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Kim, Hong,Jang, Eungyeong,Kim, So-Young,Choi, Ji-Yoon,Lee, Na-Rae,Kim, Dae-Sung,Lee, Kyung-Tae,Inn, Kyung-Soo,Kim, Bum-Joon,Lee, Jang-Hoon Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P>Hepatitis B virus (HBV) infectious diseases currently remain incurable due to limitations of conventional antivirals such as incapability of eradicating HBV DNA, prolonged use, drug resistance, and virological relapse. KCT-01, a 30% ethanol extract consisting of<I> Artemisia capillaris</I>,<I> Sanguisorba officinalis</I>, and<I> Curcuma longa</I>, was newly developed. The objective of this study was to investigate pharmacological activities of KCT-01 against HBV using HepG2.2.15 cells and a hydrodynamic injection model. KCT-01 significantly lowered antigen secretion, virion production, and pgRNA synthesis in HepG2.2.15 cells without affecting cell viability. KCT-01 administration also resulted in significant decrease of serum virion production, liver covalently closed circular (ccc) DNA levels, and mRNA synthesis of cytokines in the liver of mice injected with HBV DNA hydrodynamically. Interestingly, coadministration of KCT-01 with entecavir enhanced its<I> in vitro</I> and<I> in vivo</I> antiviral activities. Moreover, safety of KCT-01 was assured up to 5000 mg/kg in rats in both single and repeated-dose preclinical studies. Taken together, our findings demonstrate that KCT-01 is capable of suppressing HBV replication and inflammatory cytokine production in<I> in vitro</I> and<I> in vivo</I> models without showing toxicity, suggesting the potential of using KCT-01 alone or in combination with entecavir as antiviral agent.</P>
오영애,하귀현,박인경,김미향,김미정,김미경,정자림,이명숙,김순동 대구효성가톨릭대학교 식품과학연구소 1992 식품과학지 Vol.4 No.-
This paper showed the summarization of the preservative method of wild vegetables in the house and the precessing method of Japanese pickles. The preservative methods of wild vegetables were explained devided into long, short term, fresh state, heat treatment and drying. Salt, soybean fermented sauce, soybean fermented paste, lees of refined rice wine and residue in the preparation of bean curd were used as the materials of Japanese pickles.
Kim, Taesik,Woo, Sang Inn,Choi, Eunsoo,Jung, Young-Hoon Elsevier 2018 Computers and geotechnics Vol.94 No.-
<P><B>Abstract</B></P> <P>This paper introduces a new method for quantifying the morphological evolution of the strain response envelope (SRE). The Fourier series approximation was used to trace the morphological characteristics of SREs. Two SREs computed via numerical simulations using the Modified Cam Clay (MCC) model and three SREs obtained from stress-probing experiments on Chicago clay were used to validate the proposed method of Fourier series approximation. The results show that using a harmonic number of 1 or 2, the target shape of the SRE can be approximated within a 10% error.</P>
Kim, Young-Inn,Choi, Sung-Nak,Ro, Chul-Un Korean Chemical Society 1994 Bulletin of the Korean Chemical Society Vol.15 No.7
The 2-(dimethylaminomethyl)thiophene (dmamt) complexes with copper(II) chloride and bromide were prepared and characterized by optical, EPR, XPS spectroscopies and magnetic susceptibility measurements. The low-energy absorption band above 850 nm and the relatively small EPR hyperfine coupling constant ($A_{//}{\simeq}$125 G) indicate the pseudotetrahedral site symmetry around copper(II) ion both in Cu(dmamt)$Cl_2$ and Cu(dmamt)$Br_2$ complexes. The higher satellite to main peak intensity of Cu $2P_{3/2}$ core electron binding energy in XPS spectra also supports the pseudotetrahedral geometry around the copper(II) ions having $CuNSX_2$ chromophores. The distortion from square-planar to pseudotetrahedral symmetry is likely to arise from the steric hindrance of the bulky dmamt ligand in the complex. Magnetic susceptibility study shows that these compounds follow Curie-Weiss law in the temperature range of 77-300 K with positive Weiss constant exhibiting the ferromagnetic interaction between copper(II) ions in solid state.
The Role of Sodium-taurocholate Co-transporting Polypeptide as a Receptor during HBV Infection
Kim, So-Young,Jang, Eungyeong,Inn, Kyung-Soo 대한미생물학회 2016 Journal of Bacteriology and Virology Vol.46 No.4
According to World Health Organization, more than 200 million people suffer with chronic hepatitis caused by Hepatitis B virus (HBV) infection worldwide. Chronic hepatitis B causes various complications including liver cirrhosis and hepatocellular carcinoma and approximately 0.5~4.2 million deaths occur annually due to HBV infection. Current therapies such as antivirals and vaccine are often hampered by drug intolerance, side effects, and long-time medication, therefore, the development of powerful anti-HBV drugs is demanded. Recently, sodium taurocholate co-transporting polypeptide (NTCP) receptor was revealed to play a pivotal role in HBV entry into hepatocytes. Cell lines transfected with NTCP receptor enables to analyze HBV life cycle by inducing HBV infection stably, but in vivo models still have some limitations such as high costs, restrictive differentiation, and unveiled cofactors related to human NTCP. Therefore, it requires well-established in vivo models to develop and evaluate novel therapeutic agents targeting NTCP receptor, and viral entry inhibitors that inhibit the early step of viral infection are potent sufficient to substitute for existing antivirals.
