Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

스테레오 비젼과 레이저포인터를 이용한 거리 측정 시스템

조현,진광식,윤태성,이용중 國立 昌原大學校 産業技術硏究所 1999 産技硏論文集 Vol.13 No.-

In this paper, we studied on the environment map building for the autonomous mobile robot navigation using the vergence controllable stereo camera system. First of all, distance measurements are necessary to build the environment map. So, we present the distance measurement method using the stereo camera system and a laser pointer. To measure the distance using the stereo camera system, finding the common points in the left and the right images are needed. In this study, we use a laser pointer to solve this problem. Secondly, we present the method how to obtain the 3-dimension position information using 3-D geometric schematic of the stereo camera and the measured distance information. This information is essential to the mobile robot navigation. Finally, we prove the presented method experimentally. An image of a corridor is taken by the stereo camera. The door and pillar in this image are landmarks. Therefore, we find such landmarks in the image and measure the 3-D position information for those landmarks. And the, we construct the environment map for the navigation of the mobile robot.

개에 있어서 심장사상충증을 동반한 창상성 횡격막 허니아의 수술적 치료 1례

조승혁,임영환,손정민,노경완,박창식,전무형,김명철,송근호,정성목 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

A 7-month old. castrated male Shih-tzu dog was referred to the Veterinary Medical Teaching Hospital of Chungnam National University with history of depression. dyspnea. mild scale. tachypnea. exercise intolerance and severe leanness. On physical examination. cardiac arrhythmias was heard and heart worm ELISA test was positive. Microfilaria was found on the direct blood smear. Survey radiographs showed loss of diaphragmatic line and cardiac silhouette. displacement of lung fields and presence of gas filled intestines in the thoracic cavity. Rib fracture and pelvic fracture with callus formation were found incidentally. On the basis of physical examination and radiographic findings. it was diagnosed as traumatic diaphragmatic hernia and heart worm disease. Herniorrhaphy was performed. Postoperatively. it was treated for heart worm disease and scale. There is no evidence of recurrence of diaphragmatic hernia and heart worm disease over 1 year.

개에 있어서 심장사상충증을 동반한 창상성 횡격막 허니아의 수술적 치료 1례

조승혁,임영환,손정민,노경완,박창식,전무형,김명철,송근호,정성목 忠南大學校 獸醫科大學 動物醫科學硏究所 2005 動物醫科學硏究誌 Vol.13 No.-

A 7-month old, castrated male Shih-tzu dog was referred to the Veterinary Medical Teaching Hospital of Chungnam National University with history of depression, dyspnea, mild scale, tachypnea, exercise intolerance and severe leanness. On physical examination, cardiac arrhythmias was heard and heart worm ELISA test was positive. Microfilaria was found on the direct blood smear. Survey radiographs showed loss of diaphragmatic line and cardiac silhouette, displacement of lung fields and presence of gas filled intestines in the thoracic cavity. Rib fracture and pelvic fracture with callus formation were found incidentally. On the basis of physical examination and radiographic findings, it was diagnosed as traumatic diaphragmatic hernia and heart worm disease. Herniorrhaphy was performed. Postoperatively, it was treated for heart worm disease and scale. There is no evidence of recurrence of diaphragmatic hernia and heart worm disease over 1 year.

