chang Gi ) 대한신장학회 2002 춘계학술대회 초록집 Vol.21 No.1
교통사고로 인한 후방십자인대 파열 환자에 대한 증례보고 2예
배준효 ( Jun-Hyo Bae ),권용수 ( Yong-su Kwon ),유재은 ( Jae-eun Yu ),이희원 ( Hee-won Lee ),구지은 ( Ji-eun Koo ),김가현 ( Ka-hyun Kim ),최성원 ( Sung-won Choi ),윤주영 ( Joo-young Yoon ),박지원 ( Ji-won Park ) 한방재활의학과학회 2021 한방재활의학과학회지 Vol.31 No.3
This study’s purpose is to report the effectiveness of Korean medicine treatment to posterior cruciate ligament tear patients due to traffic accident. 2 patients were treated with Korean medicine by acupuncture, pharmacopuncture and herbal medication. We assessed the knee pain and functional improvement by using numeric rating scale (NRS), Western Ontario and McMaster Universities arthritis (WOMAC) index and EuroQol-5 dimension (EQ-5D) index. After treatment, NRS decreased from 6 to 2 in case 1 and from 5 to 3 in case 2. EQ-5D index chaged from 0.465 to 0.72 in case 1 and from 0.719 to -0.171 in case 2. WOMAC index decreased from 82 to 13 in case 1 and from 55 to 54 in case 2. NRS improved in both cases, but WOMAC index and EQ-5D index improved in only one case. Korean medicine treatment could be helpful for posterior cruciate ligament tear traffic accident patients. However, further clinical studies are needed to clarify the effectiveness to the patients with old age, degeneration and accompanying injury. (J Korean Med Rehabil 2021;31(3):141-147)
유승화 ( Seung-hwa Yu ),김영근 ( Young-keun Kim ),우제근 ( Jea-keun Woo ),신소영 ( So-young Shin ),김동원 ( Dong-won Kim ),김수배 ( Su-bae Kim ),김경철 ( Kyoung-chul Kim ),최인찬 ( In-chan Choi ),최용 ( Yong Choi ) 한국농업기계학회 2021 한국농업기계학회 학술발표논문집 Vol.26 No.2
2003년 국내 유입된 외래종 등검은말벌(Asian Hornet)은 2016년 전국으로 확산되어 양봉 농가에 큰 피해(꿀벌 봉군 전체의 약 30% 이상)를 주고 있다(Kim et al., 2017, Yu et al., 2020.). 이에 따른 방제 비용과 피해액은 연간 약 1,750억원 이상이 발생하는 것으로 추정하고 있다(Kim, 2017). 양봉장 주변의 나무 높은 곳에 위치하고 있는 등검은말벌을 퇴치하기 위해서는 여왕벌이 서식하는 말벌집을 물리적으로 제거하거나 화학적 살충 방제하는 것이 효과적이다. 이에 최근 농업에 활발히 보급되고 있는 방제용 드론을 개량해 말벌집에 직접 약액을 살포하는 기술 개발이 필요하다(YU, et. al., 2020). 본 연구에서는 선행 말벌집 퇴치 현황 등 설계요인을 분석한 결과를 기초로 하여 드론에 탑재가 가능하고 말벌집에 직접 살충제를 분사할 수 있는 드론용 살포장치를 설계 제작하였다. 드론용 약액 살포장치는 선행된 설계요인을 분석하여 물리적 제거와 화학적 살충 방법 각각의 강점을 복합적으로 사용하여 상호 보완할 수 있도록 설계하였다. 드론용 약액 살포를 위하여 살포 분사대(카본 φ10mm X 1m, 직분사노즐, 모터펌프(9bar 이상), 타깃팅용 영상모니터링 장치, 살포 각 제어장치 등으로 구성하였다. 또한 말벌집 표면은 물에 잘 젖지 않는 특성이 있어 분사 약액만으로 말벌집 전체 살충에 어려움이 있어 말벌집 표면에 구멍을 뚫어 살충액을 내부까지 침투시키고자 하였다. 이에 말벌집으로부터 3~5m 거리에서 약액 살포와 동시에 말벌집 표면에 구멍을 뚫을 수 있는 타공장치를 제작하였다. 이 타공장치는 공기압축 방식의 전동식 공기압축 실린더를 사용하였으며, 이 실린더에 장착이 가능한 원형 탄환을 적용하여 실린터 압축력으로 이 탄환이 날아가 말벌집 표면을 타공할 수 있도록 하였다. 이와 같이 제작된 타공장치는 분당 최대 300회 구멍을 뚫을 수 있으며, 동시에 약액을 말벌집 내부까지 분사해 살충 효과를 높일 수 있도록 제작 하였다.
( Yu Jung Jo ),( Kyung Ah Kim ),( June Sung Lee ),( Nam Hoon Kim ),( Won Ki Bae ),( Tae June Song ),( Jeong Wook Kim ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.2
Background/Aims: The clinical outcome of patients with a partial virological response (PVR) to entecavir (ETV), in particular nucloes(t)ide analogue (NA)-experienced patients, has not been thoroughly investigated. The aim of the present study was to assess long-term outcomes in NA-naive and NA-experienced chronic hepatitis B patients with a PVR to ETV. Methods: Chronic hepatitis B patients treated with ETV (0.5 mg/day) for at least 1 year were enrolled retrospectively. PVR was defined as a decrease in hepatitis B virus (HBV) DNA titer of more than 2 log10 IU/mL, yet with residual serum HBV DNA, as determined by real time-polymerase chain reaction, at week 48 of ETV therapy. Results: A total of 202 patients (127 NA-naive and 75 NA-experienced, male 70.8%, antigen positive 53.2%, baseline serum HBV DNA 6.2 ± 1.5 log10 IU/mL) were analyzed. Twenty-eight patients demonstrated a PVR. The PVR was associated with a high serum HBV DNA titer at baseline and at week 24. Virological response (< 60 IU/mL) was achieved in 46.2%, 61.5%, 77.6%, and 85% of patients with PVR at week 72, 96, 144, and 192, respectively. Resistance to antivirals developed in two NA-experienced patients. Failure of virological response (VR) in patients with PVR was associated with high levels of serum HBV DNA at week 48. Conclusions: Patients with PVR to ETV had favorable long-term virological outcomes. The low serum level of HBV DNA (< 200 IU/mL) at week 48 was associated with subsequent development of a VR in patients with PVR to ETV.