Kim, Jee Wook,Lee, Dong Young,Seo, Eun Hyun,Sohn, Bo Kyung,Park, Shin Young,Choo, IL Han,Youn, Jong Chul,Jhoo, Jin Hyeong,Kim, Ki Woong,Woo, Jong Inn The Korean Academy of Medical Sciences 2013 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.28 No.10
<P>This study aimed to investigate whether the demographic variable-adjustment and supplementation of Frontal Assessment Battery (FAB) score can improve the screening ability of Mini-Mental State Examination (MMSE) for dementia and its subtypes. Five hundred forty-one non-demented comparison (NC) and 474 dementia (320 Alzheimer's disease [AD]; 139 non-Alzheimer's disease dementia [NAD]; and 15 mixed AD-NAD dementia) individuals living in the community were included. Education-adjusted MMSE (MMSE-edu) score showed significantly better screening accuracy for overall dementia, AD, and NAD than MMSE raw score. FAB-supplemented MMSE (MMSE-FAB) score had significantly better screening ability for NAD, but not for overall dementia and AD, than MMSE raw score alone. Additional supplementation of FAB to MMSE-edu further increased the ability for overall dementia or NAD screening, but not for AD screening. Further education adjustment of MMSE-FAB also improved its ability for overall dementia, AD, and NAD screening. These results strongly support the usefulness of education-adjustment and supplementation of frontal function assessment to improve screening performance of MMSE for dementia and its subtypes, NAD in particular.</P>
Kim, Yun-Jung,Hwang, So-Young,Oh, Eok-Soo,Oh, Seikwan,Han, Inn-Oc Wiley Subscription Services, Inc., A Wiley Company 2006 Journal of neuroscience research Vol.84 No.5
<P>In the present study we sought to examine cell–cell interactions by investigating the effects of factors released by stimulated microglia on inducible nitric oxide (NO) synthase (iNOS) induction in astrocytoma cells. After examining the temporal profiles of proinflammatory molecules induced by lipopolysaccharide (LPS) stimulation in BV2 microglial cells, iNOS and IL-1β were observed to be the first immediate-response molecules. Removal of LPS after 3 hr stimulation abrogated NO release, whereas a full induction of IL-1β was retained in BV2 cells. We observed consistently that conditioned medium (CM) from activated microglia resulted in the induction of iNOS in C6 cells, and IL-1β was shown to be a key regulator of iNOS induction. An IL-1β-neutralizing antibody diminished NO induction. Incubation with recombinant IL-1β stimulated NO release to a lesser extent compared to microglial CM; co-treatment of LPS and IL-1β had a potent, synergistic effect on NO release from C6 cells. Transient transfection with MEK kinase 1 (MEKK1) or nuclear factor-kappa B (NF-κB) expression plasmids induced iNOS, and IL-1β further enhanced the MEKK1 response. Furthermore, IL-1β-mediated NO release from C6 cells was significantly suppressed by inhibition of p38 mitogen activated protein kinase (MAPK) or NF-κB by specific chemical inhibitors. Both IL-1β and MEKK1 stimulated p38 and JNK MAPKs, as well as the NF-κB pathway, to induce iNOS in C6 cells. Microglia may represent an anti-tumor response in the central nervous system, which is potentiated by the local secretion of immunomodulatory factors that in turn affects astrocytoma (glioma) cells. A better understanding of microglia–glioma or microglia–astrocyte interactions will help in the design of novel immune-based therapies for brain tumors or neuronal diseases. © 2006 Wiley-Liss, Inc.</P>
Cyclopolymerization of 1,6-Heptadiyne Derivatives by Transition Metal Catalysis
Kim, Yun-Hi,Moon, Seong-bae,Kim, Young-Inn,Kyung, Kyu-Jung 부산대학교 사범대학 과학교육연구소 1997 科學敎育硏究報 Vol.24 No.-
본 연구에서는 4-위치에 에틸기와 히드록실기를 동시에 갖는 1,6-heptadiyne 유도체를 합성하여 이를 여러가지 전이 금속 촉매를 사용하여 합성하였다. MoCl_5-단독 촉매를 사용할 경우 가장 높은 중합수율을 보였으며 WCl_6-계 촉매의 경우 중합체가 얻어지지 않았다. 합성된 고분자는 여러 가지 분광 법으로 확인한 결과 주 사슬에 6각형 고리 구조를 가지면서 공액이중결합을 구조를 갖는 것으로 확인되었다. 중합된 고분자는 치환기의 효과로 여러 용매에 쉽게 용해되었으며 산화안정성도 높은 것으로 확인되었다. 합성된 고분자를 요오드로 도핑 시켜 전도도를 조사한 결과 1.2-2.5×10^-4 Scm^-1를 갖는 것으로 확인되었다. The cyclopolymerization of 4-ethyl-4-hydroxy-1,6-heptadiyne was carried out by transition metal catalysts such as MoCl_5 or WCl_6-based catalysts. The catalytic activity of MoCl_5 for this cyclopolymerization was greater than that of WCl_6. The polymerization of 4-ethyl-4-hydroxy-1,6-heptadiyne by MoCl_5 alone gives a quantitative yield of polymer. WCl_6-based catalyst system was not effective in this polymerization. The obtained polymer was generally insoluble in common organic solvents. The IR spectrum of poly(EHH) showed the stretching band of the carbon-carbon double bond at 1590-1650 cm^-1 indicate a high conjugation. The thermal properties and oxidative stability of poly(EHH) were also studied. The electrical conductivity of the 12 doped poly(EHH) was 1.2-2.5×10^-4 Scm^-1.