자발성 뇌교출혈 환자의 예후에 관한 임상 분석

조재영,석종식,민병국,권정택,최덕영,황성남,김영백,박승원 중앙대학교 의과대학 의과학연구소 2002 中央醫大誌 Vol.27 No.1

Patients with spontaneous pontine hemorrhage very often develop setvere disturbances of consciousness,pupilary abnormalities, respiratory and motor. They have high mortality rate. Therefore, I analyzed the correlation between the Glasgow outcome scale(GOS)and clincial manifestations or computed tomographic(CT)findings in 48 patients with spontaneous pontine hemorrhage to clarify factors predicting the prognosis. I examined 48 Patients with spontaneous pontine hemorrhage; 33 males and 15 females, age 54.6±8.99(mean±S.D.;range 39 to 68)brought to our hospital between January 1995 and December 1999, retrospectively. Correlations between the clinical manifestations, CT findings and the GOS was assessed with multivariate regression analysis. The results were as follow: 1) Patients with the pontine hemorrhage were of 8.8% in those with intracerebral hemorrhage. The ratio of male and female was 33 to 15. The incidence of age is eqial to 40,50 and 60. Total mortality was 41.6%. 2) The poor prognostic factor were that; Glasgow coma scale(GCS)3∼8, irregular respiration. pupilary abnormality, quadriplegia, Brain CT typeⅠ(massive), hydrocephalus, extrapontine extension, Intraventricular hemorrhage(IVH). These clinical analysis should be useful in determining the level of care and future resuscitative efforts.

pH 변화에 따른 클로라민 생성과 분해 특성

조관형,김평청,우달식,조영태 한국환경과학회 2002 한국환경과학회지 Vol.11 No.4

본 연구의 시료는 현재 서울특별시와 수도권 도시들에서 상수원수로 이용하고 있는 한강수를 대상으로 수행되었다. 배·급수계통의 2차 소독을 위한 클로라민소독의 특성에 관하여 고찰하였으며 그 결과는 다음과 같다. 1) 25 ℃, Cl_2 / NH_3-N비 1:1 ~ 14:1에서 pH6, 7, 8의 불연속점은 각각 Cl_2 / NH_3-N비 11:1, 9:1, 10:1이었다. pH6의 경우, Cl_2 / NH_3-N비가 9:1일 때 총 잔류염소량이 최대인 반면, pH7, 8의 경우 Cl_2 / NH_3-N비가 각각 6:1, 5:1일 때 최대가 되었다. 2) pH가 6, 7, 8로 증가함에 따라 모노클로라민이 최대로 생성되는 Cl_2 / NH_3-N비는 7:1에서 5:1로 이동하였으며, pH6 ~ 8 범위에서 pH가 증가함에 따라 모노클로라민의 생성량이 많았다. 3) 클로라민의 분해는 Cl_2 / NH_3-N비가 증가하고 pH가 낮을수록 증가하였다. 클로라민의 잔류성은 유리염소보다 월등히 좋았다. pH6에서 모노클로라민과 디클로라민이 생성된 이후, 접촉시간이 경과함에 따라 디클로라민의 분포비가 증가하였다. This study was conducted to investigate the characteristics of chloramination as a secondary disinfection in a drinking water distribution system. At the range from pH 6 to pH 8, monochloramine was predominant with a trace of dichloramine, and the free chlorine was detected after breakpoint. At 25℃, the breakpoints of pH 6, 7 and 8 appeared when the weight ratios of chlorine to ammonia nitrogen were 11:1, 9:1 and 10:1 respectively, and the peak points on the breakpoint curves at pH 6, 7 and 8 were in the Cl_2 / NH_3-N ratio of 9:1, 6:1 and 5:1 respectively. As pH increased from 6 to 8, maximum point of monochloramine on the breakpoint curve was moved from 7:1 to 5:1 in the weight ratio of chlorine to ammonia nitrogen. The maximum concentration of monochloramine was formed at the pH values of 7~8 and in the Cl_2 / NH_3-N ratio below 5:1. As the Cl_2 / NH_3-N ratio increased and the pH lowered, chloramines decay proceeded at an increased rate, and residual chloramines lasted longer than the residual free chlorine. The monochloramine and the dichloramine were formed at pH 6, and then the dichloramine continued increasing with contact lime.

내시경적 밴드 결찰술로 치료한 출혈을 동반한 위 혈관이형성증 1예

김갑식,허종현,성용완,조영화,구동영,유재훈,노지훈,문원 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Gastric angiodysplasia is vascular ectasia in mucosa and submucosa of the gastric wall. It is an uncommon cause of upper gastrointesinal hemorrhage that may occur in the stomach or duodenum. There are many kinds of endoscopic treatments, such as argon plasma coagulation, electrocoagulation, heat probe, and submucosal injection of hypertonic saline mixed with epinephrine for gastric angiodysplasia. However, these treatment methods are associated with high rate of rebleeding. In order to avoid the recurrence, endoscopic band ligation has recently been used as an alternative method for endoscopic treatment of gastric angiodysplasia. We encountered a case of gastric angiodysplasia that presented with overt bleeding and anemia, and was successfully treated with endoscopic band ligation.

Effect of gel spinning accompanied with cross-linking using boric acid on the structure and properties of high-molecular-weight poly(vinyl alcohol) fiber

Jo, Yong Gu,Shin, Eun Joo,Lee, Young Jae,Yoon, Won Sik,Han, Sung Soo,Lee, Yang Hun,Lee, Yong Rok,Noh, Seok Kyun,Gal, Yeong Soon,Lyoo, Won Seok Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of applied polymer science Vol.113 No.3

<P>To enhance the thermal stability of poly(vinyl alcohol) (PVA) fiber, the fiber was prepared from the gel spinning of high molecular weight (HMW) PVA by using dimethyl sulfoxide/water (8/2, v/v) as a solvent, accompanied with the cross-link by boric acid (B-PVA). In addition, the structure and properties of the B-PVA fiber were compared with those of the HMW PVA fiber obtained by using the same spinning system without cross-linking (NB-PVA). Through a series of experiments, it turned out that cross-linking actualized by an optimum amount of boric acid (0.3 wt % based on PVA) and zone drawing caused significant changes in the properties of HMW PVA gel fiber. That is, cross-linking increased thermal degradation temperatures at each degradation step and amounts of final residues, resulting in improving thermal properties of the PVA fiber. On the contrary, it was found that in the case of the B-PVA fiber, some broadening of the original PVA unit cell occurred, which was identified by the peak shift to lower angle in X-ray diffractogram. The tensile strength and Young's modulus of B-PVA fiber with draw ratio of 15 are 23.1 and 308.3 g/d, respectively. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009</P>

국내산 석탄회를 이용한 제올라이트 흡착제 합성 고찰

최진식,조영민 경희대학교 2006 環境硏究 論文集 Vol.15 No.-

A domestic coal fly ash was modified to zeolitic materials by two contrast methods : alkali hydrothermal method and direct synthesis. The method of direct synthesis using a high pressure hydrothermal reactor enabled more rapid to synthesize the stable structure of zealots. The reaction for 48 hours was found to be enough to form the crystalline materials. Adsorption by synthesized zeolitic materials was as good as a commercial zeolite(13X), but Cr could not be adsorbed in high efficiency.

자발성 뇌지주막하출혈 환자에서 Cardiac Troponin Ⅰ를 이용한 심근손상의 발생율

김용권,류진호,소정일,문원식,전병조,허탁,민용일 대한응급의학회 1999 대한응급의학회지 Vol.10 No.4

Background : More than 90% of acute stroke patients have measurable cardiovascular sequelae, but we have been often overlooked in formal discussions of treatment. If we estimate the incidence of myocardial injury in patients with spontaneous SAH, we may figure the possibility of cardiac dysfunction in such patients. This study was designed to investigate the incidence of myocardial injury in patients with spontaneous SAH using cardiac troponin I(cTnI). Methods : A prospective single emergency center study was performed to determined preoperative incidence of unrecognized cardiac injury in patients suffering spontaneous SAH. We include the spontaneous SAH patients who underwent serum measurements of the cardic troponin I immediately upon admission last six month period. ECG, CK, CK-MB and myoglobin were also performed at admission. We excluded the spontaneous SAH patients who had past history of myocardial ischemia and ECG abnormality. Results : Fifty-two patients(34 females, 18 males) with spontaneous SAH were studied prospectively. 18 patients(34.6% of the total study population) had cTnI level above 0.5ng/ml. ECG was performed in 52 patients and was abnormal in 15 of the 52 patients(28.8%). Conclusion : The measurement of cTnI has provided physicians with a myocardial marker that has a cardiac sensitivity for cardiac injury equal to that of CK-MB yet with greater specificity. So, cardiac troponin I is useful to estimate the incidence of myocardial injury in patients with spontaneous SAH. And we may estimate the possibility of cardiac dysfunction in such patients. This knowledge will hopefully aid in the care and improve the outcome.